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Compile Data Set for Download or QSAR

Found 186 hits of ic50 for UniProtKB: P35400   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305863
PNG
(3-(3-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Show SMILES COc1cccc(c1)-c1noc2cc(-c3ccccc3)n(C)c(=O)c12
Show InChI InChI=1S/C20H16N2O3/c1-22-16(13-7-4-3-5-8-13)12-17-18(20(22)23)19(21-25-17)14-9-6-10-15(11-14)24-2/h3-12H,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305859
PNG
(5-methyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)...)
Show SMILES Cn1c(cc2onc(-c3ccccc3)c2c1=O)-c1ccccc1
Show InChI InChI=1S/C19H14N2O2/c1-21-15(13-8-4-2-5-9-13)12-16-17(19(21)22)18(20-23-16)14-10-6-3-7-11-14/h2-12H,1H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305864
PNG
(3-(2-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Show SMILES COc1ccccc1-c1noc2cc(-c3ccccc3)n(C)c(=O)c12
Show InChI InChI=1S/C20H16N2O3/c1-22-15(13-8-4-3-5-9-13)12-17-18(20(22)23)19(21-25-17)14-10-6-7-11-16(14)24-2/h3-12H,1-2H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50196289
PNG
(6-(4-methoxyphenyl)-5-methyl-3-phenylisoxazolo[4,5...)
Show SMILES COc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
Show InChI InChI=1S/C20H16N2O3/c1-22-16(13-8-10-15(24-2)11-9-13)12-17-18(20(22)23)19(21-25-17)14-6-4-3-5-7-14/h3-12H,1-2H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50196291
PNG
(6-(benzo[d][1,3]dioxol-5-yl)-5-methyl-3-phenylisox...)
Show SMILES Cn1c(cc2onc(-c3ccccc3)c2c1=O)-c1ccc2OCOc2c1
Show InChI InChI=1S/C20H14N2O4/c1-22-14(13-7-8-15-16(9-13)25-11-24-15)10-17-18(20(22)23)19(21-26-17)12-5-3-2-4-6-12/h2-10H,11H2,1H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305877
PNG
(6-(4-methoxyphenyl)-5-methyl-3-(pyridin-4-yl)isoxa...)
Show SMILES COc1ccc(cc1)-c1cc2onc(-c3ccncc3)c2c(=O)n1C
Show InChI InChI=1S/C19H15N3O3/c1-22-15(12-3-5-14(24-2)6-4-12)11-16-17(19(22)23)18(21-25-16)13-7-9-20-10-8-13/h3-11H,1-2H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305862
PNG
(3-(4-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Show SMILES COc1ccc(cc1)-c1noc2cc(-c3ccccc3)n(C)c(=O)c12
Show InChI InChI=1S/C20H16N2O3/c1-22-16(13-6-4-3-5-7-13)12-17-18(20(22)23)19(21-25-17)14-8-10-15(24-2)11-9-14/h3-12H,1-2H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305873
PNG
(6-(3-(dimethylamino)phenyl)-5-methyl-3-phenylisoxa...)
Show SMILES CN(C)c1cccc(c1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
Show InChI InChI=1S/C21H19N3O2/c1-23(2)16-11-7-10-15(12-16)17-13-18-19(21(25)24(17)3)20(22-26-18)14-8-5-4-6-9-14/h4-13H,1-3H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305868
PNG
(5-methyl-3-phenyl-6-p-tolylisoxazolo[4,5-c]pyridin...)
Show SMILES Cc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
Show InChI InChI=1S/C20H16N2O2/c1-13-8-10-14(11-9-13)16-12-17-18(20(23)22(16)2)19(21-24-17)15-6-4-3-5-7-15/h3-12H,1-2H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305869
PNG
(6-(4-fluorophenyl)-5-methyl-3-phenylisoxazolo[4,5-...)
Show SMILES Cn1c(cc2onc(-c3ccccc3)c2c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C19H13FN2O2/c1-22-15(12-7-9-14(20)10-8-12)11-16-17(19(22)23)18(21-24-16)13-5-3-2-4-6-13/h2-11H,1H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305874
PNG
(5-methyl-3-phenyl-6-(3-(trifluoromethyl)phenyl)iso...)
Show SMILES Cn1c(cc2onc(-c3ccccc3)c2c1=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H13F3N2O2/c1-25-15(13-8-5-9-14(10-13)20(21,22)23)11-16-17(19(25)26)18(24-27-16)12-6-3-2-4-7-12/h2-11H,1H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305865
PNG
(5-methyl-6-phenyl-3-(pyridin-4-yl)isoxazolo[4,5-c]...)
Show SMILES Cn1c(cc2onc(-c3ccncc3)c2c1=O)-c1ccccc1
Show InChI InChI=1S/C18H13N3O2/c1-21-14(12-5-3-2-4-6-12)11-15-16(18(21)22)17(20-23-15)13-7-9-19-10-8-13/h2-11H,1H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305870
PNG
(6-(4-(dimethylamino)phenyl)-5-methyl-3-phenylisoxa...)
Show SMILES CN(C)c1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
Show InChI InChI=1S/C21H19N3O2/c1-23(2)16-11-9-14(10-12-16)17-13-18-19(21(25)24(17)3)20(22-26-18)15-7-5-4-6-8-15/h4-13H,1-3H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305872
PNG
(5-methyl-3-phenyl-6-(4-propylphenyl)isoxazolo[4,5-...)
Show SMILES CCCc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
Show InChI InChI=1S/C22H20N2O2/c1-3-7-15-10-12-16(13-11-15)18-14-19-20(22(25)24(18)2)21(23-26-19)17-8-5-4-6-9-17/h4-6,8-14H,3,7H2,1-2H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305875
PNG
(6-(3-fluoro-4-methoxyphenyl)-5-methyl-3-phenylisox...)
Show SMILES COc1ccc(cc1F)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
Show InChI InChI=1S/C20H15FN2O3/c1-23-15(13-8-9-16(25-2)14(21)10-13)11-17-18(20(23)24)19(22-26-17)12-6-4-3-5-7-12/h3-11H,1-2H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305866
PNG
(5-methyl-6-phenyl-3-(pyridin-3-yl)isoxazolo[4,5-c]...)
Show SMILES Cn1c(cc2onc(-c3cccnc3)c2c1=O)-c1ccccc1
Show InChI InChI=1S/C18H13N3O2/c1-21-14(12-6-3-2-4-7-12)10-15-16(18(21)22)17(20-23-15)13-8-5-9-19-11-13/h2-11H,1H3
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Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50589650
PNG
(CHEMBL5202961)
Show SMILES COc1cc(OCC(=O)Nc2cc(OC(F)(F)F)ccc2-n2cncn2)ccc1OC1COC1
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Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128923
BindingDB Entry DOI: 10.7270/Q2KD22VT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50589650
PNG
(CHEMBL5202961)
Show SMILES COc1cc(OCC(=O)Nc2cc(OC(F)(F)F)ccc2-n2cncn2)ccc1OC1COC1
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Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128923
BindingDB Entry DOI: 10.7270/Q2KD22VT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50531687
PNG
(CHEMBL4445682)
Show SMILES COc1cc(ccc1OCC1CC1)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C21H19F3N4O4/c1-30-19-8-14(4-7-18(19)31-10-13-2-3-13)20(29)27-16-9-15(32-21(22,23)24)5-6-17(16)28-12-25-11-26-28/h4-9,11-13H,2-3,10H2,1H3,(H,27,29)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preinc...

J Med Chem 62: 1690-1695 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01810
BindingDB Entry DOI: 10.7270/Q2QC070T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50531687
PNG
(CHEMBL4445682)
Show SMILES COc1cc(ccc1OCC1CC1)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C21H19F3N4O4/c1-30-19-8-14(4-7-18(19)31-10-13-2-3-13)20(29)27-16-9-15(32-21(22,23)24)5-6-17(16)28-12-25-11-26-28/h4-9,11-13H,2-3,10H2,1H3,(H,27,29)
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Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128923
BindingDB Entry DOI: 10.7270/Q2KD22VT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50531687
PNG
(CHEMBL4445682)
Show SMILES COc1cc(ccc1OCC1CC1)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C21H19F3N4O4/c1-30-19-8-14(4-7-18(19)31-10-13-2-3-13)20(29)27-16-9-15(32-21(22,23)24)5-6-17(16)28-12-25-11-26-28/h4-9,11-13H,2-3,10H2,1H3,(H,27,29)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preinc...

J Med Chem 62: 1690-1695 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01810
BindingDB Entry DOI: 10.7270/Q2QC070T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50553636
PNG
(CHEMBL4750685)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1-c1cnc(c(OC)c1)-c1ccccc1OC
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n/an/a 350n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...

Citation and Details

Article DOI: 10.1016/j.bmcl.2020.127529
BindingDB Entry DOI: 10.7270/Q28K7DQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50553631
PNG
(CHEMBL4739931)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1-c1ccc(nc1)-c1ccccc1OCC
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n/an/a 370n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...

Citation and Details

Article DOI: 10.1016/j.bmcl.2020.127529
BindingDB Entry DOI: 10.7270/Q28K7DQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50553632
PNG
(CHEMBL4745605)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1-c1ccc(nc1)-c1ccccc1SC
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n/an/a 410n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...

Citation and Details

Article DOI: 10.1016/j.bmcl.2020.127529
BindingDB Entry DOI: 10.7270/Q28K7DQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50523865
PNG
(CHEMBL4476495)
Show SMILES COc1ccc(cc1OC)-c1nnc(o1)-c1cc(OC(F)(F)F)ccc1-n1ccnc1
Show InChI InChI=1S/C20H15F3N4O4/c1-28-16-6-3-12(9-17(16)29-2)18-25-26-19(30-18)14-10-13(31-20(21,22)23)4-5-15(14)27-8-7-24-11-27/h3-11H,1-2H3
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n/an/a 501n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128923
BindingDB Entry DOI: 10.7270/Q2KD22VT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280369
PNG
(CHEMBL4169114)
Show SMILES CCOc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C19H17F3N4O4/c1-3-29-16-7-4-12(8-17(16)28-2)18(27)25-14-9-13(30-19(20,21)22)5-6-15(14)26-11-23-10-24-26/h4-11H,3H2,1-2H3,(H,25,27)
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n/an/a 501n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128923
BindingDB Entry DOI: 10.7270/Q2KD22VT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50523865
PNG
(CHEMBL4476495)
Show SMILES COc1ccc(cc1OC)-c1nnc(o1)-c1cc(OC(F)(F)F)ccc1-n1ccnc1
Show InChI InChI=1S/C20H15F3N4O4/c1-28-16-6-3-12(9-17(16)29-2)18-25-26-19(30-18)14-10-13(31-20(21,22)23)4-5-15(14)27-8-7-24-11-27/h3-11H,1-2H3
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n/an/a 501n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128923
BindingDB Entry DOI: 10.7270/Q2KD22VT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50553610
PNG
(CHEMBL4793197)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(CC1)c1ccccc1SC
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n/an/a 510n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...

Citation and Details

Article DOI: 10.1016/j.bmcl.2020.127529
BindingDB Entry DOI: 10.7270/Q28K7DQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280369
PNG
(CHEMBL4169114)
Show SMILES CCOc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C19H17F3N4O4/c1-3-29-16-7-4-12(8-17(16)28-2)18(27)25-14-9-13(30-19(20,21)22)5-6-15(14)26-11-23-10-24-26/h4-11H,3H2,1-2H3,(H,25,27)
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n/an/a 510n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280369
PNG
(CHEMBL4169114)
Show SMILES CCOc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C19H17F3N4O4/c1-3-29-16-7-4-12(8-17(16)28-2)18(27)25-14-9-13(30-19(20,21)22)5-6-15(14)26-11-23-10-24-26/h4-11H,3H2,1-2H3,(H,25,27)
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n/an/a 513n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50553635
PNG
(CHEMBL4743016)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1-c1cnc(cn1)-c1ccccc1OC
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n/an/a 540n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...

Citation and Details

Article DOI: 10.1016/j.bmcl.2020.127529
BindingDB Entry DOI: 10.7270/Q28K7DQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280369
PNG
(CHEMBL4169114)
Show SMILES CCOc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C19H17F3N4O4/c1-3-29-16-7-4-12(8-17(16)28-2)18(27)25-14-9-13(30-19(20,21)22)5-6-15(14)26-11-23-10-24-26/h4-11H,3H2,1-2H3,(H,25,27)
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n/an/a 550n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128923
BindingDB Entry DOI: 10.7270/Q2KD22VT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50523865
PNG
(CHEMBL4476495)
Show SMILES COc1ccc(cc1OC)-c1nnc(o1)-c1cc(OC(F)(F)F)ccc1-n1ccnc1
Show InChI InChI=1S/C20H15F3N4O4/c1-28-16-6-3-12(9-17(16)29-2)18-25-26-19(30-18)14-10-13(31-20(21,22)23)4-5-15(14)27-8-7-24-11-27/h3-11H,1-2H3
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n/an/a 570n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...

Bioorg Med Chem Lett 29: 1211-1214 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.016
BindingDB Entry DOI: 10.7270/Q2WH2TDX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50305876
PNG
(6-(3-bromo-4-methoxyphenyl)-5-methyl-3-phenylisoxa...)
Show SMILES COc1ccc(cc1Br)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
Show InChI InChI=1S/C20H15BrN2O3/c1-23-15(13-8-9-16(25-2)14(21)10-13)11-17-18(20(23)24)19(22-26-17)12-6-4-3-5-7-12/h3-11H,1-2H3
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n/an/a 580n/an/an/an/an/an/a



Banyu Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPR

Bioorg Med Chem Lett 20: 726-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.070
BindingDB Entry DOI: 10.7270/Q2F18ZSX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50553630
PNG
(CHEMBL4758459)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1-c1ccc(nc1)-c1ccccc1OC
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n/an/a 600n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...

Citation and Details

Article DOI: 10.1016/j.bmcl.2020.127529
BindingDB Entry DOI: 10.7270/Q28K7DQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50553603
PNG
(CHEMBL1349403)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(CC1)c1ccccc1OC
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n/an/a 647n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...

Citation and Details

Article DOI: 10.1016/j.bmcl.2020.127529
BindingDB Entry DOI: 10.7270/Q28K7DQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280374
PNG
(CHEMBL4174742)
Show SMILES CCc1nc2c(CC(CC2=O)c2ccc(C)cc2C)o1
Show InChI InChI=1S/C17H19NO2/c1-4-16-18-17-14(19)8-12(9-15(17)20-16)13-6-5-10(2)7-11(13)3/h5-7,12H,4,8-9H2,1-3H3
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n/an/a 650n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as decrease in glutamate-induced thallium...

ACS Med Chem Lett 8: 1110-1115 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00317
BindingDB Entry DOI: 10.7270/Q2B85BN1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50553644
PNG
(CHEMBL4785180)
Show SMILES CCOC(=O)c1cnc2c(OC)cc(OC)cc2c1N1CCN(CC1)c1ccccc1OC
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n/an/a 670n/an/an/an/an/an/a


TBA

Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...

Citation and Details

Article DOI: 10.1016/j.bmcl.2020.127529
BindingDB Entry DOI: 10.7270/Q28K7DQ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280374
PNG
(CHEMBL4174742)
Show SMILES CCc1nc2c(CC(CC2=O)c2ccc(C)cc2C)o1
Show InChI InChI=1S/C17H19NO2/c1-4-16-18-17-14(19)8-12(9-15(17)20-16)13-6-5-10(2)7-11(13)3/h5-7,12H,4,8-9H2,1-3H3
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n/an/a 676n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280374
PNG
(CHEMBL4174742)
Show SMILES CCc1nc2c(CC(CC2=O)c2ccc(C)cc2C)o1
Show InChI InChI=1S/C17H19NO2/c1-4-16-18-17-14(19)8-12(9-15(17)20-16)13-6-5-10(2)7-11(13)3/h5-7,12H,4,8-9H2,1-3H3
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n/an/a 676n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280370
PNG
(CHEMBL4160395)
Show SMILES COc1cc(ccc1OC1CC1)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C20H17F3N4O4/c1-29-18-8-12(2-7-17(18)30-13-3-4-13)19(28)26-15-9-14(31-20(21,22)23)5-6-16(15)27-11-24-10-25-27/h2,5-11,13H,3-4H2,1H3,(H,26,28)
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n/an/a 708n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280370
PNG
(CHEMBL4160395)
Show SMILES COc1cc(ccc1OC1CC1)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C20H17F3N4O4/c1-29-18-8-12(2-7-17(18)30-13-3-4-13)19(28)26-15-9-14(31-20(21,22)23)5-6-16(15)27-11-24-10-25-27/h2,5-11,13H,3-4H2,1H3,(H,26,28)
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n/an/a 710n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280368
PNG
(CHEMBL4176971)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C18H15F3N4O4/c1-27-15-6-3-11(7-16(15)28-2)17(26)24-13-8-12(29-18(19,20)21)4-5-14(13)25-10-22-9-23-25/h3-10H,1-2H3,(H,24,26)
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n/an/a 759n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preinc...

J Med Chem 62: 1690-1695 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01810
BindingDB Entry DOI: 10.7270/Q2QC070T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280368
PNG
(CHEMBL4176971)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C18H15F3N4O4/c1-27-15-6-3-11(7-16(15)28-2)17(26)24-13-8-12(29-18(19,20)21)4-5-14(13)25-10-22-9-23-25/h3-10H,1-2H3,(H,24,26)
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n/an/a 759n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128923
BindingDB Entry DOI: 10.7270/Q2KD22VT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280368
PNG
(CHEMBL4176971)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C18H15F3N4O4/c1-27-15-6-3-11(7-16(15)28-2)17(26)24-13-8-12(29-18(19,20)21)4-5-14(13)25-10-22-9-23-25/h3-10H,1-2H3,(H,24,26)
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n/an/a 759n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280368
PNG
(CHEMBL4176971)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C18H15F3N4O4/c1-27-15-6-3-11(7-16(15)28-2)17(26)24-13-8-12(29-18(19,20)21)4-5-14(13)25-10-22-9-23-25/h3-10H,1-2H3,(H,24,26)
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n/an/a 760n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280368
PNG
(CHEMBL4176971)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C18H15F3N4O4/c1-27-15-6-3-11(7-16(15)28-2)17(26)24-13-8-12(29-18(19,20)21)4-5-14(13)25-10-22-9-23-25/h3-10H,1-2H3,(H,24,26)
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n/an/a 760n/an/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preinc...

J Med Chem 62: 1690-1695 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01810
BindingDB Entry DOI: 10.7270/Q2QC070T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280373
PNG
(CHEMBL4161847)
Show SMILES CCCOc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C20H19F3N4O4/c1-3-8-30-17-7-4-13(9-18(17)29-2)19(28)26-15-10-14(31-20(21,22)23)5-6-16(15)27-12-24-11-25-27/h4-7,9-12H,3,8H2,1-2H3,(H,26,28)
PDB

UniProtKB/SwissProt

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UniChem

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n/an/a 776n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280372
PNG
(CHEMBL4165849)
Show SMILES COc1cc(ccc1OC(C)C)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C20H19F3N4O4/c1-12(2)30-17-7-4-13(8-18(17)29-3)19(28)26-15-9-14(31-20(21,22)23)5-6-16(15)27-11-24-10-25-27/h4-12H,1-3H3,(H,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 776n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Rattus norvegicus (Rat))		BDBM50280373
PNG
(CHEMBL4161847)
Show SMILES CCCOc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1
Show InChI InChI=1S/C20H19F3N4O4/c1-3-8-30-17-7-4-13(9-18(17)29-2)19(28)26-15-10-14(31-20(21,22)23)5-6-16(15)27-12-24-11-25-27/h4-7,9-12H,3,8H2,1-2H3,(H,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 780n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin I converting enzyme of rats.

ACS Med Chem Lett 8: 1326-1330 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00429
BindingDB Entry DOI: 10.7270/Q25X2CG2
More data for this
Ligand-Target Pair
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