Compile Data Set for Download or QSAR

Found 319 hits of ec50 for UniProtKB: P08912   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50258656 (1-(4-methoxybenzyl)-5-(trifluoromethoxy)indoline-2...) Show SMILES COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1 Show InChI InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	0.512	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Muscarinic acetylcholine receptors are family A GPCRs comprised of...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q290226P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM10759 (2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...) Show SMILES CC(=O)OCC[N+](C)(C)C Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay				J Med Chem 53: 6386-97 (2010) Article DOI: 10.1021/jm100697g BindingDB Entry DOI: 10.7270/Q2765G9K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM10759 (2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...) Show SMILES CC(=O)OCC[N+](C)(C)C Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining				Bioorg Med Chem Lett 22: 5134-40 (2012) Article DOI: 10.1016/j.bmcl.2012.05.048 BindingDB Entry DOI: 10.7270/Q24M95MM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475448 (CHEMBL195011) Show SMILES CCCCCCCC(=O)OC1CC2CC(OC(C)=O)C(C1)N2C |TLB:9:10:21:14.13,THB:15:14:21:20.11.10| Show InChI InChI=1S/C18H31NO4/c1-4-5-6-7-8-9-18(21)23-15-10-14-11-17(22-13(2)20)16(12-15)19(14)3/h14-17H,4-12H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.74	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475454 (CHEMBL196218) Show SMILES CCCCCC(=O)OC1CC2CC(CC1N2C)OC(=O)CCCCC |TLB:17:12:15:8.9,THB:7:8:15:13.11.12| Show InChI InChI=1S/C20H35NO4/c1-4-6-8-10-19(22)24-16-12-15-13-18(17(14-16)21(15)3)25-20(23)11-9-7-5-2/h15-18H,4-14H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.79	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50064609 (6-acetoxy-8-azonia-bicyclo[3.2.1]octane | Acetic a...) Show SMILES CC(=O)OC1CC2CCCC1N2 |TLB:3:4:11:9.8.7| Show InChI InChI=1S/C9H15NO2/c1-6(11)12-9-5-7-3-2-4-8(9)10-7/h7-10H,2-5H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.17	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475459 (CHEMBL194008) Show SMILES CCCCCC(=O)OC1CC2CC(OC(C)=O)C(C1)N2C |TLB:7:8:19:12.11,THB:13:12:19:18.9.8| Show InChI InChI=1S/C16H27NO4/c1-4-5-6-7-16(19)21-13-8-12-9-15(20-11(2)18)14(10-13)17(12)3/h12-15H,4-10H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.46	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50416732 (CHEMBL1223754) Show SMILES CCCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)n1c2cc(C)c(F)cc2[nH]c1=O |r,wD:4.3,7.7,(20.55,1.43,;19.01,1.41,;18.26,.07,;16.72,.05,;15.96,-1.29,;14.42,-1.31,;13.66,-2.66,;14.46,-3.98,;12.91,-3.97,;16,-3.95,;16.75,-2.62,;13.7,-5.32,;14.49,-6.64,;13.75,-7.98,;12.21,-8.01,;11.41,-6.69,;12.16,-5.34,;11.47,-9.36,;9.99,-9.84,;8.65,-9.08,;7.32,-9.85,;5.99,-9.07,;7.32,-11.41,;5.99,-12.18,;8.66,-12.17,;9.99,-11.41,;11.47,-11.88,;12.38,-10.62,;13.92,-10.63,)| Show InChI InChI=1S/C23H34FN3O2/c1-4-13-29-18-5-9-23(3,10-6-18)26-11-7-17(8-12-26)27-21-14-16(2)19(24)15-20(21)25-22(27)28/h14-15,17-18H,4-13H2,1-3H3,(H,25,28)/t18-,23-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	12.6	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 20: 5434-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.097 BindingDB Entry DOI: 10.7270/Q2MG7QR7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM10759 (2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...) Show SMILES CC(=O)OCC[N+](C)(C)C Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay				Bioorg Med Chem Lett 25: 4158-63 (2015) Article DOI: 10.1016/j.bmcl.2015.08.011 BindingDB Entry DOI: 10.7270/Q2GM8938
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50416733 (CHEMBL1223803) Show SMILES CCCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)N1C(=O)Cc2ccc(C)cc12 |r,wD:4.3,7.7,(20.54,1.43,;19,1.41,;18.25,.07,;16.71,.05,;15.96,-1.29,;14.42,-1.31,;13.66,-2.66,;14.45,-3.97,;12.91,-3.97,;15.99,-3.95,;16.74,-2.62,;13.7,-5.32,;14.49,-6.64,;13.74,-7.98,;12.2,-8.01,;11.41,-6.69,;12.16,-5.34,;11.47,-9.36,;12.38,-10.62,;13.92,-10.62,;11.47,-11.88,;9.99,-11.4,;8.65,-12.17,;7.32,-11.4,;7.32,-9.84,;5.99,-9.07,;8.65,-9.08,;9.98,-9.84,)| Show InChI InChI=1S/C24H36N2O2/c1-4-15-28-21-7-11-24(3,12-8-21)25-13-9-20(10-14-25)26-22-16-18(2)5-6-19(22)17-23(26)27/h5-6,16,20-21H,4,7-15,17H2,1-3H3/t21-,24-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	19.9	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 20: 5434-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.097 BindingDB Entry DOI: 10.7270/Q2MG7QR7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50416734 (CHEMBL1223804) Show SMILES CCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)N1C(=O)Cc2ccc(C)cc12 |r,wD:3.2,6.6,(19,1.41,;18.25,.07,;16.71,.05,;15.96,-1.29,;14.42,-1.31,;13.66,-2.66,;14.45,-3.97,;12.91,-3.97,;15.99,-3.95,;16.74,-2.62,;13.7,-5.32,;14.49,-6.64,;13.74,-7.98,;12.2,-8,;11.4,-6.69,;12.16,-5.34,;11.46,-9.36,;12.38,-10.62,;13.92,-10.62,;11.47,-11.88,;9.98,-11.4,;8.65,-12.16,;7.32,-11.4,;7.32,-9.84,;5.99,-9.07,;8.65,-9.08,;9.98,-9.84,)| Show InChI InChI=1S/C23H34N2O2/c1-4-27-20-7-11-23(3,12-8-20)24-13-9-19(10-14-24)25-21-15-17(2)5-6-18(21)16-22(25)26/h5-6,15,19-20H,4,7-14,16H2,1-3H3/t20-,23-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	19.9	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 20: 5434-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.097 BindingDB Entry DOI: 10.7270/Q2MG7QR7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475443 (CHEMBL364454) Show SMILES CCCCCCC(=O)OC1CC2CC(OC(C)=O)C(C1)N2C |TLB:8:9:20:13.12,THB:14:13:20:19.10.9| Show InChI InChI=1S/C17H29NO4/c1-4-5-6-7-8-17(20)22-14-9-13-10-16(21-12(2)19)15(11-14)18(13)3/h13-16H,4-11H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	26.9	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50046728 (1-Methyl-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-1,2,3,...) Show SMILES CN1CCC=C(C1)c1nc(C)no1 |c:4| Show InChI InChI=1S/C9H13N3O/c1-7-10-9(13-11-7)8-4-3-5-12(2)6-8/h4H,3,5-6H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Ferrosan A/S Curated by ChEMBL					Assay Description Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.				J Med Chem 34: 687-92 (1991) BindingDB Entry DOI: 10.7270/Q2RN3B25
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50024542 (CHEMBL3334991) Show SMILES O[C@H]1C[C@H](C1)NC(=O)c1ccc(cn1)C#Cc1cccc(F)c1 |r,wD:3.5,1.0,(35.3,-13.38,;33.97,-14.16,;32.48,-13.77,;32.09,-15.25,;33.58,-15.65,;30.76,-16.03,;29.43,-15.26,;29.42,-13.72,;28.1,-16.04,;26.76,-15.28,;25.43,-16.05,;25.43,-17.59,;26.76,-18.36,;28.1,-17.59,;24.09,-18.36,;22.76,-19.13,;21.43,-19.9,;21.43,-21.43,;20.1,-22.2,;18.76,-21.43,;18.76,-19.89,;17.43,-19.12,;20.09,-19.12,)| Show InChI InChI=1S/C18H15FN2O2/c19-14-3-1-2-12(8-14)4-5-13-6-7-17(20-11-13)18(23)21-15-9-16(22)10-15/h1-3,6-8,11,15-16,22H,9-10H2,(H,21,23)/t15-,16+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader				J Med Chem 57: 7485-98 (2014) Article DOI: 10.1021/jm5011786 BindingDB Entry DOI: 10.7270/Q2XG9SQ5
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50263888 (CHEMBL491209 | Ethyl 4-(2-oxo-2,3-dihydro-1Hbenzo[...) Show SMILES CCOC(=O)N1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C20H28N4O3/c1-2-27-20(26)23-13-7-15(8-14-23)22-11-9-16(10-12-22)24-18-6-4-3-5-17(18)21-19(24)25/h3-6,15-16H,2,7-14H2,1H3,(H,21,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	34.3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at muscarinic M5 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50275588 (2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-...) Show SMILES NC(=O)OCCN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C20H29N5O3/c21-19(26)28-14-13-23-9-5-15(6-10-23)24-11-7-16(8-12-24)25-18-4-2-1-3-17(18)22-20(25)27/h1-4,15-16H,5-14H2,(H2,21,26)(H,22,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	34.3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at muscarinic M5 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5443-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.032 BindingDB Entry DOI: 10.7270/Q29K4B1C
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475458 (CHEMBL194793) Show SMILES CN1C2CC(OC(C)=O)C1CC(C2)OS(=O)(=O)c1ccc(cc1)[N+]([O-])=O |TLB:5:4:1:11.10.12,THB:13:11:1:4.3| Show InChI InChI=1S/C16H20N2O7S/c1-10(19)24-16-8-12-7-13(9-15(16)17(12)2)25-26(22,23)14-5-3-11(4-6-14)18(20)21/h3-6,12-13,15-16H,7-9H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	44.7	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475453 (CHEMBL372536) Show SMILES CN1C2CC(OC(C)=O)C1CC(C2)OS(=O)(=O)c1ccccc1 |TLB:5:4:1:11.10.12,THB:13:11:1:4.3| Show InChI InChI=1S/C16H21NO5S/c1-11(18)21-16-9-12-8-13(10-15(16)17(12)2)22-23(19,20)14-6-4-3-5-7-14/h3-7,12-13,15-16H,8-10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	50.1	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50416738 (CHEMBL1223860) Show SMILES CCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)n1c2cc(C)c(F)cc2oc1=O |r,wD:3.2,6.6,(19.01,1.41,;18.26,.07,;16.72,.05,;15.96,-1.29,;14.42,-1.31,;13.66,-2.66,;14.46,-3.98,;12.91,-3.97,;16,-3.95,;16.75,-2.62,;13.7,-5.32,;14.49,-6.64,;13.75,-7.98,;12.21,-8.01,;11.41,-6.69,;12.16,-5.34,;11.47,-9.36,;9.99,-9.84,;8.65,-9.08,;7.32,-9.85,;5.99,-9.07,;7.32,-11.41,;5.99,-12.18,;8.66,-12.17,;9.99,-11.41,;11.47,-11.88,;12.38,-10.62,;13.92,-10.63,)| Show InChI InChI=1S/C22H31FN2O3/c1-4-27-17-5-9-22(3,10-6-17)24-11-7-16(8-12-24)25-19-13-15(2)18(23)14-20(19)28-21(25)26/h13-14,16-17H,4-12H2,1-3H3/t17-,22-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	50.1	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 20: 5434-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.097 BindingDB Entry DOI: 10.7270/Q2MG7QR7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50004665 ((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...) Show SMILES O=C1CCCN1CC#CCN1CCCC1 Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)				J Med Chem 38: 2188-95 (1995) BindingDB Entry DOI: 10.7270/Q28K7838
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM46858 (1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...) Show SMILES COC(=O)C1=CCCN(C)C1 |t:4| Show InChI InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	73	n/a	n/a	n/a	n/a
Ferrosan A/S Curated by ChEMBL					Assay Description Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.				J Med Chem 34: 687-92 (1991) BindingDB Entry DOI: 10.7270/Q2RN3B25
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475449 (CHEMBL197092) Show SMILES CC(=O)OC1CC2NC1CCC2O |TLB:3:4:7:11.9.10,THB:12:11:7:4.5| Show InChI InChI=1S/C9H15NO3/c1-5(11)13-9-4-7-8(12)3-2-6(9)10-7/h6-10,12H,2-4H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	79.4	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475450 (CHEMBL194196) Show SMILES CN1C2CC(OC(C)=O)C1CC(C2)OS(=O)(=O)c1cccc(C)c1 |TLB:5:4:1:11.10.12,THB:13:11:1:4.3| Show InChI InChI=1S/C17H23NO5S/c1-11-5-4-6-15(7-11)24(20,21)23-14-8-13-9-17(22-12(2)19)16(10-14)18(13)3/h4-7,13-14,16-17H,8-10H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	89.1	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475446 (CHEMBL196151) Show SMILES COc1ccc(cc1)S(=O)(=O)OC1CC2CC(OC(C)=O)C(C1)N2C |TLB:11:12:23:16.15,THB:17:16:23:12.22.13| Show InChI InChI=1S/C17H23NO6S/c1-11(19)23-17-9-12-8-14(10-16(17)18(12)2)24-25(20,21)15-6-4-13(22-3)5-7-15/h4-7,12,14,16-17H,8-10H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	93.3	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50228570 (CHEMBL1788202) Show SMILES C[C@H](C#CCN1CCCC1)N(C)C(C)=O |r| Show InChI InChI=1S/C12H20N2O/c1-11(13(3)12(2)15)7-6-10-14-8-4-5-9-14/h11H,4-5,8-10H2,1-3H3/t11-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	94	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Compound was tested for its potency against Muscarinic acetylcholine receptor in guinea pig ileum				J Med Chem 33: 3182-9 (1990) BindingDB Entry DOI: 10.7270/Q2QV3PR1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50229049 (CHEMBL351934) Show SMILES OC(=O)C(O)=O.CCCc1noc(n1)C1=CCCN(C)C1 |t:14| Show InChI InChI=1S/C11H17N3O/c1-3-5-10-12-11(15-13-10)9-6-4-7-14(2)8-9/h6H,3-5,7-8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Ferrosan A/S Curated by ChEMBL					Assay Description Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.				J Med Chem 34: 687-92 (1991) BindingDB Entry DOI: 10.7270/Q2RN3B25
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50004656 ((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...) Show SMILES C[N+](C)(C)CCOC(N)=O Show InChI InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Compound was tested for its potency against Muscarinic acetylcholine receptor in guinea pig ileum				J Med Chem 33: 3182-9 (1990) BindingDB Entry DOI: 10.7270/Q2QV3PR1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50475457 (CHEMBL373341) Show SMILES CN1C2CC(OC(C)=O)C1CC(C2)OS(=O)(=O)c1ccc(C)cc1 |TLB:5:4:1:11.10.12,THB:13:11:1:4.3| Show InChI InChI=1S/C17H23NO5S/c1-11-4-6-15(7-5-11)24(20,21)23-14-8-13-9-17(22-12(2)19)16(10-14)18(13)3/h4-7,13-14,16-17H,8-10H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	104	n/a	n/a	n/a	n/a
Shanghai Second Medical University Curated by ChEMBL					Assay Description Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle				Bioorg Med Chem Lett 15: 4814-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.045 BindingDB Entry DOI: 10.7270/Q23T9KZT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50004656 ((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...) Show SMILES C[N+](C)(C)CCOC(N)=O Show InChI InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description In vitro muscarinic activity was measured on isolated guinea pig ileum				J Med Chem 31: 164-8 (1988) BindingDB Entry DOI: 10.7270/Q2833V7R
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50035280 (3-Isopropoxy-5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c...) Show SMILES CC(C)Oc1noc2CCCNCc12 Show InChI InChI=1S/C10H16N2O2/c1-7(2)13-10-8-6-11-5-3-4-9(8)14-12-10/h7,11H,3-6H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)				J Med Chem 38: 2188-95 (1995) BindingDB Entry DOI: 10.7270/Q28K7838
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023269 (CHEMBL3329765) Show SMILES FC(F)(F)c1ccccc1CN(CC1CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)22-4-2-1-3-19(22)16-31(15-17-5-6-17)24(33)18-9-11-32(12-10-18)36(34,35)21-7-8-23-20(13-21)14-29-30-23/h1-4,7-8,13-14,17-18H,5-6,9-12,15-16H2,(H,29,30)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023269 (CHEMBL3329765) Show SMILES FC(F)(F)c1ccccc1CN(CC1CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)22-4-2-1-3-19(22)16-31(15-17-5-6-17)24(33)18-9-11-32(12-10-18)36(34,35)21-7-8-23-20(13-21)14-29-30-23/h1-4,7-8,13-14,17-18H,5-6,9-12,15-16H2,(H,29,30)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023268 (CHEMBL3329764) Show SMILES CC(C)(C)CN(Cc1ccccc1C(F)(F)F)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C26H31F3N4O3S/c1-25(2,3)17-32(16-19-6-4-5-7-22(19)26(27,28)29)24(34)18-10-12-33(13-11-18)37(35,36)21-8-9-23-20(14-21)15-30-31-23/h4-9,14-15,18H,10-13,16-17H2,1-3H3,(H,30,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023268 (CHEMBL3329764) Show SMILES CC(C)(C)CN(Cc1ccccc1C(F)(F)F)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C26H31F3N4O3S/c1-25(2,3)17-32(16-19-6-4-5-7-22(19)26(27,28)29)24(34)18-10-12-33(13-11-18)37(35,36)21-8-9-23-20(14-21)15-30-31-23/h4-9,14-15,18H,10-13,16-17H2,1-3H3,(H,30,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	123	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50061705 ((R)-1-Aza-bicyclo[2.2.2]oct-3-yl-[(Z)-methoxyimino...) Show SMILES CO\N=C(/C#N)[C@H]1CN2CCC1CC2 |wU:6.5,(10.77,-7.56,;9.23,-7.56,;8.14,-8.66,;8.14,-10.2,;9.41,-10.96,;10.69,-11.69,;6.8,-10.98,;6.8,-12.53,;5.46,-13.28,;4.14,-12.53,;4.14,-10.98,;5.46,-10.2,;4.95,-11.51,;5.89,-12.1,)| Show InChI InChI=1S/C10H15N3O/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13/h8-9H,2-5,7H2,1H3/b12-10+/t9-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	123	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay				Bioorg Med Chem Lett 25: 4158-63 (2015) Article DOI: 10.1016/j.bmcl.2015.08.011 BindingDB Entry DOI: 10.7270/Q2GM8938
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50416735 (CHEMBL1223805) Show SMILES CO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)N1C(=O)Cc2ccc(C)cc12 |r,wD:2.1,5.5,(18.25,.07,;16.71,.05,;15.95,-1.29,;14.41,-1.31,;13.66,-2.66,;14.45,-3.97,;12.9,-3.97,;15.99,-3.95,;16.74,-2.62,;13.69,-5.31,;14.48,-6.64,;13.74,-7.98,;12.2,-8,;11.4,-6.69,;12.15,-5.34,;11.46,-9.36,;12.37,-10.62,;13.91,-10.62,;11.46,-11.88,;9.98,-11.4,;8.65,-12.16,;7.32,-11.4,;7.32,-9.84,;5.99,-9.07,;8.65,-9.08,;9.98,-9.83,)| Show InChI InChI=1S/C22H32N2O2/c1-16-4-5-17-15-21(25)24(20(17)14-16)18-8-12-23(13-9-18)22(2)10-6-19(26-3)7-11-22/h4-5,14,18-19H,6-13,15H2,1-3H3/t19-,22-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	126	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 20: 5434-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.097 BindingDB Entry DOI: 10.7270/Q2MG7QR7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023270 (CHEMBL3329766) Show SMILES FC(F)(F)c1ccccc1CN(CC1CCC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C26H29F3N4O3S/c27-26(28,29)23-7-2-1-6-20(23)17-32(16-18-4-3-5-18)25(34)19-10-12-33(13-11-19)37(35,36)22-8-9-24-21(14-22)15-30-31-24/h1-2,6-9,14-15,18-19H,3-5,10-13,16-17H2,(H,30,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	129	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023270 (CHEMBL3329766) Show SMILES FC(F)(F)c1ccccc1CN(CC1CCC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C26H29F3N4O3S/c27-26(28,29)23-7-2-1-6-20(23)17-32(16-18-4-3-5-18)25(34)19-10-12-33(13-11-19)37(35,36)22-8-9-24-21(14-22)15-30-31-24/h1-2,6-9,14-15,18-19H,3-5,10-13,16-17H2,(H,30,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50229060 (CHEMBL161007) Show SMILES OC(=O)C(O)=O.CCCCCCCc1noc(n1)C1=CCCN(C)C1 |t:18| Show InChI InChI=1S/C15H25N3O/c1-3-4-5-6-7-10-14-16-15(19-17-14)13-9-8-11-18(2)12-13/h9H,3-8,10-12H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
Ferrosan A/S Curated by ChEMBL					Assay Description Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.				J Med Chem 34: 687-92 (1991) BindingDB Entry DOI: 10.7270/Q2RN3B25
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50003359 (5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...) Show SMILES CCCCCCOc1nsnc1C1=CCCN(C)C1 |t:13| Show InChI InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay				J Med Chem 53: 6386-97 (2010) Article DOI: 10.1021/jm100697g BindingDB Entry DOI: 10.7270/Q2765G9K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50003359 (5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...) Show SMILES CCCCCCOc1nsnc1C1=CCCN(C)C1 |t:13| Show InChI InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	142	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay				Bioorg Med Chem Lett 25: 4158-63 (2015) Article DOI: 10.1016/j.bmcl.2015.08.011 BindingDB Entry DOI: 10.7270/Q2GM8938
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Homo sapiens (Human))	BDBM50229056 (CHEMBL349025) Show SMILES OC(=O)C(O)=O.CCCCc1noc(n1)C1=CCCN(C)C1 |t:15| Show InChI InChI=1S/C12H19N3O/c1-3-4-7-11-13-12(16-14-11)10-6-5-8-15(2)9-10/h6H,3-5,7-9H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Ferrosan A/S Curated by ChEMBL					Assay Description Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.				J Med Chem 34: 687-92 (1991) BindingDB Entry DOI: 10.7270/Q2RN3B25
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023267 (CHEMBL3329763) Show SMILES CCC(C)N(Cc1ccccc1C(F)(F)F)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023267 (CHEMBL3329763) Show SMILES CCC(C)N(Cc1ccccc1C(F)(F)F)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	151	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023261 (CHEMBL3329756) Show SMILES CCCN(Cc1ccccc1C(F)(F)F)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C24H27F3N4O3S/c1-2-11-30(16-18-5-3-4-6-21(18)24(25,26)27)23(32)17-9-12-31(13-10-17)35(33,34)20-7-8-22-19(14-20)15-28-29-22/h3-8,14-15,17H,2,9-13,16H2,1H3,(H,28,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	155	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50416725 (CHEMBL1223862) Show SMILES CCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)n1c2cc(OC)ccc2oc1=O |r,wD:3.2,6.6,(19.01,1.41,;18.25,.07,;16.71,.05,;15.96,-1.29,;14.42,-1.31,;13.66,-2.66,;14.46,-3.98,;12.91,-3.97,;16,-3.95,;16.75,-2.62,;13.7,-5.32,;14.49,-6.64,;13.75,-7.98,;12.21,-8.01,;11.41,-6.69,;12.16,-5.34,;11.47,-9.36,;9.99,-9.84,;8.65,-9.08,;7.32,-9.84,;6,-9.08,;4.66,-9.84,;7.32,-11.4,;8.65,-12.17,;9.99,-11.4,;11.47,-11.88,;12.38,-10.62,;13.92,-10.62,)| Show InChI InChI=1S/C22H32N2O4/c1-4-27-17-7-11-22(2,12-8-17)23-13-9-16(10-14-23)24-19-15-18(26-3)5-6-20(19)28-21(24)25/h5-6,15-17H,4,7-14H2,1-3H3/t17-,22-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 20: 5434-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.097 BindingDB Entry DOI: 10.7270/Q2MG7QR7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50416730 (CHEMBL1223940) Show SMILES COCCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)n1c2cc(C)ccc2oc1=O |r,wD:5.4,8.8,(21.77,-.95,;21.02,-2.29,;19.48,-2.31,;18.72,-3.65,;17.18,-3.67,;16.43,-5.02,;14.89,-5.04,;14.13,-6.38,;14.92,-7.7,;13.38,-7.7,;16.47,-7.68,;17.21,-6.34,;14.17,-9.04,;14.96,-10.37,;14.22,-11.71,;12.67,-11.73,;11.88,-10.42,;12.63,-9.07,;11.94,-13.09,;10.45,-13.56,;9.12,-12.81,;7.79,-13.57,;6.46,-12.8,;7.79,-15.13,;9.12,-15.89,;10.45,-15.13,;11.94,-15.61,;12.85,-14.35,;14.39,-14.35,)| Show InChI InChI=1S/C23H34N2O4/c1-17-4-5-21-20(16-17)25(22(26)29-21)18-8-12-24(13-9-18)23(2)10-6-19(7-11-23)28-15-14-27-3/h4-5,16,18-19H,6-15H2,1-3H3/t19-,23-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 20: 5434-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.097 BindingDB Entry DOI: 10.7270/Q2MG7QR7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50416739 (CHEMBL1223861) Show SMILES CCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)n1c2cc(C)cc(F)c2oc1=O |r,wD:3.2,6.6,(19.01,1.41,;18.26,.07,;16.72,.05,;15.96,-1.29,;14.42,-1.31,;13.66,-2.66,;14.46,-3.98,;12.91,-3.97,;16,-3.95,;16.75,-2.62,;13.7,-5.32,;14.49,-6.64,;13.75,-7.98,;12.21,-8.01,;11.41,-6.69,;12.16,-5.34,;11.47,-9.36,;9.99,-9.84,;8.65,-9.08,;7.32,-9.85,;5.99,-9.07,;7.32,-11.41,;8.66,-12.17,;8.66,-13.71,;9.99,-11.41,;11.47,-11.88,;12.38,-10.62,;13.92,-10.63,)| Show InChI InChI=1S/C22H31FN2O3/c1-4-27-17-5-9-22(3,10-6-17)24-11-7-16(8-12-24)25-19-14-15(2)13-18(23)20(19)28-21(25)26/h13-14,16-17H,4-12H2,1-3H3/t17-,22-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 20: 5434-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.097 BindingDB Entry DOI: 10.7270/Q2MG7QR7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50023261 (CHEMBL3329756) Show SMILES CCCN(Cc1ccccc1C(F)(F)F)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C24H27F3N4O3S/c1-2-11-30(16-18-5-3-4-6-21(18)24(25,26)27)23(32)17-9-12-31(13-10-17)35(33,34)20-7-8-22-19(14-20)15-28-29-22/h3-8,14-15,17H,2,9-13,16H2,1H3,(H,28,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay				J Med Chem 57: 7804-10 (2014) Article DOI: 10.1021/jm500995y BindingDB Entry DOI: 10.7270/Q2ST7RFM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50122054 (8-Chloro-11-piperazin-1-yl-5H-dibenzo[b,e][1,4]dia...) Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCNCC1 |c:13| Show InChI InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay				J Med Chem 53: 6386-97 (2010) Article DOI: 10.1021/jm100697g BindingDB Entry DOI: 10.7270/Q2765G9K
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 319 total )  |  Next  |  Last  >>

Jump to: