Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Karachi Curated by ChEMBL | Assay Description Inhibitory activity against BuChE from horse serum | Bioorg Med Chem Lett 16: 573-80 (2005) Article DOI: 10.1016/j.bmcl.2005.10.042 BindingDB Entry DOI: 10.7270/Q29P3170 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.20E+4 | -26.1 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of Karachi | Assay Description AChE and BChE inhibitory activities were measured in vitro by a modified spectrophotometric method. all the inhibition studies were performed using ... | J Enzyme Inhib Med Chem 21: 703-10 (2006) Article DOI: 10.1080/14756360600889708 BindingDB Entry DOI: 10.7270/Q26D5RJS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University | Assay Description The IC50 values were determined using the spectrophotometric Ellman's method. All of the tested compounds were dissolved in 0.01 M DMSO and then ... | Bioorg Chem 71: 244-256 (2017) Article DOI: 10.1016/j.bioorg.2017.02.010 BindingDB Entry DOI: 10.7270/Q2222SNQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University Curated by ChEMBL | Assay Description Inhibition of BChE from rat serum by Ellmans method | Eur J Med Chem 44: 772-84 (2009) Article DOI: 10.1016/j.ejmech.2008.04.018 BindingDB Entry DOI: 10.7270/Q24Q7TS0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University in Prague | Assay Description The reaction mixture containing phosphate buffer, AChE or BChE and chosen compounds was prepared and intensively stirred. In given times (5, 10, 15, ... | Bioorg Chem 58: 48-52 (2015) Article DOI: 10.1016/j.bioorg.2014.11.005 BindingDB Entry DOI: 10.7270/Q26D5RQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Schiller-Universität Jena Curated by ChEMBL | Assay Description Inhibition of horse serum BChE | J Med Chem 49: 5411-3 (2006) Article DOI: 10.1021/jm060682m BindingDB Entry DOI: 10.7270/Q28P6042 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Schiller-Universität Jena Curated by ChEMBL | Assay Description Inhibition of equine serum BuChE by Ellman's assay | Bioorg Med Chem 16: 4252-61 (2008) Article DOI: 10.1016/j.bmc.2008.02.083 BindingDB Entry DOI: 10.7270/Q2Q81CV1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Karachi Curated by ChEMBL | Assay Description Inhibitory activity against BuChE from horse serum | Bioorg Med Chem Lett 16: 573-80 (2005) Article DOI: 10.1016/j.bmcl.2005.10.042 BindingDB Entry DOI: 10.7270/Q29P3170 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Universidad de Talcaa | Assay Description In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH... | Chem Biol Drug Des 88: 498-510 (2016) Article DOI: 10.1111/cbdd.12773 BindingDB Entry DOI: 10.7270/Q2NP237J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Waterloo Curated by ChEMBL | Assay Description Inhibition of equine BChE incubated with compounf for 5 mins before addition of substrate S-butyrylthiocholine iodide by Ellman's method | Bioorg Med Chem 19: 2269-81 (2011) Article DOI: 10.1016/j.bmc.2011.02.030 BindingDB Entry DOI: 10.7270/Q2Q240JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-Sen University Curated by ChEMBL | Assay Description Inhibition of equine serum BuChE | Bioorg Med Chem Lett 17: 3765-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.015 BindingDB Entry DOI: 10.7270/Q28C9X2C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | 8.0 | 30 | |
University of Sargodha | Assay Description AChE and BChE inhibitory assay was carried out by following Ellman's methodology [Ellman et al., Biochem. Pharmacol., 7:88-95] using AChE (Electric e... | Bioorg Chem 72: 256-267 (2017) BindingDB Entry DOI: 10.7270/Q23B5Z1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Sargodha | Assay Description Galantamine was used as reference drugs. The synthesized quinazolines were dissolved in 0.1 M phosphate buffer of pH 8.0. (KH2PO4/K2HPO4. The reactio... | Bioorg Chem 70: 237-244 (2017) Article DOI: 10.1016/j.bioorg.2017.01.004 BindingDB Entry DOI: 10.7270/Q2M0448Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Hazara University | Assay Description The synthesized compounds (each separately) were dissolved in a mixture of DMSO (1 ml) and methanol (9 ml) and then diluted in KH2PO4/K2HPO4 buffer (... | Bioorg Chem 69: 91-101 (2016) Article DOI: 10.1016/j.bioorg.2016.10.002 BindingDB Entry DOI: 10.7270/Q2X34W8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of BuChE in horse serum | Bioorg Med Chem Lett 17: 2123-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.091 BindingDB Entry DOI: 10.7270/Q2RX9BQQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.57E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institute of Biomedicine and Health Curated by ChEMBL | Assay Description Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method | Bioorg Med Chem 19: 7228-35 (2011) Article DOI: 10.1016/j.bmc.2011.09.040 BindingDB Entry DOI: 10.7270/Q23F4Q3K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.57E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of equine serum Butyrylcholinesterase | Bioorg Med Chem 19: 2298-305 (2011) Article DOI: 10.1016/j.bmc.2011.02.025 BindingDB Entry DOI: 10.7270/Q2XS5VP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.74E+4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Bezmialem Vakif University | Assay Description The substrates of the reaction were acetylthiocholine iodide and butyrylthiocholine iodide. 5,5'-dithio-bis(2-nitrobenzoic) acid (DTNB) was used ... | Bioorg Chem 59: 80-90 (2015) Article DOI: 10.1016/j.bioorg.2015.02.002 BindingDB Entry DOI: 10.7270/Q2668BXT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.33E+4 | n/a | n/a | n/a | n/a | 8.0 | 30 |
Brno University of Technology | Assay Description The assay was carried out according to the Ellman method [Ellman et al., Biochem. Pharmacol., 7:88-95], optimized for 96-well microplates using a Tec... | J Enzyme Inhib Med Chem 25: 414-20 (2010) Article DOI: 10.3109/14756360903213481 BindingDB Entry DOI: 10.7270/Q2PK0F2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Equus caballus (Horse)) | BDBM10404 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Évora | Assay Description The in vitro BuChE assay was performed similarly to the method described above. A standard enzyme activity curve was drawn for each enzyme using seve... | Bioorg Chem 67: 1-8 (2016) Article DOI: 10.1016/j.bioorg.2016.05.004 BindingDB Entry DOI: 10.7270/Q2XP73Q6 | |||||||||||
More data for this Ligand-Target Pair |