new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 13 hits Enz. Inhib. hit(s) with all data for entry = 50034201   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358788
PNG
(CHEMBL1922756)
Show SMILES FC(F)(F)c1ccc(OCC(=O)c2ccc(Cl)nc2)cc1
Show InChI InChI=1S/C14H9ClF3NO2/c15-13-6-1-9(7-19-13)12(20)8-21-11-4-2-10(3-5-11)14(16,17)18/h1-7H,8H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobili...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358787
PNG
(CHEMBL1922750)
Show SMILES Clc1ccc(cn1)C(=O)COc1cccc(Br)c1
Show InChI InChI=1S/C13H9BrClNO2/c14-10-2-1-3-11(6-10)18-8-12(17)9-4-5-13(15)16-7-9/h1-7H,8H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.70E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobili...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358780
PNG
(CHEMBL1922760)
Show SMILES Clc1ccc(cn1)C(=O)COc1ccccc1-c1ccccn1
Show InChI InChI=1S/C18H13ClN2O2/c19-18-9-8-13(11-21-18)16(22)12-23-17-7-2-1-5-14(17)15-6-3-4-10-20-15/h1-11H,12H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobili...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358785
PNG
(CHEMBL1922728)
Show SMILES Clc1ccc(cn1)C(=O)COc1ccccc1Br
Show InChI InChI=1S/C13H9BrClNO2/c14-10-3-1-2-4-12(10)18-8-11(17)9-5-6-13(15)16-7-9/h1-7H,8H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.20E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobili...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358786
PNG
(CHEMBL1922742)
Show SMILES Brc1ccccc1OCC(=O)c1ccc(NCCc2cccnc2)nc1
Show InChI InChI=1S/C20H18BrN3O2/c21-17-5-1-2-6-19(17)26-14-18(25)16-7-8-20(24-13-16)23-11-9-15-4-3-10-22-12-15/h1-8,10,12-13H,9,11,14H2,(H,23,24)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobili...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358781
PNG
(CHEMBL1922765)
Show SMILES Clc1ccc(cn1)C(=O)COc1ccccc1-c1cncnc1
Show InChI InChI=1S/C17H12ClN3O2/c18-17-6-5-12(9-21-17)15(22)10-23-16-4-2-1-3-14(16)13-7-19-11-20-8-13/h1-9,11H,10H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobili...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358782
PNG
(CHEMBL1922768)
Show SMILES Cn1cc(cn1)-c1ccccc1OCC(=O)c1ccc(Cl)nc1
Show InChI InChI=1S/C17H14ClN3O2/c1-21-10-13(9-20-21)14-4-2-3-5-16(14)23-11-15(22)12-6-7-17(18)19-8-12/h2-10H,11H2,1H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobili...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358779
PNG
(CHEMBL1922759)
Show SMILES Clc1ccc(cn1)C(=O)COc1ccccc1-c1ccccc1
Show InChI InChI=1S/C19H14ClNO2/c20-19-11-10-15(12-21-19)17(22)13-23-18-9-5-4-8-16(18)14-6-2-1-3-7-14/h1-12H,13H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobili...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50358783
PNG
(CHEMBL1346011)
Show SMILES Oc1ccc(C(=O)COc2ccccc2Br)c(O)c1
Show InChI InChI=1S/C14H11BrO4/c15-11-3-1-2-4-14(11)19-8-13(18)10-6-5-9(16)7-12(10)17/h1-7,16-17H,8H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human muscarinic acetylcholine receptor 1 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-in...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50358783
PNG
(CHEMBL1346011)
Show SMILES Oc1ccc(C(=O)COc2ccccc2Br)c(O)c1
Show InChI InChI=1S/C14H11BrO4/c15-11-3-1-2-4-14(11)19-8-13(18)10-6-5-9(16)7-12(10)17/h1-7,16-17H,8H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at human muscarinic acetylcholine receptor 4 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-in...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358784
PNG
(CHEMBL1922727)
Show SMILES Brc1ccccc1OCC(=O)c1ccccn1
Show InChI InChI=1S/C13H10BrNO2/c14-10-5-1-2-7-13(10)17-9-12(16)11-6-3-4-8-15-11/h1-8H,9H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.60E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as potentiation of EC20 glutamate-induced c...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50358783
PNG
(CHEMBL1346011)
Show SMILES Oc1ccc(C(=O)COc2ccccc2Br)c(O)c1
Show InChI InChI=1S/C14H11BrO4/c15-11-3-1-2-4-14(11)19-8-13(18)10-6-5-9(16)7-12(10)17/h1-7,16-17H,8H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.40E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as potentiation of EC20 glutamate-induced c...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50358783
PNG
(CHEMBL1346011)
Show SMILES Oc1ccc(C(=O)COc2ccccc2Br)c(O)c1
Show InChI InChI=1S/C14H11BrO4/c15-11-3-1-2-4-14(11)19-8-13(18)10-6-5-9(16)7-12(10)17/h1-7,16-17H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu4 receptor expressed in human HEK293 cells co-expressing GIRK potassium channels assessed as potentiation o...


Bioorg Med Chem Lett 21: 6955-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.131
BindingDB Entry DOI: 10.7270/Q2S75GRQ
More data for this
Ligand-Target Pair