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Compile Data Set for Download or QSAR

Found 142 hits of ic50 for UniProtKB: P43405   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311138
PNG
(example 6.09 on page 559 of WO15017610)
Show SMILES C[C@@H](Oc1cc(cn2ncc(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C21H27N5O2/c1-13-8-23-25-11-16(17-10-24-26(12-17)21(3,4)5)6-18(20(13)25)28-14(2)15-7-19(27)22-9-15/h6,8,10-12,14-15H,7,9H2,1-5H3,(H,22,27)/t14-,15-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375967
PNG
(US10947243, Example 45 | US9914735, Example 45)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)cc12)-c1cnn(c1)C1CCNCC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H28N6O2/c1-14(16-9-22(29)24-10-16)30-21-8-15(7-20-19(21)13-27(2)26-20)17-11-25-28(12-17)18-3-5-23-6-4-18/h7-8,11-14,16,18,23H,3-6,9-10H2,1-2H3,(H,24,29)/t14-,16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311136
PNG
(example 5.20 on page 506 of WO15017610)
Show SMILES C[C@@H](Oc1nc(cn2ncc(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H26N6O2/c1-12-7-22-25-11-16(15-9-23-26(10-15)20(3,4)5)24-19(18(12)25)28-13(2)14-6-17(27)21-8-14/h7,9-11,13-14H,6,8H2,1-5H3,(H,21,27)/t13-,14-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM140389
PNG
(US10947243, Example 114 | US8912173, 114 | US99147...)
Show SMILES CCCn1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1S/C21H24N4O2/c1-3-7-25-13-17(12-24-25)15-8-19-18(5-4-6-22-19)20(9-15)27-14(2)16-10-21(26)23-11-16/h4-6,8-9,12-14,16H,3,7,10-11H2,1-2H3,(H,23,26)/t14-,16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM140390
PNG
(US10947243, Example 115 | US8912173, 115 | US99147...)
Show SMILES CC(C)n1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1S/C21H24N4O2/c1-13(2)25-12-17(11-24-25)15-7-19-18(5-4-6-22-19)20(8-15)27-14(3)16-9-21(26)23-10-16/h4-8,11-14,16H,9-10H2,1-3H3,(H,23,26)/t14-,16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311139
PNG
(example 3B.22 on page 219 of WO15017610)
Show SMILES C[C@@H](Oc1cc(cc2ncn(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C21H27N5O2/c1-13(15-8-19(27)22-9-15)28-18-7-14(6-17-20(18)25(5)12-23-17)16-10-24-26(11-16)21(2,3)4/h6-7,10-13,15H,8-9H2,1-5H3,(H,22,27)/t13-,15-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311126
PNG
(US10155751, Example 13)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H29N5O2/c1-13-21-18(25-26(13)6)7-15(17-11-24-27(12-17)22(3,4)5)8-19(21)29-14(2)16-9-20(28)23-10-16/h7-8,11-12,14,16H,9-10H2,1-6H3,(H,23,28)/t14-,16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375942
PNG
(US10947243, Example 8 | US9914735, Example 8)
Show SMILES COc1cc(ccc1O)-c1cc2nn(C)cc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H22N4O4/c1-11(13-7-19(26)21-9-13)28-20-14-10-24(2)23-16(14)8-15(22-20)12-4-5-17(25)18(6-12)27-3/h4-6,8,10-11,13,25H,7,9H2,1-3H3,(H,21,26)/t11-,13-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311114
PNG
(US10155751, Example 1)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(c1)C1CCC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C21H24FN5O2/c1-12(14-8-19(28)23-9-14)29-18-7-13(6-17-20(18)21(22)26(2)25-17)15-10-24-27(11-15)16-4-3-5-16/h6-7,10-12,14,16H,3-5,8-9H2,1-2H3,(H,23,28)/t12-,14-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375966
PNG
(US10947243, Example 43 | US9914735, Example 43)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)cc12)-c1cnc2ccc(cn12)C#N)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H20N6O2/c1-13(16-7-22(29)25-9-16)30-20-6-15(5-18-17(20)12-27(2)26-18)19-10-24-21-4-3-14(8-23)11-28(19)21/h3-6,10-13,16H,7,9H2,1-2H3,(H,25,29)/t13-,16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375944
PNG
(US10947243, Example 10 | US9914735, Example 10)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)cc12)-c1cnn(c1)C1CCC(F)(F)CC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H26F2N6O2/c1-13(14-7-20(31)25-9-14)32-21-17-12-29(2)28-19(17)8-18(27-21)15-10-26-30(11-15)16-3-5-22(23,24)6-4-16/h8,10-14,16H,3-7,9H2,1-2H3,(H,25,31)/t13-,14-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375964
PNG
(US10947243, Example 41 | US9914735, Example 41)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)cc12)-c1ccc(F)cn1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C19H19FN4O2/c1-11(13-7-19(25)22-8-13)26-18-6-12(16-4-3-14(20)9-21-16)5-17-15(18)10-24(2)23-17/h3-6,9-11,13H,7-8H2,1-2H3,(H,22,25)/t11-,13-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM140369
PNG
(US10947243, Example 94 | US8912173, 94 | US9914735...)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2n(C)cnc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C23H22N4O2/c1-14(17-11-23(28)25-12-17)29-22-10-16(9-19-18(22)4-3-7-24-19)15-5-6-21-20(8-15)26-13-27(21)2/h3-10,13-14,17H,11-12H2,1-2H3,(H,25,28)/t14-,17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM140380
PNG
(US10947243, Example 105 | US8912173, 105 | US99147...)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2n(C)c(C)nc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C24H24N4O2/c1-14(18-12-24(29)26-13-18)30-23-11-17(10-20-19(23)5-4-8-25-20)16-6-7-22-21(9-16)27-15(2)28(22)3/h4-11,14,18H,12-13H2,1-3H3,(H,26,29)/t14-,18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375942
PNG
(US10947243, Example 8 | US9914735, Example 8)
Show SMILES COc1cc(ccc1O)-c1cc2nn(C)cc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C20H22N4O4/c1-11(13-7-19(26)21-9-13)28-20-14-10-24(2)23-16(14)8-15(22-20)12-4-5-17(25)18(6-12)27-3/h4-6,8,10-11,13,25H,7,9H2,1-3H3,(H,21,26)/t11-,13-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM140384
PNG
(US10947243, Example 109 | US8912173, 109 | US99147...)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2[nH]c(C)nc2c1)[C@H]1CNC(=O)C1 |r|
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375960
PNG
(US10947243, Example 35 | US9914735, Example 35)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)cc12)-c1csc(n1)C(F)F)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C18H18F2N4O2S/c1-9(11-5-16(25)21-6-11)26-15-4-10(3-13-12(15)7-24(2)23-13)14-8-27-18(22-14)17(19)20/h3-4,7-9,11,17H,5-6H2,1-2H3,(H,21,25)/t9-,11-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311131
PNG
(US10155751, Example 18)
Show SMILES CC(C)n1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2c(C)n(C)nc2c1 |r|
Show InChI InChI=1S/C21H27N5O2/c1-12(2)26-11-17(10-23-26)15-6-18-21(13(3)25(5)24-18)19(7-15)28-14(4)16-8-20(27)22-9-16/h6-7,10-12,14,16H,8-9H2,1-5H3,(H,22,27)/t14-,16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311122
PNG
(US10155751, Example 9)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)[C@@H]1CCOC(C)(C)C1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C25H33N5O3/c1-15-24-21(28-29(15)5)8-17(9-22(24)33-16(2)18-10-23(31)26-12-18)19-13-27-30(14-19)20-6-7-32-25(3,4)11-20/h8-9,13-14,16,18,20H,6-7,10-12H2,1-5H3,(H,26,31)/t16-,18-,20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311134
PNG
(US10155751, Example 21)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C1CCC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H27N5O2/c1-13-22-19(25-26(13)3)7-15(17-11-24-27(12-17)18-5-4-6-18)8-20(22)29-14(2)16-9-21(28)23-10-16/h7-8,11-12,14,16,18H,4-6,9-10H2,1-3H3,(H,23,28)/t14-,16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311135
PNG
(US10155751, Example 22)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C1CCC(F)(F)C1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C23H27F2N5O2/c1-13-22-19(28-29(13)3)6-15(7-20(22)32-14(2)16-8-21(31)26-10-16)17-11-27-30(12-17)18-4-5-23(24,25)9-18/h6-7,11-12,14,16,18H,4-5,8-10H2,1-3H3,(H,26,31)/t14-,16-,18?/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311115
PNG
(US10155751, Example 2)
Show SMILES CC(C)n1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2c(F)n(C)nc2c1 |r|
Show InChI InChI=1S/C20H24FN5O2/c1-11(2)26-10-15(9-23-26)13-5-16-19(20(21)25(4)24-16)17(6-13)28-12(3)14-7-18(27)22-8-14/h5-6,9-12,14H,7-8H2,1-4H3,(H,22,27)/t12-,14-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311120
PNG
(US10155751, Example 7)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(c1)C1CCC(F)(F)C1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H24F3N5O2/c1-12(14-7-19(31)26-9-14)32-18-6-13(5-17-20(18)21(23)29(2)28-17)15-10-27-30(11-15)16-3-4-22(24,25)8-16/h5-6,10-12,14,16H,3-4,7-9H2,1-2H3,(H,26,31)/t12-,14-,16?/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311121
PNG
(US10155751, Example 8)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(CC2CC2)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H27N5O2/c1-13-22-19(25-26(13)3)6-16(18-10-24-27(12-18)11-15-4-5-15)7-20(22)29-14(2)17-8-21(28)23-9-17/h6-7,10,12,14-15,17H,4-5,8-9,11H2,1-3H3,(H,23,28)/t14-,17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311124
PNG
(US10155751, Example 11)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(CCF)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H24FN5O2/c1-12-20-17(24-25(12)3)6-14(16-10-23-26(11-16)5-4-21)7-18(20)28-13(2)15-8-19(27)22-9-15/h6-7,10-11,13,15H,4-5,8-9H2,1-3H3,(H,22,27)/t13-,15-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311132
PNG
(US10155751, Example 19)
Show SMILES CC(C)Cn1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2c(C)n(C)nc2c1 |r|
Show InChI InChI=1S/C22H29N5O2/c1-13(2)11-27-12-18(10-24-27)16-6-19-22(14(3)26(5)25-19)20(7-16)29-15(4)17-8-21(28)23-9-17/h6-7,10,12-13,15,17H,8-9,11H2,1-5H3,(H,23,28)/t15-,17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311137
PNG
(example 3A.02, on page 196 of WO15017610)
Show SMILES C[C@@H](Oc1nc(cc2ncn(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H26N6O2/c1-12(13-6-17(27)21-8-13)28-19-18-16(22-11-25(18)5)7-15(24-19)14-9-23-26(10-14)20(2,3)4/h7,9-13H,6,8H2,1-5H3,(H,21,27)/t12-,13-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375957
PNG
(US10947243, Example 29 | US9914735, Example 29)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)cc12)-c1cscn1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(15-8-24-9-19-15)3-14-13(16)7-21(2)20-14/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1
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Boehringer Ingelheim International GmbH

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Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM140376
PNG
(US10947243, Example 101 | US8912173, 101 | US99147...)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2CCNCc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C24H25N3O2/c1-15(19-12-24(28)27-14-19)29-23-11-18(10-22-21(23)3-2-7-26-22)17-5-4-16-6-8-25-13-20(16)9-17/h2-5,7,9-11,15,19,25H,6,8,12-14H2,1H3,(H,27,28)/t15-,19-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375949
PNG
(US10947243, Example 76 | US9914735, Example 15 | U...)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)cc12)-c1cnn(CCC(F)(F)F)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C19H21F3N6O2/c1-11(12-5-17(29)23-7-12)30-18-14-10-27(2)26-16(14)6-15(25-18)13-8-24-28(9-13)4-3-19(20,21)22/h6,8-12H,3-5,7H2,1-2H3,(H,23,29)/t11-,12-/m1/s1
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Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311116
PNG
(US10155751, Example 3)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)c(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)O1 |r|
Show InChI InChI=1S/C20H26N6O3/c1-11-17-15(24-25(11)6)7-14(13-8-22-26(10-13)20(3,4)5)23-18(17)28-12(2)16-9-21-19(27)29-16/h7-8,10,12,16H,9H2,1-6H3,(H,21,27)/t12-,16-/m1/s1
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Boehringer Ingelheim International GmbH

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Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375945
PNG
(US10947243, Example 11 | US9914735, Example 11)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)cc12)-c1cc2nn(C)cc2c(O[C@H](C)[C@@H]2CNC(=O)C2)n1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C26H30N8O4/c1-13(15-5-23(35)27-9-15)37-25-17-11-33(3)31-19(17)7-21(29-25)22-8-20-18(12-34(4)32-20)26(30-22)38-14(2)16-6-24(36)28-10-16/h7-8,11-16H,5-6,9-10H2,1-4H3,(H,27,35)(H,28,36)/t13-,14-,15-,16+/m1/s1
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Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375941
PNG
(US10947243, Example 7 | US9914735, Example 7)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)cc12)-c1cnn(c1)C1CCCCC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H28N6O2/c1-14(15-8-21(29)23-10-15)30-22-18-13-27(2)26-20(18)9-19(25-22)16-11-24-28(12-16)17-6-4-3-5-7-17/h9,11-15,17H,3-8,10H2,1-2H3,(H,23,29)/t14-,15-/m1/s1
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Boehringer Ingelheim International GmbH

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Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM140360
PNG
(US10947243, Example 85 | US8912173, 85 | US9914735...)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2nc(C)sc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C23H21N3O2S/c1-13(17-11-23(27)25-12-17)28-21-9-16(8-20-18(21)4-3-7-24-20)15-5-6-19-22(10-15)29-14(2)26-19/h3-10,13,17H,11-12H2,1-2H3,(H,25,27)/t13-,17-/m1/s1
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Boehringer Ingelheim International GmbH

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Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375982
PNG
(US10947243, Example 61 | US9914735, Example 61)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)cc12)-c1ccc(nc1)C(F)(F)F)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C19H18F3N5O2/c1-10(12-5-17(28)24-8-12)29-18-13-9-27(2)26-15(13)6-14(25-18)11-3-4-16(23-7-11)19(20,21)22/h3-4,6-7,9-10,12H,5,8H2,1-2H3,(H,24,28)/t10-,12-/m1/s1
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Boehringer Ingelheim International GmbH

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Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375965
PNG
(US10947243, Example 42 | US9914735, Example 42)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)cc12)-c1ccc(cc1)C1CCN(C)CC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C26H32N4O2/c1-17(22-14-26(31)27-15-22)32-25-13-21(12-24-23(25)16-30(3)28-24)19-6-4-18(5-7-19)20-8-10-29(2)11-9-20/h4-7,12-13,16-17,20,22H,8-11,14-15H2,1-3H3,(H,27,31)/t17-,22-/m1/s1
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Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311128
PNG
(US10155751, Example 15)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)c(C)c12)C1=CN[N](=C1)C(C)(C)C)[C@H]1CNC(=O)C1 |r,c:19,t:16|
Show InChI InChI=1S/C21H29N6O2/c1-12-19-17(25-26(12)6)8-16(15-10-23-27(11-15)21(3,4)5)24-20(19)29-13(2)14-7-18(28)22-9-14/h8,10-11,13-14,23H,7,9H2,1-6H3,(H,22,28)/t13-,14-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311117
PNG
(US10155751, Example 4)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)c(C)c12)-c1c[nH]nc1C(C)(C)C)[C@H]1CNC(=O)C1 |r|
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311133
PNG
(US10155751, Example 20)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C1CC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C21H25N5O2/c1-12-21-18(24-25(12)3)6-14(16-10-23-26(11-16)17-4-5-17)7-19(21)28-13(2)15-8-20(27)22-9-15/h6-7,10-11,13,15,17H,4-5,8-9H2,1-3H3,(H,22,27)/t13-,15-/m1/s1
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Boehringer Ingelheim International GmbH

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Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311119
PNG
(US10155751, Example 6)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(CC2CC2)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C21H24FN5O2/c1-12(15-7-19(28)23-8-15)29-18-6-14(5-17-20(18)21(22)26(2)25-17)16-9-24-27(11-16)10-13-3-4-13/h5-6,9,11-13,15H,3-4,7-8,10H2,1-2H3,(H,23,28)/t12-,15-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311130
PNG
(US10155751, Example 17)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C(C)(C)C#N)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C22H26N6O2/c1-13-21-18(26-27(13)5)6-15(17-10-25-28(11-17)22(3,4)12-23)7-19(21)30-14(2)16-8-20(29)24-9-16/h6-7,10-11,14,16H,8-9H2,1-5H3,(H,24,29)/t14-,16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311125
PNG
(US10155751, Example 12)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(CCC(F)(F)F)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H21F4N5O2/c1-11(13-7-17(30)25-8-13)31-16-6-12(5-15-18(16)19(21)28(2)27-15)14-9-26-29(10-14)4-3-20(22,23)24/h5-6,9-11,13H,3-4,7-8H2,1-2H3,(H,25,30)/t11-,13-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM376002
PNG
(US10947243, Example 81 | US9914735, Example 81)
Show SMILES COc1cc(ccc1OC(C)C)-c1cc2nn(C)cc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C23H28N4O4/c1-13(2)30-20-7-6-15(8-21(20)29-5)18-10-19-17(12-27(4)26-19)23(25-18)31-14(3)16-9-22(28)24-11-16/h6-8,10,12-14,16H,9,11H2,1-5H3,(H,24,28)/t14-,16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM144453
PNG
(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Show SMILES COc1cc(ccc1OC(F)(F)F)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C22H20F3N3O4/c1-12(14-9-20(29)27-11-14)31-21-15-4-3-7-26-17(15)10-16(28-21)13-5-6-18(19(8-13)30-2)32-22(23,24)25/h3-8,10,12,14H,9,11H2,1-2H3,(H,27,29)/t12-,14-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311129
PNG
(US10155751, Example 16)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C1CC(C)(C)OC1(C)C)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C26H35N5O3/c1-15-24-20(29-30(15)7)8-17(9-21(24)33-16(2)18-10-23(32)27-12-18)19-13-28-31(14-19)22-11-25(3,4)34-26(22,5)6/h8-9,13-14,16,18,22H,10-12H2,1-7H3,(H,27,32)/t16-,18-,22?/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311127
PNG
(US10155751, Example 14)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(c1)C1CC(C)(C)OC1(C)C)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C25H32FN5O3/c1-14(16-9-21(32)27-11-16)33-19-8-15(7-18-22(19)23(26)30(6)29-18)17-12-28-31(13-17)20-10-24(2,3)34-25(20,4)5/h7-8,12-14,16,20H,9-11H2,1-6H3,(H,27,32)/t14-,16-,20?/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311123
PNG
(US10155751, Example 10)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)[C@H]1CO[C@@H]2CCCO[C@H]12)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C25H31N5O4/c1-14-24-19(28-29(14)3)7-16(8-22(24)34-15(2)17-9-23(31)26-10-17)18-11-27-30(12-18)20-13-33-21-5-4-6-32-25(20)21/h7-8,11-12,15,17,20-21,25H,4-6,9-10,13H2,1-3H3,(H,26,31)/t15-,17-,20+,21-,25-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM311118
PNG
(US10155751, Example 5)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(c1)C1CC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H22FN5O2/c1-11(13-7-18(27)22-8-13)28-17-6-12(5-16-19(17)20(21)25(2)24-16)14-9-23-26(10-14)15-3-4-15/h5-6,9-11,13,15H,3-4,7-8H2,1-2H3,(H,22,27)/t11-,13-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...

US Patent US10155751 (2018)


BindingDB Entry DOI: 10.7270/Q2PK0J60
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM140280
PNG
(US10947243, Example 6 | US8912173, 6 | US9914735, ...)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccccn1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C20H19N3O2/c1-13(15-11-20(24)23-12-15)25-19-10-14(17-6-2-3-7-21-17)9-18-16(19)5-4-8-22-18/h2-10,13,15H,11-12H2,1H3,(H,23,24)/t13-,15-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [342-635]


(Homo sapiens (Human))		BDBM375952
PNG
(US10947243, Example 18 | US9914735, Example 18)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)cc12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C21H27N5O2/c1-13(15-8-20(27)22-9-15)28-19-7-14(6-18-17(19)12-25(5)24-18)16-10-23-26(11-16)21(2,3)4/h6-7,10-13,15H,8-9H2,1-5H3,(H,22,27)/t13-,15-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...

US Patent US10947243 (2021)


BindingDB Entry DOI: 10.7270/Q2ZP4964
More data for this
Ligand-Target Pair
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