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Compile Data Set for Download or QSAR

Found 283 hits of ic50 for UniProtKB: P35439   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140341
PNG
(6-(3-(4-(4-fluorobenzyl)piperidin-1-yl)prop-1-ynyl...)
Show SMILES Fc1ccc(CC2CCN(CC#Cc3cnc4[nH]c(=O)[nH]c4c3)CC2)cc1
Show InChI InChI=1S/C21H21FN4O/c22-18-5-3-15(4-6-18)12-16-7-10-26(11-8-16)9-1-2-17-13-19-20(23-14-17)25-21(27)24-19/h3-6,13-14,16H,7-12H2,(H2,23,24,25,27)
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n/an/a 2n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50091636
PNG
(5-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Fc1ccc(CC2CCN(CC#Cc3ccc4[nH]c(=O)[nH]c4c3)CC2)cc1
Show InChI InChI=1S/C22H22FN3O/c23-19-6-3-17(4-7-19)14-18-9-12-26(13-10-18)11-1-2-16-5-8-20-21(15-16)25-22(27)24-20/h3-8,15,18H,9-14H2,(H2,24,25,27)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140339
PNG
(5-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Cc1cc2[nH]c(=O)[nH]c2cc1C#CCN1CCC(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C23H24FN3O/c1-16-13-21-22(26-23(28)25-21)15-19(16)3-2-10-27-11-8-18(9-12-27)14-17-4-6-20(24)7-5-17/h4-7,13,15,18H,8-12,14H2,1H3,(H2,25,26,28)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50066544
PNG
(4-[2-(5-Phenyl-pentylamino)-ethyl]-phenol | CHEMBL...)
Show SMILES Oc1ccc(CCNCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C19H25NO/c21-19-12-10-18(11-13-19)14-16-20-15-6-2-5-9-17-7-3-1-4-8-17/h1,3-4,7-8,10-13,20-21H,2,5-6,9,14-16H2
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n/an/a 8n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptor

J Med Chem 41: 3499-506 (1998)


Article DOI: 10.1021/jm980235+
BindingDB Entry DOI: 10.7270/Q29Z95MM
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50080029
PNG
(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA receptor NR1C/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiologica...

J Med Chem 55: 10532-9 (2012)


Article DOI: 10.1021/jm301508d
BindingDB Entry DOI: 10.7270/Q2RN3919
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50080029
PNG
(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.

J Med Chem 42: 3412-20 (1999)


Article DOI: 10.1021/jm990199u
BindingDB Entry DOI: 10.7270/Q2RR1XFD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140333
PNG
(5-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES COc1cc2[nH]c(=O)[nH]c2cc1C#CCN1CCC(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C23H24FN3O2/c1-29-22-15-21-20(25-23(28)26-21)14-18(22)3-2-10-27-11-8-17(9-12-27)13-16-4-6-19(24)7-5-16/h4-7,14-15,17H,8-13H2,1H3,(H2,25,26,28)
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n/an/a 9n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50080029
PNG
(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Antagonist activity against rat 1A/2B subtype of N-methyl-D-aspartate(NMDA) receptor in xenopus oocytes.

Bioorg Med Chem Lett 9: 1619-24 (1999)


BindingDB Entry DOI: 10.7270/Q29022ZJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50369783
PNG
(CHEMBL1203902)
Show SMILES Oc1ccc(cc1)C1=CCN(CCCCc2ccccc2)CC1 |t:8|
Show InChI InChI=1S/C21H25NO/c23-21-11-9-19(10-12-21)20-13-16-22(17-14-20)15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-13,23H,4-5,8,14-17H2
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n/an/a 11n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50085922
PNG
(4-(4-Hydroxy-phenyl)-1-(4-phenyl-butyl)-piperidin-...)
Show SMILES Oc1ccc(cc1)C1(O)CCN(CCCCc2ccccc2)CC1
Show InChI InChI=1S/C21H27NO2/c23-20-11-9-19(10-12-20)21(24)13-16-22(17-14-21)15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-12,23-24H,4-5,8,13-17H2
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n/an/a 12n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50091635
PNG
(5-{3-[4-(3-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Fc1cccc(CC2CCN(CC#Cc3ccc4[nH]c(=O)[nH]c4c3)CC2)c1
Show InChI InChI=1S/C22H22FN3O/c23-19-5-1-3-18(14-19)13-17-8-11-26(12-9-17)10-2-4-16-6-7-20-21(15-16)25-22(27)24-20/h1,3,5-7,14-15,17H,8-13H2,(H2,24,25,27)
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n/an/a 14n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50066538
PNG
(4-[3-(4-Phenyl-butylamino)-propyl]-phenol | CHEMBL...)
Show SMILES Oc1ccc(CCCNCCCCc2ccccc2)cc1
Show InChI InChI=1S/C19H25NO/c21-19-13-11-18(12-14-19)10-6-16-20-15-5-4-9-17-7-2-1-3-8-17/h1-3,7-8,11-14,20-21H,4-6,9-10,15-16H2
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n/an/a 15n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptor

J Med Chem 41: 3499-506 (1998)


Article DOI: 10.1021/jm980235+
BindingDB Entry DOI: 10.7270/Q29Z95MM
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140331
PNG
(6-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Fc1ccc(CC2CCN(CC#Cc3ccc4[nH]c(=O)oc4c3)CC2)cc1
Show InChI InChI=1S/C22H21FN2O2/c23-19-6-3-17(4-7-19)14-18-9-12-25(13-10-18)11-1-2-16-5-8-20-21(15-16)27-22(26)24-20/h3-8,15,18H,9-14H2,(H,24,26)
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n/an/a 15n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50080029
PNG
(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of rat NMDA receptor NR1F/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiologica...

J Med Chem 55: 10532-9 (2012)


Article DOI: 10.1021/jm301508d
BindingDB Entry DOI: 10.7270/Q2RN3919
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50085933
PNG
(4-[1-(5-Phenyl-pentyl)-pyrrolidin-3-yl]-phenol | C...)
Show SMILES Oc1ccc(cc1)C1CCN(CCCCCc2ccccc2)C1
Show InChI InChI=1S/C21H27NO/c23-21-12-10-19(11-13-21)20-14-16-22(17-20)15-6-2-5-9-18-7-3-1-4-8-18/h1,3-4,7-8,10-13,20,23H,2,5-6,9,14-17H2
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CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50038168
PNG
(7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...)
Show SMILES Oc1c(-c2cccc(Oc3ccccc3)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
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n/an/a 18n/an/an/an/an/an/a



Université Louis Pasteur

Curated by ChEMBL


Assay Description
Antagonistic activity for suppression of membrane current response elicited by fixed concentration of glycine and glutamate in Xenopus oocyte express...

J Med Chem 42: 4394-404 (1999)


BindingDB Entry DOI: 10.7270/Q2HT2NJB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50085927
PNG
(4-[1-(2-Hydroxy-4-phenyl-butyl)-piperidin-4-yl]-ph...)
Show SMILES OC(CCc1ccccc1)CN1CCC(CC1)c1ccc(O)cc1
Show InChI InChI=1S/C21H27NO2/c23-20-10-7-18(8-11-20)19-12-14-22(15-13-19)16-21(24)9-6-17-4-2-1-3-5-17/h1-5,7-8,10-11,19,21,23-24H,6,9,12-16H2
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n/an/a 19n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50369786
PNG
(CHEMBL1201889)
Show SMILES Oc1ccc(cc1)C1CCN(CCOCc2ccccc2)CC1
Show InChI InChI=1S/C20H25NO2/c22-20-8-6-18(7-9-20)19-10-12-21(13-11-19)14-15-23-16-17-4-2-1-3-5-17/h1-9,19,22H,10-16H2
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n/an/a 19n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140334
PNG
(5-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Fc1ccc(CC2CCN(CC#Cc3ccc4[nH]c(=S)[nH]c4c3)CC2)cc1
Show InChI InChI=1S/C22H22FN3S/c23-19-6-3-17(4-7-19)14-18-9-12-26(13-10-18)11-1-2-16-5-8-20-21(15-16)25-22(27)24-20/h3-8,15,18H,9-14H2,(H2,24,25,27)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140327
PNG
(6-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Cc1cc(cc2[nH]c(=O)[nH]c12)C#CCN1CCC(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C23H24FN3O/c1-16-13-19(15-21-22(16)26-23(28)25-21)3-2-10-27-11-8-18(9-12-27)14-17-4-6-20(24)7-5-17/h4-7,13,15,18H,8-12,14H2,1H3,(H2,25,26,28)
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n/an/a 20n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50066538
PNG
(4-[3-(4-Phenyl-butylamino)-propyl]-phenol | CHEMBL...)
Show SMILES Oc1ccc(CCCNCCCCc2ccccc2)cc1
Show InChI InChI=1S/C19H25NO/c21-19-13-11-18(12-14-19)10-6-16-20-15-5-4-9-17-7-2-1-3-8-17/h1-3,7-8,11-14,20-21H,4-6,9-10,15-16H2
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n/an/a 20n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Antagonist activity against rat 1A/2B subtype of N-methyl-D-aspartate(NMDA) receptor in xenopus oocytes.

Bioorg Med Chem Lett 9: 1619-24 (1999)


BindingDB Entry DOI: 10.7270/Q29022ZJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50081743
PNG
(1-[4-(1H-Imidazol-4-yl)-but-3-ynyl]-4-(4-methyl-be...)
Show SMILES Cc1ccc(CC2CCN(CCC#Cc3cnc[nH]3)CC2)cc1
Show InChI InChI=1S/C20H25N3/c1-17-5-7-18(8-6-17)14-19-9-12-23(13-10-19)11-3-2-4-20-15-21-16-22-20/h5-8,15-16,19H,3,9-14H2,1H3,(H,21,22)
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n/an/a 20n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of NMDA response at NR1A/2B receptor expressed in Xenopus oocytes

Bioorg Med Chem Lett 9: 2815-8 (1999)


BindingDB Entry DOI: 10.7270/Q2Z037BT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50091629
PNG
(5-{3-[4-(4-Fluoro-benzyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(Cc2ccc(F)cc2)CCN(CC#Cc2ccc3[nH]c(=O)[nH]c3c2)CC1
Show InChI InChI=1S/C22H22FN3O2/c23-18-6-3-17(4-7-18)15-22(28)9-12-26(13-10-22)11-1-2-16-5-8-19-20(14-16)25-21(27)24-19/h3-8,14,28H,9-13,15H2,(H2,24,25,27)
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n/an/a 21n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50369791
PNG
(CHEMBL1202296)
Show SMILES Oc1ccc(cc1)C1CCN(CCCCc2ccccc2)CC1
Show InChI InChI=1S/C21H27NO/c23-21-11-9-19(10-12-21)20-13-16-22(17-14-20)15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-12,20,23H,4-5,8,13-17H2
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n/an/a 22n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50082020
PNG
(2-Chloro-N-{2-[3-(7-chloro-4-hydroxy-2-oxo-1,2-dih...)
Show SMILES Oc1c(-c2cccc(Oc3ccccc3NC(=O)CCl)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C23H16Cl2N2O4/c24-12-20(28)26-17-6-1-2-7-19(17)31-15-5-3-4-13(10-15)21-22(29)16-9-8-14(25)11-18(16)27-23(21)30/h1-11H,12H2,(H,26,28)(H2,27,29,30)
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n/an/a 24n/an/an/an/an/an/a



Université Louis Pasteur

Curated by ChEMBL


Assay Description
Antagonistic activity for suppression of membrane current response elicited by fixed concentration of glycine and glutamate in Xenopus oocyte express...

J Med Chem 42: 4394-404 (1999)


BindingDB Entry DOI: 10.7270/Q2HT2NJB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140335
PNG
(6-{3-[4-(4-Fluoro-benzyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(Cc2ccc(F)cc2)CCN(CC#Cc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H21FN2O2S/c23-18-6-3-17(4-7-18)15-22(27)9-12-25(13-10-22)11-1-2-16-5-8-19-20(14-16)28-21(26)24-19/h3-8,14,27H,9-13,15H2,(H,24,26)
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n/an/a 24n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50079386
PNG
(4-[2-(4-Benzyl-piperidin-1-yl)-ethoxy]-phenol | 4-...)
Show SMILES Oc1ccc(OCCN2CCC(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C20H25NO2/c22-19-6-8-20(9-7-19)23-15-14-21-12-10-18(11-13-21)16-17-4-2-1-3-5-17/h1-9,18,22H,10-16H2
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n/an/a 25n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytes

J Med Chem 42: 2993-3000 (1999)


Article DOI: 10.1021/jm990246i
BindingDB Entry DOI: 10.7270/Q2RX9B8W
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50085929
PNG
(4-(4-Hydroxy-phenyl)-1-(2-hydroxy-4-phenyl-butyl)-...)
Show SMILES OC(CCc1ccccc1)CN1CCC(O)(CC1)c1ccc(O)cc1
Show InChI InChI=1S/C21H27NO3/c23-19-10-7-18(8-11-19)21(25)12-14-22(15-13-21)16-20(24)9-6-17-4-2-1-3-5-17/h1-5,7-8,10-11,20,23-25H,6,9,12-16H2
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n/an/a 26n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50079389
PNG
(4-{2-[4-(4-Methyl-benzyl)-piperidin-1-yl]-ethoxy}-...)
Show SMILES Cc1ccc(CC2CCN(CCOc3ccc(O)cc3)CC2)cc1
Show InChI InChI=1S/C21H27NO2/c1-17-2-4-18(5-3-17)16-19-10-12-22(13-11-19)14-15-24-21-8-6-20(23)7-9-21/h2-9,19,23H,10-16H2,1H3
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n/an/a 28n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytes

J Med Chem 42: 2993-3000 (1999)


Article DOI: 10.1021/jm990246i
BindingDB Entry DOI: 10.7270/Q2RX9B8W
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50081749
PNG
(4-(4-Chloro-benzyl)-1-[4-(1H-imidazol-4-yl)-but-3-...)
Show SMILES Clc1ccc(CC2CCN(CCC#Cc3cnc[nH]3)CC2)cc1
Show InChI InChI=1S/C19H22ClN3/c20-18-6-4-16(5-7-18)13-17-8-11-23(12-9-17)10-2-1-3-19-14-21-15-22-19/h4-7,14-15,17H,2,8-13H2,(H,21,22)
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n/an/a 28n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of NMDA response at NR1A/2B receptor expressed in Xenopus oocytes

Bioorg Med Chem Lett 9: 2815-8 (1999)


BindingDB Entry DOI: 10.7270/Q2Z037BT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140325
PNG
(6-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Cc1c(C)c2[nH]c(=O)[nH]c2cc1C#CCN1CCC(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C24H26FN3O/c1-16-17(2)23-22(26-24(29)27-23)15-20(16)4-3-11-28-12-9-19(10-13-28)14-18-5-7-21(25)8-6-18/h5-8,15,19H,9-14H2,1-2H3,(H2,26,27,29)
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n/an/a 31n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50082024
PNG
(2-{2-[3-(7-Chloro-4-hydroxy-2-oxo-1,2-dihydro-quin...)
Show SMILES Oc1c(-c2cccc(Oc3ccccc3NCCS(F)(=O)=O)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C23H18ClFN2O5S/c24-15-8-9-17-19(13-15)27-23(29)21(22(17)28)14-4-3-5-16(12-14)32-20-7-2-1-6-18(20)26-10-11-33(25,30)31/h1-9,12-13,26H,10-11H2,(H2,27,28,29)
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n/an/a 32n/an/an/an/an/an/a



Université Louis Pasteur

Curated by ChEMBL


Assay Description
Antagonistic activity for suppression of membrane current response elicited by fixed concentration of glycine and glutamate in Xenopus oocyte express...

J Med Chem 42: 4394-404 (1999)


BindingDB Entry DOI: 10.7270/Q2HT2NJB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50066547
PNG
(4-[2-(6-Phenyl-hexylamino)-ethyl]-phenol | CHEMBL4...)
Show SMILES Oc1ccc(CCNCCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C20H27NO/c22-20-13-11-19(12-14-20)15-17-21-16-7-2-1-4-8-18-9-5-3-6-10-18/h3,5-6,9-14,21-22H,1-2,4,7-8,15-17H2
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n/an/a 35n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptor

J Med Chem 41: 3499-506 (1998)


Article DOI: 10.1021/jm980235+
BindingDB Entry DOI: 10.7270/Q29Z95MM
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50081748
PNG
(4-Benzyl-1-[4-(1H-imidazol-4-yl)-but-3-ynyl]-piper...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)C#Cc1cnc[nH]1
Show InChI InChI=1S/C19H23N3/c1-2-6-17(7-3-1)14-18-9-12-22(13-10-18)11-5-4-8-19-15-20-16-21-19/h1-3,6-7,15-16,18H,5,9-14H2,(H,20,21)
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n/an/a 37n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of NMDA response at NR1A/2B receptor expressed in Xenopus oocytes

Bioorg Med Chem Lett 9: 2815-8 (1999)


BindingDB Entry DOI: 10.7270/Q2Z037BT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50082027
PNG
(2-Chloro-N-{3-[3-(7-chloro-4-hydroxy-2-oxo-1,2-dih...)
Show SMILES Oc1c(-c2cccc(Oc3cccc(NC(=O)CCl)c3)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C23H16Cl2N2O4/c24-12-20(28)26-15-4-2-6-17(11-15)31-16-5-1-3-13(9-16)21-22(29)18-8-7-14(25)10-19(18)27-23(21)30/h1-11H,12H2,(H,26,28)(H2,27,29,30)
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n/an/a 39n/an/an/an/an/an/a



Université Louis Pasteur

Curated by ChEMBL


Assay Description
Antagonistic activity for suppression of membrane current response elicited by fixed concentration of glycine and glutamate in Xenopus oocyte express...

J Med Chem 42: 4394-404 (1999)


BindingDB Entry DOI: 10.7270/Q2HT2NJB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50066539
PNG
(4-[2-(4-Phenyl-butylamino)-ethyl]-phenol | CHEMBL1...)
Show SMILES Oc1ccc(CCNCCCCc2ccccc2)cc1
Show InChI InChI=1S/C18H23NO/c20-18-11-9-17(10-12-18)13-15-19-14-5-4-8-16-6-2-1-3-7-16/h1-3,6-7,9-12,19-20H,4-5,8,13-15H2
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n/an/a 43n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptor

J Med Chem 41: 3499-506 (1998)


Article DOI: 10.1021/jm980235+
BindingDB Entry DOI: 10.7270/Q29Z95MM
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50079385
PNG
(1-[2-(4-Hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl...)
Show SMILES Cc1ccc(CC2(O)CCN(CCOc3ccc(O)cc3)CC2)cc1
Show InChI InChI=1S/C21H27NO3/c1-17-2-4-18(5-3-17)16-21(24)10-12-22(13-11-21)14-15-25-20-8-6-19(23)7-9-20/h2-9,23-24H,10-16H2,1H3
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n/an/a 43n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytes

J Med Chem 42: 2993-3000 (1999)


Article DOI: 10.1021/jm990246i
BindingDB Entry DOI: 10.7270/Q2RX9B8W
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50066546
PNG
(4-[3-(5-Phenyl-pentylamino)-propyl]-phenol | CHEMB...)
Show SMILES Oc1ccc(CCCNCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C20H27NO/c22-20-14-12-19(13-15-20)11-7-17-21-16-6-2-5-10-18-8-3-1-4-9-18/h1,3-4,8-9,12-15,21-22H,2,5-7,10-11,16-17H2
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n/an/a 45n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Functional antagonism by electrical assays in Xenopus oocytes expressing the 1A/2B NMDA receptor

J Med Chem 41: 3499-506 (1998)


Article DOI: 10.1021/jm980235+
BindingDB Entry DOI: 10.7270/Q29Z95MM
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50081753
PNG
(4-(4-Fluoro-benzyl)-1-[4-(1H-imidazol-4-yl)-but-3-...)
Show SMILES Fc1ccc(CC2CCN(CCC#Cc3cnc[nH]3)CC2)cc1
Show InChI InChI=1S/C19H22FN3/c20-18-6-4-16(5-7-18)13-17-8-11-23(12-9-17)10-2-1-3-19-14-21-15-22-19/h4-7,14-15,17H,2,8-13H2,(H,21,22)
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n/an/a 50n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of NMDA response at NR1A/2B receptor expressed in Xenopus oocytes

Bioorg Med Chem Lett 9: 2815-8 (1999)


BindingDB Entry DOI: 10.7270/Q2Z037BT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50078318
PNG
(2-(4-Phenyl-butyl)-2,3,4,9-tetrahydro-1H-beta-carb...)
Show SMILES Oc1ccc2c3CCN(CCCCc4ccccc4)Cc3[nH]c2c1
Show InChI InChI=1S/C21H24N2O/c24-17-9-10-18-19-11-13-23(15-21(19)22-20(18)14-17)12-5-4-8-16-6-2-1-3-7-16/h1-3,6-7,9-10,14,22,24H,4-5,8,11-13,15H2
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n/an/a 50n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Antagonist activity against rat 1A/2B subtype of N-methyl-D-aspartate(NMDA) receptor in xenopus oocytes.

Bioorg Med Chem Lett 9: 1619-24 (1999)


BindingDB Entry DOI: 10.7270/Q29022ZJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50079388
PNG
(4-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-ethoxy}-...)
Show SMILES Oc1ccc(OCCN2CCC(Cc3ccc(F)cc3)CC2)cc1
Show InChI InChI=1S/C20H24FNO2/c21-18-3-1-16(2-4-18)15-17-9-11-22(12-10-17)13-14-24-20-7-5-19(23)6-8-20/h1-8,17,23H,9-15H2
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n/an/a 50n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytes

J Med Chem 42: 2993-3000 (1999)


Article DOI: 10.1021/jm990246i
BindingDB Entry DOI: 10.7270/Q2RX9B8W
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140336
PNG
(6-{3-[4-(4-Fluoro-benzyl)-4-hydroxy-piperidin-1-yl...)
Show SMILES OC1(Cc2ccc(F)cc2)CCN(CC#Cc2ccc3[nH]c(=O)oc3c2)CC1
Show InChI InChI=1S/C22H21FN2O3/c23-18-6-3-17(4-7-18)15-22(27)9-12-25(13-10-22)11-1-2-16-5-8-19-20(14-16)28-21(26)24-19/h3-8,14,27H,9-13,15H2,(H,24,26)
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n/an/a 51n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50140340
PNG
(5-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Fc1ccc(CC2CCN(CC#Cc3ccc4NC(=O)Cc4c3)CC2)cc1
Show InChI InChI=1S/C23H23FN2O/c24-21-6-3-18(4-7-21)14-19-9-12-26(13-10-19)11-1-2-17-5-8-22-20(15-17)16-23(27)25-22/h3-8,15,19H,9-14,16H2,(H,25,27)
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n/an/a 56n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity against NR1A/2B receptor in rat brains by [3H]-ifenprodil displacement.

Bioorg Med Chem Lett 14: 1213-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.049
BindingDB Entry DOI: 10.7270/Q2057FBV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50304085
PNG
(CHEMBL607819 | N-(2-(3,4-Dichlorophenylamino)ethyl...)
Show SMILES CS(=O)(=O)Nc1ccc(OCC(=O)NCCNc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C17H19Cl2N3O4S/c1-27(24,25)22-12-2-5-14(6-3-12)26-11-17(23)21-9-8-20-13-4-7-15(18)16(19)10-13/h2-7,10,20,22H,8-9,11H2,1H3,(H,21,23)
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n/an/a 57n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at wild type rat NR1/NR2B receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced curren...

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50304085
PNG
(CHEMBL607819 | N-(2-(3,4-Dichlorophenylamino)ethyl...)
Show SMILES CS(=O)(=O)Nc1ccc(OCC(=O)NCCNc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C17H19Cl2N3O4S/c1-27(24,25)22-12-2-5-14(6-3-12)26-11-17(23)21-9-8-20-13-4-7-15(18)16(19)10-13/h2-7,10,20,22H,8-9,11H2,1H3,(H,21,23)
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n/an/a 57n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1/NR2B receptor expressed in frog oocytes assessed as inhibition of glutamate/glycine-induced current by two...

Bioorg Med Chem 17: 6463-80 (2009)


Article DOI: 10.1016/j.bmc.2009.05.085
BindingDB Entry DOI: 10.7270/Q2M61KB5
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50085921
PNG
(4-[1-(3-Phenyl-propyl)-piperidin-4-ylmethyl]-pheno...)
Show SMILES Oc1ccc(CC2CCN(CCCc3ccccc3)CC2)cc1
Show InChI InChI=1S/C21H27NO/c23-21-10-8-19(9-11-21)17-20-12-15-22(16-13-20)14-4-7-18-5-2-1-3-6-18/h1-3,5-6,8-11,20,23H,4,7,12-17H2
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n/an/a 59n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50369784
PNG
(CHEMBL1202295)
Show SMILES Oc1ccc(CC2CCN(CCCCc3ccccc3)CC2)cc1
Show InChI InChI=1S/C22H29NO/c24-22-11-9-20(10-12-22)18-21-13-16-23(17-14-21)15-5-4-8-19-6-2-1-3-7-19/h1-3,6-7,9-12,21,24H,4-5,8,13-18H2
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n/an/a 71n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50032651
PNG
(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)
Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(O)(CC1)c1ccccc1
Show InChI InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1
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n/an/a 73n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.

J Med Chem 42: 3412-20 (1999)


Article DOI: 10.1021/jm990199u
BindingDB Entry DOI: 10.7270/Q2RR1XFD
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50369782
PNG
(CHEMBL1203909)
Show SMILES Oc1ccc(cc1)C1CCN(CCCc2ccccc2)CC1
Show InChI InChI=1S/C20H25NO/c22-20-10-8-18(9-11-20)19-12-15-21(16-13-19)14-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-11,19,22H,4,7,12-16H2
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n/an/a 74n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus oocytes expressing rat N-Methyl-D-aspartate (NR1A/2B) Receptor subtype.

J Med Chem 43: 984-94 (2000)


BindingDB Entry DOI: 10.7270/Q20G3KVT
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Rattus norvegicus (Rat)-RAT)		BDBM50081747
PNG
(4-Benzyl-1-[4-(1H-pyrazol-4-yl)-but-3-ynyl]-piperi...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)C#Cc1cn[nH]c1
Show InChI InChI=1S/C19H23N3/c1-2-6-17(7-3-1)14-18-9-12-22(13-10-18)11-5-4-8-19-15-20-21-16-19/h1-3,6-7,15-16,18H,5,9-14H2,(H,20,21)
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n/an/a 74n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested in vitro for inhibition of NMDA response at cloned NR1A/2A receptor expressed in Xenopus oocytes

Bioorg Med Chem Lett 9: 2815-8 (1999)


BindingDB Entry DOI: 10.7270/Q2Z037BT
More data for this
Ligand-Target Pair
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