Compile Data Set for Download or QSAR

Found 127 hits of ic50 for UniProtKB: P04049   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210020 (US10576087, Compound 2.26 | US9273046, 2.26 | US98...) Show SMILES Clc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.25	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210021 (US10576087, Compound 2.27 | US9273046, 2.27 | US98...) Show SMILES Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.25	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210051 (US10576087, Compound 2.29 | US9273046, 2.29 | US98...) Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(no3)-c3ccccc3)ccnc2N1 Show InChI InChI=1S/C25H18N4O4/c30-19-9-7-15-18(10-11-26-24(15)27-19)31-14-6-8-17-16(12-14)20-21(22(20)32-17)25-28-23(29-33-25)13-4-2-1-3-5-13/h1-6,8,10-12,20-22H,7,9H2,(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.25	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM373010 (US9895376, Compound 2.30) Show SMILES O=C(COC(=O)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12)c1ccccc1 Show InChI InChI=1S/C26H20N2O6/c29-18(14-4-2-1-3-5-14)13-32-26(31)23-22-17-12-15(6-8-19(17)34-24(22)23)33-20-10-11-27-25-16(20)7-9-21(30)28-25/h1-6,8,10-12,22-24H,7,9,13H2,(H,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.25	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210037 (US10576087, Compound 2.1 | US9273046, 2.1 | US9895...) Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210022 (US10576087, Compound 2.31 | US9273046, 2.31 | US98...) Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(c[nH]3)-c3ccncc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210015 (US10576087, Compound 2.21 | US9273046, 2.21 | US98...) Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4cc5CCCc5cc4[nH]3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccsc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322529 (5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3cccs3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM372977 (US10576087, Compound 2.4a | US9895376, Compound 2....) Show SMILES Cc1cc2[nH]c(nc2cc1F)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210044 (US10576087, Compound 2.4 | US9273046, 2.4 | US9895...) Show SMILES Cc1cc2[nH]c(nc2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.560	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210024 (US10576087, Compound 2.33 | US9273046, 2.33 | US98...) Show SMILES FC(F)(F)c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210002 (US10576087, Compound 2.8 | US9273046, 2.8 | US9895...) Show SMILES Cc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210023 (US10576087, Compound 2.32 | US9273046, 2.32 | US98...) Show SMILES Clc1ccccc1-c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210016 (US10576087, Compound 2.22 | US9273046, 2.22 | US98...) Show SMILES NC(=O)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM372967 (US10576087, Compound 2.2a | US9895376, Compound 2....) Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210038 (US10576087, Compound 2.2 | US9273046, 2.2 | US9895...) Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210034 (US10576087, Compound 1.1 | US9273046, 1.1 | US9895...) Show SMILES O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210013 (US10576087, Compound 2.19 | US9273046, 2.19 | US98...) Show SMILES Fc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210007 (US10576087, Compound 2.13 | US9273046, 2.13 | US98...) Show SMILES Brc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210001 (US10576087, Compound 2.7 | US9273046, 2.7 | US9895...) Show SMILES Fc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM372985 (US10576087, Compound 2.5b | US9895376, Compound 2....) Show SMILES FC(F)(F)c1cc2[nH]c(nc2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM372978 (US10576087, Compound 2.4b | US9895376, Compound 2....) Show SMILES Cc1cc2[nH]c(nc2cc1F)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM622280 (4-amino-N-(1-((2-fluorophenyl)amino)-6-methylisoqu...) Show SMILES COc1ccc(CNc2ncnc3c(cccc23)C(=O)Nc2c(C)ccc3c(Nc4ccccc4F)nccc23)c(OC)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM622284 (4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-me...) Show SMILES Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1cnc2c(N)ncnn12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.68	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM238347 (US9388165, 3) Show SMILES Cc1ccc(cc1NC(=O)c1cccc2c(N)nccc12)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-15(23(33)31-17-5-2-4-16(13-17)25(26,27)28)12-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
HANMI PHARM. CO., LTD. US Patent					Assay Description The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...				US Patent US9388165 (2016) BindingDB Entry DOI: 10.7270/Q2F76BF9
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM372973 (US10576087, Compound 2.3b | US9895376, Compound 2....) Show SMILES Clc1cc2nc([nH]c2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM622285 (4-amino-N-(1-((2-fluoro-4-methoxyphenyl)amino)-6-m...) Show SMILES COc1ccc(Nc2nccc3c(NC(=O)c4cccc5c(NCc6ccc(OC)cc6OC)ncnc45)c(C)ccc23)c(F)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210032 (US10576087, Compound 3.7 | US9273046, 3.7 | US9895...) Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)OCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210005 (US10576087, Compound 2.11 | US9273046, 2.11 | US98...) Show SMILES Fc1cc2nc([nH]c2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM622277 (4-amino-N-(1-(4-chloro-2-fluorobenzoyl)-6-methylis...) Show SMILES Cc1ccc2c(nccc2c1NC(=O)c1csc2c(N)ncnc12)C(O)c1ccc(Cl)cc1F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.48	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210009 (US10576087, Compound 2.15 | US9273046, 2.15 | US98...) Show SMILES Cn1c(nc2ccccc12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI InChI=1S/C25H20N4O3/c1-29-17-5-3-2-4-16(17)27-25(29)22-21-15-12-13(6-8-18(15)32-23(21)22)31-19-10-11-26-24-14(19)7-9-20(30)28-24/h2-6,8,10-12,21-23H,7,9H2,1H3,(H,26,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM210010 (US10576087, Compound 2.16 | US9273046, 2.16 | US98...) Show SMILES COc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM622276 (4-amino-N-(6-methyl-1-(3-(trifluoromethyl)benzoyl)...) Show SMILES Cc1ccc2c(nccc2c1NC(=O)c1csc2c(N)ncnc12)C(O)c1cccc(c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.93	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322533 (5-[3-[5-(3-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3ncc([nH]3)-c3cccnc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322532 (5-[3-[4-(benzofuran-3-yl)-1H-imidazol-2-yl]chroman...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3coc4ccccc34)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322531 (5-[3-[5-(3-chlorophenyl)-1H-imidazol-2-yl]chroman-...) Show SMILES Clc1cccc(c1)-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322530 (5-[3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]chroman-...) Show SMILES Clc1ccccc1-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322529 (5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3cccs3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccsc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322527 (5-[3-(4-tert-butyl-1H-imidazol-2-yl)chroman-6-yl]o...) Show SMILES CC(C)(C)c1c[nH]c(n1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322525 (5-[3[4-(4-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]o...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccncc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322535 (5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]chroman-...) Show SMILES Fc1ccc(cc1)-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322536 (5-[3-[5-(1,3-benzodioxol-5-yl)-1H-imidazol-2-yl]ch...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3ncc([nH]3)-c3ccc4OCOc4c3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human))	BDBM322537 (5-[3-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-imid...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3ncc([nH]3)-c3ccc4OCCOc4c3)ccnc2N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair

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