BindingDB PrimarySearch

Found 10 hits Enz. Inhib. hit(s) with Target = 'Kinase suppressor of Ras 2'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kinase suppressor of Ras 2 (Human)	BDBM429286 (APS-2-79 \| US10548897, Compound 21) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai US Patent					Assay Description The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...				US Patent US10548897 (2020) BindingDB Entry DOI: 10.7270/Q25H7JMP
Icahn School of Medicine at Mount Sinai US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinase suppressor of Ras 2 (Human)	BDBM50095227 ((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	602	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai US Patent					Assay Description The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...				US Patent US10548897 (2020) BindingDB Entry DOI: 10.7270/Q25H7JMP
Icahn School of Medicine at Mount Sinai US Patent					More data for this Ligand-Target Pair
Kinase suppressor of Ras 2 (Human)	BDBM429418 (APS-2-12 \| US10548897, Compound 10) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai US Patent					Assay Description The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...				US Patent US10548897 (2020) BindingDB Entry DOI: 10.7270/Q25H7JMP
Icahn School of Medicine at Mount Sinai US Patent					More data for this Ligand-Target Pair
Kinase suppressor of Ras 2 (Human)	BDBM429420 (APS-2-16 \| D3RKN_87 \| US10548897, Compound 11) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai US Patent					Assay Description The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...				US Patent US10548897 (2020) BindingDB Entry DOI: 10.7270/Q25H7JMP
Icahn School of Medicine at Mount Sinai US Patent					More data for this Ligand-Target Pair
Kinase suppressor of Ras 2 (Human)	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human KSR2 using KRREILSRRPSYR as substrate by [gamma-33P]-ATP assay				Citation and Details Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8
TBA					More data for this Ligand-Target Pair
Kinase suppressor of Ras 2 (Human)	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of human KSR2 using KRREILSRRPSYR as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 161: 456-467 (2019) Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Kinase suppressor of Ras 2 (Human)	BDBM50227519 (4-(6,7-dimethoxyquinazolin-4-ylamino)phenol \| CHEM...) Show SMILES COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai US Patent					Assay Description The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...				US Patent US10548897 (2020) BindingDB Entry DOI: 10.7270/Q25H7JMP
Icahn School of Medicine at Mount Sinai US Patent					More data for this Ligand-Target Pair
Kinase suppressor of Ras 2 (Human)	BDBM50291090 ((6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hyd...) Show SMILES COc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai US Patent					Assay Description The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...				US Patent US10548897 (2020) BindingDB Entry DOI: 10.7270/Q25H7JMP
Icahn School of Medicine at Mount Sinai US Patent					More data for this Ligand-Target Pair
Kinase suppressor of Ras 2 (Human)	BDBM429421 (APS-3-6 \| US10548897, Compound 32) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai US Patent					Assay Description The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...				US Patent US10548897 (2020) BindingDB Entry DOI: 10.7270/Q25H7JMP
Icahn School of Medicine at Mount Sinai US Patent					More data for this Ligand-Target Pair
Kinase suppressor of Ras 2 (Human)	BDBM429415 (APS-3-77 \| US10548897, Compound 50) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai US Patent					Assay Description The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...				US Patent US10548897 (2020) BindingDB Entry DOI: 10.7270/Q25H7JMP
Icahn School of Medicine at Mount Sinai US Patent					More data for this Ligand-Target Pair