Compile Data Set for Download or QSAR

Found 105 hits of ec50 for UniProtKB: O88871   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360710 (US9828381, 5-1) Show SMILES CCCC(c1cc2nc(C)cc(N3CCCCC3CCO)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H31ClN4O/c1-3-6-21(18-8-10-19(25)11-9-18)22-16-23-26-17(2)15-24(29(23)27-22)28-13-5-4-7-20(28)12-14-30/h8-11,15-16,20-21,30H,3-7,12-14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360708 (US9828381, 4-1) Show SMILES CC(C)C(c1cc2nc(C)cc(N3CCCCC3CCO)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H31ClN4O/c1-16(2)24(18-7-9-19(25)10-8-18)21-15-22-26-17(3)14-23(29(22)27-21)28-12-5-4-6-20(28)11-13-30/h7-10,14-16,20,24,30H,4-6,11-13H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360711 (US9828381, 5-2) Show SMILES CCCC(c1cc2nc(C)cc(N3CCCC(F)(F)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClF2N4/c1-3-5-18(16-6-8-17(23)9-7-16)19-13-20-26-15(2)12-21(29(20)27-19)28-11-4-10-22(24,25)14-28/h6-9,12-13,18H,3-5,10-11,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360706 (US9828381, 3-1) Show SMILES CCC(c1cc2nc(C)cc(N3CCCCC3CCO)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C23H29ClN4O/c1-3-20(17-7-9-18(24)10-8-17)21-15-22-25-16(2)14-23(28(22)26-21)27-12-5-4-6-19(27)11-13-29/h7-10,14-15,19-20,29H,3-6,11-13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24195 (3-aminopropylphosphinic derivative, (R)-7 | AZD335...) Show SMILES NC[C@@H](F)CP(O)=O |r| Show InChI InChI=1S/C3H9FNO2P/c4-3(1-5)2-8(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	5.10	-11.2	n/a	n/a	8.64	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360709 (US9828381, 4-2) Show SMILES CC(C)C(c1cc2nc(C)cc(N3CCCC(F)(F)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClF2N4/c1-14(2)21(16-5-7-17(23)8-6-16)18-12-19-26-15(3)11-20(29(19)27-18)28-10-4-9-22(24,25)13-28/h5-8,11-12,14,21H,4,9-10,13H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24198 (3-aminopropylphosphinic derivative, (R)-8 | [(2R)-...) Show SMILES CP(O)(=O)C[C@H](F)CN |r| Show InChI InChI=1S/C4H11FNO2P/c1-9(7,8)3-4(5)2-6/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.30	-11.3	n/a	n/a	14	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360707 (US9828381, 3-2) Show SMILES CCC(c1cc2nc(C)cc(N3CCCC(F)(F)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClF2N4/c1-3-17(15-5-7-16(22)8-6-15)18-12-19-25-14(2)11-20(28(19)26-18)27-10-4-9-21(23,24)13-27/h5-8,11-12,17H,3-4,9-10,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24193 ((3-amino-2-fluoropropyl)phosphinic acid | 3-aminop...) Show SMILES NCC(F)CP(O)=O Show InChI InChI=1S/C3H9FNO2P/c4-3(1-5)2-8(6)7/h3,8H,1-2,5H2,(H,6,7)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	10	-10.8	n/a	n/a	15	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24184 ((3-aminopropyl)phosphinic acid | 3-aminopropylphos...) Show SMILES NCCCP(O)=O Show InChI InChI=1S/C3H10NO2P/c4-2-1-3-7(5)6/h7H,1-4H2,(H,5,6)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	15	-10.6	n/a	n/a	19	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24196 ((3-amino-2-fluoropropyl)(methyl)phosphinic acid | ...) Show SMILES CP(O)(=O)CC(F)CN Show InChI InChI=1S/C4H11FNO2P/c1-9(7,8)3-4(5)2-6/h4H,2-3,6H2,1H3,(H,7,8)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	14	-10.6	n/a	n/a	23	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...) Show SMILES CP(O)(=O)CCCN Show InChI InChI=1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	33	-10.1	n/a	n/a	41	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360693 (US9828381, 2-11) Show SMILES CC(c1cc2nc(C)cc(N3CCC[C@@H](O)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H23ClN4O/c1-13-10-20(24-9-3-4-17(26)12-24)25-19(22-13)11-18(23-25)14(2)15-5-7-16(21)8-6-15/h5-8,10-11,14,17,26H,3-4,9,12H2,1-2H3/t14?,17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	57	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360704 (US9828381, 2-22) Show SMILES CC[C@@H]1CCCCN1c1cc(C)nc2cc(nn12)C(C)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H27ClN4/c1-4-19-7-5-6-12-26(19)22-13-15(2)24-21-14-20(25-27(21)22)16(3)17-8-10-18(23)11-9-17/h8-11,13-14,16,19H,4-7,12H2,1-3H3/t16?,19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360690 (US9828381, 2-8) Show SMILES CC(c1cc2nc(C)cc(NC(C)(C)C)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H23ClN4/c1-12-10-18(22-19(3,4)5)24-17(21-12)11-16(23-24)13(2)14-6-8-15(20)9-7-14/h6-11,13,22H,1-5H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24191 ((3-amino-2-oxopropyl)phosphinic acid | (3-amino-2-...) Show SMILES NCC(=O)CP(O)=O Show InChI InChI=1S/C3H8NO3P/c4-1-3(5)2-8(6)7/h8H,1-2,4H2,(H,6,7)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	48	-9.88	n/a	n/a	81	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360717 (US9828381, 8-2) Show SMILES CC(c1cc2nc(C)cc(N3CCCCC3CCO)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H27F3N4O/c1-15-13-22(29-11-4-3-5-19(29)10-12-31)30-21(27-15)14-20(28-30)16(2)17-6-8-18(9-7-17)23(24,25)26/h6-9,13-14,16,19,31H,3-5,10-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	87	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360702 (US9828381, 2-20) Show SMILES CC(c1cc2nc(C)cc(N3CCC4(CCC4O)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClN4O/c1-14-11-21(26-10-9-22(13-26)8-7-19(22)28)27-20(24-14)12-18(25-27)15(2)16-3-5-17(23)6-4-16/h3-6,11-12,15,19,28H,7-10,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	93	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360683 (US9828381, 2-1) Show SMILES CC(c1cc2nc(C)cc(N3CCCCC3CCO)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H27ClN4O/c1-15-13-22(26-11-4-3-5-19(26)10-12-28)27-21(24-15)14-20(25-27)16(2)17-6-8-18(23)9-7-17/h6-9,13-14,16,19,28H,3-5,10-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	118	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360686 (US9828381, 2-4) Show SMILES CC(c1cc2nc(C)cc(N3CCC(F)CC3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22ClFN4/c1-13-11-20(25-9-7-17(22)8-10-25)26-19(23-13)12-18(24-26)14(2)15-3-5-16(21)6-4-15/h3-6,11-12,14,17H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	128	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) Show SMILES NCC(=O)CP(O)O Show InChI InChI=1S/C3H8NO3P/c4-1-3(5)2-8(6)7/h6-7H,1-2,4H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	-9.85	n/a	n/a	130	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360687 (US9828381, 2-5) Show SMILES CC(c1cc2nc(C)cc(N3CCCCC3CO)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H25ClN4O/c1-14-11-21(25-10-4-3-5-18(25)13-27)26-20(23-14)12-19(24-26)15(2)16-6-8-17(22)9-7-16/h6-9,11-12,15,18,27H,3-5,10,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	146	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24189 (3-aminopropylphosphinic derivative, (R)-4 | 3-amin...) Show SMILES CP(O)(O)CC(=O)CN Show InChI InChI=1S/C4H12NO3P/c1-9(7,8)3-4(6)2-5/h7-9H,2-3,5H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	180	-9.10	n/a	n/a	150	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360692 (US9828381, 2-10) Show SMILES CC(c1cc2nc(C)cc(N3CCC[C@H](O)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H23ClN4O/c1-13-10-20(24-9-3-4-17(26)12-24)25-19(22-13)11-18(23-25)14(2)15-5-7-16(21)8-6-15/h5-8,10-11,14,17,26H,3-4,9,12H2,1-2H3/t14?,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	152	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360696 (US9828381, 2-14) Show SMILES CC(c1cc2nc(C)cc(NC3CC(F)C3)n2n1)c1ccc(Cl)cc1 |(-3.48,-2.64,;-2.71,-1.3,;-1.17,-1.3,;-.27,-.06,;1.2,-.53,;2.53,.24,;3.86,-.53,;5.2,.24,;3.86,-2.07,;2.53,-2.84,;2.53,-4.38,;1.2,-5.15,;.8,-6.64,;-.69,-6.24,;-2.02,-7.01,;-.29,-4.75,;1.2,-2.07,;-.27,-2.55,;-3.48,.03,;-2.71,1.36,;-3.48,2.7,;-5.02,2.7,;-5.79,4.03,;-5.79,1.36,;-5.02,.03,)| Show InChI InChI=1S/C19H20ClFN4/c1-11-7-18(23-16-8-15(21)9-16)25-19(22-11)10-17(24-25)12(2)13-3-5-14(20)6-4-13/h3-7,10,12,15-16,23H,8-9H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	165	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360689 (US9828381, 2-7) Show SMILES CC(c1cc2nc(C)cc(N3CCCC(F)(F)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H21ClF2N4/c1-13-10-19(26-9-3-8-20(22,23)12-26)27-18(24-13)11-17(25-27)14(2)15-4-6-16(21)7-5-15/h4-7,10-11,14H,3,8-9,12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	185	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) Show SMILES NCC(=O)CP(O)O Show InChI InChI=1S/C3H8NO3P/c4-1-3(5)2-8(6)7/h6-7H,1-2,4H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	94	-9.48	n/a	n/a	220	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360688 (US9828381, 2-6) Show SMILES CC(c1cc2nc(C)cc(N3CCCC(F)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22ClFN4/c1-13-10-20(25-9-3-4-17(22)12-25)26-19(23-13)11-18(24-26)14(2)15-5-7-16(21)8-6-15/h5-8,10-11,14,17H,3-4,9,12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	242	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24194 (3-aminopropylphosphinic derivative, (S)-7 | [(2S)-...) Show SMILES NC[C@H](F)CP(O)=O |r| Show InChI InChI=1S/C3H9FNO2P/c4-3(1-5)2-8(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	70	-9.66	n/a	n/a	250	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24192 ((3-amino-2-oxopropyl)(methyl)phosphinic acid | (3-...) Show SMILES CP(O)(=O)CC(=O)CN Show InChI InChI=1S/C4H10NO3P/c1-9(7,8)3-4(6)2-5/h2-3,5H2,1H3,(H,7,8)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	200	-9.04	n/a	n/a	270	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360734 (US9828381, 8-19) Show SMILES CC(c1cc2nc(C)cc(NC(C)(C)C)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H23F3N4/c1-12-10-18(25-19(3,4)5)27-17(24-12)11-16(26-27)13(2)14-6-8-15(9-7-14)20(21,22)23/h6-11,13,25H,1-5H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	274	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360724 (US9828381, 8-9) Show SMILES CC(c1cc2nc(C)cc(N3CCCCC3CO)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H25F3N4O/c1-14-11-21(28-10-4-3-5-18(28)13-30)29-20(26-14)12-19(27-29)15(2)16-6-8-17(9-7-16)22(23,24)25/h6-9,11-12,15,18,30H,3-5,10,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	344	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360720 ((3R)-1-(5-methyl-2-{1-[4-(trifluoromethyl)phenyl]e...) Show SMILES CC(c1cc2nc(C)cc(N3CCC[C@@H](O)C3)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H23F3N4O/c1-13-10-20(27-9-3-4-17(29)12-27)28-19(25-13)11-18(26-28)14(2)15-5-7-16(8-6-15)21(22,23)24/h5-8,10-11,14,17,29H,3-4,9,12H2,1-2H3/t14?,17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	365	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360727 (US9828381, 8-12) Show SMILES CC(c1cc2nc(C)cc(N3CCCC(F)C3)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H22F4N4/c1-13-10-20(28-9-3-4-17(22)12-28)29-19(26-13)11-18(27-29)14(2)15-5-7-16(8-6-15)21(23,24)25/h5-8,10-11,14,17H,3-4,9,12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360726 (US9828381, 8-11) Show SMILES CC(c1cc2nc(C)cc(N3CCC(F)CC3)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H22F4N4/c1-13-11-20(28-9-7-17(22)8-10-28)29-19(26-13)12-18(27-29)14(2)15-3-5-16(6-4-15)21(23,24)25/h3-6,11-12,14,17H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	378	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360703 (US9828381, 2-21) Show SMILES CC(c1cc2nc(C)cc(NC3CC(F)(F)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H19ClF2N4/c1-11-7-17(24-15-9-19(21,22)10-15)26-18(23-11)8-16(25-26)12(2)13-3-5-14(20)6-4-13/h3-8,12,15,24H,9-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	394	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360718 (US9828381, 8-3) Show SMILES CC(c1cc2nc(C)cc(N3CCC4(COC4)C3)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H23F3N4O/c1-14-9-20(28-8-7-21(11-28)12-30-13-21)29-19(26-14)10-18(27-29)15(2)16-3-5-17(6-4-16)22(23,24)25/h3-6,9-10,15H,7-8,11-13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	420	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360684 (US9828381, 2-2) Show SMILES CC(c1cc2nc(C)cc(NC3(C)CC3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H21ClN4/c1-12-10-18(22-19(3)8-9-19)24-17(21-12)11-16(23-24)13(2)14-4-6-15(20)7-5-14/h4-7,10-11,13,22H,8-9H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	435	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360695 (US9828381, 2-13) Show SMILES CC(c1cc2nc(C)cc(N3CC4(C3)CCOCC4)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClN4O/c1-15-11-21(26-13-22(14-26)7-9-28-10-8-22)27-20(24-15)12-19(25-27)16(2)17-3-5-18(23)6-4-17/h3-6,11-12,16H,7-10,13-14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	446	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360700 (US9828381, 2-18) Show SMILES CC(c1cc2nc(C)cc(N[C@@H]3C[C@H](O)C3)n2n1)c1ccc(Cl)cc1 |r,wU:11.10,13.13,(-3.48,-2.64,;-2.71,-1.3,;-1.17,-1.3,;-.27,-.06,;1.2,-.53,;2.53,.24,;3.86,-.53,;5.2,.24,;3.86,-2.07,;2.53,-2.84,;2.53,-4.38,;1.2,-5.15,;-.29,-4.75,;-.69,-6.24,;-2.02,-7.01,;.8,-6.64,;1.2,-2.07,;-.27,-2.55,;-3.48,.03,;-2.71,1.36,;-3.48,2.7,;-5.02,2.7,;-5.79,4.03,;-5.79,1.36,;-5.02,.03,)| Show InChI InChI=1S/C19H21ClN4O/c1-11-7-18(22-15-8-16(25)9-15)24-19(21-11)10-17(23-24)12(2)13-3-5-14(20)6-4-13/h3-7,10,12,15-16,22,25H,8-9H2,1-2H3/t12?,15-,16+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	499	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360735 (US9828381, 8-20) Show SMILES CC(c1cc2nc(C)cc(NC3CC(F)(F)C3)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H19F5N4/c1-11-7-17(27-15-9-19(21,22)10-15)29-18(26-11)8-16(28-29)12(2)13-3-5-14(6-4-13)20(23,24)25/h3-8,12,15,27H,9-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360685 (US9828381, 2-3) Show SMILES CC(c1cc2nc(C)cc(N3CCC(F)(F)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H19ClF2N4/c1-12-9-18(25-8-7-19(21,22)11-25)26-17(23-12)10-16(24-26)13(2)14-3-5-15(20)6-4-14/h3-6,9-10,13H,7-8,11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	508	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360721 (US9828381, 8-6) Show SMILES CC(c1cc2nc(C)cc(NC3CC(F)C3)n2n1)c1ccc(cc1)C(F)(F)F |(.11,-.56,;.88,.77,;2.42,.77,;3.32,-.48,;4.79,,;6.12,-.77,;7.45,,;8.79,-.77,;7.45,1.54,;6.12,2.31,;6.12,3.85,;7.45,4.62,;8.94,4.22,;9.34,5.71,;10.67,6.48,;7.85,6.11,;4.79,1.54,;3.32,2.02,;.11,2.1,;-1.43,2.1,;-2.2,3.44,;-1.43,4.77,;.11,4.77,;.88,3.44,;-2.2,6.1,;-2.97,7.44,;-.87,6.87,;-3.54,5.33,)| Show InChI InChI=1S/C20H20F4N4/c1-11-7-18(26-16-8-15(21)9-16)28-19(25-11)10-17(27-28)12(2)13-3-5-14(6-4-13)20(22,23)24/h3-7,10,12,15-16,26H,8-9H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	509	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360736 (US9828381, 8-21) Show SMILES CC(c1cc2nc(C)cc(N3CCC4(COC4)CC3)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H25F3N4O/c1-15-11-21(29-9-7-22(8-10-29)13-31-14-22)30-20(27-15)12-19(28-30)16(2)17-3-5-18(6-4-17)23(24,25)26/h3-6,11-12,16H,7-10,13-14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	561	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360730 (US9828381, 8-15) Show SMILES CC(c1cc2nc(C)cc(N3CCC(F)(F)C3)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H19F5N4/c1-12-9-18(28-8-7-19(21,22)11-28)29-17(26-12)10-16(27-29)13(2)14-3-5-15(6-4-14)20(23,24)25/h3-6,9-10,13H,7-8,11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	570	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360698 (US9828381, 2-16) Show SMILES CC(c1cc2nc(C)cc(NCC3CC(F)(F)C3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H21ClF2N4/c1-12-7-18(24-11-14-9-20(22,23)10-14)27-19(25-12)8-17(26-27)13(2)15-3-5-16(21)6-4-15/h3-8,13-14,24H,9-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	586	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360729 (US9828381, 8-14) Show SMILES CC(c1cc2nc(C)cc(NCC3CC(F)(F)C3)n2n1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H21F5N4/c1-12-7-18(27-11-14-9-20(22,23)10-14)30-19(28-12)8-17(29-30)13(2)15-3-5-16(6-4-15)21(24,25)26/h3-8,13-14,27H,9-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	593	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat))	BDBM24189 (3-aminopropylphosphinic derivative, (R)-4 | 3-amin...) Show SMILES CP(O)(O)CC(=O)CN Show InChI InChI=1S/C4H12NO3P/c1-9(7,8)3-4(6)2-5/h7-9H,2-3,5H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	840	-8.20	n/a	n/a	600	n/a	n/a	7.4	22
AstraZeneca					Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...				J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360691 (US9828381, 2-9) Show SMILES CC(c1cc2nc(C)cc(N3CCC4(COC4)CC3)n2n1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H25ClN4O/c1-15-11-21(26-9-7-22(8-10-26)13-28-14-22)27-20(24-15)12-19(25-27)16(2)17-3-5-18(23)6-4-17/h3-6,11-12,16H,7-10,13-14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	604	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 2 (Rattus norvegicus)	BDBM360741 (US9828381, 9-4) Show SMILES CC(c1cc2nc(C)cc(N3CCCC(F)(F)C3)n2n1)c1ccc(Cl)cn1 Show InChI InChI=1S/C19H20ClF2N5/c1-12-8-18(26-7-3-6-19(21,22)11-26)27-17(24-12)9-16(25-27)13(2)15-5-4-14(20)10-23-15/h4-5,8-10,13H,3,6-7,11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	628	n/a	n/a	n/a	n/a
AbbVie Deutschland GmbH & Co. KG; AbbVie Inc. US Patent					Assay Description The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...				US Patent US9828381 (2017) BindingDB Entry DOI: 10.7270/Q21C205Q
					More data for this Ligand-Target Pair

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