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Compile Data Set for Download or QSAR

Found 833 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 7046   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169403
PNG
(US9079866, 808 | US9745328, Compound 808 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1cccnc1S(=O)(=O)C1CCCCC1
Show InChI InChI=1S/C21H21FN4O2S/c22-18-11-14(8-9-17(18)19-12-26-20(23)13-25-19)16-7-4-10-24-21(16)29(27,28)15-5-2-1-3-6-15/h4,7-13,15H,1-3,5-6H2,(H2,23,26)
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 0.400n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169405
PNG
(US9079866, 810 | US9745328, Compound 810 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1cccnc1S(=O)(=O)C1CCCC1
Show InChI InChI=1S/C20H19FN4O2S/c21-17-10-13(7-8-16(17)18-11-25-19(22)12-24-18)15-6-3-9-23-20(15)28(26,27)14-4-1-2-5-14/h3,6-12,14H,1-2,4-5H2,(H2,22,25)
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 0.600n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169201
PNG
(US9079866, 602 | US9745328, Compound 602 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C26H18F2N6/c27-21-9-15(5-7-19(21)23-11-33-25(29)13-31-23)17-3-1-2-4-18(17)16-6-8-20(22(28)10-16)24-12-34-26(30)14-32-24/h1-14H,(H2,29,33)(H2,30,34)
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 0.600n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169270
PNG
(US9079866, 675 | US9745328, Compound 675 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1cnc(c(F)c1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H20FN5O2S/c1-19(2,3)25-28(26,27)16-7-5-4-6-14(16)12-8-15(20)17(22-9-12)13-10-23-18(21)24-11-13/h4-11,25H,1-3H3,(H2,21,23,24)
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 0.700n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169421
PNG
(US9079866, 826 | US9745328, Compound 826 | US98848...)
Show SMILES CC(C)S(=O)(=O)c1ncccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C21H18FN3O2S/c1-13(2)28(26,27)21-18(4-3-8-24-21)14-5-6-17(19(22)11-14)16-10-15-7-9-23-20(15)25-12-16/h3-13H,1-2H3,(H,23,25)
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 0.700n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168692
PNG
(US9079866, 69 | US9745328, Compound 69 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCC(CCO)CC1
Show InChI InChI=1S/C23H25FN4O3S/c24-20-13-17(5-6-19(20)21-14-27-23(25)15-26-21)18-3-1-2-4-22(18)32(30,31)28-10-7-16(8-11-28)9-12-29/h1-6,13-16,29H,7-12H2,(H2,25,27)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168701
PNG
(US9079866, 78 | US9745328, Compound 78 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@@H](CO)[C@@H](O)c1ccccc1 |r|
Show InChI InChI=1S/C25H23FN4O4S/c26-20-12-17(10-11-19(20)21-13-29-24(27)14-28-21)18-8-4-5-9-23(18)35(33,34)30-22(15-31)25(32)16-6-2-1-3-7-16/h1-14,22,25,30-32H,15H2,(H2,27,29)/t22-,25-/m0/s1
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168705
PNG
(US9079866, 82 | US9745328, Compound 82 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@@H](CO)c1ccccc1 |r|
Show InChI InChI=1S/C24H21FN4O3S/c25-20-12-17(10-11-19(20)21-13-28-24(26)14-27-21)18-8-4-5-9-23(18)33(31,32)29-22(15-30)16-6-2-1-3-7-16/h1-14,22,29-30H,15H2,(H2,26,28)/t22-/m0/s1
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168706
PNG
(US9079866, 83 | US9745328, Compound 83 | US9884878...)
Show SMILES C[C@H](NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)[C@@H](O)c1ccccc1 |r|
Show InChI InChI=1S/C25H23FN4O3S/c1-16(25(31)17-7-3-2-4-8-17)30-34(32,33)23-10-6-5-9-19(23)18-11-12-20(21(26)13-18)22-14-29-24(27)15-28-22/h2-16,25,30-31H,1H3,(H2,27,29)/t16-,25+/m0/s1
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168713
PNG
(US9079866, 90 | US9745328, Compound 90 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C20H19FN4O2S/c21-17-9-14(7-8-16(17)18-11-24-20(22)12-23-18)15-3-1-2-4-19(15)28(26,27)25-10-13-5-6-13/h1-4,7-9,11-13,25H,5-6,10H2,(H2,22,24)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169465
PNG
(US9079866, 109 | US9745328, Compound 109 | US98848...)
Show SMILES CC(C)[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r|
Show InChI InChI=1S/C21H23FN4O3S/c1-13(2)19(12-27)26-30(28,29)20-6-4-3-5-15(20)14-7-8-16(17(22)9-14)18-10-25-21(23)11-24-18/h3-11,13,19,26-27H,12H2,1-2H3,(H2,23,25)/t19-/m0/s1
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168733
PNG
(US9079866, 120 | US9079866, 162 | US9745328, Compo...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@H]1CCCC[C@@H]1O |r|
Show InChI InChI=1S/C22H23FN4O3S/c23-17-11-14(9-10-16(17)19-12-26-22(24)13-25-19)15-5-1-4-8-21(15)31(29,30)27-18-6-2-3-7-20(18)28/h1,4-5,8-13,18,20,27-28H,2-3,6-7H2,(H2,24,26)/t18-,20-/m0/s1
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168735
PNG
(US9079866, 122 | US9745328, Compound 122 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@@H]1CCCC[C@@H]1CO |r|
Show InChI InChI=1S/C23H25FN4O3S/c24-19-11-15(9-10-18(19)21-12-27-23(25)13-26-21)17-6-2-4-8-22(17)32(30,31)28-20-7-3-1-5-16(20)14-29/h2,4,6,8-13,16,20,28-29H,1,3,5,7,14H2,(H2,25,27)/t16-,20-/m1/s1
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168743
PNG
(US9079866, 133 | US9745328, Compound 133 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NCCCCCCO
Show InChI InChI=1S/C22H25FN4O3S/c23-19-13-16(9-10-18(19)20-14-26-22(24)15-25-20)17-7-3-4-8-21(17)31(29,30)27-11-5-1-2-6-12-28/h3-4,7-10,13-15,27-28H,1-2,5-6,11-12H2,(H2,24,26)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168744
PNG
(US9079866, 134 | US9745328, Compound 134 | US98848...)
Show SMILES N[C@H]1CC[C@H](CC1)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r,wU:4.7,1.0,(-6.16,-5.33,;-5.39,-4,;-6.16,-2.67,;-5.39,-1.33,;-3.85,-1.33,;-3.08,-2.67,;-3.85,-4,;-3.08,,;-3.85,1.33,;-5.18,.56,;-2.52,2.1,;-4.62,2.67,;-6.16,2.67,;-6.93,4,;-6.16,5.33,;-4.62,5.33,;-3.85,4,;-2.31,4,;-1.54,5.33,;,5.33,;.77,4,;,2.67,;.77,1.33,;-1.54,2.67,;2.31,4,;3.08,5.33,;4.62,5.33,;5.39,4,;6.93,4,;4.62,2.67,;3.08,2.67,)|
Show InChI InChI=1S/C22H24FN5O2S/c23-19-11-14(5-10-18(19)20-12-27-22(25)13-26-20)17-3-1-2-4-21(17)31(29,30)28-16-8-6-15(24)7-9-16/h1-5,10-13,15-16,28H,6-9,24H2,(H2,25,27)/t15-,16+
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168750
PNG
(US9079866, 140 | US9745328, Compound 140 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N(C1CC1)C1CCOCC1
Show InChI InChI=1S/C24H25FN4O3S/c25-21-13-16(5-8-20(21)22-14-28-24(26)15-27-22)19-3-1-2-4-23(19)33(30,31)29(17-6-7-17)18-9-11-32-12-10-18/h1-5,8,13-15,17-18H,6-7,9-12H2,(H2,26,28)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168751
PNG
(US9079866, 141 | US9745328, Compound 141 | US98848...)
Show SMILES CC(C)N(CCO)S(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C21H23FN4O3S/c1-14(2)26(9-10-27)30(28,29)20-6-4-3-5-16(20)15-7-8-17(18(22)11-15)19-12-25-21(23)13-24-19/h3-8,11-14,27H,9-10H2,1-2H3,(H2,23,25)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168754
PNG
(US9079866, 147 | US9745328, Compound 147 | US98848...)
Show SMILES CC(CO)(CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C20H21FN4O4S/c1-20(11-26,12-27)25-30(28,29)18-5-3-2-4-14(18)13-6-7-15(16(21)8-13)17-9-24-19(22)10-23-17/h2-10,25-27H,11-12H2,1H3,(H2,22,24)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168757
PNG
(US9079866, 151 | US9745328, Compound 151 | US98848...)
Show SMILES CC(C)(C)OC(=O)NCCNS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C23H26FN5O4S/c1-23(2,3)33-22(30)26-10-11-29-34(31,32)20-7-5-4-6-16(20)15-8-9-17(18(24)12-15)19-13-28-21(25)14-27-19/h4-9,12-14,29H,10-11H2,1-3H3,(H2,25,28)(H,26,30)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168730
PNG
(US9079866, 116 | US9745328, Compound 116 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@H](CO)Cc1ccccc1 |r|
Show InChI InChI=1S/C25H23FN4O3S/c26-22-13-18(10-11-21(22)23-14-29-25(27)15-28-23)20-8-4-5-9-24(20)34(32,33)30-19(16-31)12-17-6-2-1-3-7-17/h1-11,13-15,19,30-31H,12,16H2,(H2,27,29)/t19-/m0/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168739
PNG
(US9079866, 128 | US9745328, Compound 128 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCc2[nH]ncc2C1
Show InChI InChI=1S/C22H19FN6O2S/c23-18-9-14(5-6-17(18)20-11-26-22(24)12-25-20)16-3-1-2-4-21(16)32(30,31)29-8-7-19-15(13-29)10-27-28-19/h1-6,9-12H,7-8,13H2,(H2,24,26)(H,27,28)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168746
PNG
(US9079866, 136 | US9745328, Compound 136 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N(CCO)C1CCCCC1
Show InChI InChI=1S/C24H27FN4O3S/c25-21-14-17(10-11-20(21)22-15-28-24(26)16-27-22)19-8-4-5-9-23(19)33(31,32)29(12-13-30)18-6-2-1-3-7-18/h4-5,8-11,14-16,18,30H,1-3,6-7,12-13H2,(H2,26,28)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM60470
PNG
(BDBM168646 | US9079866, 127 | US9745328, Compound ...)
Show SMILES C[C@@H](NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F |r|
Show InChI InChI=1S/C19H16F4N4O2S/c1-11(19(21,22)23)27-30(28,29)17-5-3-2-4-13(17)12-6-7-14(15(20)8-12)16-9-26-18(24)10-25-16/h2-11,27H,1H3,(H2,24,26)/t11-/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168648
PNG
(US9079866, 22 | US9079866, 23 | US9745328, Compoun...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@@H]1CCc2ccccc12 |r|
Show InChI InChI=1S/C25H21FN4O2S/c26-21-13-17(9-11-20(21)23-14-29-25(27)15-28-23)19-7-3-4-8-24(19)33(31,32)30-22-12-10-16-5-1-2-6-18(16)22/h1-9,11,13-15,22,30H,10,12H2,(H2,27,29)/t22-/m1/s1
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168649
PNG
(US9079866, 26 | US9745328, Compound 26 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C22H17FN4O2S/c23-19-12-15(10-11-18(19)20-13-26-22(24)14-25-20)17-8-4-5-9-21(17)30(28,29)27-16-6-2-1-3-7-16/h1-14,27H,(H2,24,26)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168670
PNG
(US9079866, 47 | US9745328, Compound 47 | US9884878...)
Show SMILES CCN(CC)S(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C20H21FN4O2S/c1-3-25(4-2)28(26,27)19-8-6-5-7-15(19)14-9-10-16(17(21)11-14)18-12-24-20(22)13-23-18/h5-13H,3-4H2,1-2H3,(H2,22,24)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168673
PNG
(US9079866, 50 | US9745328, Compound 50 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCCC(F)(F)C1
Show InChI InChI=1S/C21H19F3N4O2S/c22-17-10-14(6-7-16(17)18-11-27-20(25)12-26-18)15-4-1-2-5-19(15)31(29,30)28-9-3-8-21(23,24)13-28/h1-2,4-7,10-12H,3,8-9,13H2,(H2,25,27)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169037
PNG
(US9079866, 438 | US9745328, Compound 438 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2nnc(N)s2)c(F)c1
Show InChI InChI=1S/C18H19FN4O2S2/c1-18(2,3)23-27(24,25)15-7-5-4-6-12(15)11-8-9-13(14(19)10-11)16-21-22-17(20)26-16/h4-10,23H,1-3H3,(H2,20,22)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169040
PNG
(US9079866, 441 | US9745328, Compound 441 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)c(Cl)n1
Show InChI InChI=1S/C20H20ClFN4O2S/c1-20(2,3)26-29(27,28)17-7-5-4-6-13(17)12-8-9-14(15(22)10-12)16-11-24-19(23)18(21)25-16/h4-11,26H,1-3H3,(H2,23,24)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169155
PNG
(US9079866, 556 | US9745328, Compound 556 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1Oc1nccc(N)n1)C(F)(F)F
Show InChI InChI=1S/C21H14F4N6O/c22-15-7-11(1-3-14(15)16-9-30-19(27)10-29-16)13-4-2-12(21(23,24)25)8-17(13)32-20-28-6-5-18(26)31-20/h1-10H,(H2,27,30)(H2,26,28,31)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168678
PNG
(US9079866, 55 | US9745328, Compound 55 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCC(O)(CC1)C(F)(F)F
Show InChI InChI=1S/C22H20F4N4O3S/c23-17-11-14(5-6-16(17)18-12-29-20(27)13-28-18)15-3-1-2-4-19(15)34(32,33)30-9-7-21(31,8-10-30)22(24,25)26/h1-6,11-13,31H,7-10H2,(H2,27,29)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168719
PNG
(US9079866, 100 | US9745328, Compound 100 | US98848...)
Show SMILES CC(C)(CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C20H21FN4O3S/c1-20(2,12-26)25-29(27,28)18-6-4-3-5-14(18)13-7-8-15(16(21)9-13)17-10-24-19(22)11-23-17/h3-11,25-26H,12H2,1-2H3,(H2,22,24)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168631
PNG
(US9079866, 4 | US9745328, Compound 4 | US9884878, ...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C20H21FN4O2S/c1-20(2,3)25-28(26,27)18-7-5-4-6-14(18)13-8-9-15(16(21)10-13)17-11-24-19(22)12-23-17/h4-12,25H,1-3H3,(H2,22,24)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168633
PNG
(US9079866, 6 | US9745328, Compound 6 | US9884878, ...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NC1CCCCC1
Show InChI InChI=1S/C22H23FN4O2S/c23-19-12-15(10-11-18(19)20-13-26-22(24)14-25-20)17-8-4-5-9-21(17)30(28,29)27-16-6-2-1-3-7-16/h4-5,8-14,16,27H,1-3,6-7H2,(H2,24,26)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168635
PNG
(US9079866, 8 | US9745328, Compound 8 | US9884878, ...)
Show SMILES CC(NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F
Show InChI InChI=1S/C19H16F4N4O2S/c1-11(19(21,22)23)27-30(28,29)17-5-3-2-4-13(17)12-6-7-14(15(20)8-12)16-9-26-18(24)10-25-16/h2-11,27H,1H3,(H2,24,26)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168640
PNG
(US9079866, 13 | US9745328, Compound 13)
Show SMILES CC(C)(NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F
Show InChI InChI=1S/C20H18F4N4O2S/c1-19(2,20(22,23)24)28-31(29,30)17-6-4-3-5-13(17)12-7-8-14(15(21)9-12)16-10-27-18(25)11-26-16/h3-11,28H,1-2H3,(H2,25,27)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169041
PNG
(US9079866, 442 | US9745328, Compound 442 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)c(Br)n1
Show InChI InChI=1S/C20H20BrFN4O2S/c1-20(2,3)26-29(27,28)17-7-5-4-6-13(17)12-8-9-14(15(22)10-12)16-11-24-19(23)18(21)25-16/h4-11,26H,1-3H3,(H2,23,24)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169044
PNG
(US9079866, 445 | US9745328, Compound 445 | US98848...)
Show SMILES Cc1nc(cnc1N)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C21H23FN4O2S/c1-13-20(23)24-12-18(25-13)16-10-9-14(11-17(16)22)15-7-5-6-8-19(15)29(27,28)26-21(2,3)4/h5-12,26H,1-4H3,(H2,23,24)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169054
PNG
(US9079866, 455 | US9745328, Compound 455 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]cc(CO)c2c1
Show InChI InChI=1S/C24H24FN3O3S/c1-24(2,3)28-32(30,31)22-7-5-4-6-19(22)15-8-9-18(21(25)11-15)16-10-20-17(14-29)13-27-23(20)26-12-16/h4-13,28-29H,14H2,1-3H3,(H,26,27)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169122
PNG
(US9079866, 523 | US9745328, Compound 523 | US98848...)
Show SMILES Nc1nccc(Oc2ccccc2-c2ccc(c(F)c2)-c2cnc3[nH]ccc3c2)n1
Show InChI InChI=1S/C23H16FN5O/c24-19-12-14(5-6-17(19)16-11-15-7-9-26-22(15)28-13-16)18-3-1-2-4-20(18)30-21-8-10-27-23(25)29-21/h1-13H,(H,26,28)(H2,25,27,29)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169123
PNG
(US9079866, 524 | US9745328, Compound 524 | US98848...)
Show SMILES Nc1ccnc(Oc2ccccc2-c2ccc(c(F)c2)-c2cnc3[nH]ccc3c2)n1
Show InChI InChI=1S/C23H16FN5O/c24-19-12-14(5-6-17(19)16-11-15-7-9-26-22(15)28-13-16)18-3-1-2-4-20(18)30-23-27-10-8-21(25)29-23/h1-13H,(H,26,28)(H2,25,27,29)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM169134
PNG
(US9079866, 535 | US9745328, Compound 535 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1Oc1cc(N)ncn1
Show InChI InChI=1S/C20H15FN6O/c21-15-7-12(5-6-14(15)16-9-25-19(23)10-24-16)13-3-1-2-4-17(13)28-20-8-18(22)26-11-27-20/h1-11H,(H2,23,25)(H2,22,26,27)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168948
PNG
(US9079866, 349 | US9745328, Compound 349 | US98848...)
Show SMILES CCC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1
Show InChI InChI=1S/C22H24FN3O2S/c1-4-22(2,3)26-29(27,28)20-8-6-5-7-18(20)15-9-11-17(19(23)13-15)16-10-12-21(24)25-14-16/h5-14,26H,4H2,1-3H3,(H2,24,25)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168952
PNG
(US9079866, 353 | US9745328, Compound 353 | US98848...)
Show SMILES CC1(CCC1)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1
Show InChI InChI=1S/C22H22FN3O2S/c1-22(11-4-12-22)26-29(27,28)20-6-3-2-5-18(20)15-7-9-17(19(23)13-15)16-8-10-21(24)25-14-16/h2-3,5-10,13-14,26H,4,11-12H2,1H3,(H2,24,25)
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168961
PNG
(US9079866, 362 | US9884878, Compound 362)
Show SMILES C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1 |r|
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 1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168962
PNG
(US9079866, 363 | US9884878, Compound 363)
Show SMILES C[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1 |r|
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168965
PNG
(US9079866, 366 | US9884878, Compound 366)
Show SMILES OCCNS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C21H18FN3O3S/c22-19-12-14(18-3-1-2-4-20(18)29(27,28)25-9-10-26)5-6-17(19)16-11-15-7-8-23-21(15)24-13-16/h1-8,11-13,25-26H,9-10H2,(H,23,24)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168966
PNG
(US9079866, 367 | US9745328, Compound 367 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C23H22FN3O2S/c1-23(2,3)27-30(28,29)21-7-5-4-6-19(21)15-8-9-18(20(24)13-15)17-12-16-10-11-25-22(16)26-14-17/h4-14,27H,1-3H3,(H,25,26)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168970
PNG
(US9079866, 371 | US9745328, Compound 371 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C22H21FN4O2S/c1-22(2,3)27-30(28,29)20-7-5-4-6-15(20)14-8-9-16(17(23)12-14)19-13-25-21-18(26-19)10-11-24-21/h4-13,27H,1-3H3,(H,24,25)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM168972
PNG
(US9079866, 373 | US9745328, Compound 373 | US98848...)
Show SMILES CCN(CC)S(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C22H21FN4O2S/c1-3-27(4-2)30(28,29)21-8-6-5-7-16(21)15-9-10-17(18(23)13-15)20-14-25-22-19(26-20)11-12-24-22/h5-14H,3-4H2,1-2H3,(H,24,25)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9079866 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R3Q
More data for this
Ligand-Target Pair
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