Compile Data Set for Download or QSAR

Found 189 hits of ec50 for UniProtKB: P32745   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50352489 (CHEMBL1824052) Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r| Show InChI InChI=1S/C78H105N17O19S2/c1-43(81)66(101)83-39-63(100)84-60-41-115-116-42-61(78(113)114)93-74(109)59(40-96)92-77(112)65(45(3)98)95-73(108)56(36-48-23-11-6-12-24-48)91-76(111)64(44(2)97)94-68(103)53(28-16-18-32-80)85-69(104)57(37-49-29-30-50-25-13-14-26-51(50)33-49)89-71(106)54(34-46-19-7-4-8-20-46)87-70(105)55(35-47-21-9-5-10-22-47)88-72(107)58(38-62(82)99)90-67(102)52(86-75(60)110)27-15-17-31-79/h4-14,19-26,29-30,33,43-45,52-61,64-65,96-98H,15-18,27-28,31-32,34-42,79-81H2,1-3H3,(H2,82,99)(H,83,101)(H,84,100)(H,85,104)(H,86,110)(H,87,105)(H,88,107)(H,89,106)(H,90,102)(H,91,111)(H,92,112)(H,93,109)(H,94,103)(H,95,108)(H,113,114)/t43-,44+,45+,52-,53-,54-,55-,56-,57+,58-,59-,60-,61-,64-,65-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.230	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay				J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523757 (US11136312, Compound MM-I-87) Show SMILES Fc1ccc2c(Cc3nnc(Cc4cccc(c4)C(F)(F)F)n3CCCc3c[nH]cn3)c[nH]c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.249	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523756 (US11136312, Compound MM-I-83) Show SMILES Fc1ccc2c(Cc3nnc(Cc4cccc(Br)c4)n3CCCc3c[nH]cn3)c[nH]c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.276	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50352480 (CHEMBL1824051) Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r| Show InChI InChI=1S/C78H105N17O19S2/c1-43(81)66(101)83-39-63(100)84-60-41-115-116-42-61(78(113)114)93-74(109)59(40-96)92-77(112)65(45(3)98)95-73(108)56(36-48-23-11-6-12-24-48)91-76(111)64(44(2)97)94-68(103)53(28-16-18-32-80)85-69(104)57(37-49-29-30-50-25-13-14-26-51(50)33-49)89-71(106)54(34-46-19-7-4-8-20-46)87-70(105)55(35-47-21-9-5-10-22-47)88-72(107)58(38-62(82)99)90-67(102)52(86-75(60)110)27-15-17-31-79/h4-14,19-26,29-30,33,43-45,52-61,64-65,96-98H,15-18,27-28,31-32,34-42,79-81H2,1-3H3,(H2,82,99)(H,83,101)(H,84,100)(H,85,104)(H,86,110)(H,87,105)(H,88,107)(H,89,106)(H,90,102)(H,91,111)(H,92,112)(H,93,109)(H,94,103)(H,95,108)(H,113,114)/t43-,44+,45+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.350	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay				J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50154508 (CHEMBL3775042) Show SMILES Cc1nc(no1)[C@@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccccc1)c1cnn(C)c1 |r| Show InChI InChI=1S/C27H24N8O/c1-16-30-26(34-36-16)27(18-13-29-35(2)15-18)24-20(19-10-6-7-11-21(19)31-24)12-22(33-27)25-28-14-23(32-25)17-8-4-3-5-9-17/h3-11,13-15,22,31,33H,12H2,1-2H3,(H,28,32)/t22-,27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.460	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50021074 (CHEMBL3287628) Show SMILES Clc1ccc(CN[C@H]2CCCC[C@H]2NC(=O)c2ccc3ccccc3c2)cc1Cl |r| Show InChI InChI=1S/C24H24Cl2N2O/c25-20-12-9-16(13-21(20)26)15-27-22-7-3-4-8-23(22)28-24(29)19-11-10-17-5-1-2-6-18(17)14-19/h1-2,5-6,9-14,22-23,27H,3-4,7-8,15H2,(H,28,29)/t22-,23+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.516	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay				ACS Med Chem Lett 5: 690-5 (2014) Article DOI: 10.1021/ml500079u BindingDB Entry DOI: 10.7270/Q22N53V4
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50352483 (CHEMBL1824056) Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O |r| Show InChI InChI=1S/C56H67N9O10S2/c1-34(66)48-55(73)63-45(30-37-19-9-4-10-20-37)54(72)64-47(56(74)75)33-77-76-32-41(58)49(67)60-43(28-35-15-5-2-6-16-35)52(70)61-44(29-36-17-7-3-8-18-36)53(71)62-46(31-38-24-25-39-21-11-12-22-40(39)27-38)51(69)59-42(50(68)65-48)23-13-14-26-57/h2-12,15-22,24-25,27,34,41-48,66H,13-14,23,26,28-33,57-58H2,1H3,(H,59,69)(H,60,67)(H,61,70)(H,62,71)(H,63,73)(H,64,72)(H,65,68)(H,74,75)/t34-,41+,42+,43+,44+,45+,46-,47+,48+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.530	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay				J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523754 (US11136312, Compound MM-I-66) Show SMILES FC(F)(F)c1cccc(Cc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.585	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523801 (US11136312, Compound SK-I-128) Show SMILES Fc1ccc(Sc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.619	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM82547 (SRIF-D-Trp8) Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r| Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55+,56-,57-,58-,59-,62-,63-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.630	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay				J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523770 (US11136312, Compound SK-I-124) Show SMILES Fc1ccc2c(Cc3nnc(Cc4c[nH]c5cc(F)ccc45)n3CCCc3c[nH]cn3)c[nH]c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.725	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM81767 (15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...) Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r| Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.780	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay				J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50352481 (CHEMBL1824050) Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H](C)O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N |r| Show InChI InChI=1S/C74H103N17O20S2/c1-40(77)62(98)79-36-59(97)80-56-38-112-113-39-57(74(110)111)89-70(106)55(37-92)88-73(109)61(42(3)94)91-69(105)53(33-45-21-11-6-12-22-45)87-72(108)60(41(2)93)90-64(100)49(24-14-16-30-76)81-65(101)52(34-46-25-27-47(95)28-26-46)84-66(102)50(31-43-17-7-4-8-18-43)83-67(103)51(32-44-19-9-5-10-20-44)85-68(104)54(35-58(78)96)86-63(99)48(82-71(56)107)23-13-15-29-75/h4-12,17-22,25-28,40-42,48-57,60-61,92-95H,13-16,23-24,29-39,75-77H2,1-3H3,(H2,78,96)(H,79,98)(H,80,97)(H,81,101)(H,82,107)(H,83,103)(H,84,102)(H,85,104)(H,86,99)(H,87,108)(H,88,109)(H,89,106)(H,90,100)(H,91,105)(H,110,111)/t40-,41+,42+,48-,49-,50-,51-,52+,53-,54-,55-,56-,57-,60-,61-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.870	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay				J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50400517 (CHEMBL2204935) Show SMILES Cc1nc(no1)[C@@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cc1)c1cnn(C)c1 |r| Show InChI InChI=1S/C27H23FN8O/c1-15-31-26(35-37-15)27(17-12-30-36(2)14-17)24-20(19-5-3-4-6-21(19)32-24)11-22(34-27)25-29-13-23(33-25)16-7-9-18(28)10-8-16/h3-10,12-14,22,32,34H,11H2,1-2H3,(H,29,33)/t22-,27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.950	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523803 (US11136312, Compound SK-I-132) Show SMILES COc1cccc(Sc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.992	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523766 (US11136312, Compound SK-I-57) Show SMILES COc1ccc2[nH]cc(Cc3nnc(Cc4cccc(c4)C(F)(F)F)n3CCCc3c[nH]cn3)c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523760 (US11136312, Compound SK-I-22) Show SMILES Clc1ccc(Cc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.28	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50021075 (CHEMBL3287629) Show SMILES Fc1ccc2cc(ccc2c1)C(=O)N[C@@H]1CCCC[C@@H]1NCc1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C24H23Cl2FN2O/c25-20-10-5-15(11-21(20)26)14-28-22-3-1-2-4-23(22)29-24(30)18-7-6-17-13-19(27)9-8-16(17)12-18/h5-13,22-23,28H,1-4,14H2,(H,29,30)/t22-,23+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay				ACS Med Chem Lett 5: 690-5 (2014) Article DOI: 10.1021/ml500079u BindingDB Entry DOI: 10.7270/Q22N53V4
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523759 (US11136312, Compound SK-I-16) Show SMILES Fc1ccc(Cc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.76	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523762 (US11136312, Compound SK-I-25) Show SMILES C(Cc1c[nH]cn1)Cn1c(Cc2c[nH]c3ccccc23)nnc1Cc1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.03	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50091557 (CHEMBL3582317) Show SMILES Cc1nc(no1)[C@@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cn1)c1cnn(C)c1 |r| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523758 (US11136312, Compound MM-I-89) Show SMILES Fc1ccc2c(Cc3nnc(Cc4ccccc4)n3CCCc3c[nH]cn3)c[nH]c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50021063 (CHEMBL3287613) Show SMILES Fc1ccc(cc1)C(=O)N[C@@H]1CCCC[C@@H]1NCc1c[nH]c2ccccc12 |r| Show InChI InChI=1S/C22H24FN3O/c23-17-11-9-15(10-12-17)22(27)26-21-8-4-3-7-20(21)25-14-16-13-24-19-6-2-1-5-18(16)19/h1-2,5-6,9-13,20-21,24-25H,3-4,7-8,14H2,(H,26,27)/t20-,21+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.90	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay				ACS Med Chem Lett 5: 690-5 (2014) Article DOI: 10.1021/ml500079u BindingDB Entry DOI: 10.7270/Q22N53V4
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523802 (US11136312, Compound SK-I-130) Show SMILES Cc1ccc(Sc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.09	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50154509 (CHEMBL3775387) Show SMILES COc1cccc(n1)-c1c[nH]c(n1)[C@H]1Cc2c([nH]c3ccccc23)[C@H](N1)C1CCOCC1 |r| Show InChI InChI=1S/C25H27N5O2/c1-31-22-8-4-7-19(27-22)21-14-26-25(30-21)20-13-17-16-5-2-3-6-18(16)28-24(17)23(29-20)15-9-11-32-12-10-15/h2-8,14-15,20,23,28-29H,9-13H2,1H3,(H,26,30)/t20-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.10	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523767 (US11136312, Compound SK-I-91) Show SMILES Fc1ccc(Cc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.17	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50154507 (CHEMBL3775630) Show SMILES Cc1nc(no1)[C@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccccc1)c1cnn(C)c1 |r| Show InChI InChI=1S/C27H24N8O/c1-16-30-26(34-36-16)27(18-13-29-35(2)15-18)24-20(19-10-6-7-11-21(19)31-24)12-22(33-27)25-28-14-23(32-25)17-8-4-3-5-9-17/h3-11,13-15,22,31,33H,12H2,1-2H3,(H,28,32)/t22-,27+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523755 (US11136312, Compound MM-I-72) Show SMILES CS(=O)(=O)c1cccc(Cc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.32	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40+,41-,42+,43+,44+,45+,46-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.33	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay				J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50021090 (CHEMBL3287632) Show SMILES Fc1ccc(cc1)C(=O)N[C@@H]1CCCC[C@H]1NCc1c[nH]c2ccccc12 |r| Show InChI InChI=1S/C22H24FN3O/c23-17-11-9-15(10-12-17)22(27)26-21-8-4-3-7-20(21)25-14-16-13-24-19-6-2-1-5-18(16)19/h1-2,5-6,9-13,20-21,24-25H,3-4,7-8,14H2,(H,26,27)/t20-,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay				ACS Med Chem Lett 5: 690-5 (2014) Article DOI: 10.1021/ml500079u BindingDB Entry DOI: 10.7270/Q22N53V4
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523742 (US11136312, Compound SM-I-50) Show SMILES Brc1cccc(Cc2nnc(CCc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.35	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50021073 (CHEMBL3287627) Show SMILES Fc1ccc(cc1F)C(=O)N[C@@H]1CCCC[C@@H]1NCc1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C20H20Cl2F2N2O/c21-14-7-5-12(9-15(14)22)11-25-18-3-1-2-4-19(18)26-20(27)13-6-8-16(23)17(24)10-13/h5-10,18-19,25H,1-4,11H2,(H,26,27)/t18-,19+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay				ACS Med Chem Lett 5: 690-5 (2014) Article DOI: 10.1021/ml500079u BindingDB Entry DOI: 10.7270/Q22N53V4
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50352482 (CHEMBL1824055) Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O |r| Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38+,40+,41+,42+,43+,44+,45+,46+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.70	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Partial agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay				J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50154423 (CHEMBL3774684) Show SMILES COc1cccc(n1)-c1c[nH]c(n1)[C@H]1Cc2c([nH]c3ccccc23)[C@](N1)(c1cnn(C)c1)c1noc(C)n1 |r| Show InChI InChI=1S/C27H25N9O2/c1-15-30-26(35-38-15)27(16-12-29-36(2)14-16)24-18(17-7-4-5-8-19(17)32-24)11-21(34-27)25-28-13-22(33-25)20-9-6-10-23(31-20)37-3/h4-10,12-14,21,32,34H,11H2,1-3H3,(H,28,33)/t21-,27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.80	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50110470 (CHEMBL3605798) Show SMILES Cc1ccc(cc1)-c1c[nH]c(n1)C1(CCCC1)NCCCc1ccccc1 Show InChI InChI=1S/C24H29N3/c1-19-11-13-21(14-12-19)22-18-25-23(27-22)24(15-5-6-16-24)26-17-7-10-20-8-3-2-4-9-20/h2-4,8-9,11-14,18,26H,5-7,10,15-17H2,1H3,(H,25,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 25: 3520-5 (2015) Article DOI: 10.1016/j.bmcl.2015.06.087 BindingDB Entry DOI: 10.7270/Q29W0H9M
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50154465 (CHEMBL3775760) Show SMILES Cc1nc(no1)[C@@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccccn1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H23N9O/c1-15-30-25(34-36-15)26(16-12-29-35(2)14-16)23-18(17-7-3-4-8-19(17)31-23)11-21(33-26)24-28-13-22(32-24)20-9-5-6-10-27-20/h3-10,12-14,21,31,33H,11H2,1-2H3,(H,28,32)/t21-,26-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523765 (US11136312, Compound SK-I-56) Show SMILES COc1ccc(Cc2nnc(Cc3c[nH]c4ccc(OC)cc34)n2CCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.63	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50400519 (CHEMBL2204941) Show SMILES Fc1ccc(cc1)-c1c[nH]c(n1)[C@H]1Cc2c([nH]c3ccccc23)[C@H](N1)C1CCOCC1 |r| Show InChI InChI=1S/C25H25FN4O/c26-17-7-5-15(6-8-17)22-14-27-25(30-22)21-13-19-18-3-1-2-4-20(18)28-24(19)23(29-21)16-9-11-31-12-10-16/h1-8,14,16,21,23,28-29H,9-13H2,(H,27,30)/t21-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.70	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523763 (US11136312, Compound SK-I-53) Show SMILES COc1ccc2[nH]cc(Cc3nnc(Cc4ccccc4)n3CCCc3c[nH]cn3)c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.97	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523764 (US11136312, Compound SK-I-55) Show SMILES COc1ccc2[nH]cc(Cc3nnc(Cc4ccc(F)cc4)n3CCCc3c[nH]cn3)c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.02	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523738 (US11136312, Compound BN-VI-97) Show SMILES FC(F)(F)c1cccc(Cc2nnc(CCc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.08	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50021064 (CHEMBL3287614) Show SMILES Fc1ccc(cc1)C(=O)N[C@@H]1CCCC[C@@H]1NCc1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C20H21Cl2FN2O/c21-16-10-5-13(11-17(16)22)12-24-18-3-1-2-4-19(18)25-20(26)14-6-8-15(23)9-7-14/h5-11,18-19,24H,1-4,12H2,(H,25,26)/t18-,19+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.10	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay				ACS Med Chem Lett 5: 690-5 (2014) Article DOI: 10.1021/ml500079u BindingDB Entry DOI: 10.7270/Q22N53V4
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50154521 (CHEMBL3775532) Show SMILES Fc1ccc(cc1F)-c1c[nH]c(n1)[C@H]1Cc2c([nH]c3ccccc23)[C@H](N1)C1CCOCC1 |r| Show InChI InChI=1S/C25H24F2N4O/c26-18-6-5-15(11-19(18)27)22-13-28-25(31-22)21-12-17-16-3-1-2-4-20(16)29-24(17)23(30-21)14-7-9-32-10-8-14/h1-6,11,13-14,21,23,29-30H,7-10,12H2,(H,28,31)/t21-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.40	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523768 (US11136312, Compound SK-I-105) Show SMILES COc1ccc(Cc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.65	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523734 (US11136312, Compound BN-VI-56) Show SMILES Clc1cccc(Cc2nnc(CCc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.26	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523761 (US11136312, Compound SK-I-23) Show SMILES COc1ccc(Cc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.27	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50154451 (CHEMBL3775061) Show SMILES Cc1nc(no1)[C@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cn1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H22FN9O/c1-14-31-25(35-37-14)26(15-10-30-36(2)13-15)23-18(17-5-3-4-6-19(17)32-23)9-21(34-26)24-29-12-22(33-24)20-8-7-16(27)11-28-20/h3-8,10-13,21,32,34H,9H2,1-2H3,(H,29,33)/t21-,26+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.40	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels				Bioorg Med Chem Lett 26: 1529-35 (2016) Article DOI: 10.1016/j.bmcl.2016.02.022 BindingDB Entry DOI: 10.7270/Q2ZG6V4J
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50546560 (CHEMBL4778342) Show SMILES CN(C[C@@H]1CCCN1)Cc1c(cnc2ncn(-c3cc(O)cc(F)c3)c(=O)c12)-c1cc(C)cc(Cl)c1 |r| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.90	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SST3				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127496 BindingDB Entry DOI: 10.7270/Q2183B4R
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50110461 (CHEMBL3605789) Show SMILES Fc1ccc(cc1)-c1c[nH]c(n1)C1(CCCC1)NCc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H23FN4/c24-18-9-7-16(8-10-18)21-15-26-22(28-21)23(11-3-4-12-23)27-14-17-13-25-20-6-2-1-5-19(17)20/h1-2,5-10,13,15,25,27H,3-4,11-12,14H2,(H,26,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.10	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 25: 3520-5 (2015) Article DOI: 10.1016/j.bmcl.2015.06.087 BindingDB Entry DOI: 10.7270/Q29W0H9M
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM523793 (US11136312, Compound AH.2.165) Show SMILES Cc1cccc(CSc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.41	n/a	n/a	n/a	n/a
TBA					Assay Description Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
					More data for this Ligand-Target Pair

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