Compile Data Set for Download or QSAR

Found 43 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 3341   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249335 (US10300060, Example 15-96 | US10765676, Example 15...) Show SMILES CS(=O)(=O)c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cc(F)cnc2N)nc1)C(F)(F)F Show InChI InChI=1S/C24H18F4N6O4S/c1-39(36,37)20-7-4-14(24(26,27)28)8-19(20)34-22(35)33-16-11-31-23(32-12-16)38-17-5-2-13(3-6-17)18-9-15(25)10-30-21(18)29/h2-12H,1H3,(H2,29,30)(H2,33,34,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249337 (US10300060, Example 15-104 | US10765676, Example 1...) Show SMILES CS(=O)(=O)c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cc(Cl)cnc2N)nc1)C(F)(F)F Show InChI InChI=1S/C24H18ClF3N6O4S/c1-39(36,37)20-7-4-14(24(26,27)28)8-19(20)34-22(35)33-16-11-31-23(32-12-16)38-17-5-2-13(3-6-17)18-9-15(25)10-30-21(18)29/h2-12H,1H3,(H2,29,30)(H2,33,34,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249345 (US10300060, Example 21-65 | US10765676, Example 21...) Show SMILES Cc1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C30H21F3N8O2/c1-18-10-12-41-27(38-18)25(17-37-41)19-4-7-23(8-5-19)43-29-35-15-22(16-36-29)39-28(42)40-26-13-21(30(31,32)33)6-9-24(26)20-3-2-11-34-14-20/h2-17H,1H3,(H2,39,40,42)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249336 (US10300060, Example 15-98 | US10765676, Example 15...) Show SMILES CS(=O)(=O)c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cc(cnc2N)C(F)(F)F)nc1)C(F)(F)F Show InChI InChI=1S/C25H18F6N6O4S/c1-42(39,40)20-7-4-14(24(26,27)28)9-19(20)37-22(38)36-16-11-34-23(35-12-16)41-17-5-2-13(3-6-17)18-8-15(25(29,30)31)10-33-21(18)32/h2-12H,1H3,(H2,32,33)(H2,36,37,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249321 (US10300060, Example 11 | US10765676, Example 11 | ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(ccc3-c3cccnc3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C29H20ClF3N6O2/c30-20-13-24(27(34)37-15-20)17-3-7-22(8-4-17)41-26-10-6-21(16-36-26)38-28(40)39-25-12-19(29(31,32)33)5-9-23(25)18-2-1-11-35-14-18/h1-16H,(H2,34,37)(H2,38,39,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249323 (US10300060, Example 14-5 | US10765676, Example 14-...) Show SMILES Nc1ncc(F)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccnn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C25H17F4N9O2/c26-16-10-19(22(30)31-11-16)14-1-4-18(5-2-14)40-24-32-12-17(13-33-24)35-23(39)36-20-9-15(25(27,28)29)3-6-21(20)38-8-7-34-37-38/h1-13H,(H2,30,31)(H2,35,36,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249324 (US10300060, Example 14-6 | US10765676, Example 14-...) Show SMILES Nc1ncc(F)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-c3cccnc3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C28H19F4N7O2/c29-19-11-23(25(33)35-13-19)16-3-6-21(7-4-16)41-27-36-14-20(15-37-27)38-26(40)39-24-10-18(28(30,31)32)5-8-22(24)17-2-1-9-34-12-17/h1-15H,(H2,33,35)(H2,38,39,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249325 (US10300060, Example 15-4 | US10765676, Example 15-...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3ccc(cc3-n3cccn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H18ClF3N8O2/c27-17-11-20(23(31)32-12-17)15-2-5-19(6-3-15)40-25-33-13-18(14-34-25)36-24(39)37-21-7-4-16(26(28,29)30)10-22(21)38-9-1-8-35-38/h1-14H,(H2,31,32)(H2,36,37,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249320 (US10300060, Example 9-2 | US10765676, Example 9-2 ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(ccc3-n3ccnn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H18ClF3N8O2/c27-17-12-20(24(31)33-13-17)15-1-5-19(6-2-15)40-23-8-4-18(14-32-23)35-25(39)36-21-11-16(26(28,29)30)3-7-22(21)38-10-9-34-37-38/h1-14H,(H2,31,33)(H2,35,36,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249318 (US10300060, Example 8-4 | US10765676, Example 8-4 ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3Cl)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C23H15Cl2F3N6O2/c24-14-8-17(20(29)30-9-14)12-1-4-16(5-2-12)36-22-31-10-15(11-32-22)33-21(35)34-19-7-13(23(26,27)28)3-6-18(19)25/h1-11H,(H2,29,30)(H2,33,34,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249355 (US10300060, Example 23-12 | US10765676, Example 23...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4[nH]ncc4c3)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C29H19F3N8O2/c30-29(31,32)21-5-8-24(18-2-1-9-33-12-18)25(11-21)39-27(41)38-22-15-35-28(36-16-22)42-23-6-3-17(4-7-23)19-10-20-14-37-40-26(20)34-13-19/h1-16H,(H,34,37,40)(H2,38,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249315 (US10300060, Example 7 | US10765676, Example 7 | US...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3cccn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H18ClF3N8O2/c27-17-11-20(23(31)32-12-17)15-2-5-19(6-3-15)40-25-33-13-18(14-34-25)36-24(39)37-21-10-16(26(28,29)30)4-7-22(21)38-9-1-8-35-38/h1-14H,(H2,31,32)(H2,36,37,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249316 (US10300060, Example 8-1 | US10765676, Example 8-1 ...) Show SMILES Cc1cn(nn1)-c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cc(Cl)cnc2N)nc1)C(F)(F)F Show InChI InChI=1S/C26H19ClF3N9O2/c1-14-13-39(38-37-14)22-7-4-16(26(28,29)30)8-21(22)36-24(40)35-18-11-33-25(34-12-18)41-19-5-2-15(3-6-19)20-9-17(27)10-32-23(20)31/h2-13H,1H3,(H2,31,32)(H2,35,36,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249354 (US10300060, Example 23-11 | US10765676, Example 23...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnn4ccccc34)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C30H20F3N7O2/c31-30(32,33)21-8-11-24(20-4-3-12-34-15-20)26(14-21)39-28(41)38-22-16-35-29(36-17-22)42-23-9-6-19(7-10-23)25-18-37-40-13-2-1-5-27(25)40/h1-18H,(H2,38,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249353 (US10300060, Example 23-10 | US10765676, Example 23...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4cnccn34)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C29H19F3N8O2/c30-29(31,32)20-5-8-23(19-2-1-9-33-13-19)24(12-20)39-27(41)38-21-14-36-28(37-15-21)42-22-6-3-18(4-7-22)25-16-35-26-17-34-10-11-40(25)26/h1-17H,(H2,38,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249357 (US10300060, Example 23-3 | US10765676, Example 23-...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4ccccn34)nc2)c1)-n1cccn1 Show InChI InChI=1S/C28H19F3N8O2/c29-28(30,31)19-7-10-23(39-13-3-11-35-39)22(14-19)37-26(40)36-20-15-33-27(34-16-20)41-21-8-5-18(6-9-21)24-17-32-25-4-1-2-12-38(24)25/h1-17H,(H2,36,37,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249351 (US10300060, Example 22-34 | US10765676, Example 22...) Show SMILES CCOc1ccc2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)n2n1 Show InChI InChI=1S/C31H23F3N8O3/c1-2-44-28-12-11-27-36-18-26(42(27)41-28)19-5-8-23(9-6-19)45-30-37-16-22(17-38-30)39-29(43)40-25-14-21(31(32,33)34)7-10-24(25)20-4-3-13-35-15-20/h3-18H,2H2,1H3,(H2,39,40,43)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249356 (US10300060, Example 22-9 | US10765676, Example 22-...) Show SMILES COc1ccc2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-n5cccn5)C(F)(F)F)cn4)cc3)n2n1 Show InChI InChI=1S/C28H20F3N9O3/c1-42-25-10-9-24-32-16-23(40(24)38-25)17-3-6-20(7-4-17)43-27-33-14-19(15-34-27)36-26(41)37-21-13-18(28(29,30)31)5-8-22(21)39-12-2-11-35-39/h2-16H,1H3,(H2,36,37,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249350 (US10300060, Example 22-8 | US10765676, Example 22-...) Show SMILES COc1ccc2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)n2n1 Show InChI InChI=1S/C30H21F3N8O3/c1-43-27-11-10-26-35-17-25(41(26)40-27)18-4-7-22(8-5-18)44-29-36-15-21(16-37-29)38-28(42)39-24-13-20(30(31,32)33)6-9-23(24)19-3-2-12-34-14-19/h2-17H,1H3,(H2,38,39,42)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249344 (US10300060, Example 21-51 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5ccnn5C)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C30H25F3N10O2/c1-41(2)26-11-13-43-27(40-26)23(17-37-43)18-4-7-21(8-5-18)45-29-34-15-20(16-35-29)38-28(44)39-24-14-19(30(31,32)33)6-9-22(24)25-10-12-36-42(25)3/h4-17H,1-3H3,(H2,38,39,44)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249343 (US10300060, Example 21-37 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C31H24F3N9O2/c1-42(2)27-11-13-43-28(41-27)25(18-38-43)19-5-8-23(9-6-19)45-30-36-16-22(17-37-30)39-29(44)40-26-14-21(31(32,33)34)7-10-24(26)20-4-3-12-35-15-20/h3-18H,1-2H3,(H2,39,40,44)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249342 (US10300060, Example 21-13 | US10765676, Example 21...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnn4cccnc34)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C29H19F3N8O2/c30-29(31,32)20-6-9-23(19-3-1-10-33-14-19)25(13-20)39-27(41)38-21-15-35-28(36-16-21)42-22-7-4-18(5-8-22)24-17-37-40-12-2-11-34-26(24)40/h1-17H,(H2,38,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249341 (US10300060, Example 21-9 | US10765676, Example 21-...) Show SMILES COc1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C30H21F3N8O3/c1-43-26-10-12-41-27(40-26)24(17-37-41)18-4-7-22(8-5-18)44-29-35-15-21(16-36-29)38-28(42)39-25-13-20(30(31,32)33)6-9-23(25)19-3-2-11-34-14-19/h2-17H,1H3,(H2,38,39,42)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249340 (US10300060, Example 21-2 | US10765676, Example 21-...) Show SMILES Cn1nccc1-c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnn3ccc(nc23)N2CCC2)nc1)C(F)(F)F Show InChI InChI=1S/C31H25F3N10O2/c1-42-26(9-11-37-42)23-8-5-20(31(32,33)34)15-25(23)40-29(45)39-21-16-35-30(36-17-21)46-22-6-3-19(4-7-22)24-18-38-44-14-10-27(41-28(24)44)43-12-2-13-43/h3-11,14-18H,2,12-13H2,1H3,(H2,39,40,45)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249339 (US10300060, Example 21-1 | US10765676, Example 21-...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnn4ccc(nc34)N3CCC3)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C32H24F3N9O2/c33-32(34,35)22-6-9-25(21-3-1-11-36-16-21)27(15-22)41-30(45)40-23-17-37-31(38-18-23)46-24-7-4-20(5-8-24)26-19-39-44-14-10-28(42-29(26)44)43-12-2-13-43/h1,3-11,14-19H,2,12-13H2,(H2,40,41,45)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249334 (US10300060, Example 15-87 | US10765676, Example 15...) Show SMILES Nc1ncc(cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3cc(Cl)cn3)C(F)(F)F)cn2)cc1)C(F)(F)F Show InChI InChI=1S/C27H17ClF6N8O2/c28-17-10-39-42(13-17)22-6-3-15(26(29,30)31)8-21(22)41-24(43)40-18-11-37-25(38-12-18)44-19-4-1-14(2-5-19)20-7-16(27(32,33)34)9-36-23(20)35/h1-13H,(H2,35,36)(H2,40,41,43)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249333 (US10300060, Example 15-77 | US10765676, Example 15...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3ccc(cc3C(F)(F)F)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C24H15ClF6N6O2/c25-14-8-17(20(32)33-9-14)12-1-4-16(5-2-12)39-22-34-10-15(11-35-22)36-21(38)37-19-6-3-13(23(26,27)28)7-18(19)24(29,30)31/h1-11H,(H2,32,33)(H2,36,37,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249352 (US10300060, Example 23-7 | US10765676, Example 23-...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4[nH]ccc4c3)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C30H20F3N7O2/c31-30(32,33)22-5-8-25(20-2-1-10-34-14-20)26(13-22)40-28(41)39-23-16-37-29(38-17-23)42-24-6-3-18(4-7-24)21-12-19-9-11-35-27(19)36-15-21/h1-17H,(H,35,36)(H2,39,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249330 (US10300060, Example 15-58 | US10765676, Example 15...) Show SMILES Nc1ncc(F)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-c3ccccc3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C29H20F4N6O2/c30-20-13-24(26(34)35-14-20)18-6-9-22(10-7-18)41-28-36-15-21(16-37-28)38-27(40)39-25-12-19(29(31,32)33)8-11-23(25)17-4-2-1-3-5-17/h1-16H,(H2,34,35)(H2,38,39,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249331 (US10300060, Example 15-63 | US10765676, Example 15...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3cc(Cl)cn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H17Cl2F3N8O2/c27-16-8-20(23(32)33-9-16)14-1-4-19(5-2-14)41-25-34-11-18(12-35-25)37-24(40)38-21-7-15(26(29,30)31)3-6-22(21)39-13-17(28)10-36-39/h1-13H,(H2,32,33)(H2,37,38,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249327 (US10300060, Example 15-6 | US10765676, Example 15-...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3ccc(cc3Cl)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C23H15Cl2F3N6O2/c24-14-8-17(20(29)30-9-14)12-1-4-16(5-2-12)36-22-31-10-15(11-32-22)33-21(35)34-19-6-3-13(7-18(19)25)23(26,27)28/h1-11H,(H2,29,30)(H2,33,34,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249332 (US10300060, Example 15-71 | US10765676, Example 15...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(Cl)ccc3-n3ccc(n3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H17Cl2F3N8O2/c27-15-3-6-21(39-8-7-22(38-39)26(29,30)31)20(10-15)37-24(40)36-17-12-34-25(35-13-17)41-18-4-1-14(2-5-18)19-9-16(28)11-33-23(19)32/h1-13H,(H2,32,33)(H2,36,37,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249347 (US10300060, Example 21-70 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5ccccc5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C32H25F3N8O2/c1-42(2)28-14-15-43-29(41-28)26(19-38-43)21-8-11-24(12-9-21)45-31-36-17-23(18-37-31)39-30(44)40-27-16-22(32(33,34)35)10-13-25(27)20-6-4-3-5-7-20/h3-19H,1-2H3,(H2,39,40,44)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249322 (US10300060, Example 13-1 | US10765676, Example 13-...) Show SMILES Cn1nccc1-c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cc(Cl)cnc2N)nc1)C(F)(F)F Show InChI InChI=1S/C27H20ClF3N8O2/c1-39-23(8-9-36-39)20-7-4-16(27(29,30)31)10-22(20)38-25(40)37-18-13-34-26(35-14-18)41-19-5-2-15(3-6-19)21-11-17(28)12-33-24(21)32/h2-14H,1H3,(H2,32,33)(H2,37,38,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249317 (US10300060, Example 8-2 | US10765676, Example 8-2 ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C27H17ClF6N8O2/c28-16-10-19(23(35)36-11-16)14-1-4-18(5-2-14)44-25-37-12-17(13-38-25)39-24(43)40-20-9-15(26(29,30)31)3-6-21(20)42-8-7-22(41-42)27(32,33)34/h1-13H,(H2,35,36)(H2,39,40,43)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249326 (US10300060, Example 15-5 | US10765676, Example 15-...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3ccc(cc3F)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C23H15ClF4N6O2/c24-14-8-17(20(29)30-9-14)12-1-4-16(5-2-12)36-22-31-10-15(11-32-22)33-21(35)34-19-6-3-13(7-18(19)25)23(26,27)28/h1-11H,(H2,29,30)(H2,33,34,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249319 (US10300060, Example 9-1 | US10765676, Example 9-1 ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(ccc3-n3cccn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C27H19ClF3N7O2/c28-18-13-21(25(32)34-14-18)16-2-6-20(7-3-16)40-24-9-5-19(15-33-24)36-26(39)37-22-12-17(27(29,30)31)4-8-23(22)38-11-1-10-35-38/h1-15H,(H2,32,34)(H2,36,37,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249348 (US10300060, Example 21-73 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccc(C)c5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C33H27F3N8O2/c1-20-5-4-6-22(15-20)26-12-9-23(33(34,35)36)16-28(26)41-31(45)40-24-17-37-32(38-18-24)46-25-10-7-21(8-11-25)27-19-39-44-14-13-29(43(2)3)42-30(27)44/h4-19H,1-3H3,(H2,40,41,45)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249346 (US10300060, Example 21-67 | US10765676, Example 21...) Show SMILES CCNc1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccc(C)c5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C33H27F3N8O2/c1-3-37-29-13-14-44-30(43-29)27(19-40-44)21-7-10-25(11-8-21)46-32-38-17-24(18-39-32)41-31(45)42-28-16-23(33(34,35)36)9-12-26(28)22-6-4-5-20(2)15-22/h4-19H,3H2,1-2H3,(H,37,43)(H2,41,42,45)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249349 (US10300060, Example 21-75 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5ccccc5C)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C33H27F3N8O2/c1-20-6-4-5-7-25(20)26-13-10-22(33(34,35)36)16-28(26)41-31(45)40-23-17-37-32(38-18-23)46-24-11-8-21(9-12-24)27-19-39-44-15-14-29(43(2)3)42-30(27)44/h4-19H,1-3H3,(H2,40,41,45)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249329 (US10300060, Example 15-55 | US10765676, Example 15...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-c3ccccc3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C29H20ClF3N6O2/c30-20-13-24(26(34)35-14-20)18-6-9-22(10-7-18)41-28-36-15-21(16-37-28)38-27(40)39-25-12-19(29(31,32)33)8-11-23(25)17-4-2-1-3-5-17/h1-16H,(H2,34,35)(H2,38,39,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249328 (US10300060, Example 15-52 | US10765676, Example 15...) Show SMILES Nc1ncc(cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1)C(F)(F)F Show InChI InChI=1S/C28H17F9N8O2/c29-26(30,31)15-3-6-21(45-8-7-22(44-45)28(35,36)37)20(10-15)43-24(46)42-17-12-40-25(41-13-17)47-18-4-1-14(2-5-18)19-9-16(27(32,33)34)11-39-23(19)38/h1-13H,(H2,38,39)(H2,42,43,46)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249338 (US10300060, Example 15-105 | US10765676, Example 1...) Show SMILES CN(C)S(=O)(=O)c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cc(cnc2N)C(F)(F)F)nc1)C(F)(F)F Show InChI InChI=1S/C26H21F6N7O4S/c1-39(2)44(41,42)21-8-5-15(25(27,28)29)10-20(21)38-23(40)37-17-12-35-24(36-13-17)43-18-6-3-14(4-7-18)19-9-16(26(30,31)32)11-34-22(19)33/h3-13H,1-2H3,(H2,33,34)(H2,37,38,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair