Found 15 hits Enz. Inhib. hit(s) with Target = 'Cytochrome P450 130' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM92569
(Arylamine compound 2)Show SMILES Nc1ccc(Sc2ccc(cc2)N2C(=O)c3ccc(N)cc3C2=O)cc1 Show InChI InChI=1S/C20H15N3O2S/c21-12-1-6-15(7-2-12)26-16-8-4-14(5-9-16)23-19(24)17-10-3-13(22)11-18(17)20(23)25/h1-11H,21-22H2 | PDB MMDB
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| DrugBank MMDB PDB Article PubMed
| n/a | n/a | n/a | 1.08E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | PDB MMDB
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 1.33E+4 | n/a | n/a | n/a | n/a | n/a |
Swansea University
Curated by ChEMBL
| Assay Description Binding affinity to Mycobacterium tuberculosis CYP130 |
Antimicrob Agents Chemother 53: 1157-64 (2009)
Article DOI: 10.1128/AAC.01237-08 BindingDB Entry DOI: 10.7270/Q22V2GCB |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM92571
(Arylamine compound 5)Show SMILES Nc1ccc(Oc2ccc3nc(-c4ccccn4)c(nc3c2)-c2ccccn2)cc1 Show InChI InChI=1S/C24H17N5O/c25-16-7-9-17(10-8-16)30-18-11-12-19-22(15-18)29-24(21-6-2-4-14-27-21)23(28-19)20-5-1-3-13-26-20/h1-15H,25H2 | PDB MMDB
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 1.34E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM92572
(Aniline | Ph-NH2)Show InChI InChI=1S/C6H7N/c7-6-4-2-1-3-5-6/h1-5H,7H2 | PDB MMDB
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DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | n/a | 5.52E+4 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM10999
(Benzenemethanamine | Bn-NH2 | CHEMBL522 | benzylam...)Show InChI InChI=1S/C7H9N/c8-6-7-4-2-1-3-5-7/h1-5H,6,8H2 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | 9.99E+6 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM31773
(ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...)Show InChI InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2 | PDB MMDB
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Similars
| Article PubMed
| n/a | n/a | n/a | 1.93E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | PDB MMDB
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 1.33E+4 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM92569
(Arylamine compound 2)Show SMILES Nc1ccc(Sc2ccc(cc2)N2C(=O)c3ccc(N)cc3C2=O)cc1 Show InChI InChI=1S/C20H15N3O2S/c21-12-1-6-15(7-2-12)26-16-8-4-14(5-9-16)23-19(24)17-10-3-13(22)11-18(17)20(23)25/h1-11H,21-22H2 | PDB MMDB
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Similars
| MMDB PDB Article PubMed
| n/a | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM92570
(Arylamine compound 4)Show InChI InChI=1S/C14H13N3/c1-10-3-2-4-12(7-10)17-9-16-13-8-11(15)5-6-14(13)17/h2-9H,15H2,1H3 | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | n/a | 3.26E+4 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM92571
(Arylamine compound 5)Show SMILES Nc1ccc(Oc2ccc3nc(-c4ccccn4)c(nc3c2)-c2ccccn2)cc1 Show InChI InChI=1S/C24H17N5O/c25-16-7-9-17(10-8-16)30-18-11-12-19-22(15-18)29-24(21-6-2-4-14-27-21)23(28-19)20-5-1-3-13-26-20/h1-15H,25H2 | PDB MMDB
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 7.02E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM92572
(Aniline | Ph-NH2)Show InChI InChI=1S/C6H7N/c7-6-4-2-1-3-5-6/h1-5H,7H2 | PDB MMDB
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DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | n/a | 2.50E+6 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM10999
(Benzenemethanamine | Bn-NH2 | CHEMBL522 | benzylam...)Show InChI InChI=1S/C7H9N/c8-6-7-4-2-1-3-5-7/h1-5H,6,8H2 | PDB MMDB
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 1.00E+7 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM31773
(ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...)Show InChI InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2 | PDB MMDB
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UniProtKB/SwissProt
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DrugBank MCE KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | PDB MMDB
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UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | |
Cytochrome P450 130
(Mycobacterium tuberculosis) | BDBM92570
(Arylamine compound 4)Show InChI InChI=1S/C14H13N3/c1-10-3-2-4-12(7-10)17-9-16-13-8-11(15)5-6-14(13)17/h2-9H,15H2,1H3 | PDB MMDB
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UniProtKB/SwissProt
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DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco
| Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. |
J Biol Chem 284: 25211-9 (2009)
Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |