Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210020![]() (US10576087, Compound 2.26 | US9273046, 2.26 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210021![]() (US10576087, Compound 2.27 | US9273046, 2.27 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210051![]() (US10576087, Compound 2.29 | US9273046, 2.29 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM373010![]() (US9895376, Compound 2.30) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210037![]() (US10576087, Compound 2.1 | US9273046, 2.1 | US9895...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210022![]() (US10576087, Compound 2.31 | US9273046, 2.31 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210015![]() (US10576087, Compound 2.21 | US9273046, 2.21 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322528![]() (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322529![]() (5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM372977![]() (US10576087, Compound 2.4a | US9895376, Compound 2....) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210044![]() (US10576087, Compound 2.4 | US9273046, 2.4 | US9895...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322521![]() (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210024![]() (US10576087, Compound 2.33 | US9273046, 2.33 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210002![]() (US10576087, Compound 2.8 | US9273046, 2.8 | US9895...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322521![]() (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210023![]() (US10576087, Compound 2.32 | US9273046, 2.32 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322521![]() (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210016![]() (US10576087, Compound 2.22 | US9273046, 2.22 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM372967![]() (US10576087, Compound 2.2a | US9895376, Compound 2....) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210038![]() (US10576087, Compound 2.2 | US9273046, 2.2 | US9895...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210034![]() (US10576087, Compound 1.1 | US9273046, 1.1 | US9895...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210013![]() (US10576087, Compound 2.19 | US9273046, 2.19 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210007![]() (US10576087, Compound 2.13 | US9273046, 2.13 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210001![]() (US10576087, Compound 2.7 | US9273046, 2.7 | US9895...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM372985![]() (US10576087, Compound 2.5b | US9895376, Compound 2....) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM372978![]() (US10576087, Compound 2.4b | US9895376, Compound 2....) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM622280![]() (4-amino-N-(1-((2-fluorophenyl)amino)-6-methylisoqu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM622284![]() (4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 2.68 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM238347![]() (US9388165, 3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
HANMI PHARM. CO., LTD. US Patent | Assay Description The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B... | US Patent US9388165 (2016) BindingDB Entry DOI: 10.7270/Q2F76BF9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM372973![]() (US10576087, Compound 2.3b | US9895376, Compound 2....) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM622285![]() (4-amino-N-(1-((2-fluoro-4-methoxyphenyl)amino)-6-m...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 3.14 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210032![]() (US10576087, Compound 3.7 | US9273046, 3.7 | US9895...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210005![]() (US10576087, Compound 2.11 | US9273046, 2.11 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM622277![]() (4-amino-N-(1-(4-chloro-2-fluorobenzoyl)-6-methylis...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 3.48 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210009![]() (US10576087, Compound 2.15 | US9273046, 2.15 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM210010![]() (US10576087, Compound 2.16 | US9273046, 2.16 | US98...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM622276![]() (4-amino-N-(6-methyl-1-(3-(trifluoromethyl)benzoyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 3.93 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322533![]() (5-[3-[5-(3-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322532![]() (5-[3-[4-(benzofuran-3-yl)-1H-imidazol-2-yl]chroman...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322531![]() (5-[3-[5-(3-chlorophenyl)-1H-imidazol-2-yl]chroman-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322530![]() (5-[3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]chroman-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322529![]() (5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322528![]() (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322527![]() (5-[3-(4-tert-butyl-1H-imidazol-2-yl)chroman-6-yl]o...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322525![]() (5-[3[4-(4-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]o...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322521![]() (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322521![]() (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322535![]() (5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]chroman-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322536![]() (5-[3-[5-(1,3-benzodioxol-5-yl)-1H-imidazol-2-yl]ch...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322537![]() (5-[3-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-imid...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair |
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