Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta2 | J Med Chem 40: 4169-94 (1998) Article DOI: 10.1021/jm970377o BindingDB Entry DOI: 10.7270/Q2QF8TH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
University of Wollongong Curated by ChEMBL | Assay Description Binding affinity against nicotinic acetylcholine receptor alpha3-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells | Bioorg Med Chem Lett 14: 271-3 (2003) BindingDB Entry DOI: 10.7270/Q2MC8ZD0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Indian Institute of Technology Curated by ChEMBL | Assay Description Agonist activity at alpha-3-beta-4 nAChR in KXalpha-3-beta-4R2 cells by rubidium efflux assay | J Med Chem 47: 6691-701 (2004) Article DOI: 10.1021/jm049707c BindingDB Entry DOI: 10.7270/Q2XS5Z5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-4 (Homo sapiens (Human)) | BDBM50459884 (CHEMBL4228846) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 237 | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of human alpha4beta4 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro... | Bioorg Med Chem Lett 27: 3207-3218 (2017) Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4 (Homo sapiens (Human)) | BDBM50459884 (CHEMBL4228846) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 286 | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of human alpha2beta4 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro... | Bioorg Med Chem Lett 27: 3207-3218 (2017) Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50049750 ((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Compound was evaluated for functional potency and efficacy at rat Nicotinic acetylcholine receptor in PC12 cells (ganglionic) | J Med Chem 40: 4169-94 (1998) Article DOI: 10.1021/jm970377o BindingDB Entry DOI: 10.7270/Q2QF8TH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50397943 (CHEMBL2179959) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
Targacept, Inc. Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysis | Bioorg Med Chem Lett 23: 1450-5 (2013) Article DOI: 10.1016/j.bmcl.2012.12.054 BindingDB Entry DOI: 10.7270/Q2SQ939P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50137787 (6-(6-Chloro-pyridin-3-yl)-8-aza-bicyclo[3.2.1]octa...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a |
University of Wollongong Curated by ChEMBL | Assay Description Binding affinity of the compound was determined against Nicotinic acetylcholine receptor using [3H]-(-)-nicotine radioligand | Bioorg Med Chem Lett 14: 271-3 (2003) BindingDB Entry DOI: 10.7270/Q2MC8ZD0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50387569 (CHEMBL2057714) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a |
Targacept, Inc. Curated by ChEMBL | Assay Description Antagonist activity at human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells assessed as calcium flux by fluorescence analysis | Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50406539 (CHEMBL4175573) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a |
Istituto di Chimica Biomolecolare Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ... | Eur J Med Chem 152: 401-416 (2018) Article DOI: 10.1016/j.ejmech.2018.04.026 BindingDB Entry DOI: 10.7270/Q2930WQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50270282 ((E/Z)-3-benzylidenequinuclidine | CHEMBL478358) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
Targacept, Inc. Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysis | Bioorg Med Chem Lett 23: 1450-5 (2013) Article DOI: 10.1016/j.bmcl.2012.12.054 BindingDB Entry DOI: 10.7270/Q2SQ939P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM82070 (CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a |
University of Wollongong Curated by ChEMBL | Assay Description Agonistic potency against nicotinic acetylcholine receptor alpha3-beta4 | Bioorg Med Chem Lett 14: 271-3 (2003) BindingDB Entry DOI: 10.7270/Q2MC8ZD0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4 (Homo sapiens (Human)) | BDBM50052593 (3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4 (Homo sapiens (Human)) | BDBM50052593 (3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50387568 (CHEMBL2057713) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a |
Targacept, Inc. Curated by ChEMBL | Assay Description Antagonist activity at human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells assessed as calcium flux by fluorescence analysis | Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50369150 (CHEMBL1788226) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-4 (Homo sapiens (Human)) | BDBM82070 (CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50549595 (CHEMBL4741357) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Partial agonist activity at human alpha3beta4 transfected in rat GH4-C1 cells at holding potential of -70 mV by whole cell patch clamp electrophysiol... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01150 BindingDB Entry DOI: 10.7270/Q2K93C4G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50490639 (CHEMBL2332278) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
Targacept, Inc. Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysis | Bioorg Med Chem Lett 23: 1450-5 (2013) Article DOI: 10.1016/j.bmcl.2012.12.054 BindingDB Entry DOI: 10.7270/Q2SQ939P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-4 (Homo sapiens (Human)) | BDBM50052593 (3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-4 (Homo sapiens (Human)) | BDBM50052593 (3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4 (Homo sapiens (Human)) | BDBM50369150 (CHEMBL1788226) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes. | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50441363 (CHEMBL2332280) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Targacept, Inc. Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysis | Bioorg Med Chem Lett 23: 1450-5 (2013) Article DOI: 10.1016/j.bmcl.2012.12.054 BindingDB Entry DOI: 10.7270/Q2SQ939P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50490640 (3-Benzhydrylquinuclidine | CHEMBL2332279) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Targacept, Inc. Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysis | Bioorg Med Chem Lett 23: 1450-5 (2013) Article DOI: 10.1016/j.bmcl.2012.12.054 BindingDB Entry DOI: 10.7270/Q2SQ939P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50515333 (CHEMBL4460815) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Universit£ di Sassari Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70... | Eur J Med Chem 180: 51-61 (2019) Article DOI: 10.1016/j.ejmech.2019.06.079 BindingDB Entry DOI: 10.7270/Q24Q7ZBT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50515335 (CHEMBL4532589) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Universit£ di Sassari Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70... | Eur J Med Chem 180: 51-61 (2019) Article DOI: 10.1016/j.ejmech.2019.06.079 BindingDB Entry DOI: 10.7270/Q24Q7ZBT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4 (Homo sapiens (Human)) | BDBM82070 (CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50406688 (CHEMBL4166620) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Istituto di Chimica Biomolecolare Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ... | Eur J Med Chem 152: 401-416 (2018) Article DOI: 10.1016/j.ejmech.2018.04.026 BindingDB Entry DOI: 10.7270/Q2930WQM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50476217 (CHEMBL375281) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.38E+4 | n/a | n/a | n/a | n/a |
Indian Institute of Technology Curated by ChEMBL | Assay Description Agonist activity at alpha-3-beta-4 nAChR in KXalpha-3-beta-4R2 cells by rubidium efflux assay | J Med Chem 47: 6691-701 (2004) Article DOI: 10.1021/jm049707c BindingDB Entry DOI: 10.7270/Q2XS5Z5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4 (Homo sapiens (Human)) | BDBM86544 (CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes. | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4 (Homo sapiens (Human)) | BDBM86544 (CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50357064 (CHEMBL1917231) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Partial agonist activity at human alpha3beta4 transfected in rat GH4-C1 cells at holding potential of -70 mV by whole cell patch clamp electrophysiol... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01150 BindingDB Entry DOI: 10.7270/Q2K93C4G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50476213 (CHEMBL375732) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.82E+4 | n/a | n/a | n/a | n/a |
Indian Institute of Technology Curated by ChEMBL | Assay Description Agonist activity at alpha-3-beta-4 nAChR in KXalpha-3-beta-4R2 cells by rubidium efflux assay | J Med Chem 47: 6691-701 (2004) Article DOI: 10.1021/jm049707c BindingDB Entry DOI: 10.7270/Q2XS5Z5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50549596 (CHEMBL4785648) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Partial agonist activity at human alpha3beta4 transfected in rat GH4-C1 cells at holding potential of -70 mV by whole cell patch clamp electrophysiol... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01150 BindingDB Entry DOI: 10.7270/Q2K93C4G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM82070 (CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.98E+4 | n/a | n/a | n/a | n/a |
Indian Institute of Technology Curated by ChEMBL | Assay Description Agonist activity at alpha-3-beta-4 nAChR in KXalpha-3-beta-4R2 cells by rubidium efflux assay | J Med Chem 47: 6691-701 (2004) Article DOI: 10.1021/jm049707c BindingDB Entry DOI: 10.7270/Q2XS5Z5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50139124 (CHEMBL3759208) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano Curated by ChEMBL | Assay Description Agonist activity at human alpha3beta4 nACh receptor expressed in rat GH4C1 cells assessed as increase in current amplitudes after 2 to 3 days by patc... | Eur J Med Chem 108: 392-405 (2016) Article DOI: 10.1016/j.ejmech.2015.11.045 BindingDB Entry DOI: 10.7270/Q2ZS2ZCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50476216 (CHEMBL374956) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.08E+4 | n/a | n/a | n/a | n/a |
Indian Institute of Technology Curated by ChEMBL | Assay Description Agonist activity at alpha-3-beta-4 nAChR in KXalpha-3-beta-4R2 cells by rubidium efflux assay | J Med Chem 47: 6691-701 (2004) Article DOI: 10.1021/jm049707c BindingDB Entry DOI: 10.7270/Q2XS5Z5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM82070 (CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic) | J Med Chem 40: 4169-94 (1998) Article DOI: 10.1021/jm970377o BindingDB Entry DOI: 10.7270/Q2QF8TH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-4 (Homo sapiens (Human)) | BDBM86544 (CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50052593 (3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha3-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50052593 (3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha3-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-4 (Homo sapiens (Human)) | BDBM86544 (CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50143282 ((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2 | J Med Chem 40: 4169-94 (1998) Article DOI: 10.1021/jm970377o BindingDB Entry DOI: 10.7270/Q2QF8TH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50476218 (CHEMBL223121) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.64E+4 | n/a | n/a | n/a | n/a |
Indian Institute of Technology Curated by ChEMBL | Assay Description Agonist activity at alpha-3-beta-4 nAChR in KXalpha-3-beta-4R2 cells by rubidium efflux assay | J Med Chem 47: 6691-701 (2004) Article DOI: 10.1021/jm049707c BindingDB Entry DOI: 10.7270/Q2XS5Z5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4 (Homo sapiens (Human)) | BDBM50369150 (CHEMBL1788226) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes. | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM10759 (2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Functional potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain) | J Med Chem 40: 4169-94 (1998) Article DOI: 10.1021/jm970377o BindingDB Entry DOI: 10.7270/Q2QF8TH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM50387567 (CHEMBL2057712) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a |
Targacept, Inc. Curated by ChEMBL | Assay Description Antagonist activity at human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells assessed as calcium flux by fluorescence analysis | Bioorg Med Chem Lett 22: 5089-92 (2012) Article DOI: 10.1016/j.bmcl.2012.05.108 BindingDB Entry DOI: 10.7270/Q24X58W1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-4 (Homo sapiens (Human)) | BDBM50071366 (7-Methoxy-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-h...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by ChEMBL | Assay Description Compound was evaluated for its agonist activity against activated human recombinant Nicotinic acetylcholine receptor alpha4-beta4 in Xenopus Oocytes | Bioorg Med Chem Lett 8: 2173-8 (1999) BindingDB Entry DOI: 10.7270/Q2V9877J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM86544 (CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha3-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human)) | BDBM86544 (CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc. Curated by PDSP Ki Database | Assay Description The compound was tested on recombinant human alpha3-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... | J Med Chem 39: 3235-7 (1996) Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 | |||||||||||
More data for this Ligand-Target Pair |
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