Compile Data Set for Download or QSAR

Found 260 hits of ic50 data for polymerid = 4582,9828   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50391000 (CB-01-11 | RIFAMYCIN) Show SMILES CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(O)cc(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C |r,c:23,t:3,25| Show InChI InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Merck & Co., Inc.					Assay Description Fluorescence-detected RNAP inhibition assays in Tables 1 and 4 were performed using a DNA fragment containing the lacUV5 promoter as a template and t...				ACS Chem Biol 12: 1346-1352 (2017) Article DOI: 10.1021/acschembio.6b01133 BindingDB Entry DOI: 10.7270/Q2VM4B41
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50391000 (CB-01-11 | RIFAMYCIN) Show SMILES CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(O)cc(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C |r,c:23,t:3,25| Show InChI InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Merck & Co., Inc.					Assay Description Fluorescence-detected RNAP inhibition assays in Tables 1 and 4 were performed using a DNA fragment containing the lacUV5 promoter as a template and t...				ACS Chem Biol 12: 1346-1352 (2017) Article DOI: 10.1021/acschembio.6b01133 BindingDB Entry DOI: 10.7270/Q2VM4B41
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592137 (US11572337, Compound 0MTK149) Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccccc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592141 (US11572337, Compound 0MTK158) Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccccc3)cc2C(F)(F)F)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592173 (US11572337, Compound 0MTK267) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(cc3)-c3cccnc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592161 (US11572337, Compound 0MTK237) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cc(Cl)cc(Cl)c3)cc2)c(O)c1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50155485 (CHEMBL184023 | Myxopyronin B | methyl (E)-5-(5-((2...) Show SMILES CCCCC(C)=CC=C(C)C(=O)c1c(O)cc(CCCCC=NC(=O)OC)oc1=O |w:22.22,7.6,4.4| Show InChI InChI=1S/C23H31NO6/c1-5-6-10-16(2)12-13-17(3)21(26)20-19(25)15-18(30-22(20)27)11-8-7-9-14-24-23(28)29-4/h12-15,25H,5-11H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against RNA polymerase of Escherichia coli				Bioorg Med Chem Lett 14: 5667-72 (2004) Article DOI: 10.1016/j.bmcl.2004.08.045 BindingDB Entry DOI: 10.7270/Q2C53KBD
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592133 (US11572337, Compound 0MTK127) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Cl)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592145 (US11572337, Compound 0MTK176) Show SMILES Cc1cc(Oc2ccc(F)cc2)ccc1CNC(=O)c1c(O)cc(O)cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592132 (US11572337, Compound 0MTK107) Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Cl)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592142 (US11572337, Compound 0MTK174) Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)c(Cl)c2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592138 (US11572337, Compound 0MTK154) Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592144 (US11572337, Compound 0MTK175) Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)c(F)c2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592146 (US11572337, Compound 0MTK178) Show SMILES COc1cc(Oc2ccc(F)cc2)ccc1CNC(=O)c1c(O)cc(O)cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592164 (US11572337, Compound 0MTK256) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccc(Cl)c3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592135 (US11572337, Compound 0MTK146) Show SMILES CC(C)(CNC(=O)c1c(O)cc(O)cc1O)c1ccc(Cl)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592175 (US11572337, Compound 0MTK269) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccc(c3)-c3ccncc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592159 (US11572337, Compound 0MTK232) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(Cl)cc3)cc2)c(O)c1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592162 (US11572337, Compound 0MTK238) Show SMILES Oc1c(Cl)c(O)c(C(=O)NCCc2ccc(Oc3cc(Cl)cc(Cl)c3)cc2)c(O)c1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592166 (US11572337, Compound 0MTK260) Show SMILES COc1ccc(Oc2ccc(CCNC(=O)c3c(O)cc(O)cc3O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592139 (US11572337, Compound 0MTK155) Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)cc2C(F)(F)F)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592174 (US11572337, Compound 0MTK268) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccc(c3)C(=O)NC3CC3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592165 (US11572337, Compound 0MTK257) Show SMILES Cc1ccc(Oc2ccc(CCNC(=O)c3c(O)cc(O)cc3O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592136 (US11572337, Compound 0MTK148) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccccc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592170 (US11572337, Compound 0MTK264) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccnc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592140 (US11572337, Compound 0MTK156) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(F)cc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592147 (US11572337, Compound 0MTK180) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cc(Cl)cc(Cl)c3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50155484 (CHEMBL185761 | CHEMBL186013 | CHEMBL186014 | {(E)-...) Show SMILES CCCCC(C)=CC=C(C)C(=O)c1c(O)cc(oc1=O)C(C)CCCC=NC(=O)OC |w:26.27,7.6,4.4| Show InChI InChI=1S/C24H33NO6/c1-6-7-10-16(2)12-13-18(4)22(27)21-19(26)15-20(31-23(21)28)17(3)11-8-9-14-25-24(29)30-5/h12-15,17,26H,6-11H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against RNA polymerase of Escherichia coli				Bioorg Med Chem Lett 14: 5667-72 (2004) Article DOI: 10.1016/j.bmcl.2004.08.045 BindingDB Entry DOI: 10.7270/Q2C53KBD
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592134 (US11572337, Compound 0MTK128) Show SMILES CN(CCc1ccc(Cl)cc1)C(=O)c1c(O)cc(O)cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50155487 (CHEMBL185900 | {(E)-5-[4-Hydroxy-5-((2E,4E)-2-meth...) Show SMILES CCCCC=CC=C(C)C(=O)c1c(O)cc(oc1=O)C(C)CCCC=NC(=O)OC |w:25.26,6.5,4.3| Show InChI InChI=1S/C23H31NO6/c1-5-6-7-8-9-13-17(3)21(26)20-18(25)15-19(30-22(20)27)16(2)12-10-11-14-24-23(28)29-4/h8-9,13-16,25H,5-7,10-12H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against RNA polymerase of Escherichia coli				Bioorg Med Chem Lett 14: 5667-72 (2004) Article DOI: 10.1016/j.bmcl.2004.08.045 BindingDB Entry DOI: 10.7270/Q2C53KBD
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592172 (US11572337, Compound 0MTK266) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(cc3)-c3ccncc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50155484 (CHEMBL185761 | CHEMBL186013 | CHEMBL186014 | {(E)-...) Show SMILES CCCCC(C)=CC=C(C)C(=O)c1c(O)cc(oc1=O)C(C)CCCC=NC(=O)OC |w:26.27,7.6,4.4| Show InChI InChI=1S/C24H33NO6/c1-6-7-10-16(2)12-13-18(4)22(27)21-19(26)15-20(31-23(21)28)17(3)11-8-9-14-25-24(29)30-5/h12-15,17,26H,6-11H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against RNA polymerase of Escherichia coli				Bioorg Med Chem Lett 14: 5667-72 (2004) Article DOI: 10.1016/j.bmcl.2004.08.045 BindingDB Entry DOI: 10.7270/Q2C53KBD
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592171 (US11572337, Compound 0MTK265) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccncc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592169 (US11572337, Compound 0MTK263) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccc(c3)N3CCOCC3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592148 (US11572337, Compound 0MTK181) Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)cc2Cl)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592168 (US11572337, Compound 0MTK262) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cncnc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592167 (US11572337, Compound 0MTK261) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(cc3)N3CCOCC3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592149 (US11572337, Compound 0MTK183) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(Cl)cc3)cc2)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50491557 (CHEMBL2046886) Show SMILES CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c4nc5c(OCCCCN6CCN(CCn7ccnc7)CC6)cccc5oc4c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(=O)c2c(O)c3C |r,c:52,t:3,54| Show InChI InChI=1S/C56H70N6O13/c1-31-14-12-15-32(2)55(69)59-46-50(67)42-41(45-53(46)74-40-17-13-16-39(44(40)58-45)71-28-11-10-20-60-22-24-61(25-23-60)26-27-62-21-19-57-30-62)43-52(36(6)49(42)66)75-56(8,54(43)68)72-29-18-38(70-9)33(3)51(73-37(7)63)35(5)48(65)34(4)47(31)64/h12-19,21,29-31,33-35,38,47-48,51,64-66H,10-11,20,22-28H2,1-9H3,(H,59,69)/b14-12+,29-18+,32-15-/t31-,33+,34+,35+,38-,47-,48+,51+,56-/m0/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Pennsylvania State University Curated by ChEMBL					Assay Description Inhibition of rifamycin-resistant Escherichia coli RNA polymerase D516V mutant after 10 mins by rolling circle transcription assay in presence of DNA...				J Med Chem 56: 4758-63 (2013) Article DOI: 10.1021/jm4004889 BindingDB Entry DOI: 10.7270/Q2SF303Q
					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM228835 (MRL-436) Show SMILES CC(C)Cc1nnc2c(cccn12)C(=O)NC1c2ccccc2-c2ccccc12 Show InChI InChI=1S/C24H22N4O/c1-15(2)14-21-26-27-23-20(12-7-13-28(21)23)24(29)25-22-18-10-5-3-8-16(18)17-9-4-6-11-19(17)22/h3-13,15,22H,14H2,1-2H3,(H,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	37
Merck & Co., Inc.					Assay Description Fluorescence-detected RNAP inhibition assays in Tables 1 and 4 were performed using a DNA fragment containing the lacUV5 promoter as a template and t...				ACS Chem Biol 12: 1346-1352 (2017) Article DOI: 10.1021/acschembio.6b01133 BindingDB Entry DOI: 10.7270/Q2VM4B41
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592163 (US11572337, Compound 0MTK240) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(F)cc3)cc2)c(O)c1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50155484 (CHEMBL185761 | CHEMBL186013 | CHEMBL186014 | {(E)-...) Show SMILES CCCCC(C)=CC=C(C)C(=O)c1c(O)cc(oc1=O)C(C)CCCC=NC(=O)OC |w:26.27,7.6,4.4| Show InChI InChI=1S/C24H33NO6/c1-6-7-10-16(2)12-13-18(4)22(27)21-19(26)15-20(31-23(21)28)17(3)11-8-9-14-25-24(29)30-5/h12-15,17,26H,6-11H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against RNA polymerase of Escherichia coli				Bioorg Med Chem Lett 14: 5667-72 (2004) Article DOI: 10.1016/j.bmcl.2004.08.045 BindingDB Entry DOI: 10.7270/Q2C53KBD
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM228835 (MRL-436) Show SMILES CC(C)Cc1nnc2c(cccn12)C(=O)NC1c2ccccc2-c2ccccc12 Show InChI InChI=1S/C24H22N4O/c1-15(2)14-21-26-27-23-20(12-7-13-28(21)23)24(29)25-22-18-10-5-3-8-16(18)17-9-4-6-11-19(17)22/h3-13,15,22H,14H2,1-2H3,(H,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Merck & Co., Inc.					Assay Description Fluorescence-detected RNAP inhibition assays in Tables 1 and 4 were performed using a DNA fragment containing the lacUV5 promoter as a template and t...				ACS Chem Biol 12: 1346-1352 (2017) Article DOI: 10.1021/acschembio.6b01133 BindingDB Entry DOI: 10.7270/Q2VM4B41
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592176 (US11572337, Compound 3RKHTK161) Show SMILES CCC1=C(O)C(CC)(CC)C(=O)C(C(=O)NCCc2ccc(Oc3ccc(F)cc3)cc2)=C1O |c:2,33| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50155483 (CHEMBL185927 | {5-[5-((2E,4E)-2,5-Dimethyl-nona-2,...) Show SMILES CCCCC(C)=CC=C(C)C(=O)c1c(O)cc(oc1=O)C(C)CCCCNC(=O)OC |w:7.6,4.4| Show InChI InChI=1S/C24H35NO6/c1-6-7-10-16(2)12-13-18(4)22(27)21-19(26)15-20(31-23(21)28)17(3)11-8-9-14-25-24(29)30-5/h12-13,15,17,26H,6-11,14H2,1-5H3,(H,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against RNA polymerase of Escherichia coli				Bioorg Med Chem Lett 14: 5667-72 (2004) Article DOI: 10.1016/j.bmcl.2004.08.045 BindingDB Entry DOI: 10.7270/Q2C53KBD
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM50155489 (CHEMBL185050 | {(E)-5-[5-((2E,4E)-2,5-Dimethyl-non...) Show SMILES CCCCC(C)=CC=C(C)C(=O)c1c(OC)cc(oc1=O)C(C)CCCC=NC(=O)OC |w:27.28,7.6,4.4| Show InChI InChI=1S/C25H35NO6/c1-7-8-11-17(2)13-14-19(4)23(27)22-21(30-5)16-20(32-24(22)28)18(3)12-9-10-15-26-25(29)31-6/h13-16,18H,7-12H2,1-6H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against RNA polymerase of Escherichia coli				Bioorg Med Chem Lett 14: 5667-72 (2004) Article DOI: 10.1016/j.bmcl.2004.08.045 BindingDB Entry DOI: 10.7270/Q2C53KBD
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592160 (US11572337, Compound 0MTK233) Show SMILES Oc1c(Cl)c(O)c(C(=O)NCCc2ccc(Oc3ccc(Cl)cc3)cc2)c(O)c1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM41193 (1-(2-Chloro-benzyl)-8-hydroxy-6-methyl-1H-[1,2,4]t...) Show SMILES Cc1cc(O)c2[n+](Cc3ccccc3Cl)ncn2n1 Show InChI InChI=1S/C13H11ClN4O/c1-9-6-12(19)13-17(15-8-18(13)16-9)7-10-4-2-3-5-11(10)14/h2-6,8H,7H2,1H3/p+1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	6.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
PCMD Curated by PubChem BioAssay					Assay Description Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q23N21T1
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592155 (US11572337, Compound 0MTK223) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(cc2)C(F)(F)F)c(O)c1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase subunit beta (Escherichia coli)	BDBM592154 (US11572337, Compound 0MTK222) Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Cl)cc2)c(O)c1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Staphylococcus aureus: Fluorescence-detected RNA polymerase assays with S. aureus RNA polymerase were performed as in Example 2.1, using reaction mix...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PZ5DR6
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 260 total )  |  Next  |  Last  >>

Jump to: