Found 15 hits Enz. Inhib. hit(s) with all data for assayid = 4 entry = 50031737 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM33408
(AG1295 | CHEMBL7724 | cid_2048)Show InChI InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50318162
(CHEMBL1094423 | N-(3-bromophenyl)-6-(2-phenylethyl...)Show InChI InChI=1S/C20H17BrN4/c21-15-7-4-8-16(11-15)24-19-18-12-17(25-20(18)23-13-22-19)10-9-14-5-2-1-3-6-14/h1-8,11-13H,9-10H2,(H2,22,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50271758
(CHEMBL485320 | N4-(3-Bromophenyl)-6-(2-phenylethyl...)Show SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C20H18BrN5/c21-14-7-4-8-15(11-14)23-18-17-12-16(24-19(17)26-20(22)25-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,22,23,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50271905
(CHEMBL499067 | N4-(1H-indol-5-yl)-6-phenethyl-7H-p...)Show SMILES Nc1nc(Nc2ccc3[nH]ccc3c2)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C22H20N6/c23-22-27-20(25-16-8-9-19-15(12-16)10-11-24-19)18-13-17(26-21(18)28-22)7-6-14-4-2-1-3-5-14/h1-5,8-13,24H,6-7H2,(H4,23,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.74E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50271852
(CHEMBL482715 | N4-(4-fluoro-3-(trifluoromethyl)phe...)Show SMILES Nc1nc(Nc2ccc(F)c(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H17F4N5/c22-17-9-8-14(11-16(17)21(23,24)25)28-19-15-10-13(27-18(15)29-20(26)30-19)7-6-12-4-2-1-3-5-12/h1-5,8-11H,6-7H2,(H4,26,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50271849
(CHEMBL520803 | N4-(3-Ethynylphenyl)-6-(2-phenyleth...)Show SMILES Nc1nc(Nc2cccc(c2)C#C)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C22H19N5/c1-2-15-9-6-10-17(13-15)24-20-19-14-18(25-21(19)27-22(23)26-20)12-11-16-7-4-3-5-8-16/h1,3-10,13-14H,11-12H2,(H4,23,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50318168
(CHEMBL1097368 | N-1H-indol-5-yl-6-(2-phenylethyl)-...)Show SMILES C(Cc1ccccc1)c1cc2c(Nc3ccc4[nH]ccc4c3)ncnc2[nH]1 Show InChI InChI=1S/C22H19N5/c1-2-4-15(5-3-1)6-7-18-13-19-21(24-14-25-22(19)27-18)26-17-8-9-20-16(12-17)10-11-23-20/h1-5,8-14,23H,6-7H2,(H2,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.04E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50318165
(CHEMBL1096737 | N-(3-bromo-4-flurophenyl)-6-(2-phe...)Show InChI InChI=1S/C20H16BrFN4/c21-17-11-15(8-9-18(17)22)26-20-16-10-14(25-19(16)23-12-24-20)7-6-13-4-2-1-3-5-13/h1-5,8-12H,6-7H2,(H2,23,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.92E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50318164
(6-(2-Phenylethyl)-N-[3-(trifluoromethyl)phenyl]-7H...)Show SMILES FC(F)(F)c1cccc(Nc2ncnc3[nH]c(CCc4ccccc4)cc23)c1 Show InChI InChI=1S/C21H17F3N4/c22-21(23,24)15-7-4-8-16(11-15)27-19-18-12-17(28-20(18)26-13-25-19)10-9-14-5-2-1-3-6-14/h1-8,11-13H,9-10H2,(H2,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50271848
(6-phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrr...)Show SMILES Nc1nc(Nc2cccc(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-7-4-8-15(11-14)26-18-17-12-16(27-19(17)29-20(25)28-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50271850
(CHEMBL483313 | N4-(4-chloro-2-fluorophenyl)-6-(2-p...)Show SMILES Nc1nc(Nc2ccc(Cl)cc2F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C20H17ClFN5/c21-13-7-9-17(16(22)10-13)25-19-15-11-14(24-18(15)26-20(23)27-19)8-6-12-4-2-1-3-5-12/h1-5,7,9-11H,6,8H2,(H4,23,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50318163
(CHEMBL1096972 | N-(3-ethynylphenyl)-6-(2-phenyleth...)Show InChI InChI=1S/C22H18N4/c1-2-16-9-6-10-18(13-16)25-21-20-14-19(26-22(20)24-15-23-21)12-11-17-7-4-3-5-8-17/h1,3-10,13-15H,11-12H2,(H2,23,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50318166
(CHEMBL1096415 | N-[4-fluoro-3-(trifluoromethyl)phe...)Show SMILES Fc1ccc(Nc2ncnc3[nH]c(CCc4ccccc4)cc23)cc1C(F)(F)F Show InChI InChI=1S/C21H16F4N4/c22-18-9-8-15(11-17(18)21(23,24)25)29-20-16-10-14(28-19(16)26-12-27-20)7-6-13-4-2-1-3-5-13/h1-5,8-12H,6-7H2,(H2,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50271803
(CHEMBL483108 | N4-(3-bromo-4-fluorophenyl)-6-(2-ph...)Show SMILES Nc1nc(Nc2ccc(F)c(Br)c2)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C20H17BrFN5/c21-16-11-14(8-9-17(16)22)25-19-15-10-13(24-18(15)26-20(23)27-19)7-6-12-4-2-1-3-5-12/h1-5,8-11H,6-7H2,(H4,23,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50318167
(CHEMBL1096416 | N-(4-chloro-2-fluorophenyl)-6-(2-p...)Show InChI InChI=1S/C20H16ClFN4/c21-14-7-9-18(17(22)10-14)26-20-16-11-15(25-19(16)23-12-24-20)8-6-13-4-2-1-3-5-13/h1-5,7,9-12H,6,8H2,(H2,23,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |