Found 123 hits Enz. Inhib. hit(s) with all data for entry = 50036943 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100673
(CHEMBL538498 | methyl 2-(4-aminophenyl)-4-(4-bromo...)Show SMILES COC(=O)c1c(-c2cc(OC)c(Br)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C31H26BrN3O6/c1-38-25-14-18(15-26(39-2)28(25)32)27-23-12-11-22(41-17-20-6-4-5-13-34-20)16-24(23)30(36)35(29(27)31(37)40-3)21-9-7-19(33)8-10-21/h4-16H,17,33H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100674
(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)Show SMILES COC(=O)c1c(-c2cc(OC)c(C)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O6/c1-19-27(38-2)15-20(16-28(19)39-3)29-25-13-12-24(41-18-22-7-5-6-14-34-22)17-26(25)31(36)35(30(29)32(37)40-4)23-10-8-21(33)9-11-23/h5-17H,18,33H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100662
(CHEMBL553371 | CHEMBL77971 | methyl 2-(4-aminophen...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O7/c1-38-26-15-19(16-27(39-2)30(26)40-3)28-24-13-12-23(42-18-21-7-5-6-14-34-21)17-25(24)31(36)35(29(28)32(37)41-4)22-10-8-20(33)9-11-22/h5-17H,18,33H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100659
(CHEMBL544289 | methyl 2-(4-aminophenyl)-1-oxo-7-(3...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3cccnc3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O7/c1-38-26-14-20(15-27(39-2)30(26)40-3)28-24-12-11-23(42-18-19-6-5-13-34-17-19)16-25(24)31(36)35(29(28)32(37)41-4)22-9-7-21(33)8-10-22/h5-17H,18,33H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100656
(2-(4-Amino-phenyl)-7-benzyloxy-1-oxo-4-(3,4,5-trim...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccc3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C33H30N2O7/c1-38-27-16-21(17-28(39-2)31(27)40-3)29-25-15-14-24(42-19-20-8-6-5-7-9-20)18-26(25)32(36)35(30(29)33(37)41-4)23-12-10-22(34)11-13-23/h5-18H,19,34H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100670
(CHEMBL553786 | methyl 2-(4-aminophenyl)-1-oxo-7-(4...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccncc3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O7/c1-38-26-15-20(16-27(39-2)30(26)40-3)28-24-10-9-23(42-18-19-11-13-34-14-12-19)17-25(24)31(36)35(29(28)32(37)41-4)22-7-5-21(33)6-8-22/h5-17H,18,33H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100664
(2-(4-Amino-phenyl)-1-oxo-7-(2-pyridin-2-yl-ethoxy)...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C33H31N3O7/c1-39-27-17-20(18-28(40-2)31(27)41-3)29-25-13-12-24(43-16-14-22-7-5-6-15-35-22)19-26(25)32(37)36(30(29)33(38)42-4)23-10-8-21(34)9-11-23/h5-13,15,17-19H,14,16,34H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100663
(CHEMBL542878 | methyl 2-(4-aminophenyl)-4-(3-hydro...)Show SMILES COC(=O)c1c(-c2cc(O)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C31H27N3O7/c1-38-26-15-18(14-25(35)29(26)39-2)27-23-12-11-22(41-17-20-6-4-5-13-33-20)16-24(23)30(36)34(28(27)31(37)40-3)21-9-7-19(32)8-10-21/h4-16,35H,17,32H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100678
(2-(4-Amino-phenyl)-4-(4-hydroxy-3,5-dimethoxy-phen...)Show SMILES COC(=O)c1c(-c2cc(OC)c(O)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C31H27N3O7/c1-38-25-14-18(15-26(39-2)29(25)35)27-23-12-11-22(41-17-20-6-4-5-13-33-20)16-24(23)30(36)34(28(27)31(37)40-3)21-9-7-19(32)8-10-21/h4-16,35H,17,32H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100668
(CHEMBL542394 | ethyl 2-(4-aminophenyl)-1-oxo-7-(2-...)Show SMILES CCOC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C33H31N3O7/c1-5-42-33(38)30-29(20-16-27(39-2)31(41-4)28(17-20)40-3)25-14-13-24(43-19-22-8-6-7-15-35-22)18-26(25)32(37)36(30)23-11-9-21(34)10-12-23/h6-18H,5,19,34H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100667
(2-(4-Amino-phenyl)-7-methoxy-1-oxo-4-(3,4,5-trimet...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OC)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C27H26N2O7/c1-32-18-10-11-19-20(14-18)26(30)29(17-8-6-16(28)7-9-17)24(27(31)36-5)23(19)15-12-21(33-2)25(35-4)22(13-15)34-3/h6-14H,28H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100676
(2-(4-Amino-phenyl)-6,7-dimethoxy-1-oxo-4-(3,4,5-tr...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C28H28N2O8/c1-33-20-13-18-19(14-21(20)34-2)27(31)30(17-9-7-16(29)8-10-17)25(28(32)38-6)24(18)15-11-22(35-3)26(37-5)23(12-15)36-4/h7-14H,29H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100679
(6,7-Dimethoxy-2-morpholin-4-yl-1-oxo-4-(3,4,5-trim...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1N1CCOCC1 Show InChI InChI=1S/C26H30N2O9/c1-31-18-13-16-17(14-19(18)32-2)25(29)28(27-7-9-37-10-8-27)23(26(30)36-6)22(16)15-11-20(33-3)24(35-5)21(12-15)34-4/h11-14H,7-10H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100672
(2-(4-Amino-phenyl)-6,7-diethoxy-1-oxo-4-(3,4,5-tri...)Show SMILES CCOc1cc2c(-c3cc(OC)c(OC)c(OC)c3)c(C(=O)OC)n(-c3ccc(N)cc3)c(=O)c2cc1OCC Show InChI InChI=1S/C30H32N2O8/c1-7-39-22-15-20-21(16-23(22)40-8-2)29(33)32(19-11-9-18(31)10-12-19)27(30(34)38-6)26(20)17-13-24(35-3)28(37-5)25(14-17)36-4/h9-16H,7-8,31H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100660
(6,7-Dimethoxy-1-oxo-2-phenyl-4-(3,4,5-trimethoxy-p...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1-c1ccccc1 Show InChI InChI=1S/C28H27NO8/c1-32-20-14-18-19(15-21(20)33-2)27(30)29(17-10-8-7-9-11-17)25(28(31)37-6)24(18)16-12-22(34-3)26(36-5)23(13-16)35-4/h7-15H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100652
(6,7-Dimethoxy-1-oxo-2-piperidin-1-yl-4-(3,4,5-trim...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1N1CCCCC1 Show InChI InChI=1S/C27H32N2O8/c1-32-19-14-17-18(15-20(19)33-2)26(30)29(28-10-8-7-9-11-28)24(27(31)37-6)23(17)16-12-21(34-3)25(36-5)22(13-16)35-4/h12-15H,7-11H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100653
(2-(4-Amino-phenyl)-6-methoxy-1-oxo-4-(3,4,5-trimet...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)ccc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C27H26N2O7/c1-32-18-10-11-19-20(14-18)23(15-12-21(33-2)25(35-4)22(13-15)34-3)24(27(31)36-5)29(26(19)30)17-8-6-16(28)7-9-17/h6-14H,28H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100661
(2-(4-Hydroxy-phenyl)-6,7-dimethoxy-1-oxo-4-(3,4,5-...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1-c1ccc(O)cc1 Show InChI InChI=1S/C28H27NO9/c1-33-20-13-18-19(14-21(20)34-2)27(31)29(16-7-9-17(30)10-8-16)25(28(32)38-6)24(18)15-11-22(35-3)26(37-5)23(12-15)36-4/h7-14,30H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100665
(2-(4-Chloro-phenyl)-6,7-dimethoxy-1-oxo-4-(3,4,5-t...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1-c1ccc(Cl)cc1 Show InChI InChI=1S/C28H26ClNO8/c1-33-20-13-18-19(14-21(20)34-2)27(31)30(17-9-7-16(29)8-10-17)25(28(32)38-6)24(18)15-11-22(35-3)26(37-5)23(12-15)36-4/h7-14H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100671
(3N-methyl-2-(4-aminophenyl)-1-oxo-7-(2-pyridylmeth...)Show SMILES CNC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H30N4O6/c1-34-31(37)29-28(19-15-26(39-2)30(41-4)27(16-19)40-3)24-13-12-23(42-18-21-7-5-6-14-35-21)17-25(24)32(38)36(29)22-10-8-20(33)9-11-22/h5-17H,18,33H2,1-4H3,(H,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100682
(2-Cyclohexyl-6,7-dimethoxy-1-oxo-4-(3,4,5-trimetho...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1C1CCCCC1 Show InChI InChI=1S/C28H33NO8/c1-32-20-14-18-19(15-21(20)33-2)27(30)29(17-10-8-7-9-11-17)25(28(31)37-6)24(18)16-12-22(34-3)26(36-5)23(13-16)35-4/h12-15,17H,7-11H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100666
(6,7-Dimethoxy-2-methyl-1-oxo-4-(3,4,5-trimethoxy-p...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1C Show InChI InChI=1S/C23H25NO8/c1-24-20(23(26)32-7)19(12-8-17(29-4)21(31-6)18(9-12)30-5)13-10-15(27-2)16(28-3)11-14(13)22(24)25/h8-11H,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100658
(2-(3-Amino-phenyl)-6,7-dimethoxy-1-oxo-4-(3,4,5-tr...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1-c1cccc(N)c1 Show InChI InChI=1S/C28H28N2O8/c1-33-20-13-18-19(14-21(20)34-2)27(31)30(17-9-7-8-16(29)12-17)25(28(32)38-6)24(18)15-10-22(35-3)26(37-5)23(11-15)36-4/h7-14H,29H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB
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MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
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| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100655
(2-Benzyl-6,7-dimethoxy-1-oxo-4-(3,4,5-trimethoxy-p...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C29H29NO8/c1-33-21-14-19-20(15-22(21)34-2)28(31)30(16-17-10-8-7-9-11-17)26(29(32)38-6)25(19)18-12-23(35-3)27(37-5)24(13-18)36-4/h7-15H,16H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100673
(CHEMBL538498 | methyl 2-(4-aminophenyl)-4-(4-bromo...)Show SMILES COC(=O)c1c(-c2cc(OC)c(Br)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C31H26BrN3O6/c1-38-25-14-18(15-26(39-2)28(25)32)27-23-12-11-22(41-17-20-6-4-5-13-34-20)16-24(23)30(36)35(29(27)31(37)40-3)21-9-7-19(33)8-10-21/h4-16H,17,33H2,1-3H3 | PDB
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| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100680
(2-(4-aminophenyl)-1-oxo-7-(2-pyridylmethoxy)-4-(3,...)Show SMILES COc1cc(cc(OC)c1OC)-c1c(C(N)=O)n(-c2ccc(N)cc2)c(=O)c2cc(OCc3ccccn3)ccc12 Show InChI InChI=1S/C31H28N4O6/c1-38-25-14-18(15-26(39-2)29(25)40-3)27-23-12-11-22(41-17-20-6-4-5-13-34-20)16-24(23)31(37)35(28(27)30(33)36)21-9-7-19(32)8-10-21/h4-16H,17,32H2,1-3H3,(H2,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100668
(CHEMBL542394 | ethyl 2-(4-aminophenyl)-1-oxo-7-(2-...)Show SMILES CCOC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C33H31N3O7/c1-5-42-33(38)30-29(20-16-27(39-2)31(41-4)28(17-20)40-3)25-14-13-24(43-19-22-8-6-7-15-35-22)18-26(25)32(37)36(30)23-11-9-21(34)10-12-23/h6-18H,5,19,34H2,1-4H3 | PDB
KEGG
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PC sid
UniChem
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| PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100654
(2-Cyclopentyl-6,7-dimethoxy-1-oxo-4-(3,4,5-trimeth...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1C1CCCC1 Show InChI InChI=1S/C27H31NO8/c1-31-19-13-17-18(14-20(19)32-2)26(29)28(16-9-7-8-10-16)24(27(30)36-6)23(17)15-11-21(33-3)25(35-5)22(12-15)34-4/h11-14,16H,7-10H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50100673
(CHEMBL538498 | methyl 2-(4-aminophenyl)-4-(4-bromo...)Show SMILES COC(=O)c1c(-c2cc(OC)c(Br)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C31H26BrN3O6/c1-38-25-14-18(15-26(39-2)28(25)32)27-23-12-11-22(41-17-20-6-4-5-13-34-20)16-24(23)30(36)35(29(27)31(37)40-3)21-9-7-19(33)8-10-21/h4-16H,17,33H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
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| CHEMBL
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PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of canine lung Phosphodiesterase 4 (PDE4) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100657
(6,7-Dimethoxy-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,...)Show SMILES COC(=O)c1[nH]c(=O)c2cc(OC)c(OC)cc2c1-c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C22H23NO8/c1-26-14-9-12-13(10-15(14)27-2)21(24)23-19(22(25)31-6)18(12)11-7-16(28-3)20(30-5)17(8-11)29-4/h7-10H,1-6H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100667
(2-(4-Amino-phenyl)-7-methoxy-1-oxo-4-(3,4,5-trimet...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OC)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C27H26N2O7/c1-32-18-10-11-19-20(14-18)26(30)29(17-8-6-16(28)7-9-17)24(27(31)36-5)23(19)15-12-21(33-2)25(35-4)22(13-15)34-3/h6-14H,28H2,1-5H3 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100674
(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)Show SMILES COC(=O)c1c(-c2cc(OC)c(C)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O6/c1-19-27(38-2)15-20(16-28(19)39-3)29-25-13-12-24(41-18-22-7-5-6-14-34-22)17-26(25)31(36)35(30(29)32(37)40-4)23-10-8-21(33)9-11-23/h5-17H,18,33H2,1-4H3 | PDB
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100662
(CHEMBL553371 | CHEMBL77971 | methyl 2-(4-aminophen...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O7/c1-38-26-15-19(16-27(39-2)30(26)40-3)28-24-13-12-23(42-18-21-7-5-6-14-34-21)17-25(24)31(36)35(29(28)32(37)41-4)22-10-8-20(33)9-11-22/h5-17H,18,33H2,1-4H3 | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50100674
(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)Show SMILES COC(=O)c1c(-c2cc(OC)c(C)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O6/c1-19-27(38-2)15-20(16-28(19)39-3)29-25-13-12-24(41-18-22-7-5-6-14-34-22)17-26(25)31(36)35(30(29)32(37)40-4)23-10-8-21(33)9-11-23/h5-17H,18,33H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
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UniChem
Similars
| PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of canine lung Phosphodiesterase 4 (PDE4) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100683
(2-(4-aminophenyl)-1-oxo-7-(2-pyridylmethoxy)-4-(3,...)Show SMILES COc1cc(cc(OC)c1OC)-c1c(C(O)=O)n(-c2ccc(N)cc2)c(=O)c2cc(OCc3ccccn3)ccc12 Show InChI InChI=1S/C31H27N3O7/c1-38-25-14-18(15-26(39-2)29(25)40-3)27-23-12-11-22(41-17-20-6-4-5-13-33-20)16-24(23)30(35)34(28(27)31(36)37)21-9-7-19(32)8-10-21/h4-16H,17,32H2,1-3H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50100675
(3N,3N-dimethyl-2-(4-aminophenyl)-1-oxo-7-(2-pyridy...)Show SMILES COc1cc(cc(OC)c1OC)-c1c(C(=O)N(C)C)n(-c2ccc(N)cc2)c(=O)c2cc(OCc3ccccn3)ccc12 Show InChI InChI=1S/C33H32N4O6/c1-36(2)33(39)30-29(20-16-27(40-3)31(42-5)28(17-20)41-4)25-14-13-24(43-19-22-8-6-7-15-35-22)18-26(25)32(38)37(30)23-11-9-21(34)10-12-23/h6-18H,19,34H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100666
(6,7-Dimethoxy-2-methyl-1-oxo-4-(3,4,5-trimethoxy-p...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1C Show InChI InChI=1S/C23H25NO8/c1-24-20(23(26)32-7)19(12-8-17(29-4)21(31-6)18(9-12)30-5)13-10-15(27-2)16(28-3)11-14(13)22(24)25/h8-11H,1-7H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100656
(2-(4-Amino-phenyl)-7-benzyloxy-1-oxo-4-(3,4,5-trim...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccc3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C33H30N2O7/c1-38-27-16-21(17-28(39-2)31(27)40-3)29-25-15-14-24(42-19-20-8-6-5-7-9-20)18-26(25)32(36)35(30(29)33(37)41-4)23-12-10-22(34)11-13-23/h5-18H,19,34H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100678
(2-(4-Amino-phenyl)-4-(4-hydroxy-3,5-dimethoxy-phen...)Show SMILES COC(=O)c1c(-c2cc(OC)c(O)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C31H27N3O7/c1-38-25-14-18(15-26(39-2)29(25)35)27-23-12-11-22(41-17-20-6-4-5-13-33-20)16-24(23)30(36)34(28(27)31(37)40-3)21-9-7-19(32)8-10-21/h4-16,35H,17,32H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Bos taurus) | BDBM50100673
(CHEMBL538498 | methyl 2-(4-aminophenyl)-4-(4-bromo...)Show SMILES COC(=O)c1c(-c2cc(OC)c(Br)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C31H26BrN3O6/c1-38-25-14-18(15-26(39-2)28(25)32)27-23-12-11-22(41-17-20-6-4-5-13-34-20)16-24(23)30(36)35(29(27)31(37)40-3)21-9-7-19(33)8-10-21/h4-16H,17,33H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of bovine adrenal gland Phosphodiesterase 2 (PDE2) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100655
(2-Benzyl-6,7-dimethoxy-1-oxo-4-(3,4,5-trimethoxy-p...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C29H29NO8/c1-33-21-14-19-20(15-22(21)34-2)28(31)30(16-17-10-8-7-9-11-17)26(29(32)38-6)25(19)18-12-23(35-3)27(37-5)24(13-18)36-4/h7-15H,16H2,1-6H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Bos taurus) | BDBM50100674
(CHEMBL541818 | methyl 2-(4-aminophenyl)-4-(3,5-dim...)Show SMILES COC(=O)c1c(-c2cc(OC)c(C)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O6/c1-19-27(38-2)15-20(16-28(19)39-3)29-25-13-12-24(41-18-22-7-5-6-14-34-22)17-26(25)31(36)35(30(29)32(37)40-4)23-10-8-21(33)9-11-23/h5-17H,18,33H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of bovine adrenal gland Phosphodiesterase 2 (PDE2) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50100659
(CHEMBL544289 | methyl 2-(4-aminophenyl)-1-oxo-7-(3...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3cccnc3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O7/c1-38-26-14-20(15-27(39-2)30(26)40-3)28-24-12-11-23(42-18-19-6-5-13-34-17-19)16-25(24)31(36)35(29(28)32(37)41-4)22-9-7-21(33)8-10-22/h5-17H,18,33H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of canine lung Phosphodiesterase 4 (PDE4) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100653
(2-(4-Amino-phenyl)-6-methoxy-1-oxo-4-(3,4,5-trimet...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)ccc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C27H26N2O7/c1-32-18-10-11-19-20(14-18)23(15-12-21(33-2)25(35-4)22(13-15)34-3)24(27(31)36-5)29(26(19)30)17-8-6-16(28)7-9-17/h6-14H,28H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase
(Rattus norvegicus) | BDBM50100659
(CHEMBL544289 | methyl 2-(4-aminophenyl)-1-oxo-7-(3...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3cccnc3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O7/c1-38-26-14-20(15-27(39-2)30(26)40-3)28-24-12-11-23(42-18-19-6-5-13-34-17-19)16-25(24)31(36)35(29(28)32(37)41-4)22-9-7-21(33)8-10-22/h5-17H,18,33H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50100676
(2-(4-Amino-phenyl)-6,7-dimethoxy-1-oxo-4-(3,4,5-tr...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2cc(OC)c(OC)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C28H28N2O8/c1-33-20-13-18-19(14-21(20)34-2)27(31)30(17-9-7-16(29)8-10-17)25(28(32)38-6)24(18)15-11-22(35-3)26(37-5)23(12-15)36-4/h7-14H,29H2,1-6H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory activity against canine heart Phosphodiesterase 3 (PDE3) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50100662
(CHEMBL553371 | CHEMBL77971 | methyl 2-(4-aminophen...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C32H29N3O7/c1-38-26-15-19(16-27(39-2)30(26)40-3)28-24-13-12-23(42-18-21-7-5-6-14-34-21)17-25(24)31(36)35(29(28)32(37)41-4)22-10-8-20(33)9-11-22/h5-17H,18,33H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of canine lung Phosphodiesterase 4 (PDE4) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50100656
(2-(4-Amino-phenyl)-7-benzyloxy-1-oxo-4-(3,4,5-trim...)Show SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccc3)cc2c(=O)n1-c1ccc(N)cc1 Show InChI InChI=1S/C33H30N2O7/c1-38-27-16-21(17-28(39-2)31(27)40-3)29-25-15-14-24(42-19-20-8-6-5-7-9-20)18-26(25)32(36)35(30(29)33(37)41-4)23-12-10-22(34)11-13-23/h5-18H,19,34H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of canine lung Phosphodiesterase 4 (PDE4) |
J Med Chem 44: 2204-18 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XT5 |
More data for this
Ligand-Target Pair | |
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