Found 87 hits of ec50 for UniProtKB: P43114 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181298
(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H26F3NO4S/c24-23(25,26)16-4-1-3-15(13-16)14-18(28)8-6-17-7-11-21(29)27(17)12-2-5-19-9-10-20(32-19)22(30)31/h1,3-4,9-10,13,17-18,28H,2,5-8,11-12,14H2,(H,30,31)/t17-,18+/m0/s1 | PDB
Reactome pathway
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UniProtKB/SwissProt
GoogleScholar
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| Purchase
CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activation |
J Med Chem 53: 4332-53 (2010)
Article DOI: 10.1021/jm9018756
BindingDB Entry DOI: 10.7270/Q21R6QPF |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181298
(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H26F3NO4S/c24-23(25,26)16-4-1-3-15(13-16)14-18(28)8-6-17-7-11-21(29)27(17)12-2-5-19-9-10-20(32-19)22(30)31/h1,3-4,9-10,13,17-18,28H,2,5-8,11-12,14H2,(H,30,31)/t17-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
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CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181274
(5-(3-((S)-2-((R)-4-(3-chlorophenyl)-3-hydroxybutyl...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(Cl)c1 Show InChI InChI=1S/C22H26ClNO4S/c23-16-4-1-3-15(13-16)14-18(25)8-6-17-7-11-21(26)24(17)12-2-5-19-9-10-20(29-19)22(27)28/h1,3-4,9-10,13,17-18,25H,2,5-8,11-12,14H2,(H,27,28)/t17-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385126
(CHEMBL2036316)Show SMILES O[C@@H](Cc1cccc(OCc2ccccn2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C26H32N2O5S/c29-23(17-20-5-3-7-24(18-20)33-19-21-6-1-2-13-27-21)11-9-22-10-12-25(30)28(22)14-16-34-15-4-8-26(31)32/h1-3,5-7,9,11,13,18,22-23,29H,4,8,10,12,14-17,19H2,(H,31,32)/b11-9+/t22-,23+/m0/s1 | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 0.610 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM35847
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 | PDB
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| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP release |
Bioorg Med Chem Lett 19: 2075-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.059
BindingDB Entry DOI: 10.7270/Q2PR7W18 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360626
(CHEMBL1933722)Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r| Show InChI InChI=1S/C21H24N2O4S2/c1-14-3-2-4-15(11-14)12-17(24)7-5-16-6-8-19(25)23(16)9-10-28-21-22-18(13-29-21)20(26)27/h2-5,7,11,13,16-17,24H,6,8-10,12H2,1H3,(H,26,27)/b7-5+/t16-,17+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor |
Bioorg Med Chem 20: 2235-51 (2012)
Article DOI: 10.1016/j.bmc.2012.02.018
BindingDB Entry DOI: 10.7270/Q2542P2G |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360626
(CHEMBL1933722)Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r| Show InChI InChI=1S/C21H24N2O4S2/c1-14-3-2-4-15(11-14)12-17(24)7-5-16-6-8-19(25)23(16)9-10-28-21-22-18(13-29-21)20(26)27/h2-5,7,11,13,16-17,24H,6,8-10,12H2,1H3,(H,26,27)/b7-5+/t16-,17+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360161
(CHEMBL1929528)Show SMILES COCc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)[C@@H]2CCSCCCC(O)=O)c1 |r| Show InChI InChI=1S/C23H32O5S/c1-28-16-18-5-2-4-17(14-18)15-20(24)9-7-19-8-10-22(25)21(19)11-13-29-12-3-6-23(26)27/h2,4-5,7,9,14,19-21,24H,3,6,8,10-13,15-16H2,1H3,(H,26,27)/b9-7+/t19-,20+,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360160
(CHEMBL1929527)Show SMILES COCc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSCCCC(O)=O)c1 |r| Show InChI InChI=1S/C22H31NO5S/c1-28-16-18-5-2-4-17(14-18)15-20(24)9-7-19-8-10-21(25)23(19)11-13-29-12-3-6-22(26)27/h2,4-5,7,9,14,19-20,24H,3,6,8,10-13,15-16H2,1H3,(H,26,27)/b9-7+/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50101858
(4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxy-4-(3...)Show SMILES COCc1cccc(C[C@H](O)\C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(O)=O)c1 Show InChI InChI=1S/C23H32O6S/c1-29-15-17-5-2-4-16(12-17)13-18(24)7-8-19-20(22(26)14-21(19)25)9-11-30-10-3-6-23(27)28/h2,4-5,7-8,12,18-21,24-25H,3,6,9-11,13-15H2,1H3,(H,27,28)/b8-7+/t18-,19-,20-,21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385136
(CHEMBL2037289)Show SMILES Cc1ccc2nc(oc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r| Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-22-24(13-17)36-26(29-22)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181296
(5-(3-((S)-2-(3-hydroxy-4-phenylbutyl)-5-oxopyrroli...)Show SMILES OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C22H27NO4S/c24-18(15-16-5-2-1-3-6-16)10-8-17-9-13-21(25)23(17)14-4-7-19-11-12-20(28-19)22(26)27/h1-3,5-6,11-12,17-18,24H,4,7-10,13-15H2,(H,26,27)/t17-,18?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360148
(CHEMBL1929540)Show SMILES CCc1cccc(C[C@H](O)\C=C\[C@H]2CSC(=O)N2CCSCCCC(O)=O)c1 |r| Show InChI InChI=1S/C21H29NO4S2/c1-2-16-5-3-6-17(13-16)14-19(23)9-8-18-15-28-21(26)22(18)10-12-27-11-4-7-20(24)25/h3,5-6,8-9,13,18-19,23H,2,4,7,10-12,14-15H2,1H3,(H,24,25)/b9-8+/t18-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50156554
(4-(2-((R)-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxopyrro...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C18H31NO4S/c1-2-3-4-6-16(20)10-8-15-9-11-17(21)19(15)12-14-24-13-5-7-18(22)23/h8,10,15-16,20H,2-7,9,11-14H2,1H3,(H,22,23)/b10-8+/t15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor |
Bioorg Med Chem 20: 2235-51 (2012)
Article DOI: 10.1016/j.bmc.2012.02.018
BindingDB Entry DOI: 10.7270/Q2542P2G |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385132
(CHEMBL2036323)Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r| Show InChI InChI=1S/C27H25N3O5S2/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)35-25)10-8-19-9-11-24(32)30(19)12-13-36-27-29-22(16-37-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360173
(CHEMBL1929544)Show SMILES COCc1cccc(C[C@H](O)\C=C\[C@H]2CSC(=O)N2CCSCCCC(O)=O)c1 |r| Show InChI InChI=1S/C21H29NO5S2/c1-27-14-17-5-2-4-16(12-17)13-19(23)8-7-18-15-29-21(26)22(18)9-11-28-10-3-6-20(24)25/h2,4-5,7-8,12,18-19,23H,3,6,9-11,13-15H2,1H3,(H,24,25)/b8-7+/t18-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181289
(5-(3-((S)-2-(4-(3-fluorophenyl)-3-hydroxybutyl)-5-...)Show SMILES OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(F)c1 Show InChI InChI=1S/C22H26FNO4S/c23-16-4-1-3-15(13-16)14-18(25)8-6-17-7-11-21(26)24(17)12-2-5-19-9-10-20(29-19)22(27)28/h1,3-4,9-10,13,17-18,25H,2,5-8,11-12,14H2,(H,27,28)/t17-,18?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50156547
(4-(2-((R)-2-((S)-3-hydroxyoct-1-enyl)-5-oxopyrroli...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C21H29NO4/c1-2-3-4-5-19(23)12-10-18-11-13-20(24)22(18)15-14-16-6-8-17(9-7-16)21(25)26/h6-10,12,18-19,23H,2-5,11,13-15H2,1H3,(H,25,26)/b12-10+/t18-,19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor |
Bioorg Med Chem 20: 2235-51 (2012)
Article DOI: 10.1016/j.bmc.2012.02.018
BindingDB Entry DOI: 10.7270/Q2542P2G |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385123
(CHEMBL2036313)Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C27H30N2O4S2/c30-22(12-10-21-11-13-25(31)29(21)14-16-34-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)35-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM35847
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor |
Bioorg Med Chem 20: 2235-51 (2012)
Article DOI: 10.1016/j.bmc.2012.02.018
BindingDB Entry DOI: 10.7270/Q2542P2G |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360150
(CHEMBL1929542)Show SMILES O[C@@H](Cc1cccc(c1)C(F)(F)F)\C=C\[C@H]1CSC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C20H24F3NO4S2/c21-20(22,23)15-4-1-3-14(11-15)12-17(25)7-6-16-13-30-19(28)24(16)8-10-29-9-2-5-18(26)27/h1,3-4,6-7,11,16-17,25H,2,5,8-10,12-13H2,(H,26,27)/b7-6+/t16-,17+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360172
(CHEMBL1929539)Show SMILES O[C@@H](Cc1ccccc1)\C=C\[C@H]1CSC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C19H25NO4S2/c21-17(13-15-5-2-1-3-6-15)9-8-16-14-26-19(24)20(16)10-12-25-11-4-7-18(22)23/h1-3,5-6,8-9,16-17,21H,4,7,10-14H2,(H,22,23)/b9-8+/t16-,17+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385139
(CHEMBL2037292)Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r| Show InChI InChI=1S/C27H24ClN3O5S2/c28-18-4-8-23-21(14-18)29-25(36-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-37-27-30-22(15-38-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385131
(CHEMBL2036322)Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r| Show InChI InChI=1S/C28H26N2O5S2/c31-22(15-18-4-3-6-19(14-18)25-16-20-5-1-2-7-24(20)35-25)10-8-21-9-11-26(32)30(21)12-13-36-28-29-23(17-37-28)27(33)34/h1-8,10,14,16-17,21-22,31H,9,11-13,15H2,(H,33,34)/b10-8+/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360151
(CHEMBL1929543)Show SMILES O[C@@H](Cc1cccc(F)c1)\C=C\[C@H]1CSC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C19H24FNO4S2/c20-15-4-1-3-14(11-15)12-17(22)7-6-16-13-27-19(25)21(16)8-10-26-9-2-5-18(23)24/h1,3-4,6-7,11,16-17,22H,2,5,8-10,12-13H2,(H,23,24)/b7-6+/t16-,17+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360621
(CHEMBL1933717)Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSCCCC(O)=O)c1 |r| Show InChI InChI=1S/C21H29NO4S/c1-16-4-2-5-17(14-16)15-19(23)9-7-18-8-10-20(24)22(18)11-13-27-12-3-6-21(25)26/h2,4-5,7,9,14,18-19,23H,3,6,8,10-13,15H2,1H3,(H,25,26)/b9-7+/t18-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360149
(CHEMBL1929541)Show SMILES CCCc1cccc(C[C@H](O)\C=C\[C@H]2CSC(=O)N2CCSCCCC(O)=O)c1 |r| Show InChI InChI=1S/C22H31NO4S2/c1-2-5-17-6-3-7-18(14-17)15-20(24)10-9-19-16-29-22(27)23(19)11-13-28-12-4-8-21(25)26/h3,6-7,9-10,14,19-20,24H,2,4-5,8,11-13,15-16H2,1H3,(H,25,26)/b10-9+/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385124
(CHEMBL2036314)Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C28H31NO5S/c30-24(12-10-23-11-13-27(31)29(23)14-16-35-15-4-9-28(32)33)18-20-5-3-7-21(17-20)26-19-22-6-1-2-8-25(22)34-26/h1-3,5-8,10,12,17,19,23-24,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t23-,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360157
(CHEMBL1929550)Show SMILES COCc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=S)N2CCCCCCC(O)=O)c1 |r| Show InChI InChI=1S/C23H33NO4S/c1-28-17-19-8-6-7-18(15-19)16-21(25)12-10-20-11-13-22(29)24(20)14-5-3-2-4-9-23(26)27/h6-8,10,12,15,20-21,25H,2-5,9,11,13-14,16-17H2,1H3,(H,26,27)/b12-10+/t20-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385138
(CHEMBL2037291)Show SMILES Cc1cc(C)c2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r| Show InChI InChI=1S/C29H29N3O5S2/c1-17-12-18(2)26-23(13-17)30-27(37-26)20-5-3-4-19(14-20)15-22(33)8-6-21-7-9-25(34)32(21)10-11-38-29-31-24(16-39-29)28(35)36/h3-6,8,12-14,16,21-22,33H,7,9-11,15H2,1-2H3,(H,35,36)/b8-6+/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360158
(CHEMBL1929551)Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=S)N2CCSCCCC(O)=O)c1 |r| Show InChI InChI=1S/C21H29NO3S2/c1-16-4-2-5-17(14-16)15-19(23)9-7-18-8-10-20(26)22(18)11-13-27-12-3-6-21(24)25/h2,4-5,7,9,14,18-19,23H,3,6,8,10-13,15H2,1H3,(H,24,25)/b9-7+/t18-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50366136
(CHEMBL1957435)Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r| Show InChI InChI=1S/C26H26N2O4S2/c29-22(16-18-5-4-8-20(15-18)19-6-2-1-3-7-19)11-9-21-10-12-24(30)28(21)13-14-33-26-27-23(17-34-26)25(31)32/h1-9,11,15,17,21-22,29H,10,12-14,16H2,(H,31,32)/b11-9+/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50366136
(CHEMBL1957435)Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r| Show InChI InChI=1S/C26H26N2O4S2/c29-22(16-18-5-4-8-20(15-18)19-6-2-1-3-7-19)11-9-21-10-12-24(30)28(21)13-14-33-26-27-23(17-34-26)25(31)32/h1-9,11,15,17,21-22,29H,10,12-14,16H2,(H,31,32)/b11-9+/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor |
Bioorg Med Chem 20: 2235-51 (2012)
Article DOI: 10.1016/j.bmc.2012.02.018
BindingDB Entry DOI: 10.7270/Q2542P2G |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50142481
(7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrr...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O Show InChI InChI=1S/C19H33NO4/c1-2-3-6-9-17(21)13-11-16-12-14-18(22)20(16)15-8-5-4-7-10-19(23)24/h11,13,16-17,21H,2-10,12,14-15H2,1H3,(H,23,24)/b13-11+/t16-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor |
Bioorg Med Chem 20: 2235-51 (2012)
Article DOI: 10.1016/j.bmc.2012.02.018
BindingDB Entry DOI: 10.7270/Q2542P2G |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385135
(CHEMBL2036326)Show SMILES Cc1ccc2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r| Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-24-22(13-17)29-26(36-24)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 8.80 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181279
(7-(2-(4-(3-chlorophenyl)-3-hydroxybutyl)-5-oxopyrr...)Show InChI InChI=1S/C21H30ClNO4/c22-17-7-5-6-16(14-17)15-19(24)11-9-18-10-12-20(25)23(18)13-4-2-1-3-8-21(26)27/h5-7,14,18-19,24H,1-4,8-13,15H2,(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 8.80 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360153
(CHEMBL1929546)Show SMILES CCc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=S)N2CCCCCCC(O)=O)c1 |r| Show InChI InChI=1S/C23H33NO3S/c1-2-18-8-7-9-19(16-18)17-21(25)13-11-20-12-14-22(28)24(20)15-6-4-3-5-10-23(26)27/h7-9,11,13,16,20-21,25H,2-6,10,12,14-15,17H2,1H3,(H,26,27)/b13-11+/t20-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385134
(CHEMBL2036325)Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r| Show InChI InChI=1S/C27H24ClN3O4S3/c28-18-4-8-23-21(14-18)29-25(38-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-36-27-30-22(15-37-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360155
(CHEMBL1929548)Show SMILES O[C@@H](Cc1cccc(c1)C(F)(F)F)\C=C\[C@H]1CCC(=S)N1CCCCCCC(O)=O |r| Show InChI InChI=1S/C22H28F3NO3S/c23-22(24,25)17-7-5-6-16(14-17)15-19(27)11-9-18-10-12-20(30)26(18)13-4-2-1-3-8-21(28)29/h5-7,9,11,14,18-19,27H,1-4,8,10,12-13,15H2,(H,28,29)/b11-9+/t18-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360166
(CHEMBL1929533)Show SMILES O[C@@H](Cc1cccc(c1)C(F)(F)F)\C=C\[C@H]1COC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C20H24F3NO5S/c21-20(22,23)15-4-1-3-14(11-15)12-17(25)7-6-16-13-29-19(28)24(16)8-10-30-9-2-5-18(26)27/h1,3-4,6-7,11,16-17,25H,2,5,8-10,12-13H2,(H,26,27)/b7-6+/t16-,17+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50142488
(7-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)phen...)Show SMILES O[C@H](CC[C@H]1CCC(=O)N1CCCCCCC(O)=O)Cc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C22H30F3NO4/c23-22(24,25)17-7-5-6-16(14-17)15-19(27)11-9-18-10-12-20(28)26(18)13-4-2-1-3-8-21(29)30/h5-7,14,18-19,27H,1-4,8-13,15H2,(H,29,30)/t18-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385133
(CHEMBL2036324)Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r| Show InChI InChI=1S/C27H25N3O4S3/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)37-25)10-8-19-9-11-24(32)30(19)12-13-35-27-29-22(16-36-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385122
(CHEMBL2036312)Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C27H30N2O5S/c30-22(12-10-21-11-13-25(31)29(21)14-16-35-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)34-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360159
(CHEMBL1929526)Show SMILES COCc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCCCCCC(O)=O)c1 |r| Show InChI InChI=1S/C23H33NO5/c1-29-17-19-8-6-7-18(15-19)16-21(25)12-10-20-11-13-22(26)24(20)14-5-3-2-4-9-23(27)28/h6-8,10,12,15,20-21,25H,2-5,9,11,13-14,16-17H2,1H3,(H,27,28)/b12-10+/t20-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385128
(CHEMBL2036318)Show SMILES Cc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r| Show InChI InChI=1S/C27H28N2O4S2/c1-18-5-7-20(8-6-18)21-4-2-3-19(15-21)16-23(30)11-9-22-10-12-25(31)29(22)13-14-34-27-28-24(17-35-27)26(32)33/h2-9,11,15,17,22-23,30H,10,12-14,16H2,1H3,(H,32,33)/b11-9+/t22-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385129
(CHEMBL2036319)Show SMILES COc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r| Show InChI InChI=1S/C27H28N2O5S2/c1-34-23-10-5-19(6-11-23)20-4-2-3-18(15-20)16-22(30)9-7-21-8-12-25(31)29(21)13-14-35-27-28-24(17-36-27)26(32)33/h2-7,9-11,15,17,21-22,30H,8,12-14,16H2,1H3,(H,32,33)/b9-7+/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50181293
(7-((S)-2-((R)-3-hydroxy-4-(3-(methoxymethyl)phenyl...)Show SMILES COCc1cccc(C[C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(O)=O)c1 Show InChI InChI=1S/C23H35NO5/c1-29-17-19-8-6-7-18(15-19)16-21(25)12-10-20-11-13-22(26)24(20)14-5-3-2-4-9-23(27)28/h6-8,15,20-21,25H,2-5,9-14,16-17H2,1H3,(H,27,28)/t20-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation |
Bioorg Med Chem Lett 16: 1799-802 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.018
BindingDB Entry DOI: 10.7270/Q2SQ8ZZ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50360164
(CHEMBL1929531)Show SMILES CCc1cccc(C[C@H](O)\C=C\[C@H]2COC(=O)N2CCSCCCC(O)=O)c1 |r| Show InChI InChI=1S/C21H29NO5S/c1-2-16-5-3-6-17(13-16)14-19(23)9-8-18-15-27-21(26)22(18)10-12-28-11-4-7-20(24)25/h3,5-6,8-9,13,18-19,23H,2,4,7,10-12,14-15H2,1H3,(H,24,25)/b9-8+/t18-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 702-13 (2012)
Checked by Author
Article DOI: 10.1016/j.bmc.2011.12.009
BindingDB Entry DOI: 10.7270/Q2CJ8DXN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385125
(CHEMBL2036315)Show SMILES O[C@@H](Cc1cccc(OCc2cccnc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r| Show InChI InChI=1S/C26H32N2O5S/c29-23(16-20-4-1-6-24(17-20)33-19-21-5-2-12-27-18-21)10-8-22-9-11-25(30)28(22)13-15-34-14-3-7-26(31)32/h1-2,4-6,8,10,12,17-18,22-23,29H,3,7,9,11,13-16,19H2,(H,31,32)/b10-8+/t22-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Rattus norvegicus) | BDBM50385141
(CHEMBL2036321)Show SMILES Cc1ccc(cc1C)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r| Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-7-22(14-19(18)2)21-5-3-4-20(15-21)16-24(31)10-8-23-9-11-26(32)30(23)12-13-35-28-29-25(17-36-28)27(33)34/h3-8,10,14-15,17,23-24,31H,9,11-13,16H2,1-2H3,(H,33,34)/b10-8+/t23-,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
Minase Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay |
Bioorg Med Chem 20: 3502-22 (2012)
Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B |
More data for this
Ligand-Target Pair | |
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