BindingDB PrimarySearch

Found 26 hits of ki for UniProtKB: P49327
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fatty acid synthase (Homo sapiens (Human))	BDBM24567 ((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Antagonist activity at recombinant FASN thioesterase domain by fluorigenic assay				J Med Chem 54: 5615-38 (2011) Article DOI: 10.1021/jm2005805 BindingDB Entry DOI: 10.7270/Q21N8261
Wayne State University Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase [2202-2509] (Homo sapiens (Human))	BDBM24988 (1-(3-hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formam...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	300	-9.25	n/a	n/a	n/a	n/a	n/a	7.5	37
Burnham Institute for Medical Research					Assay Description The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...				Mol Cancer Ther 6: 2120-6 (2007) Article DOI: 10.1158/1535-7163.MCT-07-0187 BindingDB Entry DOI: 10.7270/Q2F769V8
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50124408 (CHEMBL2165266) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Alabama Curated by ChEMBL					Assay Description Inhibition of fatty acid synthase KE domain (unknown origin)				Bioorg Med Chem Lett 25: 4363-9 (2015) Article DOI: 10.1016/j.bmcl.2015.08.087 BindingDB Entry DOI: 10.7270/Q2057HR2
University of South Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase [2202-2509] (Homo sapiens (Human))	BDBM24984 ((5E)-1-(3,5-dimethylphenyl)-5-[(5-phenylfuran-2-yl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	380	-9.10	n/a	n/a	n/a	n/a	n/a	7.5	37
Burnham Institute for Medical Research					Assay Description The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...				Mol Cancer Ther 6: 2120-6 (2007) Article DOI: 10.1158/1535-7163.MCT-07-0187 BindingDB Entry DOI: 10.7270/Q2F769V8
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM24984 ((5E)-1-(3,5-dimethylphenyl)-5-[(5-phenylfuran-2-yl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Antagonist activity at human recombinant FASN thioesterase domain by fluorigenic assay				J Med Chem 54: 5615-38 (2011) Article DOI: 10.1021/jm2005805 BindingDB Entry DOI: 10.7270/Q21N8261
Wayne State University Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase [2202-2509] (Homo sapiens (Human))	BDBM24987 ((5E)-1-benzyl-5-{[5-(2-chlorophenyl)furan-2-yl]met...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	850	-8.61	n/a	n/a	n/a	n/a	n/a	7.5	37
Burnham Institute for Medical Research					Assay Description The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...				Mol Cancer Ther 6: 2120-6 (2007) Article DOI: 10.1158/1535-7163.MCT-07-0187 BindingDB Entry DOI: 10.7270/Q2F769V8
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Fatty acid synthase [2202-2509] (Homo sapiens (Human))	BDBM24986 ((5E)-1-(3-bromophenyl)-5-{[5-(2-nitrophenyl)furan-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	880	-8.59	n/a	n/a	n/a	n/a	n/a	7.5	37
Burnham Institute for Medical Research					Assay Description The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...				Mol Cancer Ther 6: 2120-6 (2007) Article DOI: 10.1158/1535-7163.MCT-07-0187 BindingDB Entry DOI: 10.7270/Q2F769V8
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Fatty acid synthase [2202-2509] (Homo sapiens (Human))	BDBM24985 ((5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	910	-8.57	n/a	n/a	n/a	n/a	n/a	7.5	37
Burnham Institute for Medical Research					Assay Description The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...				Mol Cancer Ther 6: 2120-6 (2007) Article DOI: 10.1158/1535-7163.MCT-07-0187 BindingDB Entry DOI: 10.7270/Q2F769V8
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50070208 (A-65006 \| AG-1749 \| CHEBI:6375 \| Lansoprazole \| Pr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00642 BindingDB Entry DOI: 10.7270/Q24J0K3R
TBA					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50394664 (CHEMBL2165413) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Antagonist activity at recombinant FASN thioesterase domain by fluorigenic assay				J Med Chem 54: 5615-38 (2011) Article DOI: 10.1021/jm2005805 BindingDB Entry DOI: 10.7270/Q21N8261
Wayne State University Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50241343 ((RS)-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...				J Med Chem 58: 778-84 (2015) Article DOI: 10.1021/jm501543u BindingDB Entry DOI: 10.7270/Q20K2B7H
Indiana University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50241342 (5-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...				J Med Chem 58: 778-84 (2015) Article DOI: 10.1021/jm501543u BindingDB Entry DOI: 10.7270/Q20K2B7H
Indiana University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50070208 (A-65006 \| AG-1749 \| CHEBI:6375 \| Lansoprazole \| Pr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...				J Med Chem 58: 778-84 (2015) Article DOI: 10.1021/jm501543u BindingDB Entry DOI: 10.7270/Q20K2B7H
Indiana University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50070209 (Aciphex \| CHEBI:8768 \| LY-307640 \| Rabeprazole) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...				J Med Chem 58: 778-84 (2015) Article DOI: 10.1021/jm501543u BindingDB Entry DOI: 10.7270/Q20K2B7H
Indiana University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50142501 ((+/-)-2-amino-4-(((2S,3S,4R,5R)-5-(6-amino-9H-puri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50142502 (2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50142502 (2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50142502 (2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50142505 (2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50009672 (AdoHcy \| CHEMBL418052 \| S-(5'-adenosyl)-L-homocyst...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50142506 ((2R,3R,4S,5S)-2-(6-Amino-purin-9-yl)-5-methanesulf...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50142504 ((2R,3R,4S,5S)-2-(6-Amino-purin-9-yl)-5-methanesulf...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM22111 ((2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.50E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50366942 (CHEMBL540135) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.50E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50291713 (((S)-3-Amino-3-carboxy-propyl)-dimethyl-sulfonium ...) Show SMILES C[S+](C)CC[C@H](N)C(O)=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	1.40E+8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM50142500 ((2S)-2-amino-4-(methylsulfanyl)butanoic acid \| (S)...) Show SMILES CSCC[C@H](N)C(O)=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.50E+8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Pierre et Marie Curie Curated by ChEMBL					Assay Description Inhibition constant against Escherichia coli cyclopropane fatty acid synthase				Bioorg Med Chem Lett 14: 1661-4 (2004) Article DOI: 10.1016/j.bmcl.2004.01.051 BindingDB Entry DOI: 10.7270/Q26H4HZX
Universit£ Pierre et Marie Curie Curated by ChEMBL					More data for this Ligand-Target Pair