Compile Data Set for Download or QSAR

Found 419 hits of ic50 data for polymerid = 50007432   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DCN1-like protein 1 (Homo sapiens)	BDBM50525311 (CHEMBL4448070) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCC#C)nc(Sc2nnnn2C)c1C#N Show InChI InChI=1S/C19H17N7O3S2/c1-6-7-30-18-21-15(11-8-13(27-3)16(29-5)14(9-11)28-4)12(10-20)17(22-18)31-19-23-24-25-26(19)2/h1,8-9H,7H2,2-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584177 (CHEMBL5076401) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc3ccccc3c2)nc(Sc2nnnn2CCN(C)C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584172 (CHEMBL5075399) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(C)cc2)nc(Sc2nnnn2C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584163 (CHEMBL5070367) Show SMILES COC(=O)c1ccc(CSc2nc(Sc3nccs3)c(C#N)c(n2)-c2cc(OC)c(OC)c(OC)c2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584157 (CHEMBL5091659) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2cccc(C)c2)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584169 (CHEMBL5092564) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc3ccccc3c2)nc(Sc2nnnn2C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584179 (CHEMBL5086499) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(C)cc2)nc(Sc2nnnn2CCN(C)C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584167 (CHEMBL5085822) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(Cl)cc2)nc(Sc2nnnn2C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584170 (CHEMBL5082310) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2cccc(C)c2)nc(Sc2nnnn2C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584160 (CHEMBL5078162) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(cc2)C(C)(C)C)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584173 (CHEMBL5089618) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2cccc(c2)C(F)(F)F)nc(Sc2nnnn2CCN(C)C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584178 (CHEMBL5091608) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2cccc(C)c2)nc(Sc2nnnn2CCN(C)C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584176 (CHEMBL5085047) Show SMILES COc1ccc(CSc2nc(Sc3nnnn3CCN(C)C)c(C#N)c(n2)-c2cc(OC)c(OC)c(OC)c2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50525313 (CHEMBL4592844) Show SMILES Cc1ccc(cc1)-c1nc(SCC#C)nc(Sc2nccs2)c1C#N Show InChI InChI=1S/C18H12N4S3/c1-3-9-23-17-21-15(13-6-4-12(2)5-7-13)14(11-19)16(22-17)25-18-20-8-10-24-18/h1,4-8,10H,9H2,2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Binding affinity to N-terminal GST tagged recombinant human DCN1 (58 to 259 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction i...				J Med Chem 62: 5382-5403 (2019) Article DOI: 10.1021/acs.jmedchem.9b00003 BindingDB Entry DOI: 10.7270/Q2GT5RM9
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584188 (CHEMBL5074683) Show SMILES COc1ccc(cc1OC)-c1nc(SCc2ccc(C)cc2)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50525313 (CHEMBL4592844) Show SMILES Cc1ccc(cc1)-c1nc(SCC#C)nc(Sc2nccs2)c1C#N Show InChI InChI=1S/C18H12N4S3/c1-3-9-23-17-21-15(13-6-4-12(2)5-7-13)14(11-19)16(22-17)25-18-20-8-10-24-18/h1,4-8,10H,9H2,2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50245154 (CHEMBL4067795 | US11116757, No. A10) Show SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C28H35N3O/c1-3-9-22(2)30-18-16-27(17-19-30)31(21-23-10-5-4-6-11-23)28(32)29-26-15-14-24-12-7-8-13-25(24)20-26/h4-8,10-15,20,22,27H,3,9,16-19,21H2,1-2H3,(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Binding affinity for Adenosine A1 receptor using N-[3H] cyclohexyladenosine in rat forebrain membranes				J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50525354 (CHEMBL4517307) Show SMILES CCC(=O)N[C@@H](Cc1nc2ccc(cc2s1)C(C)C)C(=O)N[C@H](CNC(=O)CCN1CCOCC1)C1CCCCC1 |r| Show InChI InChI=1S/C31H47N5O4S/c1-4-28(37)33-25(19-30-34-24-11-10-23(21(2)3)18-27(24)41-30)31(39)35-26(22-8-6-5-7-9-22)20-32-29(38)12-13-36-14-16-40-17-15-36/h10-11,18,21-22,25-26H,4-9,12-17,19-20H2,1-3H3,(H,32,38)(H,33,37)(H,35,39)/t25-,26+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Binding affinity to N-terminal His6-tagged recombinant human DCN1 expressed in Escherichia coli BL21-AI assessed as reduction in DCN1-FAM-labelled N-...				J Med Chem 62: 5382-5403 (2019) Article DOI: 10.1021/acs.jmedchem.9b00003 BindingDB Entry DOI: 10.7270/Q2GT5RM9
					More data for this Ligand-Target Pair				3D Structure (crystal)
DCN1-like protein 1 (Homo sapiens)	BDBM50569321 (CHEMBL4851208) Show SMILES CCC(=O)N[C@@H](Cc1nc2ccc(cc2s1)C(C)C)C(=O)N[C@@H](CNC(=O)CCN1CCOCC1)C1CCCCC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in DCN1/UBC12 int...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113326 BindingDB Entry DOI: 10.7270/Q25H7M1W
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584184 (CHEMBL5089246) Show SMILES COc1ccc(cc1)-c1nc(SCc2ccc(C)cc2)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584183 (CHEMBL5089944) Show SMILES Cc1ccc(CSc2nc(Sc3nccs3)c(C#N)c(n2)-c2ccc(C)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584175 (CHEMBL5089086) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(Cl)cc2)nc(Sc2nnnn2CCN(C)C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584161 (CHEMBL5080691) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(Cl)cc2)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584165 (CHEMBL5087586) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2cccc(c2)C(F)(F)F)nc(Sc2nnnn2C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50569336 (CHEMBL4865016) Show SMILES S(Sc1nnc([nH]1)-c1ccccc1-c1ccccc1)c1nnc([nH]1)-c1ccccc1-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113326 BindingDB Entry DOI: 10.7270/Q25H7M1W
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50525313 (CHEMBL4592844) Show SMILES Cc1ccc(cc1)-c1nc(SCC#C)nc(Sc2nccs2)c1C#N Show InChI InChI=1S/C18H12N4S3/c1-3-9-23-17-21-15(13-6-4-12(2)5-7-13)14(11-19)16(22-17)25-18-20-8-10-24-18/h1,4-8,10H,9H2,2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Binding affinity to N-terminal His6-tagged recombinant human DCN1 expressed in Escherichia coli BL21-AI assessed as reduction in DCN1-FAM-labelled N-...				J Med Chem 62: 5382-5403 (2019) Article DOI: 10.1021/acs.jmedchem.9b00003 BindingDB Entry DOI: 10.7270/Q2GT5RM9
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584137 (CHEMBL5080436) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccccc2)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584186 (CHEMBL5093455) Show SMILES Cc1ccc(CSc2nc(Sc3nccs3)c(C#N)c(n2)-c2ccc(Br)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584146 (CHEMBL5089436) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccccc2)nc(Sc2nnnn2CCN(C)C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584166 (CHEMBL5085671) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(cc2)C(F)(F)F)nc(Sc2nnnn2C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584155 (CHEMBL5092062) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2cccc(c2)C(F)(F)F)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584168 (CHEMBL5076837) Show SMILES COc1ccc(CSc2nc(Sc3nnnn3C)c(C#N)c(n2)-c2cc(OC)c(OC)c(OC)c2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584164 (CHEMBL5091159) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc3ccccc3c2)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584145 (CHEMBL5084048) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccccc2)nc(Sc2nnnn2C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584135 (CHEMBL5084356) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCC=C)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50525334 (CHEMBL4470342) Show SMILES Clc1ccc(cc1)-c1nc(SCC#C)nc(Sc2nccs2)c1C#N Show InChI InChI=1S/C17H9ClN4S3/c1-2-8-23-16-21-14(11-3-5-12(18)6-4-11)13(10-19)15(22-16)25-17-20-7-9-24-17/h1,3-7,9H,8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Binding affinity to N-terminal His6-tagged recombinant human DCN1 expressed in Escherichia coli BL21-AI assessed as reduction in DCN1-FAM-labelled N-...				J Med Chem 62: 5382-5403 (2019) Article DOI: 10.1021/acs.jmedchem.9b00003 BindingDB Entry DOI: 10.7270/Q2GT5RM9
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM423127 (US10500194, Example 7) Show SMILES CCC(=O)N[C@@H](Cc1nc2ccc(cc2s1)C(C)C)C(=O)N[C@H](CNC(=O)C(=C)CN1CCOCC1)Cc1ccccc1 |r| Show InChI InChI=1S/C33H43N5O4S/c1-5-30(39)36-28(19-31-37-27-12-11-25(22(2)3)18-29(27)43-31)33(41)35-26(17-24-9-7-6-8-10-24)20-34-32(40)23(4)21-38-13-15-42-16-14-38/h6-12,18,22,26,28H,4-5,13-17,19-21H2,1-3H3,(H,34,40)(H,35,41)(H,36,39)/t26-,28-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37.4	n/a	n/a	n/a	n/a	n/a	n/a
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description The Fluorescence Polarization (FP) competitive binding assays were performed to accurately determine the binding affinities of our DCN1 inhibitors. A...				US Patent US10500194 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GW1
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584147 (CHEMBL5078620) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccccc2)nc(Sc2nc(C)cs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM423124 (US10500194, Example 4) Show SMILES CCC(=O)N[C@@H](Cc1nc2ccc(Cl)cc2s1)C(=O)N[C@H](CNC(=O)C(=C)CN1CCOCC1)C1CCCCC1 |r| Show InChI InChI=1S/C29H40ClN5O4S/c1-3-26(36)32-23(16-27-33-22-10-9-21(30)15-25(22)40-27)29(38)34-24(20-7-5-4-6-8-20)17-31-28(37)19(2)18-35-11-13-39-14-12-35/h9-10,15,20,23-24H,2-8,11-14,16-18H2,1H3,(H,31,37)(H,32,36)(H,34,38)/t23-,24+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41.6	n/a	n/a	n/a	n/a	n/a	n/a
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description The Fluorescence Polarization (FP) competitive binding assays were performed to accurately determine the binding affinities of our DCN1 inhibitors. A...				US Patent US10500194 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GW1
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584158 (CHEMBL5080829) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(C)cc2)nc(Sc2nccs2)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50245237 (CHEMBL4074213 | US11116757, No. A7) Show SMILES CCCCN1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C23H29Cl2N3O/c1-2-3-13-27-14-11-20(12-15-27)28(17-18-7-5-4-6-8-18)23(29)26-19-9-10-21(24)22(25)16-19/h4-10,16,20H,2-3,11-15,17H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a...				J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
DCN1-like protein 1 (Homo sapiens)	BDBM50245225 (CHEMBL4099097 | US11116757, No. A15) Show SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H32F3N3O/c1-3-8-19(2)30-15-13-23(14-16-30)31(18-20-9-5-4-6-10-20)24(32)29-22-12-7-11-21(17-22)25(26,27)28/h4-7,9-12,17,19,23H,3,8,13-16,18H2,1-2H3,(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a...				J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50569329 (CHEMBL4878599) Show SMILES S(Sc1nnc([nH]1)-c1ccccc1)c1nnc([nH]1)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in DCN1/UBC12 int...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113326 BindingDB Entry DOI: 10.7270/Q25H7M1W
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50245227 (CHEMBL4077431 | US11116757, No. A4) Show SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc(I)cc1 Show InChI InChI=1S/C24H32IN3O/c1-3-7-19(2)27-16-14-23(15-17-27)28(18-20-8-5-4-6-9-20)24(29)26-22-12-10-21(25)11-13-22/h4-6,8-13,19,23H,3,7,14-18H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a...				J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50569336 (CHEMBL4865016) Show SMILES S(Sc1nnc([nH]1)-c1ccccc1-c1ccccc1)c1nnc([nH]1)-c1ccccc1-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in DCN1/UBC12 int...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113326 BindingDB Entry DOI: 10.7270/Q25H7M1W
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50245148 (CHEMBL4077759 | US11116757, No. A6) Show SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1cc(F)cc(c1)C(F)(F)F Show InChI InChI=1S/C25H31F4N3O/c1-3-7-18(2)31-12-10-23(11-13-31)32(17-19-8-5-4-6-9-19)24(33)30-22-15-20(25(27,28)29)14-21(26)16-22/h4-6,8-9,14-16,18,23H,3,7,10-13,17H2,1-2H3,(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a...				J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50525343 (CHEMBL4440896 | US11116757, No. A29) Show SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1NC(=O)C=C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C28H35F3N4O2/c1-4-9-20(3)34-16-14-24(15-17-34)35(19-21-10-6-7-13-25(21)33-26(36)5-2)27(37)32-23-12-8-11-22(18-23)28(29,30)31/h5-8,10-13,18,20,24H,2,4,9,14-17,19H2,1,3H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50525343 (CHEMBL4440896 | US11116757, No. A29) Show SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1NC(=O)C=C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C28H35F3N4O2/c1-4-9-20(3)34-16-14-24(15-17-34)35(19-21-10-6-7-13-25(21)33-26(36)5-2)27(37)32-23-12-8-11-22(18-23)28(29,30)31/h5-8,10-13,18,20,24H,2,4,9,14-17,19H2,1,3H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Binding affinity to N-terminal GST tagged recombinant human DCN1 (58 to 259 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction i...				J Med Chem 62: 5382-5403 (2019) Article DOI: 10.1021/acs.jmedchem.9b00003 BindingDB Entry DOI: 10.7270/Q2GT5RM9
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50525343 (CHEMBL4440896 | US11116757, No. A29) Show SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1NC(=O)C=C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C28H35F3N4O2/c1-4-9-20(3)34-16-14-24(15-17-34)35(19-21-10-6-7-13-25(21)33-26(36)5-2)27(37)32-23-12-8-11-22(18-23)28(29,30)31/h5-8,10-13,18,20,24H,2,4,9,14-17,19H2,1,3H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113326 BindingDB Entry DOI: 10.7270/Q25H7M1W
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50584174 (CHEMBL5077779) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(cc2)C(F)(F)F)nc(Sc2nnnn2CCN(C)C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ
					More data for this Ligand-Target Pair

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