Compile Data Set for Download or QSAR

Found 105 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 3475   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136642 (US10005783, 59 | US10047097, 59 | US10774085, Exam...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1 |r| Show InChI InChI=1S/C22H18F2N6O/c23-14-6-7-16(24)15(12-14)19-5-3-10-29(19)20-8-11-30-21(28-20)18(13-26-30)27-22(31)17-4-1-2-9-25-17/h1-2,4,6-9,11-13,19H,3,5,10H2,(H,27,31)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136646 (US10005783, 63 | US10047097, 63 | US10774085, Exam...) Show SMILES Cc1cccnc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-9-26-21(14)23(32)28-18-13-27-31-11-8-20(29-22(18)31)30-10-3-5-19(30)16-12-15(24)6-7-17(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,28,32)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM401674 (US10005783, 57) Show SMILES NC(=O)c1nccnc1C1=C2N=CC=CN2N(C1)N1CCC[C@@H]1c1cc(F)ccc1F |c:10,12,14| Show InChI InChI=1S/C21H19F2N7O/c22-13-4-5-16(23)14(11-13)17-3-1-9-28(17)30-12-15(21-27-6-2-10-29(21)30)18-19(20(24)31)26-8-7-25-18/h2,4-8,10-11,17H,1,3,9,12H2,(H2,24,31)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136650 (US10005783, 67 | US10047097, 67 | US10774085, Exam...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ncccn3)c2n1 |r| Show InChI InChI=1S/C21H17F2N7O/c22-13-4-5-15(23)14(11-13)17-3-1-9-29(17)18-6-10-30-20(28-18)16(12-26-30)27-21(31)19-24-7-2-8-25-19/h2,4-8,10-12,17H,1,3,9H2,(H,27,31)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136641 (US10005783, 58 | US10047097, 58 | US10774085, Exam...) Show SMILES Cc1cnc(cn1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H19F2N7O/c1-13-10-26-18(11-25-13)22(32)28-17-12-27-31-8-6-20(29-21(17)31)30-7-2-3-19(30)15-9-14(23)4-5-16(15)24/h4-6,8-12,19H,2-3,7H2,1H3,(H,28,32)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136638 (US10005783, 55 | US10047097, 55 | US10774085, Exam...) Show SMILES CC(C)Nc1nc(cs1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H23F2N7OS/c1-13(2)27-23-29-18(12-34-23)22(33)28-17-11-26-32-9-7-20(30-21(17)32)31-8-3-4-19(31)15-10-14(24)5-6-16(15)25/h5-7,9-13,19H,3-4,8H2,1-2H3,(H,27,29)(H,28,33)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136667 (US10005783, 84 | US10047097, 84 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F |r| Show InChI InChI=1S/C22H22F4N6O2/c23-13-3-4-16(22(24,25)26)15(10-13)18-2-1-7-31(18)19-6-9-32-20(29-19)17(11-27-32)28-21(34)30-8-5-14(33)12-30/h3-4,6,9-11,14,18,33H,1-2,5,7-8,12H2,(H,28,34)/t14-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136654 (US10005783, 71 | US10047097, 71 | US10774085, Exam...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cccc(Cl)n3)c2n1 |r| Show InChI InChI=1S/C22H17ClF2N6O/c23-19-5-1-3-16(27-19)22(32)28-17-12-26-31-10-8-20(29-21(17)31)30-9-2-4-18(30)14-11-13(24)6-7-15(14)25/h1,3,5-8,10-12,18H,2,4,9H2,(H,28,32)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136645 (US10005783, 62 | US10047097, 62 | US10774085, Exam...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cc(Cl)ccn3)c2n1 |r| Show InChI InChI=1S/C22H17ClF2N6O/c23-13-5-7-26-17(10-13)22(32)28-18-12-27-31-9-6-20(29-21(18)31)30-8-1-2-19(30)15-11-14(24)3-4-16(15)25/h3-7,9-12,19H,1-2,8H2,(H,28,32)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136651 (US10005783, 68 | US10047097, 68 | US10774085, Exam...) Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1 |r| Show InChI InChI=1S/C22H19FN6O/c23-16-6-3-5-15(13-16)19-8-4-11-28(19)20-9-12-29-21(27-20)18(14-25-29)26-22(30)17-7-1-2-10-24-17/h1-3,5-7,9-10,12-14,19H,4,8,11H2,(H,26,30)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136644 (US10005783, 61 | US10047097, 61 | US10774085, Exam...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccc(Cl)cn3)c2n1 |r| Show InChI InChI=1S/C22H17ClF2N6O/c23-13-3-6-17(26-11-13)22(32)28-18-12-27-31-9-7-20(29-21(18)31)30-8-1-2-19(30)15-10-14(24)4-5-16(15)25/h3-7,9-12,19H,1-2,8H2,(H,28,32)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136624 (US10005783, 41 | US10047097, 41 | US10774085, Exam...) Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C21H22ClFN6O2/c22-16-4-3-13(23)10-15(16)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136643 (US10005783, 60 | US10047097, 60 | US10774085, Exam...) Show SMILES Cc1cccc(n1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-5-18(27-14)23(32)28-19-13-26-31-11-9-21(29-22(19)31)30-10-3-6-20(30)16-12-15(24)7-8-17(16)25/h2,4-5,7-9,11-13,20H,3,6,10H2,1H3,(H,28,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136635 (US10005783, 52 | US10047097, 52 | US10774085, Exam...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)C3(CC3)C#N)c2n1 |r| Show InChI InChI=1S/C21H18F2N6O/c22-13-3-4-15(23)14(10-13)17-2-1-8-28(17)18-5-9-29-19(27-18)16(11-25-29)26-20(30)21(12-24)6-7-21/h3-5,9-11,17H,1-2,6-8H2,(H,26,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136601 (US10005783, 18 | US10047097, 18 | US10774085, Exam...) Show SMILES Fc1ccc(NC(=O)Nc2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1 |r| Show InChI InChI=1S/C23H19F3N6O/c24-14-3-6-16(7-4-14)28-23(33)29-19-13-27-32-11-9-21(30-22(19)32)31-10-1-2-20(31)17-12-15(25)5-8-18(17)26/h3-9,11-13,20H,1-2,10H2,(H2,28,29,33)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136682 (US10005783, 99 | US10047097, 99 | US10774085, Exam...) Show SMILES NC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H16F2N6O2/c19-10-3-4-12(20)11(8-10)14-2-1-6-25(14)15-5-7-26-17(24-15)13(9-22-26)23-18(28)16(21)27/h3-5,7-9,14H,1-2,6H2,(H2,21,27)(H,23,28)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.65	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136616 (US10005783, 33 | US10047097, 33 | US10774085, Exam...) Show SMILES COC(=O)C1(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H21F2N5O3/c1-32-21(31)22(7-8-22)20(30)26-16-12-25-29-10-6-18(27-19(16)29)28-9-2-3-17(28)14-11-13(23)4-5-15(14)24/h4-6,10-12,17H,2-3,7-9H2,1H3,(H,26,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136688 (US10005783, 105 | US10047097, 105 | US10774085, Ex...) Show SMILES OC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H15F2N5O3/c19-10-3-4-12(20)11(8-10)14-2-1-6-24(14)15-5-7-25-16(23-15)13(9-21-25)22-17(26)18(27)28/h3-5,7-9,14H,1-2,6H2,(H,22,26)(H,27,28)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136603 (US10005783, 20 | US10047097, 20 | US10774085, Exam...) Show SMILES COc1ccc(NC(=O)Nc2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1 |r| Show InChI InChI=1S/C24H22F2N6O2/c1-34-17-7-5-16(6-8-17)28-24(33)29-20-14-27-32-12-10-22(30-23(20)32)31-11-2-3-21(31)18-13-15(25)4-9-19(18)26/h4-10,12-14,21H,2-3,11H2,1H3,(H2,28,29,33)/t21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136587 (US10005783, 4 | US10047097, 4 | US10774085, Exampl...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)Nc3ccccc3)c2n1 |r| Show InChI InChI=1S/C23H20F2N6O/c24-15-8-9-18(25)17(13-15)20-7-4-11-30(20)21-10-12-31-22(29-21)19(14-26-31)28-23(32)27-16-5-2-1-3-6-16/h1-3,5-6,8-10,12-14,20H,4,7,11H2,(H2,27,28,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136634 (US10005783, 51 | US10047097, 51 | US10774085, Exam...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)C3(CC3)C(F)(F)F)c2n1 |r| Show InChI InChI=1S/C21H18F5N5O/c22-12-3-4-14(23)13(10-12)16-2-1-8-30(16)17-5-9-31-18(29-17)15(11-27-31)28-19(32)20(6-7-20)21(24,25)26/h3-5,9-11,16H,1-2,6-8H2,(H,28,32)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136662 (US10005783, 79 | US10047097, 79 | US10774085, Exam...) Show SMILES COc1ncccc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r| Show InChI InChI=1S/C23H21FN6O2/c1-32-23-17(7-3-10-25-23)22(31)27-18-14-26-30-12-9-20(28-21(18)30)29-11-4-8-19(29)15-5-2-6-16(24)13-15/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3,(H,27,31)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136668 (US10005783, 85 | US10047097, 85 | US10774085, Exam...) Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F |r| Show InChI InChI=1S/C22H22F4N6O2/c23-13-3-4-16(22(24,25)26)15(10-13)18-2-1-7-31(18)19-6-9-32-20(29-19)17(11-27-32)28-21(34)30-8-5-14(33)12-30/h3-4,6,9-11,14,18,33H,1-2,5,7-8,12H2,(H,28,34)/t14-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136652 (US10005783, 69 | US10047097, 69 | US10774085, Exam...) Show SMILES Cc1cccnc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r| Show InChI InChI=1S/C23H21FN6O/c1-15-5-3-10-25-21(15)23(31)27-18-14-26-30-12-9-20(28-22(18)30)29-11-4-8-19(29)16-6-2-7-17(24)13-16/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3,(H,27,31)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136628 (US10005783, 45 | US10047097, 45 | US10774085, Exam...) Show SMILES CC(C)(C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C21H23F2N5O/c1-21(2,3)20(29)25-16-12-24-28-10-8-18(26-19(16)28)27-9-4-5-17(27)14-11-13(22)6-7-15(14)23/h6-8,10-12,17H,4-5,9H2,1-3H3,(H,25,29)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136665 (US10005783, 82 | US10047097, 82 | US10774085, Exam...) Show SMILES Cc1cnc(cn1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r| Show InChI InChI=1S/C22H20FN7O/c1-14-11-25-18(12-24-14)22(31)27-17-13-26-30-9-7-20(28-21(17)30)29-8-3-6-19(29)15-4-2-5-16(23)10-15/h2,4-5,7,9-13,19H,3,6,8H2,1H3,(H,27,31)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136658 (US10005783, 75 | US10047097, 75 | US10774085, Exam...) Show SMILES COc1cccc(n1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r| Show InChI InChI=1S/C23H21FN6O2/c1-32-21-9-3-7-17(26-21)23(31)27-18-14-25-30-12-10-20(28-22(18)30)29-11-4-8-19(29)15-5-2-6-16(24)13-15/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3,(H,27,31)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136647 (US10005783, 64 | US10047097, 64 | US10774085, Exam...) Show SMILES CC(C)(CO)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C21H23F2N5O2/c1-21(2,12-29)20(30)25-16-11-24-28-9-7-18(26-19(16)28)27-8-3-4-17(27)14-10-13(22)5-6-15(14)23/h5-7,9-11,17,29H,3-4,8,12H2,1-2H3,(H,25,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136681 (US10005783, 98 | US10047097, 98 | US10774085, Exam...) Show SMILES CNC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C19H18F2N6O2/c1-22-18(28)19(29)24-14-10-23-27-8-6-16(25-17(14)27)26-7-2-3-15(26)12-9-11(20)4-5-13(12)21/h4-6,8-10,15H,2-3,7H2,1H3,(H,22,28)(H,24,29)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.65	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136687 (US10005783, 104 | US10047097, 104 | US10774085, Ex...) Show SMILES COC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C19H17F2N5O3/c1-29-19(28)18(27)23-14-10-22-26-8-6-16(24-17(14)26)25-7-2-3-15(25)12-9-11(20)4-5-13(12)21/h4-6,8-10,15H,2-3,7H2,1H3,(H,23,27)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.65	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136664 (US10005783, 81 | US10047097, 81 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C21H22ClFN6O2/c22-16-4-3-13(23)10-15(16)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136656 (US10005783, 73 | US10047097, 73 | US10774085, Exam...) Show SMILES Cn1ccc(n1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r| Show InChI InChI=1S/C21H20FN7O/c1-27-10-7-16(26-27)21(30)24-17-13-23-29-11-8-19(25-20(17)29)28-9-3-6-18(28)14-4-2-5-15(22)12-14/h2,4-5,7-8,10-13,18H,3,6,9H2,1H3,(H,24,30)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136620 (US10005783, 37 | US10047097, 37 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F |r| Show InChI InChI=1S/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136597 (US10005783, 14 | US10047097, 14 | US10774085, Exam...) Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136602 (US10005783, 19 | US10047097, 19 | US10774085, Exam...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)Nc3ccc(Cl)cc3)c2n1 |r| Show InChI InChI=1S/C23H19ClF2N6O/c24-14-3-6-16(7-4-14)28-23(33)29-19-13-27-32-11-9-21(30-22(19)32)31-10-1-2-20(31)17-12-15(25)5-8-18(17)26/h3-9,11-13,20H,1-2,10H2,(H2,28,29,33)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136684 (US10005783, 101 | US10047097, 101 | US10774085, Ex...) Show SMILES OC1CN(C1)C(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C21H20F2N6O3/c22-12-3-4-15(23)14(8-12)17-2-1-6-28(17)18-5-7-29-19(26-18)16(9-24-29)25-20(31)21(32)27-10-13(30)11-27/h3-5,7-9,13,17,30H,1-2,6,10-11H2,(H,25,31)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136674 (US10005783, 91 | US10047097, 91 | US11267818, Exam...) Show SMILES COc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(NC(=O)N3CCC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C23H27FN6O3/c1-33-20-7-6-15(24)12-17(20)19-5-3-10-29(19)21-8-11-30-22(27-21)18(13-25-30)26-23(32)28-9-2-4-16(31)14-28/h6-8,11-13,16,19,31H,2-5,9-10,14H2,1H3,(H,26,32)/t16-,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136673 (US10005783, 90 | US10047097, 90 | US10774085, Exam...) Show SMILES COc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(NC(=O)N3CC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C22H25FN6O3/c1-32-19-5-4-14(23)11-16(19)18-3-2-8-28(18)20-7-10-29-21(26-20)17(12-24-29)25-22(31)27-9-6-15(30)13-27/h4-5,7,10-12,15,18,30H,2-3,6,8-9,13H2,1H3,(H,25,31)/t15-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136605 (US10005783, 22 | US10047097, 22 | US10774085, Exam...) Show SMILES CC1(O)CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C21H22ClFN6O2/c1-21(31)11-27(12-21)20(30)25-16-10-24-29-8-6-18(26-19(16)29)28-7-2-3-17(28)14-9-13(23)4-5-15(14)22/h4-6,8-10,17,31H,2-3,7,11-12H2,1H3,(H,25,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136626 (US10005783, 43 | US10047097, 43 | US10774085, Exam...) Show SMILES O[C@@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C22H24ClFN6O2/c23-17-6-5-14(24)11-16(17)19-4-2-9-29(19)20-7-10-30-21(27-20)18(12-25-30)26-22(32)28-8-1-3-15(31)13-28/h5-7,10-12,15,19,31H,1-4,8-9,13H2,(H,26,32)/t15-,19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136588 (US10005783, 5 | US10047097, 5 | US10774085, Exampl...) Show SMILES CC(C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C20H21F2N5O/c1-12(2)20(28)24-16-11-23-27-9-7-18(25-19(16)27)26-8-3-4-17(26)14-10-13(21)5-6-15(14)22/h5-7,9-12,17H,3-4,8H2,1-2H3,(H,24,28)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136633 (US10005783, 50 | US10047097, 50 | US10774085, Exam...) Show SMILES CC(C)(O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C20H21F2N5O2/c1-20(2,29)19(28)24-15-11-23-27-9-7-17(25-18(15)27)26-8-3-4-16(26)13-10-12(21)5-6-14(13)22/h5-7,9-11,16,29H,3-4,8H2,1-2H3,(H,24,28)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM401720 (US10005783, 102) Show SMILES O[C@@H]1CCN(C1)C(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@H]1c1cc(F)ccc1F Show InChI InChI=1S/C22H22F2N6O3/c23-13-3-4-16(24)15(10-13)18-2-1-7-29(18)19-6-9-30-20(27-19)17(11-25-30)26-21(32)22(33)28-8-5-14(31)12-28/h3-4,6,9-11,14,18,31H,1-2,5,7-8,12H2,(H,26,32)/t14-,18+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136598 (US10005783, 15 | US10047097, 15 | US10774085, Exam...) Show SMILES O[C@@H]1CN(C[C@H]1O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C21H22F2N6O3/c22-12-3-4-14(23)13(8-12)16-2-1-6-28(16)19-5-7-29-20(26-19)15(9-24-29)25-21(32)27-10-17(30)18(31)11-27/h3-5,7-9,16-18,30-31H,1-2,6,10-11H2,(H,25,32)/t16-,17-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136627 (US10005783, 44 | US10047097, 44 | US10774085, Exam...) Show SMILES O[C@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C22H24ClFN6O2/c23-17-6-5-14(24)11-16(17)19-4-2-9-29(19)20-7-10-30-21(27-20)18(12-25-30)26-22(32)28-8-1-3-15(31)13-28/h5-7,10-12,15,19,31H,1-4,8-9,13H2,(H,26,32)/t15-,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136591 (US10005783, 8 | US10047097, 8 | US10774085, Exampl...) Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl |r| Show InChI InChI=1S/C20H20ClFN6O2/c21-15-4-3-12(22)8-14(15)17-2-1-6-27(17)18-5-7-28-19(25-18)16(9-23-28)24-20(30)26-10-13(29)11-26/h3-5,7-9,13,17,29H,1-2,6,10-11H2,(H,24,30)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136669 (US10005783, 86 | US10047097, 86 | US10774085, Exam...) Show SMILES O[C@@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F |r| Show InChI InChI=1S/C23H24F4N6O2/c24-14-5-6-17(23(25,26)27)16(11-14)19-4-2-9-32(19)20-7-10-33-21(30-20)18(12-28-33)29-22(35)31-8-1-3-15(34)13-31/h5-7,10-12,15,19,34H,1-4,8-9,13H2,(H,29,35)/t15-,19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136637 (US10005783, 54 | US10047097, 54 | US10774085, Exam...) Show SMILES CC(C)(F)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C20H20F3N5O/c1-20(2,23)19(29)25-15-11-24-28-9-7-17(26-18(15)28)27-8-3-4-16(27)13-10-12(21)5-6-14(13)22/h5-7,9-11,16H,3-4,8H2,1-2H3,(H,25,29)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.2	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136639 (US10005783, 56 | US10047097, 56 | US10774085, Exam...) Show SMILES CC(C)(C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F)n1cncn1 |r| Show InChI InChI=1S/C22H22F2N8O/c1-22(2,32-13-25-12-27-32)21(33)28-17-11-26-31-9-7-19(29-20(17)31)30-8-3-4-18(30)15-10-14(23)5-6-16(15)24/h5-7,9-13,18H,3-4,8H2,1-2H3,(H,28,33)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136670 (US10005783, 87 | US10047097, 87 | US10774085, Exam...) Show SMILES O[C@H]1CCCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F |r| Show InChI InChI=1S/C23H24F4N6O2/c24-14-5-6-17(23(25,26)27)16(11-14)19-4-2-9-32(19)20-7-10-33-21(30-20)18(12-28-33)29-22(35)31-8-1-3-15(34)13-31/h5-7,10-12,15,19,34H,1-4,8-9,13H2,(H,29,35)/t15-,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.6	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair

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