Compile Data Set for Download or QSAR

Found 150 hits Enz. Inhib. hit(s) with all data for entry = 9134   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374028 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C21H23F2N5O2S2/c1-14-18(27(2)16-8-9-28(12-16)11-15-6-4-3-5-7-15)10-17(22)20(19(14)23)32(29,30)26-21-24-13-25-31-21/h3-7,10,13,16H,8-9,11-12H2,1-2H3,(H,24,25,26)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374029 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C21H24F2N6O2S2/c1-13-5-4-6-15(26-13)10-29-8-7-16(11-29)28(3)18-9-17(22)20(19(23)14(18)2)33(30,31)27-21-24-12-25-32-21/h4-6,9,12,16H,7-8,10-11H2,1-3H3,(H,24,25,27)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374015 ((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...) Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1)c1ccccc1 |r| Show InChI InChI=1S/C23H25F2N3O3S2/c1-15-20(12-19(24)23(22(15)25)33(29,30)27-21-13-32-14-26-21)31-18-8-10-28(11-9-18)16(2)17-6-4-3-5-7-17/h3-7,12-14,16,18,27H,8-11H2,1-2H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373891 ((S)-4-((1-benzyl-3-methylpyrrolidin-3-yl)oxy)-2,6-...) Show SMILES Cc1c(F)c(c(F)cc1O[C@@]1(C)CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-18(30-22(2)8-9-27(13-22)11-16-6-4-3-5-7-16)10-17(23)21(20(15)24)32(28,29)26-19-12-31-14-25-19/h3-7,10,12,14,26H,8-9,11,13H2,1-2H3/t22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374012 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ccsn1 |r| Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-10-28(14-17)13-16-6-4-3-5-7-16)12-18(23)22(21(15)24)32(29,30)26-20-9-11-31-25-20/h3-7,9,11-12,17H,8,10,13-14H2,1-2H3,(H,25,26)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373837 ((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-methylpy...) Show SMILES CN(C1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H25F2N5O2S2/c1-14-5-4-6-16(26-14)10-29-8-7-17(11-29)28(3)19-9-18(23)22(21(24)15(19)2)33(30,31)27-20-12-32-13-25-20/h4-6,9,12-13,17,27H,7-8,10-11H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444553 ((S)-3-chloro-2,6-difluoro-4-(methyl (1-((6-methylp...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H21ClF2N6O2S2/c1-12-4-3-5-13(26-12)9-29-7-6-14(10-29)28(2)16-8-15(22)19(18(23)17(16)21)33(30,31)27-20-24-11-25-32-20/h3-5,8,11,14H,6-7,9-10H2,1-2H3,(H,24,25,27)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373836 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H24F2N4O2S2/c1-15-19(27(2)17-8-9-28(12-17)11-16-6-4-3-5-7-16)10-18(23)22(21(15)24)32(29,30)26-20-13-31-14-25-20/h3-7,10,13-14,17,26H,8-9,11-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444506 (4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...) Show SMILES C[C@H]1CN(Cc2ccccc2)C[C@@H]1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374010 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...) Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1ccsn1 |r| Show InChI InChI=1S/C22H25FN4O2S2/c1-16-12-21(31(28,29)25-22-9-11-30-24-22)19(23)13-20(16)26(2)18-8-10-27(15-18)14-17-6-4-3-5-7-17/h3-7,9,11-13,18H,8,10,14-15H2,1-2H3,(H,24,25)/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373764 ((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...) Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C21H22ClF2N5O2S2/c1-28(16-7-8-29(12-16)11-14-3-2-4-15(9-14)20(23)24)19-6-5-17(10-18(19)22)33(30,31)27-21-25-13-26-32-21/h2-6,9-10,13,16,20H,7-8,11-12H2,1H3,(H,25,26,27)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373749 (4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...) Show SMILES Clc1cc(ccc1O[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccccc1)S(=O)(=O)Nc1nccs1 |r,THB:16:15:14.9.8:12.11| Show InChI InChI=1S/C23H24ClN3O3S2/c24-21-14-20(32(28,29)26-23-25-10-11-31-23)8-9-22(21)30-19-12-17-6-7-18(13-19)27(17)15-16-4-2-1-3-5-16/h1-5,8-11,14,17-19H,6-7,12-13,15H2,(H,25,26)/t17-,18+,19-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373788 ((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...) Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1 |r| Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)29-21-8-7-19(15-20(21)23)31(27,28)25-22-24-11-14-30-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373839 (4-((1-benzylpiperidin-4-yl)oxy)-2,6-difluoro-3-met...) Show SMILES Cc1c(F)c(c(F)cc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-19(30-17-7-9-27(10-8-17)12-16-5-3-2-4-6-16)11-18(23)22(21(15)24)32(28,29)26-20-13-31-14-25-20/h2-6,11,13-14,17,26H,7-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373761 ((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...) Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C22H23ClF2N4O2S2/c1-28(17-7-9-29(14-17)13-15-3-2-4-16(11-15)21(24)25)20-6-5-18(12-19(20)23)33(30,31)27-22-26-8-10-32-22/h2-6,8,10-12,17,21H,7,9,13-14H2,1H3,(H,26,27)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444511 ((S)-3-chloro-4-(methyl(1-(3- methylbenzyl)pyrrolid...) Show SMILES Cc1cccc(CN2CC[C@@H](C2)Nc2ccc(cc2Cl)S(=O)(=O)Nc2ncns2)c1 |r| Show InChI InChI=1S/C20H22ClN5O2S2/c1-14-3-2-4-15(9-14)11-26-8-7-16(12-26)24-19-6-5-17(10-18(19)21)30(27,28)25-20-22-13-23-29-20/h2-6,9-10,13,16,24H,7-8,11-12H2,1H3,(H,22,23,25)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374016 ((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...) Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1 |r| Show InChI InChI=1S/C22H22ClF2N3O3S2/c1-14(15-5-3-2-4-6-15)28-9-7-16(8-10-28)31-18-11-17(24)22(21(25)20(18)23)33(29,30)27-19-12-32-13-26-19/h2-6,11-14,16,27H,7-10H2,1H3/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444513 ((R)-5-chloro-2-fluoro-4-(1-(3- methylbenzyl)pyrrol...) Show SMILES Cc1cccc(c1)N1CC[C@@H](C1)Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C20H20ClFN4O2S2/c1-13-3-2-4-15(9-13)26-7-5-14(12-26)24-18-11-17(22)19(10-16(18)21)30(27,28)25-20-23-6-8-29-20/h2-4,6,8-11,14,24H,5,7,12H2,1H3,(H,23,25)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374031 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cccc(F)n1 |r| Show InChI InChI=1S/C24H25F3N4O2S/c1-16-20(30(2)18-11-12-31(15-18)14-17-7-4-3-5-8-17)13-19(25)24(23(16)27)34(32,33)29-22-10-6-9-21(26)28-22/h3-10,13,18H,11-12,14-15H2,1-2H3,(H,28,29)/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373834 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...) Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C22H25FN4O2S2/c1-16-10-21(31(28,29)25-22-14-30-15-24-22)19(23)11-20(16)26(2)18-8-9-27(13-18)12-17-6-4-3-5-7-17/h3-7,10-11,14-15,18,25H,8-9,12-13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373815 (3-chloro-4-(1-((6-methylpyridin-2-yl)methyl)piperi...) Show SMILES Cc1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)n1 Show InChI InChI=1S/C21H23ClN4O3S2/c1-15-3-2-4-16(24-15)14-26-10-7-17(8-11-26)29-20-6-5-18(13-19(20)22)31(27,28)25-21-23-9-12-30-21/h2-6,9,12-13,17H,7-8,10-11,14H2,1H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373762 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...) Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H22ClN5O2S2/c1-25(16-9-10-26(13-16)12-15-5-3-2-4-6-15)19-8-7-17(11-18(19)21)30(27,28)24-20-22-14-23-29-20/h2-8,11,14,16H,9-10,12-13H2,1H3,(H,22,23,24)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374000 ((S)-3-chloro-2,6-difluoro-4-(methyl(1-((6-methylpy...) Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C21H22ClF2N5O2S2/c1-13-4-3-5-14(26-13)9-29-7-6-15(10-29)28(2)17-8-16(23)21(20(24)19(17)22)33(30,31)27-18-11-32-12-25-18/h3-5,8,11-12,15,27H,6-7,9-10H2,1-2H3/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373760 ((S)-3-chloro-4-((1-(3-chlorobenzyl)pyrrolidin-3-yl...) Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C21H22Cl2N4O2S2/c1-26(17-7-9-27(14-17)13-15-3-2-4-16(22)11-15)20-6-5-18(12-19(20)23)31(28,29)25-21-24-8-10-30-21/h2-6,8,10-12,17H,7,9,13-14H2,1H3,(H,24,25)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373766 ((S)-3-chloro-4-((1-(5-chloro-2-fluorobenzyl)pyrrol...) Show SMILES CN([C@H]1CCN(Cc2cc(Cl)ccc2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H20Cl2FN5O2S2/c1-27(15-6-7-28(11-15)10-13-8-14(21)2-4-18(13)23)19-5-3-16(9-17(19)22)32(29,30)26-20-24-12-25-31-20/h2-5,8-9,12,15H,6-7,10-11H2,1H3,(H,24,25,26)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373825 (3-chloro-4-(1-(3-methylbenzyl)piperidin-4-yloxy)-N...) Show SMILES Cc1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C22H24ClN3O3S2/c1-16-3-2-4-17(13-16)15-26-10-7-18(8-11-26)29-21-6-5-19(14-20(21)23)31(27,28)25-22-24-9-12-30-22/h2-6,9,12-14,18H,7-8,10-11,15H2,1H3,(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373744 (3-chloro-4-((1-(3-(difluoromethyl)benzyl)piperidin...) Show SMILES FC(F)c1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C22H22ClF2N3O3S2/c23-19-13-18(33(29,30)27-22-26-8-11-32-22)4-5-20(19)31-17-6-9-28(10-7-17)14-15-2-1-3-16(12-15)21(24)25/h1-5,8,11-13,17,21H,6-7,9-10,14H2,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373777 (3-chloro-4-(methyl((S)-1-((R)-1-phenylethyl)pyrrol...) Show SMILES C[C@@H](N1CC[C@@H](C1)N(C)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1 |r| Show InChI InChI=1S/C22H25ClN4O2S2/c1-16(17-6-4-3-5-7-17)27-12-10-18(15-27)26(2)21-9-8-19(14-20(21)23)31(28,29)25-22-24-11-13-30-22/h3-9,11,13-14,16,18H,10,12,15H2,1-2H3,(H,24,25)/t16-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444514 ((R)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro- 2-f...) Show SMILES Fc1cc(N[C@@H]2CCN(C2)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C19H18ClFN4O2S2/c20-15-10-18(29(26,27)24-19-22-7-9-28-19)16(21)11-17(15)23-13-6-8-25(12-13)14-4-2-1-3-5-14/h1-5,7,9-11,13,23H,6,8,12H2,(H,22,24)/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373792 (3-chloro-4-((1-(2-phenylpropan-2-yl)piperidin-4-yl...) Show SMILES CC(C)(N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1 Show InChI InChI=1S/C23H26ClN3O3S2/c1-23(2,17-6-4-3-5-7-17)27-13-10-18(11-14-27)30-21-9-8-19(16-20(21)24)32(28,29)26-22-25-12-15-31-22/h3-9,12,15-16,18H,10-11,13-14H2,1-2H3,(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444497 ((S)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...) Show SMILES C[C@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1 |r| Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)29-21-8-7-19(15-20(21)23)31(27,28)25-22-24-11-14-30-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373954 ((S)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...) Show SMILES C[C@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1ncns1)c1ccccc1 |r| Show InChI InChI=1S/C21H23ClN4O3S2/c1-15(16-5-3-2-4-6-16)26-11-9-17(10-12-26)29-20-8-7-18(13-19(20)22)31(27,28)25-21-23-14-24-30-21/h2-8,13-15,17H,9-12H2,1H3,(H,23,24,25)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444536 (5-chloro-4-(((S)-1-((S)-2,3-dihydro-1H-inden-1-yl)...) Show SMILES CN([C@H]1CCN(C1)C1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444509 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)- 3-...) Show SMILES CN([C@H]1CCN(C1)c1ccccc1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C20H21ClN4O2S2/c1-24(16-9-11-25(14-16)15-5-3-2-4-6-15)19-8-7-17(13-18(19)21)29(26,27)23-20-22-10-12-28-20/h2-8,10,12-13,16H,9,11,14H2,1H3,(H,22,23)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374055 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...) Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(c(F)c1C)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C22H25FN4O2S2/c1-16-19(8-9-20(22(16)23)31(28,29)25-21-14-30-15-24-21)26(2)18-10-11-27(13-18)12-17-6-4-3-5-7-17/h3-9,14-15,18,25H,10-13H2,1-2H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373794 (4-((1-benzyl-3-methylpyrrolidin-3-yl)amino)-3-chlo...) Show SMILES CC1(CCN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 Show InChI InChI=1S/C21H23ClN4O2S2/c1-21(9-11-26(15-21)14-16-5-3-2-4-6-16)24-19-8-7-17(13-18(19)22)30(27,28)25-20-23-10-12-29-20/h2-8,10,12-13,24H,9,11,14-15H2,1H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373758 (4-((1-benzyl-3-methylazetidin-3-yl)amino)-3-chloro...) Show SMILES CC1(CN(Cc2ccccc2)C1)Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1 Show InChI InChI=1S/C20H21ClN4O2S2/c1-20(13-25(14-20)12-15-5-3-2-4-6-15)23-18-8-7-16(11-17(18)21)29(26,27)24-19-22-9-10-28-19/h2-11,23H,12-14H2,1H3,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444508 ((R)-4-(1-benzylpyrrolidin-3-ylamino)-3-chloro- N-(...) Show SMILES Clc1cc(ccc1N[C@@H]1CCN(C1)c1ccccc1)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C19H19ClN4O2S2/c20-17-12-16(28(25,26)23-19-21-9-11-27-19)6-7-18(17)22-14-8-10-24(13-14)15-4-2-1-3-5-15/h1-7,9,11-12,14,22H,8,10,13H2,(H,21,23)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373799 ((R)-4-((1-benzylpyrrolidin-3-yl)amino)-3-chloro-N-...) Show SMILES Clc1cc(ccc1N[C@@H]1CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C19H20ClN5O2S2/c20-17-10-16(29(26,27)24-19-21-13-22-28-19)6-7-18(17)23-15-8-9-25(12-15)11-14-4-2-1-3-5-14/h1-7,10,13,15,23H,8-9,11-12H2,(H,21,22,24)/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373795 ((S)-3-chloro-4-(methyl(1-(2-phenylpropan-2-yl)pyrr...) Show SMILES CN([C@H]1CCN(C1)C(C)(C)c1ccccc1)c1ccc(cc1Cl)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C23H27ClN4O2S2/c1-23(2,17-7-5-4-6-8-17)28-12-11-18(14-28)27(3)21-10-9-19(13-20(21)24)32(29,30)26-22-15-31-16-25-22/h4-10,13,15-16,18,26H,11-12,14H2,1-3H3/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373838 (4-((1-benzylpiperidin-4-yl)oxy)-3-chloro-2,6-diflu...) Show SMILES Fc1cc(OC2CCN(Cc3ccccc3)CC2)c(Cl)c(F)c1S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C21H20ClF2N3O3S2/c22-19-17(30-15-6-8-27(9-7-15)11-14-4-2-1-3-5-14)10-16(23)21(20(19)24)32(28,29)26-18-12-31-13-25-18/h1-5,10,12-13,15,26H,6-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373835 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...) Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C21H21ClF2N4O2S2/c1-27(15-7-8-28(11-15)10-14-5-3-2-4-6-14)17-9-16(23)21(20(24)19(17)22)32(29,30)26-18-12-31-13-25-18/h2-6,9,12-13,15,26H,7-8,10-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373750 (4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...) Show SMILES Fc1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1 |r,THB:13:12:11.6.5:9.8| Show InChI InChI=1S/C23H23ClFN3O3S2/c24-19-12-22(33(29,30)27-23-26-8-9-32-23)20(25)13-21(19)31-18-10-16-6-7-17(11-18)28(16)14-15-4-2-1-3-5-15/h1-5,8-9,12-13,16-18H,6-7,10-11,14H2,(H,26,27)/t16-,17+,18-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	155	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373833 (4-(1-benzylpiperidin-4-yloxy)-3-chloro-N-(1,2,4-th...) Show SMILES Clc1cc(ccc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C20H21ClN4O3S2/c21-18-12-17(30(26,27)24-20-22-14-23-29-20)6-7-19(18)28-16-8-10-25(11-9-16)13-15-4-2-1-3-5-15/h1-7,12,14,16H,8-11,13H2,(H,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	164	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373759 (4-((1-benzylpyrrolidin-3-yl)amino)-3-chloro-N-(1,2...) Show SMILES Clc1cc(ccc1NC1CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C19H20ClN5O2S2/c20-17-10-16(29(26,27)24-19-21-13-22-28-19)6-7-18(17)23-15-8-9-25(12-15)11-14-4-2-1-3-5-14/h1-7,10,13,15,23H,8-9,11-12H2,(H,21,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	164	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373990 ((S)-5-chloro-2-fluoro-4-(methyl(1-(2-phenylpropan-...) Show SMILES CN([C@H]1CCN(C1)C(C)(C)c1ccccc1)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C23H26ClFN4O2S2/c1-23(2,16-7-5-4-6-8-16)29-10-9-17(13-29)28(3)20-12-19(25)21(11-18(20)24)33(30,31)27-22-14-32-15-26-22/h4-8,11-12,14-15,17,27H,9-10,13H2,1-3H3/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373828 (4-(1-benzylpiperidin-4-yloxy)-3-chloro-N-(thiazol-...) Show SMILES Clc1cc(ccc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1nccs1 Show InChI InChI=1S/C21H22ClN3O3S2/c22-19-14-18(30(26,27)24-21-23-10-13-29-21)6-7-20(19)28-17-8-11-25(12-9-17)15-16-4-2-1-3-5-16/h1-7,10,13-14,17H,8-9,11-12,15H2,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	177	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373790 ((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...) Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1 |r| Show InChI InChI=1S/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-11-9-18(10-12-26)29-21-8-7-19(13-20(21)23)31(27,28)25-22-14-30-15-24-22/h2-8,13-16,18,25H,9-12H2,1H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	268	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373779 (4-((1-benzylpiperidin-4-yl)amino)-3-chloro-N-(1,2,...) Show SMILES Clc1cc(ccc1NC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C20H22ClN5O2S2/c21-18-12-17(30(27,28)25-20-22-14-23-29-20)6-7-19(18)24-16-8-10-26(11-9-16)13-15-4-2-1-3-5-15/h1-7,12,14,16,24H,8-11,13H2,(H,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	278	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373955 ((R)-5-chloro-2-fluoro-4-((1-(1-phenylethyl)piperid...) Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1 |r| Show InChI InChI=1S/C22H23ClFN3O3S2/c1-15(16-5-3-2-4-6-16)27-9-7-17(8-10-27)30-20-12-19(24)21(11-18(20)23)32(28,29)26-22-13-31-14-25-22/h2-6,11-15,17,26H,7-10H2,1H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	278	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair

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