Compile Data Set for Download or QSAR

Found 194 hits Enz. Inhib. hit(s) with all data for entry = 968   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM300973 (2-fluoro-6- ((6S,8R)-1- fluoro-8- methyl-7- (2,2,2...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]nc(F)c23)[C@H](N1CC(F)(F)F)c1ccc(NC2CN(CCCF)C2)c(F)n1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0480	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300961 (1-(3-Fluoropropyl)-N-(4-((6R,8R)-8-methyl-7-(2,2,2...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1ccc(NC2CN(CCCF)C2)cc1 |r,$;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300933 (N-(3,5-difluoro-4-((6S,8R)-8-methyl-7-(2,2,2-trifl...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1c(F)cc(NC2CN(CCCF)C2)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300956 ((6S,8R)-7-(2,2-difluoroethyl)-6-(4-((1-(3-fluoropr...) Show SMILES COc1cc(OC2CN(CCCF)C2)ccc1[C@H]1N(CC(F)F)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0620	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300953 (N-(4-((6S,8R)-7-(2,2-difluoropropyl)-8-methyl-6,7,...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC(C)(F)F)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300962 (1-(3-fluoropropyl)-N-(3-methoxy-4-((6S,8R)-8-methy...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC(F)(F)F)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0650	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300983 (N-(4-((6S,8R)- 7-(2,2- difluoroethyl)- 8-methyl- 6...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)F)c1c(F)cc(NC2CN(CCCF)C2)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0750	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300929 (3-((6S,8R)-6-(2,6-difluoro-4-((1-(3-fluoropropyl)a...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)CO)c1c(F)cc(NC2CN(CCCF)C2)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0770	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300982 (N-(4-((6R,8R)- 7-(2,2- difluoroethyl)- 8-methyl- 6...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)F)c1ccc(NC2CN(CCCF)C2)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0780	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300942 (BDBM436225 | N-(3,5-difluoro-4-((6S,8R)-7-((1-fluo...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC1(F)CC1)c1c(F)cc(NC2CN(CCCF)C2)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0940	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300966 (6-((6S,8R)-1-fluoro-8-methyl-7-(2,2,2-trifluoroeth...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]nc(F)c23)[C@H](N1CC(F)(F)F)c1ccc(NC2CN(CCCF)C2)cn1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0960	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300955 (N-(4-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC(F)F)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0980	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300967 (5-Fluoro-6-((6S,8R)-1-fluoro-8-methyl-7-(2,2,2-tri...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]nc(F)c23)[C@H](N1CC(F)(F)F)c1ncc(NC2CN(CCCF)C2)cc1F |r,$;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300919 (N-(4-((6S,8R)-7-(2,2-difluoro-3-methoxypropyl)-8-m...) Show SMILES COCC(F)(F)CN1[C@H](C)Cc2c(ccc3[nH]ncc23)[C@H]1c1ccc(NC2CN(CCCF)C2)cc1OC |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300974 (6-fluoro-N-(1- (3- fluoropropyl) azetidin-3-yl)-5-...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1ccc(NC2CN(CCCF)C2)nc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300944 (US10131663, Example 13) Show SMILES COC[C@@](C)(F)CN1[C@H](C)Cc2c(ccc3[nH]ncc23)[C@H]1c1ccc(OC2CN(CCCF)C2)cc1OC |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300969 (BDBM300970 | N-(1-(3- fluoropropyl) azetidin-3-yl)...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1ccc(NC2CN(CCCF)C2)cn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300995 (2,2-difluoro-3- ((6S,8R)-1- fluoro-6-(5- ((1-(3- f...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]nc(F)c23)[C@H](N1CC(F)(F)CO)c1ccc(NC2CN(CCCF)C2)cn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300996 (2,2-difluoro-3- ((6S,8R)-1- fluoro-6-(6- fluoro-5-...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]nc(F)c23)[C@H](N1CC(F)(F)CO)c1ccc(NC2CN(CCCF)C2)c(F)n1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300957 (3-((6S,8R)-6-(2,6-difluoro-4-(1-(3-fluoropropyl)az...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1C[C@](C)(F)CO)c1c(F)cc(NC2CN(CCCF)C2)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300951 (N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-m...) Show SMILES C[C@H](Cc1cccc(N)c1C)NC(=O)C(F)(F)F |r| Show InChI InChI=1S/C12H15F3N2O/c1-7(17-11(18)12(13,14)15)6-9-4-3-5-10(16)8(9)2/h3-5,7H,6,16H2,1-2H3,(H,17,18)/t7-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300975 (N-(2-fluoro-4- ((6R,8R)-8- methyl-7- (2,2,2- trifl...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1ccc(NC2CN(CCCF)C2)c(F)c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300969 (BDBM300970 | N-(1-(3- fluoropropyl) azetidin-3-yl)...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1ccc(NC2CN(CCCF)C2)cn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM301005 (5-fluoro-N-(1- (3- fluoropropyl) azetidin-3-yl)-6-...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)CF)c1ncc(NC2CN(CCCF)C2)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300972 (5-((6S,8R)-1- fluoro-8- methyl-7- (2,2,2- trifluor...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]nc(F)c23)[C@H](N1CC(F)(F)F)c1cnc(NC2CN(CCCF)C2)cn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300994 (2,2-difluoro-3- ((6S,8R)-6-(4- ((1-(3- fluoropropy...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC(F)(F)CO)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300963 (2-fluoro-N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1ccc(NC2CN(CCCF)C2)c(F)n1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300986 (N-(4-((6S,8R)- 7-((1- fluorocyclo- propyl)methyl)-...) Show SMILES COc1cc(ccc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1ccc1[nH]ncc21)N(C)C1CN(CCCF)C1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300958 (US10131663, Example 24) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1C[C@@](C)(F)CO)c1c(F)cc(NC2CN(CCCF)C2)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300968 (N-(1-(3- fluoropropyl) azetidin-3-yl)- N-methyl-6-...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1ccc(cn1)N(C)C1CN(CCCF)C1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300998 (N-(4-((6S,8R)- 7-(2-fluoro-2- methylpropyl)- 8-met...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC(C)(C)F)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300977 (6-((6S,8R)-7- (2,2- difluoroethyl)- 8-methyl- 6,7,...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)F)c1ccc(cn1)N(C)C1CN(CCCF)C1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300943 ((6S,8R)-7-(2-fluoro-3-methoxy-2-methylpropyl)-6-(4...) Show SMILES COC[C@](C)(F)CN1[C@H](C)Cc2c(ccc3[nH]ncc23)[C@H]1c1ccc(OC2CN(CCCF)C2)cc1OC |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300987 (N-(2-fluoro-4- ((6S,8R)-7-((1- fluorocyclo- propyl...) Show SMILES COc1cc(NC2CN(CCCF)C2)c(F)cc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300936 (N-(4-((6S,8R)-7-((3-(fluoromethyl)oxetan-3-yl)meth...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC2(CF)COC2)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM301001 (1-(3- fluoropropyl)- N-(4-((6S,8R)- 7-(2- fluoropr...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC(C)F)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300976 (N-(1-(3- fluoropropyl) azetidin-3-yl)-5- ((6S,8R)-...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1cnc(NC2CN(CCCF)C2)cn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300964 (5-fluoro-N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1ncc(NC2CN(CCCF)C2)cc1F |r,$;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300979 (N-(4-((6S,8R)- 7-(2,2- difluoroethyl)- 6,8-dimethy...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@@]1(C)N(CC(F)F)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300997 (6-((6S,8R)-7- (2-fluoro-2- methylpropyl)- 8-methyl...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(C)(C)F)c1ccc(NC2CN(CCCF)C2)cn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM301004 (6-((6S,8R)-7- (2,2- difluoropropyl)- 8-methyl- 6,7...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(C)(F)F)c1ccc(NC2CN(CCCF)C2)cn1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300947 (US10131663, Example 15) Show SMILES COC[C@@](C)(F)CN1[C@H](C)Cc2c(ccc3[nH]ncc23)[C@H]1c1ccc(NC2CN(CCCF)C2)cc1OC |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300959 (6-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8,9-...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)F)c1ccc(NC2CN(CCCF)C2)cn1 |r,$;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300925 (N-(4-((6S,8R)-7-(2-fluoro-3-methoxy-2-methylpropyl...) Show SMILES COCC(C)(F)CN1[C@H](C)Cc2c(ccc3[nH]ncc23)[C@H]1c1ccc(NC2CN(CCCF)C2)cc1OC |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300930 (N-(4-((6S,8R)-7-((1-fluorocyclopropyl)methyl)-8-me...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300991 (6-((6S,8R)-7- ((1- fluorocyclo- propyl)methyl)-8- ...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC1(F)CC1)c1ccc(cn1)N(C)C1CN(CCCF)C1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300954 (N-(3-ethoxy-4-((6S,8R)-7-((1-fluorocyclopropyl)met...) Show SMILES CCOc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM301001 (1-(3- fluoropropyl)- N-(4-((6S,8R)- 7-(2- fluoropr...) Show SMILES COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC(C)F)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300980 (6-((6S,8R)-7- (2,2- difluoroethyl)- 8-methyl- 6,7,...) Show SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)F)c1ncc(NC2CN(CCCF)C2)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM300931 ((6S,8R)-7-((1-fluorocyclopropyl)methyl)-6-(4-((1-(...) Show SMILES COc1cc(OC2CN(CCCF)C2)ccc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1ccc1[nH]ncc21 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10131663 (2018) BindingDB Entry DOI: 10.7270/Q2P55QJ9
					More data for this Ligand-Target Pair

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