Compile Data Set for Download or QSAR

Found 45 hits of ic50 for UniProtKB: P29597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM103727 (US10112907, Example 00033 | US10206907, Compound 2...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	72.7	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US11000528 (2021) BindingDB Entry DOI: 10.7270/Q2KS6VPD
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM103727 (US10112907, Example 00033 | US10206907, Compound 2...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description JAK2 (Kd): JAK2 (Invitrogen, PV4210) is used at a final concentration of 5 nM. The binding experiment is performed in 50 mM Hepes pH 7.5, 0.01% Brij-...				US Patent US10708263 (2020) BindingDB Entry DOI: 10.7270/Q2542RMG
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM349171 (2-{4-[2- (Cyclopropanecarbonyl- amino)-[1,2,4]tria...) Show SMILES NC(=O)c1ccccc1NCc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C24H22N6O2/c25-22(31)18-4-1-2-5-19(18)26-14-15-8-10-16(11-9-15)20-6-3-7-21-27-24(29-30(20)21)28-23(32)17-12-13-17/h1-11,17,26H,12-14H2,(H2,25,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM349137 (Cyclopropanecarboxylic acid (5-[4-(3,3-difluoro- p...) Show SMILES FC1(F)CCN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C21H19F2N5O2/c22-21(23)10-11-27(12-21)19(30)15-8-4-13(5-9-15)16-2-1-3-17-24-20(26-28(16)17)25-18(29)14-6-7-14/h1-5,8-9,14H,6-7,10-12H2,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM349167 (Cyclopropanecarboxylic acid {5-[4-(isoxazol-3- yla...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(CNc4ccon4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C20H18N6O2/c27-19(15-8-9-15)23-20-22-18-3-1-2-16(26(18)24-20)14-6-4-13(5-7-14)12-21-17-10-11-28-25-17/h1-7,10-11,15H,8-9,12H2,(H,21,25)(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM294916 (US10112907, Example 00027 | US10206907, Compound 1...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1 Show InChI InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM103737 (US10206907, Compound 234 | US11000528, Cpd # 11 | ...) Show SMILES FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1 Show InChI InChI=1S/C22H23F2N5O/c23-22(24)10-12-28(13-11-22)14-15-4-6-16(7-5-15)18-2-1-3-19-25-21(27-29(18)19)26-20(30)17-8-9-17/h1-7,17H,8-14H2,(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US11000528 (2021) BindingDB Entry DOI: 10.7270/Q2KS6VPD
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM128101 (US10206907, Compound 330 | US8796457, 1 | US950575...) Show SMILES CC1(C)CN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	219	n/a	n/a	n/a	n/a	7.5	30
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US9505754 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VDQ
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348922 (N-(5-(4-(pyridin-3- ylmethoxy)phenyl)- [1,2,4]tria...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4cccnc4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C22H19N5O2/c28-21(17-6-7-17)25-22-24-20-5-1-4-19(27(20)26-22)16-8-10-18(11-9-16)29-14-15-3-2-12-23-13-15/h1-5,8-13,17H,6-7,14H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM349184 (Cyclopropanecarboxylic acid (5-{4-[2-oxo-2-(4- tri...) Show SMILES FC(F)(F)C1CCN(CC1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C24H24F3N5O2/c25-24(26,27)18-10-12-31(13-11-18)21(33)14-15-4-6-16(7-5-15)19-2-1-3-20-28-23(30-32(19)20)29-22(34)17-8-9-17/h1-7,17-18H,8-14H2,(H,29,30,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM349038 (N-(5-(4-(4-benzyl-4- hydroxypiperidine-1- carbonyl...) Show SMILES OC1(Cc2ccccc2)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C29H29N5O3/c35-26(22-11-12-22)31-28-30-25-8-4-7-24(34(25)32-28)21-9-13-23(14-10-21)27(36)33-17-15-29(37,16-18-33)19-20-5-2-1-3-6-20/h1-10,13-14,22,37H,11-12,15-19H2,(H,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM349182 (Cyclopropanecarboxylic acid (5-{4-[2-(3,3-difluoro...) Show SMILES FC1(F)CN(C1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C21H19F2N5O2/c22-21(23)11-27(12-21)18(29)10-13-4-6-14(7-5-13)16-2-1-3-17-24-20(26-28(16)17)25-19(30)15-8-9-15/h1-7,15H,8-12H2,(H,25,26,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM50031742 (CHEMBL3360348 | US10206907, Compound 59) Show SMILES O=C(Nc1nc2cccc(-c3ccc(NS(=O)(=O)C4CC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C19H19N5O3S/c25-18(13-4-5-13)21-19-20-17-3-1-2-16(24(17)22-19)12-6-8-14(9-7-12)23-28(26,27)15-10-11-15/h1-3,6-9,13,15,23H,4-5,10-11H2,(H,21,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348919 (N-(5-(4-(4- fluorophenylsulfonamido) phenyl)-[1,2,...) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H18FN5O3S/c23-16-8-12-18(13-9-16)32(30,31)27-17-10-6-14(7-11-17)19-2-1-3-20-24-22(26-28(19)20)25-21(29)15-4-5-15/h1-3,6-13,15,27H,4-5H2,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348940 (N-(5-(4-(2- fluorophenylsulfonamido) phenyl)-[1,2,...) Show SMILES Fc1ccccc1S(=O)(=O)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H18FN5O3S/c23-17-4-1-2-6-19(17)32(30,31)27-16-12-10-14(11-13-16)18-5-3-7-20-24-22(26-28(18)20)25-21(29)15-8-9-15/h1-7,10-13,15,27H,8-9H2,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348926 (N-(5-(4- (cyclopentyloxy)phenyl)- [1,2,4]triazolo[...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OC4CCCC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C21H22N4O2/c26-20(15-8-9-15)23-21-22-19-7-3-6-18(25(19)24-21)14-10-12-17(13-11-14)27-16-4-1-2-5-16/h3,6-7,10-13,15-16H,1-2,4-5,8-9H2,(H,23,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348903 (N-(5-(4-(piperidine-1- carbonyl(phenyl)- [1,2,4]tr...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCCCC3)n2n1)C1CC1 Show InChI InChI=1S/C22H23N5O2/c28-20(16-9-10-16)24-22-23-19-6-4-5-18(27(19)25-22)15-7-11-17(12-8-15)21(29)26-13-2-1-3-14-26/h4-8,11-12,16H,1-3,9-10,13-14H2,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348946 (4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCCOc3ccccc3)n2n1)C1CC1 Show InChI InChI=1S/C25H23N5O3/c31-23(26-15-16-33-20-5-2-1-3-6-20)18-11-9-17(10-12-18)21-7-4-8-22-27-25(29-30(21)22)28-24(32)19-13-14-19/h1-12,19H,13-16H2,(H,26,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348952 (N-(5-(4-(pyridin-3-yl)phenyl)- [1,2,4]triazolo[1,5...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)-c3cccnc3)n2n1)C1CC1 Show InChI InChI=1S/C21H17N5O/c27-20(16-10-11-16)24-21-23-19-5-1-4-18(26(19)25-21)15-8-6-14(7-9-15)17-3-2-12-22-13-17/h1-9,12-13,16H,10-11H2,(H,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348923 (N-(5-(4-(pyridin-2- ylmethoxy)phenyl)- [1,2,4]tria...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccccn4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C22H19N5O2/c28-21(16-7-8-16)25-22-24-20-6-3-5-19(27(20)26-22)15-9-11-18(12-10-15)29-14-17-4-1-2-13-23-17/h1-6,9-13,16H,7-8,14H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348937 (N-(5-(4-(2-(3,5-dimethyl-1H- pyrazol-4-yl)ethyldim...) Show SMILES Cc1n[nH]c(C)c1CCOc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C23H24N6O2/c1-14-19(15(2)27-26-14)12-13-31-18-10-8-16(9-11-18)20-4-3-5-21-24-23(28-29(20)21)25-22(30)17-6-7-17/h3-5,8-11,17H,6-7,12-13H2,1-2H3,(H,26,27)(H,25,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348938 (N-(5-(4-((5-methylisoxazol-3- yl)methoxy)phenyl)- ...) Show SMILES Cc1cc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)no1 Show InChI InChI=1S/C21H19N5O3/c1-13-11-16(25-29-13)12-28-17-9-7-14(8-10-17)18-3-2-4-19-22-21(24-26(18)19)23-20(27)15-5-6-15/h2-4,7-11,15H,5-6,12H2,1H3,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348900 (N-(5-(4-(N- cyclopropylsulfamoyl)phenyl)- [1,2,4]t...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)S(=O)(=O)NC3CC3)n2n1)C1CC1 Show InChI InChI=1S/C19H19N5O3S/c25-18(13-4-5-13)21-19-20-17-3-1-2-16(24(17)22-19)12-6-10-15(11-7-12)28(26,27)23-14-8-9-14/h1-3,6-7,10-11,13-14,23H,4-5,8-9H2,(H,21,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348899 (N-(5-(4-(benzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C23H20N4O2/c28-22(18-9-10-18)25-23-24-21-8-4-7-20(27(21)26-23)17-11-13-19(14-12-17)29-15-16-5-2-1-3-6-16/h1-8,11-14,18H,9-10,15H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM349003 (Cyclopropanecarboxylic Acid [5-(1-benzyl-1H-indol-...) Show SMILES O=C(Nc1nc2cccc(-c3ccc4n(Cc5ccccc5)ccc4c3)n2n1)C1CC1 Show InChI InChI=1S/C25H21N5O/c31-24(18-9-10-18)27-25-26-23-8-4-7-22(30(23)28-25)19-11-12-21-20(15-19)13-14-29(21)16-17-5-2-1-3-6-17/h1-8,11-15,18H,9-10,16H2,(H,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM349001 ((S)-N-(1-benzylpyrrolidin-3- yl)-4-(2- (cyclopropa...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N[C@H]3CCN(Cc4ccccc4)C3)n2n1)C1CC1 |r| Show InChI InChI=1S/C28H28N6O2/c35-26(29-23-15-16-33(18-23)17-19-5-2-1-3-6-19)21-11-9-20(10-12-21)24-7-4-8-25-30-28(32-34(24)25)31-27(36)22-13-14-22/h1-12,22-23H,13-18H2,(H,29,35)(H,31,32,36)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348998 (N-(5-(4-(2-(3- fluorophenylamino)-2- oxoethoxy)phe...) Show SMILES Fc1cccc(NC(=O)COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1 Show InChI InChI=1S/C24H20FN5O3/c25-17-3-1-4-18(13-17)26-22(31)14-33-19-11-9-15(10-12-19)20-5-2-6-21-27-24(29-30(20)21)28-23(32)16-7-8-16/h1-6,9-13,16H,7-8,14H2,(H,26,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348993 (4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...) Show SMILES Fc1cc(ccc1-c1cccc2nc(NC(=O)C3CC3)nn12)C(=O)NCCc1ccccc1 Show InChI InChI=1S/C25H22FN5O2/c26-20-15-18(23(32)27-14-13-16-5-2-1-3-6-16)11-12-19(20)21-7-4-8-22-28-25(30-31(21)22)29-24(33)17-9-10-17/h1-8,11-12,15,17H,9-10,13-14H2,(H,27,32)(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348991 (N-(5-(4-(3- phenylpropanamido)phenyl)- [1,2,4]tria...) Show SMILES O=C(CCc1ccccc1)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C25H23N5O2/c31-23(16-9-17-5-2-1-3-6-17)26-20-14-12-18(13-15-20)21-7-4-8-22-27-25(29-30(21)22)28-24(32)19-10-11-19/h1-8,12-15,19H,9-11,16H2,(H,26,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348948 (N-(5-(4-((1,5-dimethyl-1H- pyrazol-3-yl)methyldime...) Show SMILES Cc1cc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)nn1C Show InChI InChI=1S/C22H22N6O2/c1-14-12-17(25-27(14)2)13-30-18-10-8-15(9-11-18)19-4-3-5-20-23-22(26-28(19)20)24-21(29)16-6-7-16/h3-5,8-12,16H,6-7,13H2,1-2H3,(H,24,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348944 (N-(5-(4-(1,2,3,4- tetrahydroisoquinoline-2- carbon...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCc4ccccc4C3)n2n1)C1CC1 Show InChI InChI=1S/C26H23N5O2/c32-24(19-10-11-19)28-26-27-23-7-3-6-22(31(23)29-26)18-8-12-20(13-9-18)25(33)30-15-14-17-4-1-2-5-21(17)16-30/h1-9,12-13,19H,10-11,14-16H2,(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348943 (Cyclopropanecarboxylic Acid [5-(6-benzyloxy-pyridi...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)nc3)n2n1)C1CC1 Show InChI InChI=1S/C22H19N5O2/c28-21(16-9-10-16)25-22-24-19-8-4-7-18(27(19)26-22)17-11-12-20(23-13-17)29-14-15-5-2-1-3-6-15/h1-8,11-13,16H,9-10,14H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348942 (N-benzyl-4-(2- (cyclopropanecarboxamido)- [1,2,4]t...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCc3ccccc3)n2n1)C1CC1 Show InChI InChI=1S/C24H21N5O2/c30-22(25-15-16-5-2-1-3-6-16)18-11-9-17(10-12-18)20-7-4-8-21-26-24(28-29(20)21)27-23(31)19-13-14-19/h1-12,19H,13-15H2,(H,25,30)(H,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348936 (N-(5-(4-((1,3-dimethyl-1H- pyrazol-5-yl)methyldime...) Show SMILES Cc1cc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)n(C)n1 Show InChI InChI=1S/C22H22N6O2/c1-14-12-17(27(2)25-14)13-30-18-10-8-15(9-11-18)19-4-3-5-20-23-22(26-28(19)20)24-21(29)16-6-7-16/h3-5,8-12,16H,6-7,13H2,1-2H3,(H,24,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348935 (N-(5-(4-((3,5- dimethylisoxazol-4- yl)methoxy)phen...) Show SMILES Cc1noc(C)c1COc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H21N5O3/c1-13-18(14(2)30-26-13)12-29-17-10-8-15(9-11-17)19-4-3-5-20-23-22(25-27(19)20)24-21(28)16-6-7-16/h3-5,8-11,16H,6-7,12H2,1-2H3,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348934 (N-(5-(4-((1-methyl-1H- pyrazol-3-yl)methylmethyl- ...) Show SMILES Cn1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)n1 Show InChI InChI=1S/C21H20N6O2/c1-26-12-11-16(24-26)13-29-17-9-7-14(8-10-17)18-3-2-4-19-22-21(25-27(18)19)23-20(28)15-5-6-15/h2-4,7-12,15H,5-6,13H2,1H3,(H,23,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348932 (N-(5-(4-phenoxyphenyl)- [1,2,4]triazolo[1,5-a]pyri...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(Oc4ccccc4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C22H18N4O2/c27-21(16-9-10-16)24-22-23-20-8-4-7-19(26(20)25-22)15-11-13-18(14-12-15)28-17-5-2-1-3-6-17/h1-8,11-14,16H,9-10H2,(H,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348929 (4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)Nc3ccccc3)n2n1)C1CC1 Show InChI InChI=1S/C23H19N5O2/c29-21(24-18-5-2-1-3-6-18)16-11-9-15(10-12-16)19-7-4-8-20-25-23(27-28(19)20)26-22(30)17-13-14-17/h1-12,17H,13-14H2,(H,24,29)(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348928 (4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCc3cccnc3)n2n1)C1CC1 Show InChI InChI=1S/C23H20N6O2/c30-21(25-14-15-3-2-12-24-13-15)17-8-6-16(7-9-17)19-4-1-5-20-26-23(28-29(19)20)27-22(31)18-10-11-18/h1-9,12-13,18H,10-11,14H2,(H,25,30)(H,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348927 (N-(5-(4- (cyclohexylmethoxy)phenyl)- [1,2,4]triazo...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCC4CCCCC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C23H26N4O2/c28-22(18-9-10-18)25-23-24-21-8-4-7-20(27(21)26-23)17-11-13-19(14-12-17)29-15-16-5-2-1-3-6-16/h4,7-8,11-14,16,18H,1-3,5-6,9-10,15H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348925 (N-(5-(4- (cyclobutylmethoxy)phenyl)- [1,2,4]triazo...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCC4CCC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C21H22N4O2/c26-20(16-7-8-16)23-21-22-19-6-2-5-18(25(19)24-21)15-9-11-17(12-10-15)27-13-14-3-1-4-14/h2,5-6,9-12,14,16H,1,3-4,7-8,13H2,(H,23,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM103728 (US10206907, Compound 18 | US11000528, Cpd # 2 | US...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C21H23N5O2/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-28-13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348902 (N-(5-(4-(benzyloxy)-3- fluorophenyl)- [1,2,4]triaz...) Show SMILES Fc1cc(ccc1OCc1ccccc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C23H19FN4O2/c24-18-13-17(11-12-20(18)30-14-15-5-2-1-3-6-15)19-7-4-8-21-25-23(27-28(19)21)26-22(29)16-9-10-16/h1-8,11-13,16H,9-10,14H2,(H,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348886 (N-(5-(4-(4-methylpiperazin-1- yl)phenyl)-[1,2,4]tr...) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C21H24N6O/c1-25-11-13-26(14-12-25)17-9-7-15(8-10-17)18-3-2-4-19-22-21(24-27(18)19)23-20(28)16-5-6-16/h2-4,7-10,16H,5-6,11-14H2,1H3,(H,23,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM103728 (US10206907, Compound 18 | US11000528, Cpd # 2 | US...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C21H23N5O2/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-28-13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US11000528 (2021) BindingDB Entry DOI: 10.7270/Q2KS6VPD
					More data for this Ligand-Target Pair