Compile Data Set for Download or QSAR

Found 73 hits Enz. Inhib. hit(s) with all data for entry = 50000167   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C (Homo sapiens (Human))	BDBM50241875 (CHEMBL4091527) Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cn[nH]c1 Show InChI InChI=1S/C22H23N5O2/c28-22(6-3-18-13-23-8-7-21(18)19-14-24-25-15-19)26-20-4-1-17(2-5-20)16-27-9-11-29-12-10-27/h1-8,13-15H,9-12,16H2,(H,24,25)(H,26,28)/b6-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241879 (CHEMBL4082587) Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1ccc2[nH]cnc2c1 Show InChI InChI=1S/C26H25N5O2/c32-26(30-22-5-1-19(2-6-22)17-31-11-13-33-14-12-31)8-4-21-16-27-10-9-23(21)20-3-7-24-25(15-20)29-18-28-24/h1-10,15-16,18H,11-14,17H2,(H,28,29)(H,30,32)/b8-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241892 (CHEMBL4072106) Show SMILES Cn1cnc2ccc(cc12)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C27H27N5O2/c1-31-19-29-25-8-4-21(16-26(25)31)24-10-11-28-17-22(24)5-9-27(33)30-23-6-2-20(3-7-23)18-32-12-14-34-15-13-32/h2-11,16-17,19H,12-15,18H2,1H3,(H,30,33)/b9-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241862 (CHEMBL4059523) Show SMILES FC1(F)CN(Cc2ccc(NC(=O)\C=C\c3cnccc3-c3cnn(c3)C3CC3)cc2)C1 Show InChI InChI=1S/C24H23F2N5O/c25-24(26)15-30(16-24)13-17-1-4-20(5-2-17)29-23(32)8-3-18-11-27-10-9-22(18)19-12-28-31(14-19)21-6-7-21/h1-5,8-12,14,21H,6-7,13,15-16H2,(H,29,32)/b8-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241864 (CHEMBL4069244) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc2CCN(CC(F)(F)F)Cc2c1 Show InChI InChI=1S/C23H22F3N5O/c1-30-13-19(12-28-30)21-6-8-27-11-17(21)3-5-22(32)29-20-4-2-16-7-9-31(14-18(16)10-20)15-23(24,25)26/h2-6,8,10-13H,7,9,14-15H2,1H3,(H,29,32)/b5-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241882 (CHEMBL4101552) Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cnn(Cc2ccccc2)c1 Show InChI InChI=1S/C29H29N5O2/c35-29(32-27-9-6-24(7-10-27)20-33-14-16-36-17-15-33)11-8-25-18-30-13-12-28(25)26-19-31-34(22-26)21-23-4-2-1-3-5-23/h1-13,18-19,22H,14-17,20-21H2,(H,32,35)/b11-8+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241863 (CHEMBL4060561) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc2CN(CC(F)(F)F)CCc2c1 Show InChI InChI=1S/C23H22F3N5O/c1-30-13-19(12-28-30)21-6-8-27-11-17(21)3-5-22(32)29-20-4-2-18-14-31(15-23(24,25)26)9-7-16(18)10-20/h2-6,8,10-13H,7,9,14-15H2,1H3,(H,29,32)/b5-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241896 (CHEMBL4081088) Show SMILES Cn1cc(cn1)-c1c(F)cncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H24FN5O2/c1-28-16-19(13-26-28)23-18(12-25-14-21(23)24)4-7-22(30)27-20-5-2-17(3-6-20)15-29-8-10-31-11-9-29/h2-7,12-14,16H,8-11,15H2,1H3,(H,27,30)/b7-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241890 (CHEMBL4098004) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCC(F)(F)C2)cc1 Show InChI InChI=1S/C23H23F2N5O/c1-29-15-19(13-27-29)21-8-10-26-12-18(21)4-7-22(31)28-20-5-2-17(3-6-20)14-30-11-9-23(24,25)16-30/h2-8,10,12-13,15H,9,11,14,16H2,1H3,(H,28,31)/b7-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241858 (CHEMBL4070459) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2C3CCC2COC3)cc1 Show InChI InChI=1S/C25H27N5O2/c1-29-15-20(13-27-29)24-10-11-26-12-19(24)4-9-25(31)28-21-5-2-18(3-6-21)14-30-22-7-8-23(30)17-32-16-22/h2-6,9-13,15,22-23H,7-8,14,16-17H2,1H3,(H,28,31)/b9-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241868 (CHEMBL4092865) Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cnn(c1)C1CC1 Show InChI InChI=1S/C25H27N5O2/c31-25(28-22-4-1-19(2-5-22)17-29-11-13-32-14-12-29)8-3-20-15-26-10-9-24(20)21-16-27-30(18-21)23-6-7-23/h1-5,8-10,15-16,18,23H,6-7,11-14,17H2,(H,28,31)/b8-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241881 (CHEMBL4063489) Show SMILES FC(F)n1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H23F2N5O2/c24-23(25)30-16-19(14-27-30)21-7-8-26-13-18(21)3-6-22(31)28-20-4-1-17(2-5-20)15-29-9-11-32-12-10-29/h1-8,13-14,16,23H,9-12,15H2,(H,28,31)/b6-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241885 (CHEMBL4060759) Show SMILES Fc1cncc(\C=C\C(=O)Nc2ccc(CN3CCOCC3)cc2)c1-c1cnn(c1)C1CC1 Show InChI InChI=1S/C25H26FN5O2/c26-23-15-27-13-19(25(23)20-14-28-31(17-20)22-6-7-22)3-8-24(32)29-21-4-1-18(2-5-21)16-30-9-11-33-12-10-30/h1-5,8,13-15,17,22H,6-7,9-12,16H2,(H,29,32)/b8-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241866 (CHEMBL4063709) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H25N5O2/c1-27-17-20(15-25-27)22-8-9-24-14-19(22)4-7-23(29)26-21-5-2-18(3-6-21)16-28-10-12-30-13-11-28/h2-9,14-15,17H,10-13,16H2,1H3,(H,26,29)/b7-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241860 (CHEMBL4079977) Show SMILES O=C(Nc1ccc(CN2CC3CC(C2)O3)cc1)\C=C\c1cnccc1-c1cnn(c1)C1CC1 Show InChI InChI=1S/C26H27N5O2/c32-26(29-21-4-1-18(2-5-21)14-30-16-23-11-24(17-30)33-23)8-3-19-12-27-10-9-25(19)20-13-28-31(15-20)22-6-7-22/h1-5,8-10,12-13,15,22-24H,6-7,11,14,16-17H2,(H,29,32)/b8-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241857 (CHEMBL4091382) Show SMILES CC1CN(Cc2ccc(NC(=O)\C=C\c3cnccc3-c3cnn(C)c3)cc2)CCO1 Show InChI InChI=1S/C24H27N5O2/c1-18-15-29(11-12-31-18)16-19-3-6-22(7-4-19)27-24(30)8-5-20-13-25-10-9-23(20)21-14-26-28(2)17-21/h3-10,13-14,17-18H,11-12,15-16H2,1-2H3,(H,27,30)/b8-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241891 (CHEMBL4082444) Show SMILES FC(F)(F)CN1CCc2cc(NC(=O)\C=C\c3cnccc3-c3cnn(c3)C3CC3)ccc2C1 Show InChI InChI=1S/C25H24F3N5O/c26-25(27,28)16-32-10-8-17-11-21(3-1-19(17)14-32)31-24(34)6-2-18-12-29-9-7-23(18)20-13-30-33(15-20)22-4-5-22/h1-3,6-7,9,11-13,15,22H,4-5,8,10,14,16H2,(H,31,34)/b6-2+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50241868 (CHEMBL4092865) Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cnn(c1)C1CC1 Show InChI InChI=1S/C25H27N5O2/c31-25(28-22-4-1-19(2-5-22)17-29-11-13-32-14-12-29)8-3-20-15-26-10-9-24(20)21-16-27-30(18-21)23-6-7-23/h1-5,8-10,15-16,18,23H,6-7,11-14,17H2,(H,28,31)/b8-3+	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to GST-tagged CDK19/CycC (unknown origin) after 60 min by TR-FRET assay				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241871 (CHEMBL4087219) Show SMILES COc1ncc(s1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H24N4O3S/c1-29-23-25-15-21(31-23)20-8-9-24-14-18(20)4-7-22(28)26-19-5-2-17(3-6-19)16-27-10-12-30-13-11-27/h2-9,14-15H,10-13,16H2,1H3,(H,26,28)/b7-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241874 (CHEMBL4079336) Show SMILES NC(=O)c1ccc(s1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O3S/c25-24(30)22-7-6-21(32-22)20-9-10-26-15-18(20)3-8-23(29)27-19-4-1-17(2-5-19)16-28-11-13-31-14-12-28/h1-10,15H,11-14,16H2,(H2,25,30)(H,27,29)/b8-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241859 (CHEMBL4063908) Show SMILES O=C(Nc1ccc(CN2CC3CC2CO3)cc1)\C=C\c1cnccc1-c1cnn(c1)C1CC1 Show InChI InChI=1S/C26H27N5O2/c32-26(29-21-4-1-18(2-5-21)14-30-16-24-11-23(30)17-33-24)8-3-19-12-27-10-9-25(19)20-13-28-31(15-20)22-6-7-22/h1-5,8-10,12-13,15,22-24H,6-7,11,14,16-17H2,(H,29,32)/b8-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241861 (CHEMBL4087859) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CC(F)(F)C2)cc1 Show InChI InChI=1S/C22H21F2N5O/c1-28-13-18(11-26-28)20-8-9-25-10-17(20)4-7-21(30)27-19-5-2-16(3-6-19)12-29-14-22(23,24)15-29/h2-11,13H,12,14-15H2,1H3,(H,27,30)/b7-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50241866 (CHEMBL4063709) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H25N5O2/c1-27-17-20(15-25-27)22-8-9-24-14-19(22)4-7-23(29)26-21-5-2-18(3-6-21)16-28-10-12-30-13-11-28/h2-9,14-15,17H,10-13,16H2,1H3,(H,26,29)/b7-4+	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to GST-tagged CDK19/CycC (unknown origin) after 60 min by TR-FRET assay				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241900 (CHEMBL4066959) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CC3CC2CO3)cc1 Show InChI InChI=1S/C24H25N5O2/c1-28-14-19(12-26-28)23-8-9-25-11-18(23)4-7-24(30)27-20-5-2-17(3-6-20)13-29-15-22-10-21(29)16-31-22/h2-9,11-12,14,21-22H,10,13,15-16H2,1H3,(H,27,30)/b7-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241897 (CHEMBL4061835) Show SMILES CC1COCCN1Cc1ccc(NC(=O)\C=C\c2cnccc2-c2cnn(C)c2)cc1 Show InChI InChI=1S/C24H27N5O2/c1-18-17-31-12-11-29(18)15-19-3-6-22(7-4-19)27-24(30)8-5-20-13-25-10-9-23(20)21-14-26-28(2)16-21/h3-10,13-14,16,18H,11-12,15,17H2,1-2H3,(H,27,30)/b8-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241870 (CHEMBL4094902) Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cnsc1 Show InChI InChI=1S/C22H22N4O2S/c27-22(6-3-18-13-23-8-7-21(18)19-14-24-29-16-19)25-20-4-1-17(2-5-20)15-26-9-11-28-12-10-26/h1-8,13-14,16H,9-12,15H2,(H,25,27)/b6-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241899 (CHEMBL4085116) Show SMILES FC(F)(F)Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C24H24F3N5O2/c25-24(26,27)17-32-16-20(14-29-32)22-7-8-28-13-19(22)3-6-23(33)30-21-4-1-18(2-5-21)15-31-9-11-34-12-10-31/h1-8,13-14,16H,9-12,15,17H2,(H,30,33)/b6-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241872 (CHEMBL4097361) Show SMILES COc1ccc(s1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C24H25N3O3S/c1-29-24-9-7-22(31-24)21-10-11-25-16-19(21)4-8-23(28)26-20-5-2-18(3-6-20)17-27-12-14-30-15-13-27/h2-11,16H,12-15,17H2,1H3,(H,26,28)/b8-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241869 (CHEMBL4093832) Show SMILES O=C(CCc1cnccc1-c1cnn(c1)C1CC1)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C25H29N5O2/c31-25(28-22-4-1-19(2-5-22)17-29-11-13-32-14-12-29)8-3-20-15-26-10-9-24(20)21-16-27-30(18-21)23-6-7-23/h1-2,4-5,9-10,15-16,18,23H,3,6-8,11-14,17H2,(H,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241895 (CHEMBL4074871) Show SMILES Cn1cc(cn1)-c1ccncc1CCC(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H27N5O2/c1-27-17-20(15-25-27)22-8-9-24-14-19(22)4-7-23(29)26-21-5-2-18(3-6-21)16-28-10-12-30-13-11-28/h2-3,5-6,8-9,14-15,17H,4,7,10-13,16H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50241869 (CHEMBL4093832) Show SMILES O=C(CCc1cnccc1-c1cnn(c1)C1CC1)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C25H29N5O2/c31-25(28-22-4-1-19(2-5-22)17-29-11-13-32-14-12-29)8-3-20-15-26-10-9-24(20)21-16-27-30(18-21)23-6-7-23/h1-2,4-5,9-10,15-16,18,23H,3,6-8,11-14,17H2,(H,28,31)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to GST-tagged CDK19/CycC (unknown origin) after 60 min by TR-FRET assay				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241898 (CHEMBL4105077) Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cncs1 Show InChI InChI=1S/C22H22N4O2S/c27-22(6-3-18-13-23-8-7-20(18)21-14-24-16-29-21)25-19-4-1-17(2-5-19)15-26-9-11-28-12-10-26/h1-8,13-14,16H,9-12,15H2,(H,25,27)/b6-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50241895 (CHEMBL4074871) Show SMILES Cn1cc(cn1)-c1ccncc1CCC(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H27N5O2/c1-27-17-20(15-25-27)22-8-9-24-14-19(22)4-7-23(29)26-21-5-2-18(3-6-21)16-28-10-12-30-13-11-28/h2-3,5-6,8-9,14-15,17H,4,7,10-13,16H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to GST-tagged CDK19/CycC (unknown origin) after 60 min by TR-FRET assay				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241889 (CHEMBL4083599) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccccc1 Show InChI InChI=1S/C18H16N4O/c1-22-13-15(12-20-22)17-9-10-19-11-14(17)7-8-18(23)21-16-5-3-2-4-6-16/h2-13H,1H3,(H,21,23)/b8-7+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Compound was evaluated for inhibition of plasma renin activity in dog				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50241875 (CHEMBL4091527) Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cn[nH]c1 Show InChI InChI=1S/C22H23N5O2/c28-22(6-3-18-13-23-8-7-21(18)19-14-24-25-15-19)26-20-4-1-17(2-5-20)16-27-9-11-29-12-10-27/h1-8,13-15H,9-12,16H2,(H,24,25)(H,26,28)/b6-3+	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to GST-tagged CDK19/CycC (unknown origin) after 60 min by TR-FRET assay				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241883 (CHEMBL4066257) Show SMILES Cn1cc(cn1)-c1cc(N)ncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H26N6O2/c1-28-16-19(14-26-28)21-12-22(24)25-13-18(21)4-7-23(30)27-20-5-2-17(3-6-20)15-29-8-10-31-11-9-29/h2-7,12-14,16H,8-11,15H2,1H3,(H2,24,25)(H,27,30)/b7-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241880 (CHEMBL4100600) Show SMILES Cn1cnc2cc(ccc12)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C27H27N5O2/c1-31-19-29-25-16-21(4-8-26(25)31)24-10-11-28-17-22(24)5-9-27(33)30-23-6-2-20(3-7-23)18-32-12-14-34-15-13-32/h2-11,16-17,19H,12-15,18H2,1H3,(H,30,33)/b9-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241888 (CHEMBL4088976) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(N)=O Show InChI InChI=1S/C12H12N4O/c1-16-8-10(7-15-16)11-4-5-14-6-9(11)2-3-12(13)17/h2-8H,1H3,(H2,13,17)/b3-2+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50241884 (CHEMBL4099122) Show SMILES Cn1cc(cn1)-c1ccnc(O)c1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H25N5O3/c1-27-16-18(14-25-27)20-8-9-24-23(30)21(20)6-7-22(29)26-19-4-2-17(3-5-19)15-28-10-12-31-13-11-28/h2-9,14,16H,10-13,15H2,1H3,(H,24,30)(H,26,29)/b7-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241891 (CHEMBL4082444) Show SMILES FC(F)(F)CN1CCc2cc(NC(=O)\C=C\c3cnccc3-c3cnn(c3)C3CC3)ccc2C1 Show InChI InChI=1S/C25H24F3N5O/c26-25(27,28)16-32-10-8-17-11-21(3-1-19(17)14-32)31-24(34)6-2-18-12-29-9-7-23(18)20-13-30-33(15-20)22-4-5-22/h1-3,6-7,9,11-13,15,22H,4-5,8,10,14,16H2,(H,31,34)/b6-2+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241858 (CHEMBL4070459) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2C3CCC2COC3)cc1 Show InChI InChI=1S/C25H27N5O2/c1-29-15-20(13-27-29)24-10-11-26-12-19(24)4-9-25(31)28-21-5-2-18(3-6-21)14-30-22-7-8-23(30)17-32-16-22/h2-6,9-13,15,22-23H,7-8,14,16-17H2,1H3,(H,28,31)/b9-4+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of [3H]WIN-35428l binding to Dopamine transporter				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241869 (CHEMBL4093832) Show SMILES O=C(CCc1cnccc1-c1cnn(c1)C1CC1)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C25H29N5O2/c31-25(28-22-4-1-19(2-5-22)17-29-11-13-32-14-12-29)8-3-20-15-26-10-9-24(20)21-16-27-30(18-21)23-6-7-23/h1-2,4-5,9-10,15-16,18,23H,3,6-8,11-14,17H2,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241895 (CHEMBL4074871) Show SMILES Cn1cc(cn1)-c1ccncc1CCC(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H27N5O2/c1-27-17-20(15-25-27)22-8-9-24-14-19(22)4-7-23(29)26-21-5-2-18(3-6-21)16-28-10-12-30-13-11-28/h2-3,5-6,8-9,14-15,17H,4,7,10-13,16H2,1H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	95	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241862 (CHEMBL4059523) Show SMILES FC1(F)CN(Cc2ccc(NC(=O)\C=C\c3cnccc3-c3cnn(c3)C3CC3)cc2)C1 Show InChI InChI=1S/C24H23F2N5O/c25-24(26)15-30(16-24)13-17-1-4-20(5-2-17)29-23(32)8-3-18-11-27-10-9-22(18)19-12-28-31(14-19)21-6-7-21/h1-5,8-12,14,21H,6-7,13,15-16H2,(H,29,32)/b8-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.40	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241864 (CHEMBL4069244) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc2CCN(CC(F)(F)F)Cc2c1 Show InChI InChI=1S/C23H22F3N5O/c1-30-13-19(12-28-30)21-6-8-27-11-17(21)3-5-22(32)29-20-4-2-16-7-9-31(14-18(16)10-20)15-23(24,25)26/h2-6,8,10-13H,7,9,14-15H2,1H3,(H,29,32)/b5-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.40	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241898 (CHEMBL4105077) Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cncs1 Show InChI InChI=1S/C22H22N4O2S/c27-22(6-3-18-13-23-8-7-20(18)21-14-24-16-29-21)25-19-4-1-17(2-5-19)15-26-9-11-28-12-10-26/h1-8,13-14,16H,9-12,15H2,(H,25,27)/b6-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241866 (CHEMBL4063709) Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H25N5O2/c1-27-17-20(15-25-27)22-8-9-24-14-19(22)4-7-23(29)26-21-5-2-18(3-6-21)16-28-10-12-30-13-11-28/h2-9,14-15,17H,10-13,16H2,1H3,(H,26,29)/b7-4+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241892 (CHEMBL4072106) Show SMILES Cn1cnc2ccc(cc12)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C27H27N5O2/c1-31-19-29-25-8-4-21(16-26(25)31)24-10-11-28-17-22(24)5-9-27(33)30-23-6-2-20(3-7-23)18-32-12-14-34-15-13-32/h2-11,16-17,19H,12-15,18H2,1H3,(H,30,33)/b9-5+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241899 (CHEMBL4085116) Show SMILES FC(F)(F)Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C24H24F3N5O2/c25-24(26,27)17-32-16-20(14-29-32)22-7-8-28-13-19(22)3-6-23(33)30-21-4-1-18(2-5-21)15-31-9-11-34-12-10-31/h1-8,13-14,16H,9-12,15,17H2,(H,30,33)/b6-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibition of leukotriene B4 synthesis in human whole blood by inhibiting 5-lipoxygenase				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50241896 (CHEMBL4081088) Show SMILES Cn1cc(cn1)-c1c(F)cncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C23H24FN5O2/c1-28-16-19(13-26-28)23-18(12-25-14-21(23)24)4-7-22(30)27-20-5-2-17(3-6-20)15-29-8-10-31-11-9-29/h2-7,12-14,16H,8-11,15H2,1H3,(H,27,30)/b7-4+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.60	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...				Bioorg Med Chem 25: 3018-3033 (2017) Article DOI: 10.1016/j.bmc.2017.03.049 BindingDB Entry DOI: 10.7270/Q24X59XW
					More data for this Ligand-Target Pair

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