Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Antithrombin-III (Homo sapiens (Human)) | BDBM50037996 (1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemistry Curated by ChEMBL | Assay Description Antithrombin III (ATIII)-mediated anti-Xa activity was determined | Bioorg Med Chem Lett 9: 2013-8 (1999) BindingDB Entry DOI: 10.7270/Q26H4HXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III/Prothrombin (Homo sapiens (Human)) | BDBM264613 (US9718760, C157) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.44E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph... | US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III/Prothrombin (Homo sapiens (Human)) | BDBM264597 (US9718760, C152) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.70E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph... | US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III/Coagulation factor X (Homo sapiens (Human)) | BDBM50393527 (CHEMBL2158198) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto (CEQUIMED-UP) Curated by ChEMBL | Assay Description Inhibition of human factor 10a/antithrombin 3 assessed as CBS 31.39 substrate hydrolysis by spectrophotometric analysis | J Med Chem 54: 5373-84 (2011) Article DOI: 10.1021/jm2006589 BindingDB Entry DOI: 10.7270/Q27P90HT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310312 (CHEMBL597509 | N,N'-bis(3,4-dihydroxybenzenesulfon...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310299 (CHEMBL599342 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310309 (CHEMBL596879 | N-(3,4-dihydroxyphenylsulfonyl)-N-h...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310311 (CHEMBL601265 | N-cyclohexyl-N-(3,4-dihydroxyphenyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310310 (CHEMBL596880 | N-benzyl-N-(3,4-dihydroxyphenylsulf...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310306 (CHEMBL611972 | N,N'-(ethane-1,2-diyl)bis(N-ethylbe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310313 (CHEMBL596860 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310305 (CHEMBL596859 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III/Prothrombin (Homo sapiens (Human)) | BDBM264614 (US9718760, C158) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.47E+5 | n/a | n/a | n/a | n/a | n/a | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph... | US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310308 (CHEMBL597478 | N-(3,4-dihydroxyphenylsulfonyl)-3,4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310304 (CHEMBL597510 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310301 (CHEMBL599742 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III/Prothrombin (Homo sapiens (Human)) | BDBM264648 (US9718760, C161) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.67E+6 | n/a | n/a | n/a | n/a | n/a | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph... | US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III/Prothrombin (Homo sapiens (Human)) | BDBM264598 (US9718760, C155) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.33E+6 | n/a | n/a | n/a | n/a | n/a | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph... | US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III/Prothrombin (Homo sapiens (Human)) | BDBM264627 (US9718760, C160) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.33E+6 | n/a | n/a | n/a | n/a | n/a | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph... | US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310303 (CHEMBL599769 | N,N'-(hexane-1,6-diyl)bis(3,4-dihyd...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310307 (CHEMBL596861 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >3.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310302 (CHEMBL611992 | N,N'-(butane-1,4-diyl)bis(3,4-dihyd...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50310300 (CHEMBL606451 | N,N'-(ethane-1,2-diyl)bis(3,4-dihyd...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of antithrombin-3 assessed as residual alpha-thrombin activity | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair |