Compile Data Set for Download or QSAR

Found 162 hits of ic50 for UniProtKB: P43405   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50400044 (CHEMBL2177726 | US9169259, I-54) Show SMILES COc1ccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)C(O)=O)nc1OC Show InChI InChI=1S/C27H22N6O5/c1-37-22-10-11-23(31-26(22)38-2)30-21-15-20(32-33-13-12-28-24(21)33)17-4-3-5-18(14-17)25(34)29-19-8-6-16(7-9-19)27(35)36/h3-15H,1-2H3,(H,29,34)(H,30,31)(H,35,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188174 (US9169259, I-57) Show SMILES COc1ccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(C(O)=O)c(OC)c2)nc1OC Show InChI InChI=1S/C28H24N6O6/c1-38-22-9-10-24(32-27(22)40-3)31-21-15-20(33-34-12-11-29-25(21)34)16-5-4-6-17(13-16)26(35)30-18-7-8-19(28(36)37)23(14-18)39-2/h4-15H,1-3H3,(H,30,35)(H,31,32)(H,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.55	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188128 (US9169259, I-10) Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)C(O)=O)n1 Show InChI InChI=1S/C30H27N7O3/c1-19-5-4-15-36(19)27-9-3-8-26(34-27)33-25-18-24(35-37-16-14-31-28(25)37)21-6-2-7-22(17-21)29(38)32-23-12-10-20(11-13-23)30(39)40/h2-3,6-14,16-19H,4-5,15H2,1H3,(H,32,38)(H,33,34)(H,39,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.65	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227529 (US9334278, I-18) Show SMILES Cc1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)sn1 Show InChI InChI=1S/C15H18N6OS/c1-8-5-11(23-21-8)18-10-7-17-13-12(19-10)9(6-16-13)14(22)20-15(2,3)4/h5-7H,1-4H3,(H,16,17)(H,18,19)(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM295272 (6-(1-aminomethyl-3- methyl-butylamino)- 4-(6-isopr...) Show SMILES CC(C)CC(CN)Nc1cc(Nc2ccc(C)c(n2)C(C)C)c(nn1)C(N)=O Show InChI InChI=1S/C20H31N7O/c1-11(2)8-14(10-21)23-17-9-15(19(20(22)28)27-26-17)24-16-7-6-13(5)18(25-16)12(3)4/h6-7,9,11-12,14H,8,10,21H2,1-5H3,(H2,22,28)(H2,23,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188188 (US9169259, I-72) Show SMILES COc1ccc(Nc2cc(nn3ccnc23)N2CCCC(C2)NC(=O)c2ccc(cc2)C(O)=O)nc1OC Show InChI InChI=1S/C26H27N7O5/c1-37-20-9-10-21(30-25(20)38-2)29-19-14-22(31-33-13-11-27-23(19)33)32-12-3-4-18(15-32)28-24(34)16-5-7-17(8-6-16)26(35)36/h5-11,13-14,18H,3-4,12,15H2,1-2H3,(H,28,34)(H,29,30)(H,35,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227523 (US9334278, I-12) Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cc1 Show InChI InChI=1S/C18H21N5O/c1-11-5-7-12(8-6-11)21-14-10-20-16-15(22-14)13(9-19-16)17(24)23-18(2,3)4/h5-10H,1-4H3,(H,19,20)(H,21,22)(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227549 (US9334278, I-37) Show SMILES Cc1nc2[nH]cc(C(=O)NC(C)(C)C)c2nc1Nc1ccccc1 Show InChI InChI=1S/C18H21N5O/c1-11-15(21-12-8-6-5-7-9-12)22-14-13(10-19-16(14)20-11)17(24)23-18(2,3)4/h5-10H,1-4H3,(H,19,20)(H,21,22)(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227537 (US9334278, I-26) Show SMILES CC(C)(CO)NC(=O)c1c[nH]c2ncc(Nc3cccnc3)nc12 Show InChI InChI=1S/C16H18N6O2/c1-16(2,9-23)22-15(24)11-7-18-14-13(11)21-12(8-19-14)20-10-4-3-5-17-6-10/h3-8,23H,9H2,1-2H3,(H,18,19)(H,20,21)(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227535 (US9334278, I-24) Show SMILES CC(O)c1cccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM295270 (6-(1-amino-4- methylpentan-2- ylamino)-4-(6-tert- ...) Show SMILES CC(C)CC(CN)Nc1cc(Nc2cccc(n2)C(C)(C)C)c(nn1)C(N)=O Show InChI InChI=1S/C20H31N7O/c1-12(2)9-13(11-21)23-17-10-14(18(19(22)28)27-26-17)24-16-8-6-7-15(25-16)20(3,4)5/h6-8,10,12-13H,9,11,21H2,1-5H3,(H2,22,28)(H2,23,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50007104 (CHEMBL3237572 | US10112928, Compound I-17) Show SMILES CC(C)C[C@H](CN)Nc1cc(Nc2cccc(n2)C(C)(C)C)c(nn1)C(N)=O |r| Show InChI InChI=1S/C20H31N7O/c1-12(2)9-13(11-21)23-17-10-14(18(19(22)28)27-26-17)24-16-8-6-7-15(25-16)20(3,4)5/h6-8,10,12-13H,9,11,21H2,1-5H3,(H2,22,28)(H2,23,24,25,26)/t13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM295281 (6-(2- aminoethylamino)-4- (6-(trifluoromethyl) pyr...) Show SMILES NCCNc1cc(Nc2cccc(n2)C(F)(F)F)c(nn1)C(N)=O Show InChI InChI=1S/C13H14F3N7O/c14-13(15,16)8-2-1-3-9(21-8)20-7-6-10(19-5-4-17)22-23-11(7)12(18)24/h1-3,6H,4-5,17H2,(H2,18,24)(H2,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188172 (US9169259, I-55) Show SMILES COc1ccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc3[nH]ncc3c2)nc1OC Show InChI InChI=1S/C27H22N8O3/c1-37-23-8-9-24(32-27(23)38-2)31-22-14-21(34-35-11-10-28-25(22)35)16-4-3-5-17(12-16)26(36)30-19-6-7-20-18(13-19)15-29-33-20/h3-15H,1-2H3,(H,29,33)(H,30,36)(H,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.33	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227512 (US9334278, I-1) Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)nc1 Show InChI InChI=1S/C17H20N6O/c1-10-5-6-12(18-7-10)21-13-9-20-15-14(22-13)11(8-19-15)16(24)23-17(2,3)4/h5-9H,1-4H3,(H,19,20)(H,23,24)(H,18,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM295287 (6-(2- aminoethylamino)-4- (5-isopropyl-6- methoxyp...) Show SMILES COc1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1C(C)C Show InChI InChI=1S/C16H23N7O2/c1-9(2)10-4-5-12(21-16(10)25-3)20-11-8-13(19-7-6-17)22-23-14(11)15(18)24/h4-5,8-9H,6-7,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.25	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227522 (US9334278, I-11) Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c(F)c1 Show InChI InChI=1S/C18H20FN5O/c1-10-5-6-13(12(19)7-10)22-14-9-21-16-15(23-14)11(8-20-16)17(25)24-18(2,3)4/h5-9H,1-4H3,(H,20,21)(H,22,23)(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.9	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50007160 (CHEMBL3237578 | US10112928, Compound I-20) Show SMILES COc1ccc(Nc2cc(NCCN)nnc2C(N)=O)nc1C(C)C Show InChI InChI=1S/C16H23N7O2/c1-9(2)14-11(25-3)4-5-12(21-14)20-10-8-13(19-7-6-17)22-23-15(10)16(18)24/h4-5,8-9H,6-7,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM295289 (6-(2- aminoethylamino)-4- (6-isopropoxypyridin- 2-...) Show SMILES CC(C)Oc1cccc(Nc2cc(NCCN)nnc2C(N)=O)n1 Show InChI InChI=1S/C15H21N7O2/c1-9(2)24-13-5-3-4-11(20-13)19-10-8-12(18-7-6-16)21-22-14(10)15(17)23/h3-5,8-9H,6-7,16H2,1-2H3,(H2,17,23)(H2,18,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.4	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227524 (US9334278, I-13) Show SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3cccc(c3)S(C)(=O)=O)nc12 Show InChI InChI=1S/C18H21N5O3S/c1-18(2,3)23-17(24)13-9-19-16-15(13)22-14(10-20-16)21-11-6-5-7-12(8-11)27(4,25)26/h5-10H,1-4H3,(H,19,20)(H,21,22)(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM295273 (6-(2- aminoethylamino)-4- (6-tert-butylpyridin- 2-...) Show SMILES CC(C)(C)c1cccc(Nc2cc(NCCN)nnc2C(N)=O)n1 Show InChI InChI=1S/C16H23N7O/c1-16(2,3)11-5-4-6-12(21-11)20-10-9-13(19-8-7-17)22-23-14(10)15(18)24/h4-6,9H,7-8,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227516 (US9334278, I-5) Show SMILES Cn1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1 Show InChI InChI=1S/C15H19N7O/c1-15(2,3)21-14(23)10-6-16-13-12(10)20-11(7-17-13)19-9-5-18-22(4)8-9/h5-8H,1-4H3,(H,16,17)(H,19,20)(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188190 (US9169259, I-74) Show SMILES COc1ccc(Nc2cc(nn3ccnc23)N2CCCC(C2)C(=O)Nc2ccc(cc2)C(O)=O)nc1OC Show InChI InChI=1S/C26H27N7O5/c1-37-20-9-10-21(30-25(20)38-2)29-19-14-22(31-33-13-11-27-23(19)33)32-12-3-4-17(15-32)24(34)28-18-7-5-16(6-8-18)26(35)36/h5-11,13-14,17H,3-4,12,15H2,1-2H3,(H,28,34)(H,29,30)(H,35,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.9	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227520 (US9334278, I-9) Show SMILES Cc1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)[nH]n1 Show InChI InChI=1S/C15H19N7O/c1-8-5-10(22-21-8)18-11-7-17-13-12(19-11)9(6-16-13)14(23)20-15(2,3)4/h5-7H,1-4H3,(H,16,17)(H,20,23)(H2,18,19,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.5	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50400035 (CHEMBL2177735 | US9169259, I-84) Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CN)c2)n1 Show InChI InChI=1S/C23H25N7/c1-16-5-4-11-29(16)22-9-3-8-21(27-22)26-20-14-19(28-30-12-10-25-23(20)30)18-7-2-6-17(13-18)15-24/h2-3,6-10,12-14,16H,4-5,11,15,24H2,1H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.6	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188169 (US9169259, I-51) Show SMILES C[C@H]1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(N)=O)n1 |r| Show InChI InChI=1S/C23H23N7O/c1-15-5-4-11-29(15)21-9-3-8-20(27-21)26-19-14-18(28-30-12-10-25-23(19)30)16-6-2-7-17(13-16)22(24)31/h2-3,6-10,12-15H,4-5,11H2,1H3,(H2,24,31)(H,26,27)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16.1	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227521 (US9334278, I-10) Show SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3cccnc3)nc12 Show InChI InChI=1S/C16H18N6O/c1-16(2,3)22-15(23)11-8-18-14-13(11)21-12(9-19-14)20-10-5-4-6-17-7-10/h4-9H,1-3H3,(H,18,19)(H,20,21)(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.3	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227517 (US9334278, I-6) Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1 Show InChI InChI=1S/C17H20N6O/c1-10-5-6-11(7-18-10)21-13-9-20-15-14(22-13)12(8-19-15)16(24)23-17(2,3)4/h5-9H,1-4H3,(H,19,20)(H,21,22)(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.1	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227542 (US9334278, I-31) Show SMILES Cc1nsc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)n1 Show InChI InChI=1S/C14H17N7OS/c1-7-17-13(23-21-7)19-9-6-16-11-10(18-9)8(5-15-11)12(22)20-14(2,3)4/h5-6H,1-4H3,(H,15,16)(H,20,22)(H,17,18,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.8	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227538 (US9334278, I-27) Show SMILES CC(N)c1cccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.8	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188168 (US9169259, I-50) Show SMILES C[C@H]1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(cc2)C(N)=O)n1 |r| Show InChI InChI=1S/C23H23N7O/c1-15-4-3-12-29(15)21-6-2-5-20(27-21)26-19-14-18(28-30-13-11-25-23(19)30)16-7-9-17(10-8-16)22(24)31/h2,5-11,13-15H,3-4,12H2,1H3,(H2,24,31)(H,26,27)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18.9	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM295283 (6-(2- aminoethylamino)-4- (6-(dimethylamino)- 5-me...) Show SMILES CN(C)c1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1C Show InChI InChI=1S/C15H22N8O/c1-9-4-5-11(20-15(9)23(2)3)19-10-8-12(18-7-6-16)21-22-13(10)14(17)24/h4-5,8H,6-7,16H2,1-3H3,(H2,17,24)(H2,18,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227514 (US9334278, I-3) Show SMILES Cn1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)n1 Show InChI InChI=1S/C15H19N7O/c1-15(2,3)20-14(23)9-7-16-13-12(9)19-11(8-17-13)18-10-5-6-22(4)21-10/h5-8H,1-4H3,(H,16,17)(H,20,23)(H,18,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.1	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188208 (US9169259, I-93) Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CNC3CCNCC3)c2)n1 Show InChI InChI=1S/C28H34N8/c1-20-5-4-15-35(20)27-9-3-8-26(33-27)32-25-18-24(34-36-16-14-30-28(25)36)22-7-2-6-21(17-22)19-31-23-10-12-29-13-11-23/h2-3,6-9,14,16-18,20,23,29,31H,4-5,10-13,15,19H2,1H3,(H,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.4	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50007097 (CHEMBL3237566 | US10112928, Compound I-34) Show SMILES Cc1ccc(Nc2cc(NCCN)nnc2C(N)=O)nc1C Show InChI InChI=1S/C14H19N7O/c1-8-3-4-11(18-9(8)2)19-10-7-12(17-6-5-15)20-21-13(10)14(16)22/h3-4,7H,5-6,15H2,1-2H3,(H2,16,22)(H2,17,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.4	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50400036 (CHEMBL2177734 | US9169259, I-68) Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(CO)c2)n1 Show InChI InChI=1S/C23H24N6O/c1-16-5-4-11-28(16)22-9-3-8-21(26-22)25-20-14-19(27-29-12-10-24-23(20)29)18-7-2-6-17(13-18)15-30/h2-3,6-10,12-14,16,30H,4-5,11,15H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.7	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227533 (US9334278, I-22) Show SMILES Cc1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)on1 Show InChI InChI=1S/C15H18N6O2/c1-8-5-11(23-21-8)18-10-7-17-13-12(19-10)9(6-16-13)14(22)20-15(2,3)4/h5-7H,1-4H3,(H,16,17)(H,18,19)(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.1	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227513 (US9334278, I-2) Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)CO)c3n2)nc1 Show InChI InChI=1S/C17H20N6O2/c1-10-4-5-12(18-6-10)21-13-8-20-15-14(22-13)11(7-19-15)16(25)23-17(2,3)9-24/h4-8,24H,9H2,1-3H3,(H,19,20)(H,23,25)(H,18,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.4	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227531 (US9334278, I-20) Show SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(cc3)S(C)(=O)=O)nc12 Show InChI InChI=1S/C18H21N5O3S/c1-18(2,3)23-17(24)13-9-19-16-15(13)22-14(10-20-16)21-11-5-7-12(8-6-11)27(4,25)26/h5-10H,1-4H3,(H,19,20)(H,21,22)(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188135 (US9169259, I-17) Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(cc2)C(N)=O)n1 Show InChI InChI=1S/C23H23N7O/c1-15-4-3-12-29(15)21-6-2-5-20(27-21)26-19-14-18(28-30-13-11-25-23(19)30)16-7-9-17(10-8-16)22(24)31/h2,5-11,13-15H,3-4,12H2,1H3,(H2,24,31)(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33.1	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227525 (US9334278, I-14) Show SMILES CCn1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1 Show InChI InChI=1S/C16H21N7O/c1-5-23-9-10(6-19-23)20-12-8-18-14-13(21-12)11(7-17-14)15(24)22-16(2,3)4/h6-9H,5H2,1-4H3,(H,17,18)(H,20,21)(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.9	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188170 (US9169259, I-52) Show SMILES C[C@H]1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc3ncsc3c2)n1 |r| Show InChI InChI=1S/C23H21N7S/c1-15-4-3-10-29(15)22-6-2-5-21(27-22)26-19-13-18(28-30-11-9-24-23(19)30)16-7-8-17-20(12-16)31-14-25-17/h2,5-9,11-15H,3-4,10H2,1H3,(H,26,27)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36.1	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50007187 (CHEMBL3237581 | US10112928, Compound I-32) Show SMILES CC(C)c1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1F Show InChI InChI=1S/C15H20FN7O/c1-8(2)13-9(16)3-4-11(21-13)20-10-7-12(19-6-5-17)22-23-14(10)15(18)24/h3-4,7-8H,5-6,17H2,1-2H3,(H2,18,24)(H2,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37.8	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50007161 (CHEMBL3237579 | US10112928, Compound I-26) Show SMILES CCCc1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1OC Show InChI InChI=1S/C16H23N7O2/c1-3-4-10-12(25-2)5-6-13(20-10)21-11-9-14(19-8-7-17)22-23-15(11)16(18)24/h5-6,9H,3-4,7-8,17H2,1-2H3,(H2,18,24)(H2,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50011187 (CHEMBL3260323 | US10112928, Compound I-30) Show SMILES Cc1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)ccc2C(N)=O)n1 |r| Show InChI InChI=1S/C19H25N5O/c1-12-5-4-8-18(22-12)24-17-11-13(9-10-14(17)19(21)25)23-16-7-3-2-6-15(16)20/h4-5,8-11,15-16,23H,2-3,6-7,20H2,1H3,(H2,21,25)(H,22,24)/t15-,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	41.8	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188192 (US9169259, I-76) Show SMILES COc1ccc(Nc2cc(nn3ccnc23)N2CCC(C2)NC(=O)c2ccc(cc2)C(O)=O)nc1OC Show InChI InChI=1S/C25H25N7O5/c1-36-19-7-8-20(29-24(19)37-2)28-18-13-21(30-32-12-10-26-22(18)32)31-11-9-17(14-31)27-23(33)15-3-5-16(6-4-15)25(34)35/h3-8,10,12-13,17H,9,11,14H2,1-2H3,(H,27,33)(H,28,29)(H,34,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	42.1	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188158 (US9169259, I-40) Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2cccc(c2)C(=O)NCCO)n1 Show InChI InChI=1S/C25H27N7O2/c1-17-5-4-12-31(17)23-9-3-8-22(29-23)28-21-16-20(30-32-13-10-26-24(21)32)18-6-2-7-19(15-18)25(34)27-11-14-33/h2-3,6-10,13,15-17,33H,4-5,11-12,14H2,1H3,(H,27,34)(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	42.5	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227515 (US9334278, I-4) Show SMILES CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(C)cn3)nc12 Show InChI InChI=1S/C16H18N6O/c1-9(2)20-16(23)11-7-18-15-14(11)22-13(8-19-15)21-12-5-4-10(3)6-17-12/h4-9H,1-3H3,(H,18,19)(H,20,23)(H,17,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42.8	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM227543 (US9334278, I-32) Show SMILES Cn1cc2N(CCCc2n1)c1cnc2[nH]cc(C(=O)NC(C)(C)C)c2n1 Show InChI InChI=1S/C18H23N7O/c1-18(2,3)22-17(26)11-8-19-16-15(11)21-14(9-20-16)25-7-5-6-12-13(25)10-24(4)23-12/h8-10H,5-7H2,1-4H3,(H,19,20)(H,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43.7	n/a	n/a	n/a	n/a	n/a	30
Hoffmann-La Roche Inc. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...				US Patent US9334278 (2016) BindingDB Entry DOI: 10.7270/Q2JD4VN3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM188199 (US9169259, I-83) Show SMILES CC1CCCN1c1cccc(Nc2cc(nn3ccnc23)-c2ccc(OCCN3CCCC3)cc2)n1 Show InChI InChI=1S/C28H33N7O/c1-21-6-5-16-34(21)27-8-4-7-26(31-27)30-25-20-24(32-35-17-13-29-28(25)35)22-9-11-23(12-10-22)36-19-18-33-14-2-3-15-33/h4,7-13,17,20-21H,2-3,5-6,14-16,18-19H2,1H3,(H,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	47.5	n/a	n/a	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Assay plates: 96-well MultiScreen 0.65 um filter plates (Millipore Cat. No.: MADVNOB10)Streptavidin coated beads: Streptavidin Sepharose, suspension ...				US Patent US9169259 (2015) BindingDB Entry DOI: 10.7270/Q2H130S2
					More data for this Ligand-Target Pair

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