Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/delta (Rattus norvegicus (Rat)) | BDBM50457439 (CHEMBL4213357) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Johannes Gutenberg University Mainz Curated by ChEMBL | Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha1beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assay | J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3 (Rattus norvegicus (Rat)) | BDBM50457439 (CHEMBL4213357) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Johannes Gutenberg University Mainz Curated by ChEMBL | Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha1beta3 expressed in HEK293 cells in presence of GABA by patch-clamp assay | J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/delta (Rattus norvegicus (Rat)) | BDBM50457445 (CHEMBL4212818) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 860 | n/a | n/a | n/a | n/a |
Johannes Gutenberg University Mainz Curated by ChEMBL | Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha1beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assay | J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Rattus norvegicus (Rat)) | BDBM50457439 (CHEMBL4213357) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.01E+3 | n/a | n/a | n/a | n/a |
Johannes Gutenberg University Mainz Curated by ChEMBL | Assay Description Modulation of rat eGFP-fused GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cells in presence of GABA by patch-clamp assay | J Med Chem 61: 1951-1968 (2018) Article DOI: 10.1021/acs.jmedchem.7b01484 BindingDB Entry DOI: 10.7270/Q2P271Q0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat)) | BDBM24183 (4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
Johannes Gutenberg-UniVersity Curated by ChEMBL | Assay Description Activity at rat wild type GABAAalpha1beta2 receptor expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method | J Med Chem 51: 4430-48 (2008) Article DOI: 10.1021/jm701562x BindingDB Entry DOI: 10.7270/Q2FF3S6G | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat)) | BDBM50459891 (CHEMBL4229086) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Agonist activity at GABAA receptor in Sprague-Dawley rat forebrain membranes assessed as enhancement of [3H]muscimol binding after 2 hrs by radiometr... | Bioorg Med Chem Lett 27: 3207-3218 (2017) Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Rattus norvegicus (Rat)) | BDBM50452383 (CHEMBL4218339) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >2.40E+4 | n/a | n/a | n/a | n/a |
Roche Pharma Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]-flumazenil from rat GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assay | Bioorg Med Chem Lett 27: 5415-5419 (2017) Article DOI: 10.1016/j.bmcl.2017.11.008 BindingDB Entry DOI: 10.7270/Q27D2XQ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Mus musculus-Rattus norvegicus (Rat)) | BDBM50229715 (CHEMBL4070615) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of C57BL/6 mouse GABAA receptor alpha1beta3gamma2 assessed as increase in GABA-induced current response at -60 mV hold... | Bioorg Med Chem Lett 27: 3207-3218 (2017) Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Rattus norvegicus (Rat)) | BDBM50462450 (CHEMBL4238712) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta... | Bioorg Med Chem Lett 28: 2697-2700 (2018) Article DOI: 10.1016/j.bmcl.2018.04.003 BindingDB Entry DOI: 10.7270/Q20P12N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Rattus norvegicus (Rat)) | BDBM50462446 (CHEMBL4238634) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta... | Bioorg Med Chem Lett 28: 2697-2700 (2018) Article DOI: 10.1016/j.bmcl.2018.04.003 BindingDB Entry DOI: 10.7270/Q20P12N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Rattus norvegicus (Rat)) | BDBM50427613 (CHEMBL2322935) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta... | Bioorg Med Chem Lett 28: 2697-2700 (2018) Article DOI: 10.1016/j.bmcl.2018.04.003 BindingDB Entry DOI: 10.7270/Q20P12N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Rattus norvegicus (Rat)) | BDBM50462443 (CHEMBL4238315) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta... | Bioorg Med Chem Lett 28: 2697-2700 (2018) Article DOI: 10.1016/j.bmcl.2018.04.003 BindingDB Entry DOI: 10.7270/Q20P12N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Rattus norvegicus (Rat)) | BDBM50462444 (CHEMBL4244129) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta... | Bioorg Med Chem Lett 28: 2697-2700 (2018) Article DOI: 10.1016/j.bmcl.2018.04.003 BindingDB Entry DOI: 10.7270/Q20P12N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat)) | BDBM50273002 (5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.80E+5 | n/a | n/a | n/a | n/a |
Johannes Gutenberg-UniVersity Curated by ChEMBL | Assay Description Agonist activity at rat recombinant GABAAalpha1beta3gamma2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current by wh... | J Med Chem 51: 4430-48 (2008) Article DOI: 10.1021/jm701562x BindingDB Entry DOI: 10.7270/Q2FF3S6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat)) | BDBM50273004 (5-Piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione Hydr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9.50E+6 | n/a | n/a | n/a | n/a |
Johannes Gutenberg-UniVersity Curated by ChEMBL | Assay Description Agonist activity at rat wild type GABAAalpha1beta2 receptor expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method | J Med Chem 51: 4430-48 (2008) Article DOI: 10.1021/jm701562x BindingDB Entry DOI: 10.7270/Q2FF3S6G | |||||||||||
More data for this Ligand-Target Pair |