Compile Data Set for Download or QSAR

Found 114 hits Enz. Inhib. hit(s) with all data for entry = 2702   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376040 (2-chloro-5-(1-methyl-1H- pyrazol-3-yl)-N-(1-phenyl...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)-c2ccncc2)c(Cl)cc1C(F)(F)F Show InChI InChI=1S/C26H18ClF3N6O/c1-35-12-9-22(33-35)18-13-19(21(27)14-20(18)26(28,29)30)25(37)32-24-15-23(16-7-10-31-11-8-16)34-36(24)17-5-3-2-4-6-17/h2-15H,1H3,(H,32,37)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376080 (5-({[2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-4- (tr...) Show SMILES Cc1cc([nH]n1)-n1nc(cc1NC(=O)c1cc(-c2ccn(C)n2)c(cc1F)C(F)(F)F)C(=O)NCc1cccnc1 Show InChI InChI=1S/C26H21F4N9O2/c1-14-8-23(35-34-14)39-22(11-21(37-39)25(41)32-13-15-4-3-6-31-12-15)33-24(40)17-9-16(20-5-7-38(2)36-20)18(10-19(17)27)26(28,29)30/h3-12H,13H2,1-2H3,(H,32,41)(H,33,40)(H,34,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376106 (2-fluoro-N-(1-(4- fluorophenyl)-3-((1-methyl- 1H-t...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(Cc3nnnn3C)nn2-c2ccc(F)cc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C24H18F5N9O/c1-36-8-7-20(33-36)16-11-17(19(26)12-18(16)24(27,28)29)23(39)30-21-9-14(10-22-31-34-35-37(22)2)32-38(21)15-5-3-13(25)4-6-15/h3-9,11-12H,10H2,1-2H3,(H,30,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376085 (N-[3-(4-carbamoylphenyl)-1- (4-fluorophenyl)-1H-py...) Show SMILES NC(=O)c1ccc(cc1)-c1cc(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C28H17F5N6O2/c29-17-6-8-18(9-7-17)39-24(14-23(38-39)15-2-4-16(5-3-15)25(34)40)37-27(41)20-12-19(26-35-10-1-11-36-26)21(13-22(20)30)28(31,32)33/h1-14H,(H2,34,40)(H,37,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376063 (2-chloro-5-(1-methyl-1H- pyrazol-3-yl)-N-{3-[(1- m...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(Cc3nnnn3C)nn2-c2ccccc2)c(Cl)cc1C(F)(F)F Show InChI InChI=1S/C24H19ClF3N9O/c1-35-9-8-20(32-35)16-12-17(19(25)13-18(16)24(26,27)28)23(38)29-21-10-14(11-22-30-33-34-36(22)2)31-37(21)15-6-4-3-5-7-15/h3-10,12-13H,11H2,1-2H3,(H,29,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.780	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376052 (2-chloro-N-(3,5'-dimethyl-1'H- 1,3'-bipyrazol-5-yl...) Show SMILES Cc1cc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2Cl)C(F)(F)F)n(n1)-c1cc(C)[nH]n1 Show InChI InChI=1S/C20H17ClF3N7O/c1-10-6-18(27-26-10)31-17(7-11(2)28-31)25-19(32)13-8-12(16-4-5-30(3)29-16)14(9-15(13)21)20(22,23)24/h4-9H,1-3H3,(H,25,32)(H,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376009 (N-(1$#8243;,5-dimethyl-1H,1$#8243;H- 3,1':3',4$#82...) Show SMILES Cc1csc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(nn1-c1cc(C)[nH]n1)-c1cnn(C)c1 Show InChI InChI=1S/C23H19F3N8OS/c1-12-6-20(31-30-12)34-19(8-18(32-34)15-9-27-33(3)10-15)29-21(35)14-4-5-17(23(24,25)26)16(7-14)22-28-13(2)11-36-22/h4-11H,1-3H3,(H,29,35)(H,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376109 (2-fluoro-N-(1-(4- fluorophenyl)-3-((6-oxo-1,6- dih...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(Cc3ccc(=O)[nH]n3)nn2-c2ccc(F)cc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C26H18F5N7O2/c1-37-9-8-22(36-37)18-12-19(21(28)13-20(18)26(29,30)31)25(40)32-23-11-16(10-15-4-7-24(39)34-33-15)35-38(23)17-5-2-14(27)3-6-17/h2-9,11-13H,10H2,1H3,(H,32,40)(H,34,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376111 ((S or R)-2-fluoro-N-(1-(4- fluorophenyl)-3-(5-(1- ...) Show SMILES CC(O)c1cnc(nc1)-c1cc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C27H20F5N7O2/c1-14(40)15-12-33-25(34-13-15)23-11-24(39(37-23)17-5-3-16(28)4-6-17)35-26(41)19-9-18(22-7-8-38(2)36-22)20(10-21(19)29)27(30,31)32/h3-14,40H,1-2H3,(H,35,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376089 (2-fluoro-N-(1-(4- fluorophenyl)-3-((2-methyl- 2H-t...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(Cc3nnn(C)n3)nn2-c2ccc(F)cc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C24H18F5N9O/c1-36-8-7-20(33-36)16-11-17(19(26)12-18(16)24(27,28)29)23(39)30-22-10-14(9-21-31-35-37(2)34-21)32-38(22)15-5-3-13(25)4-6-15/h3-8,10-12H,9H2,1-2H3,(H,30,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376096 (N-(3-((5-amino-1,3,4- oxadiazol-2-yl)methyl)-1-(4-...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2nnc(N)o2)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C24H18F4N8O2/c1-35-9-8-19(34-35)17-10-13(2-7-18(17)24(26,27)28)22(37)30-20-11-15(12-21-31-32-23(29)38-21)33-36(20)16-5-3-14(25)4-6-16/h2-11H,12H2,1H3,(H2,29,32)(H,30,37)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376099 (N-(1-(4-fluorophenyl)-3- (pyrimidin-5-ylmethyl)-1H...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2cncnc2)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C26H19F4N7O/c1-36-9-8-23(35-36)21-11-17(2-7-22(21)26(28,29)30)25(38)33-24-12-19(10-16-13-31-15-32-14-16)34-37(24)20-5-3-18(27)4-6-20/h2-9,11-15H,10H2,1H3,(H,33,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376059 (2-chloro-5-(1-methyl-1H- pyrazol-3-yl)-N-[3-(6-oxo...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)-c2ccc(=O)[nH]n2)c(Cl)cc1C(F)(F)F Show InChI InChI=1S/C25H17ClF3N7O2/c1-35-10-9-19(33-35)15-11-16(18(26)12-17(15)25(27,28)29)24(38)30-22-13-21(20-7-8-23(37)32-31-20)34-36(22)14-5-3-2-4-6-14/h2-13H,1H3,(H,30,38)(H,32,37)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376087 (5'-methyl-5-(3-(1-methyl-1H- pyrazol-3-yl)-4- (tri...) Show SMILES Cc1cc([nH]n1)-n1nc(cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F)C(=O)NCc1cncnc1 Show InChI InChI=1S/C25H21F3N10O2/c1-14-7-22(34-33-14)38-21(9-20(36-38)24(40)31-12-15-10-29-13-30-11-15)32-23(39)16-3-4-18(25(26,27)28)17(8-16)19-5-6-37(2)35-19/h3-11,13H,12H2,1-2H3,(H,31,40)(H,32,39)(H,33,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376082 (N-[1-(4-fluorophenyl)-3-({2- [2-(methylamino)-2-ox...) Show SMILES CNC(=O)Cn1nnc(Cc2cc(NC(=O)c3ccc(c(c3)-c3ccn(C)n3)C(F)(F)F)n(n2)-c2ccc(F)cc2)n1 Show InChI InChI=1S/C26H22F4N10O2/c1-31-24(41)14-39-36-22(33-37-39)12-17-13-23(40(34-17)18-6-4-16(27)5-7-18)32-25(42)15-3-8-20(26(28,29)30)19(11-15)21-9-10-38(2)35-21/h3-11,13H,12,14H2,1-2H3,(H,31,41)(H,32,42)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376108 (2-fluoro-N-(1-(4- fluorophenyl)-3-((1-methyl- 1H-t...) Show SMILES Cn1nnnc1Cc1cc(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C24H16F5N9O/c1-37-21(33-35-36-37)10-14-9-20(38(34-14)15-5-3-13(25)4-6-15)32-23(39)17-11-16(22-30-7-2-8-31-22)18(12-19(17)26)24(27,28)29/h2-9,11-12H,10H2,1H3,(H,32,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376063 (2-chloro-5-(1-methyl-1H- pyrazol-3-yl)-N-{3-[(1- m...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(Cc3nnnn3C)nn2-c2ccccc2)c(Cl)cc1C(F)(F)F Show InChI InChI=1S/C24H19ClF3N9O/c1-35-9-8-20(32-35)16-12-17(19(25)13-18(16)24(26,27)28)23(38)29-21-10-14(11-22-30-33-34-36(22)2)31-37(21)15-6-4-3-5-7-15/h3-10,12-13H,11H2,1-2H3,(H,29,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376029 (N-(isothiazol-5-ylmethyl)-5'- methyl-5-({[3-(1-met...) Show SMILES Cc1cc([nH]n1)-n1nc(cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F)C(=O)NCc1ccns1 Show InChI InChI=1S/C24H20F3N9O2S/c1-13-9-21(32-31-13)36-20(11-19(34-36)23(38)28-12-15-5-7-29-39-15)30-22(37)14-3-4-17(24(25,26)27)16(10-14)18-6-8-35(2)33-18/h3-11H,12H2,1-2H3,(H,28,38)(H,30,37)(H,31,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376010 (N-(5'-methyl-3-pyridin-2-yl- 1'H-1,3'-bipyrazol-5-...) Show SMILES Cc1csc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(nn1-c1cc(C)[nH]n1)-c1ccccn1 Show InChI InChI=1S/C24H18F3N7OS/c1-13-9-21(32-31-13)34-20(11-19(33-34)18-5-3-4-8-28-18)30-22(35)15-6-7-17(24(25,26)27)16(10-15)23-29-14(2)12-36-23/h3-12H,1-2H3,(H,30,35)(H,31,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376098 (N-(3-((5-aminopyrazin-2- yl)methyl)-1-(4-fluorophe...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2cnc(N)cn2)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C26H20F4N8O/c1-37-9-8-22(36-37)20-10-15(2-7-21(20)26(28,29)30)25(39)34-24-12-17(11-18-13-33-23(31)14-32-18)35-38(24)19-5-3-16(27)4-6-19/h2-10,12-14H,11H2,1H3,(H2,31,33)(H,34,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376116 (N-(3-((2,5-dioxoimidazolidin- 1-yl)methyl)-1-(4- f...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(CN3C(=O)CNC3=O)nn2-c2ccc(F)cc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C25H18F5N7O3/c1-35-7-6-20(34-35)16-9-17(19(27)10-18(16)25(28,29)30)23(39)32-21-8-14(12-36-22(38)11-31-24(36)40)33-37(21)15-4-2-13(26)3-5-15/h2-10H,11-12H2,1H3,(H,31,40)(H,32,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376070 (3-(1-methyl-1H-pyrazol-3-yl)- N-[1-phenyl-3-(1H-te...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cn2cnnn2)nn1-c1ccccc1 Show InChI InChI=1S/C23H18F3N9O/c1-33-10-9-20(30-33)18-11-15(7-8-19(18)23(24,25)26)22(36)28-21-12-16(13-34-14-27-31-32-34)29-35(21)17-5-3-2-4-6-17/h2-12,14H,13H2,1H3,(H,28,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376115 (N-(3-(2-amino-2-oxoethyl)-1- (4-fluorophenyl)-1H-p...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(CC(O)=O)nn2-c2ccc(F)cc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C23H16F5N5O3/c1-32-7-6-19(31-32)15-10-16(18(25)11-17(15)23(26,27)28)22(36)29-20-8-13(9-21(34)35)30-33(20)14-4-2-12(24)3-5-14/h2-8,10-11H,9H2,1H3,(H,29,36)(H,34,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376107 (N-(3-(3- (aminomethyl)phenyl)-1-(4- fluorophenyl)-...) Show SMILES NCc1cccc(c1)-c1cc(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C28H19F5N6O/c29-18-5-7-19(8-6-18)39-25(14-24(38-39)17-4-1-3-16(11-17)15-34)37-27(40)21-12-20(26-35-9-2-10-36-26)22(13-23(21)30)28(31,32)33/h1-14H,15,34H2,(H,37,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376118 (2-fluoro-N-(1-(4- fluorophenyl)-3-(2- (methylamino...) Show SMILES CNC(=O)Cc1cc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C24H19F5N6O2/c1-30-22(36)10-14-9-21(35(32-14)15-5-3-13(25)4-6-15)31-23(37)17-11-16(20-7-8-34(2)33-20)18(12-19(17)26)24(27,28)29/h3-9,11-12H,10H2,1-2H3,(H,30,36)(H,31,37)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376025 (4-chloro-3-(4-methyl-1,3- thiazol-2-yl)-N-(1-pheny...) Show SMILES Cc1csc(n1)-c1cc(ccc1Cl)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccncc1 Show InChI InChI=1S/C25H18ClN5OS/c1-16-15-33-25(28-16)20-13-18(7-8-21(20)26)24(32)29-23-14-22(17-9-11-27-12-10-17)30-31(23)19-5-3-2-4-6-19/h2-15H,1H3,(H,29,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376055 (N-[3-(hydroxymethyl)-5'- methyl-2'H-1,3'-bipyrazol...) Show SMILES Cc1cc([nH]n1)-n1nc(CO)cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F Show InChI InChI=1S/C20H18F3N7O2/c1-11-7-18(26-25-11)30-17(9-13(10-31)27-30)24-19(32)12-3-4-15(20(21,22)23)14(8-12)16-5-6-29(2)28-16/h3-9,31H,10H2,1-2H3,(H,24,32)(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376043 (2-chloro-N-(1-phenyl-3- pyridin-4-yl-1H-pyrazol-5-...) Show SMILES FC(F)(F)c1cc(Cl)c(cc1-c1cc[nH]n1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccncc1 Show InChI InChI=1S/C25H16ClF3N6O/c26-20-13-19(25(27,28)29)17(21-8-11-31-33-21)12-18(20)24(36)32-23-14-22(15-6-9-30-10-7-15)34-35(23)16-4-2-1-3-5-16/h1-14H,(H,31,33)(H,32,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376064 (N-[1-(4-fluorophenyl)-3- pyrimidin-2-yl-1H-pyrazol...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(nn1-c1ccc(F)cc1)-c1ncccn1 Show InChI InChI=1S/C25H17F4N7O/c1-35-12-9-20(33-35)18-13-15(3-8-19(18)25(27,28)29)24(37)32-22-14-21(23-30-10-2-11-31-23)34-36(22)17-6-4-16(26)5-7-17/h2-14H,1H3,(H,32,37)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376065 (3-(4-methyl-1,3-oxazol-2-yl)- N-(5-methyl-1H,1$#82...) Show SMILES Cc1coc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(nn1-c1cc(C)[nH]n1)-c1cn[nH]c1 Show InChI InChI=1S/C22H17F3N8O2/c1-11-5-19(31-30-11)33-18(7-17(32-33)14-8-26-27-9-14)29-20(34)13-3-4-16(22(23,24)25)15(6-13)21-28-12(2)10-35-21/h3-10H,1-2H3,(H,26,27)(H,29,34)(H,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376044 (4-chloro-3-(1-methyl-1H- pyrazol-3-yl)-N-[3-pyridi...) Show SMILES Cn1ccc(n1)-c1cc(ccc1Cl)C(=O)Nc1cc(nn1-c1cc(n[nH]1)C(F)(F)F)-c1ccncc1 Show InChI InChI=1S/C23H16ClF3N8O/c1-34-9-6-17(32-34)15-10-14(2-3-16(15)24)22(36)29-20-11-18(13-4-7-28-8-5-13)33-35(20)21-12-19(30-31-21)23(25,26)27/h2-12H,1H3,(H,29,36)(H,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376062 (2-chloro-5-(1-methyl-1H- pyrazol-3-yl)-N-{3-[(2- m...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(Cc3nnn(C)n3)nn2-c2ccccc2)c(Cl)cc1C(F)(F)F Show InChI InChI=1S/C24H19ClF3N9O/c1-35-9-8-20(32-35)16-12-17(19(25)13-18(16)24(26,27)28)23(38)29-22-11-14(10-21-30-34-36(2)33-21)31-37(22)15-6-4-3-5-7-15/h3-9,11-13H,10H2,1-2H3,(H,29,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376105 (2-fluoro-N-(1-(4- fluorophenyl)-3-(4-(2- hydroxyet...) Show SMILES OCCc1ccc(cc1)-c1cc(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C29H20F5N5O2/c30-19-6-8-20(9-7-19)39-26(16-25(38-39)18-4-2-17(3-5-18)10-13-40)37-28(41)22-14-21(27-35-11-1-12-36-27)23(15-24(22)31)29(32,33)34/h1-9,11-12,14-16,40H,10,13H2,(H,37,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376094 (N-(1-(4-fluorophenyl)-3-((1- methyl-1H-pyrazol-4- ...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2cnn(C)c2)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C26H21F4N7O/c1-35-10-9-23(34-35)21-12-17(3-8-22(21)26(28,29)30)25(38)32-24-13-19(11-16-14-31-36(2)15-16)33-37(24)20-6-4-18(27)5-7-20/h3-10,12-15H,11H2,1-2H3,(H,32,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376071 (3-(1-methyl-1H-pyrazol-3-yl)- N-[1-phenyl-3-(2H-te...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cn2ncnn2)nn1-c1ccccc1 Show InChI InChI=1S/C23H18F3N9O/c1-33-10-9-20(31-33)18-11-15(7-8-19(18)23(24,25)26)22(36)29-21-12-16(13-34-28-14-27-32-34)30-35(21)17-5-3-2-4-6-17/h2-12,14H,13H2,1H3,(H,29,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376100 (N-(3-((1H-pyrazol-3- yl)methyl)-1-(4-fluorophenyl)...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2cc[nH]n2)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C25H19F4N7O/c1-35-11-9-22(34-35)20-12-15(2-7-21(20)25(27,28)29)24(37)31-23-14-18(13-17-8-10-30-32-17)33-36(23)19-5-3-16(26)4-6-19/h2-12,14H,13H2,1H3,(H,30,32)(H,31,37)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376102 (N-(1-(4-fluorophenyl)-3-((2- oxo-1,2-dihydropyridi...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2ccc[nH]c2=O)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C27H20F4N6O2/c1-36-12-10-23(35-36)21-14-17(4-9-22(21)27(29,30)31)26(39)33-24-15-19(13-16-3-2-11-32-25(16)38)34-37(24)20-7-5-18(28)6-8-20/h2-12,14-15H,13H2,1H3,(H,32,38)(H,33,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376069 (2-fluoro-N-(1-methyl-3- phenyl-1H-pyrazol-4-yl)-5-...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cn(C)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C22H17F4N5O/c1-30-9-8-18(28-30)14-10-15(17(23)11-16(14)22(24,25)26)21(32)27-19-12-31(2)29-20(19)13-6-4-3-5-7-13/h3-12H,1-2H3,(H,27,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376112 (2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(6-oxo-2-...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2c3CNC(=O)Cc3nn2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C24H18F4N6O2/c1-33-8-7-19(31-33)14-9-15(18(25)10-17(14)24(26,27)28)23(36)30-22-16-12-29-21(35)11-20(16)32-34(22)13-5-3-2-4-6-13/h2-10H,11-12H2,1H3,(H,29,35)(H,30,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376093 (2-fluoro-N-(1-(4- fluorophenyl)-3-((5-oxo-4,5- dih...) Show SMILES Fc1ccc(cc1)-n1nc(Cc2n[nH]c(=O)s2)cc1NC(=O)c1cc(-c2ncccn2)c(cc1F)C(F)(F)F Show InChI InChI=1S/C24H14F5N7O2S/c25-12-2-4-14(5-3-12)36-19(8-13(35-36)9-20-33-34-23(38)39-20)32-22(37)16-10-15(21-30-6-1-7-31-21)17(11-18(16)26)24(27,28)29/h1-8,10-11H,9H2,(H,32,37)(H,34,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376088 (2-(5-(2-fluoro-5-(pyrimidin-2- yl)-4- (trifluorome...) Show SMILES NC(=O)c1ccnc(n1)-c1cc(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H15F5N8O2/c27-13-2-4-14(5-3-13)39-21(12-20(38-39)24-35-9-6-19(36-24)22(32)40)37-25(41)16-10-15(23-33-7-1-8-34-23)17(11-18(16)28)26(29,30)31/h1-12H,(H2,32,40)(H,37,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376007 (N-(3-methyl-1-phenyl-1H- pyrazol-5-yl)-3-(4-methyl...) Show SMILES Cc1csc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(C)nn1-c1ccccc1 Show InChI InChI=1S/C22H17F3N4OS/c1-13-10-19(29(28-13)16-6-4-3-5-7-16)27-20(30)15-8-9-18(22(23,24)25)17(11-15)21-26-14(2)12-31-21/h3-12H,1-2H3,(H,27,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376015 (3-(1-methyl-1H-pyrazol-3-yl)- N-[3-(6-oxo-1,6- dih...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccc(=O)[nH]n1 Show InChI InChI=1S/C25H18F3N7O2/c1-34-12-11-19(32-34)17-13-15(7-8-18(17)25(26,27)28)24(37)29-22-14-21(20-9-10-23(36)31-30-20)33-35(22)16-5-3-2-4-6-16/h2-14H,1H3,(H,29,37)(H,31,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376034 (N-[1-(4-fluorophenyl)-3- pyridin-4-yl-1H-pyrazol-5...) Show SMILES Cc1cccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(nn1-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C28H19F4N5O/c1-17-3-2-4-24(34-17)22-15-19(5-10-23(22)28(30,31)32)27(38)35-26-16-25(18-11-13-33-14-12-18)36-37(26)21-8-6-20(29)7-9-21/h2-16H,1H3,(H,35,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376026 (N-{5'-methyl-3-[2-oxo-2- (pyridin-2-ylamino)ethyl]...) Show SMILES Cc1cc([nH]n1)-n1nc(CC(=O)Nc2ccccn2)cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F Show InChI InChI=1S/C26H22F3N9O2/c1-15-11-23(34-33-15)38-22(13-17(35-38)14-24(39)31-21-5-3-4-9-30-21)32-25(40)16-6-7-19(26(27,28)29)18(12-16)20-8-10-37(2)36-20/h3-13H,14H2,1-2H3,(H,32,40)(H,33,34)(H,30,31,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376054 (1-methyl-5-({[3-(1-methyl- 1H-pyrazol-3-yl)-4- (tr...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1c(nc(C(N)=O)n1C)-c1ccccc1 Show InChI InChI=1S/C23H19F3N6O2/c1-31-11-10-17(30-31)15-12-14(8-9-16(15)23(24,25)26)22(34)29-20-18(13-6-4-3-5-7-13)28-21(19(27)33)32(20)2/h3-12H,1-2H3,(H2,27,33)(H,29,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376053 (2-chloro-5-(1-methyl-1H- pyrazol-3-yl)-N-(5-phenyl...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cn[nH]c2-c2ccccc2)c(Cl)cc1C(F)(F)F Show InChI InChI=1S/C21H15ClF3N5O/c1-30-8-7-17(29-30)13-9-14(16(22)10-15(13)21(23,24)25)20(31)27-18-11-26-28-19(18)12-5-3-2-4-6-12/h2-11H,1H3,(H,26,28)(H,27,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376036 (N-(2-methyl-4-phenyl-1,3- thiazol-5-yl)-3-(1-methy...) Show SMILES Cc1nc(c(NC(=O)c2ccc(c(c2)-c2ccn(C)n2)C(F)(F)F)s1)-c1ccccc1 Show InChI InChI=1S/C22H17F3N4OS/c1-13-26-19(14-6-4-3-5-7-14)21(31-13)27-20(30)15-8-9-17(22(23,24)25)16(12-15)18-10-11-29(2)28-18/h3-12H,1-2H3,(H,27,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376095 (N-(3-((2-aminopyrimidin-5- yl)methyl)-1-(4-fluorop...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2cnc(N)nc2)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C26H20F4N8O/c1-37-9-8-22(36-37)20-11-16(2-7-21(20)26(28,29)30)24(39)34-23-12-18(10-15-13-32-25(31)33-14-15)35-38(23)19-5-3-17(27)4-6-19/h2-9,11-14H,10H2,1H3,(H,34,39)(H2,31,32,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376032 (3-(1-methyl-1H-pyrazol-3-yl)- N-{3-[(6-oxo-1,6- di...) Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2ccc(=O)[nH]n2)nn1-c1ccccc1 Show InChI InChI=1S/C26H20F3N7O2/c1-35-12-11-22(34-35)20-13-16(7-9-21(20)26(27,28)29)25(38)30-23-15-18(14-17-8-10-24(37)32-31-17)33-36(23)19-5-3-2-4-6-19/h2-13,15H,14H2,1H3,(H,30,38)(H,32,37)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair

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