Compile Data Set for Download or QSAR

Found 41 hits of ec50 data for polymerid = 9137   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4cccc(c4)C(F)(F)F)c3c2c1 Show InChI InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.25	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341212 (1-(4-fluoro-3-(trifluoromethyl)phenyl)-9-(1H-pyrro...) Show SMILES Fc1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2[nH]ccc2c1 Show InChI InChI=1S/C26H14F4N4O/c27-21-4-3-18(11-20(21)26(28,29)30)34-23(35)6-2-16-12-32-22-5-1-14(10-19(22)24(16)34)17-9-15-7-8-31-25(15)33-13-17/h1-13H,(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341211 (9-(2-aminopyrimidin-5-yl)-1-(4-fluoro-3-(trifluoro...) Show SMILES Nc1ncc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc(F)c(c4)C(F)(F)F)c3c2c1 Show InChI InChI=1S/C23H13F4N5O/c24-18-4-3-15(8-17(18)23(25,26)27)32-20(33)6-2-13-9-29-19-5-1-12(7-16(19)21(13)32)14-10-30-22(28)31-11-14/h1-11H,(H2,28,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341213 (1-(3-chloro-4-fluorophenyl)-9-(1H-pyrrolo[2,3-b]py...) Show SMILES Fc1ccc(cc1Cl)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2[nH]ccc2c1 Show InChI InChI=1S/C25H14ClFN4O/c26-20-11-18(3-4-21(20)27)31-23(32)6-2-16-12-29-22-5-1-14(10-19(22)24(16)31)17-9-15-7-8-28-25(15)30-13-17/h1-13H,(H,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341210 (9-(6-aminopyridin-3-yl)-1-(4-fluoro-3-(trifluorome...) Show SMILES Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc(F)c(c4)C(F)(F)F)c3c2c1 Show InChI InChI=1S/C24H14F4N4O/c25-19-5-4-16(10-18(19)24(26,27)28)32-22(33)8-3-15-12-30-20-6-1-13(9-17(20)23(15)32)14-2-7-21(29)31-11-14/h1-12H,(H2,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346970 (CHEMBL1795884) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C41H35N5O2/c1-26-21-34(13-14-35(26)27-7-9-28(10-8-27)41(48)44-33-17-19-45(2)20-18-33)46-39(47)16-12-31-24-43-38-15-11-29(23-36(38)40(31)46)32-22-30-5-3-4-6-37(30)42-25-32/h3-16,21-25,33H,17-20H2,1-2H3,(H,44,48)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341214 (9-(2-aminopyrimidin-5-yl)-1-(3-chloro-4-fluorophen...) Show SMILES Nc1ncc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc(F)c(Cl)c4)c3c2c1 Show InChI InChI=1S/C22H13ClFN5O/c23-17-8-15(3-4-18(17)24)29-20(30)6-2-13-9-26-19-5-1-12(7-16(19)21(13)29)14-10-27-22(25)28-11-14/h1-11H,(H2,25,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341215 (1-(4-fluoro-3-methylphenyl)-9-(1H-pyrrolo[2,3-b]py...) Show SMILES Cc1cc(ccc1F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2[nH]ccc2c1 Show InChI InChI=1S/C26H17FN4O/c1-15-10-20(4-5-22(15)27)31-24(32)7-3-18-13-29-23-6-2-16(12-21(23)25(18)31)19-11-17-8-9-28-26(17)30-14-19/h2-14H,1H3,(H,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341216 (9-(6-aminopyridin-3-yl)-1-(3-chloro-4-fluorophenyl...) Show SMILES Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc(F)c(Cl)c4)c3c2c1 Show InChI InChI=1S/C23H14ClFN4O/c24-18-10-16(4-5-19(18)25)29-22(30)8-3-15-12-27-20-6-1-13(9-17(20)23(15)29)14-2-7-21(26)28-11-14/h1-12H,(H2,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50328584 (1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...) Show SMILES CCC(=O)N1CCN(CC1)c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341217 (1-(3,4-difluorophenyl)-9-(quinolin-3-yl)benzo[h][1...) Show SMILES Fc1ccc(cc1F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C27H15F2N3O/c28-22-8-7-20(13-23(22)29)32-26(33)10-6-18-14-31-25-9-5-16(12-21(25)27(18)32)19-11-17-3-1-2-4-24(17)30-15-19/h1-15H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346961 (CHEMBL1795875) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C41H32F3N5O2/c1-48-18-16-31(17-19-48)47-40(51)26-8-6-25(7-9-26)33-13-12-32(22-35(33)41(42,43)44)49-38(50)15-11-29-23-46-37-14-10-27(21-34(37)39(29)49)30-20-28-4-2-3-5-36(28)45-24-30/h2-15,20-24,31H,16-19H2,1H3,(H,47,51)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341221 (9-(2-aminopyrimidin-5-yl)-1-(4-fluoro-3-methylphen...) Show SMILES Cc1cc(ccc1F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc(N)nc1 Show InChI InChI=1S/C23H16FN5O/c1-13-8-17(4-5-19(13)24)29-21(30)7-3-15-10-26-20-6-2-14(9-18(20)22(15)29)16-11-27-23(25)28-12-16/h2-12H,1H3,(H2,25,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341220 (1-(4-fluoro-3-methylphenyl)-9-(1H-pyrazol-4-yl)ben...) Show SMILES Cc1cc(ccc1F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cn[nH]c1 Show InChI InChI=1S/C22H15FN4O/c1-13-8-17(4-5-19(13)23)27-21(28)7-3-15-10-24-20-6-2-14(9-18(20)22(15)27)16-11-25-26-12-16/h2-12H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341219 (1-(4-fluoro-3-methylphenyl)-9-(quinolin-3-yl)benzo...) Show SMILES Cc1cc(ccc1F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C28H18FN3O/c1-17-12-22(8-9-24(17)29)32-27(33)11-7-20-15-31-26-10-6-18(14-23(26)28(20)32)21-13-19-4-2-3-5-25(19)30-16-21/h2-16H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341218 (1-(4-fluoro-3-(trifluoromethyl)phenyl)-9-(1H-pyraz...) Show SMILES Fc1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cn[nH]c1 Show InChI InChI=1S/C22H12F4N4O/c23-18-4-3-15(8-17(18)22(24,25)26)30-20(31)6-2-13-9-27-19-5-1-12(7-16(19)21(13)30)14-10-28-29-11-14/h1-11H,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341222 (1-(3-chloro-4-fluorophenyl)-9-(quinolin-3-yl)benzo...) Show SMILES Fc1ccc(cc1Cl)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C27H15ClFN3O/c28-22-13-20(7-8-23(22)29)32-26(33)10-6-18-14-31-25-9-5-16(12-21(25)27(18)32)19-11-17-3-1-2-4-24(17)30-15-19/h1-15H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346968 (CHEMBL1795882) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc(N)nc1 Show InChI InChI=1S/C36H30F3N7O2/c1-45-14-12-26(13-15-45)44-34(48)22-4-2-21(3-5-22)28-9-8-27(17-30(28)36(37,38)39)46-32(47)11-7-24-18-41-31-10-6-23(16-29(31)33(24)46)25-19-42-35(40)43-20-25/h2-11,16-20,26H,12-15H2,1H3,(H,44,48)(H2,40,42,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346969 (CHEMBL1795883) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cn[nH]c1 Show InChI InChI=1S/C35H29F3N6O2/c1-43-14-12-26(13-15-43)42-34(46)22-4-2-21(3-5-22)28-9-8-27(17-30(28)35(36,37)38)44-32(45)11-7-24-18-39-31-10-6-23(16-29(31)33(24)44)25-19-40-41-20-25/h2-11,16-20,26H,12-15H2,1H3,(H,40,41)(H,42,46)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346962 (CHEMBL1795876) Show SMILES CNC(=O)c1ccc(cc1)-c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C36H23F3N4O2/c1-40-35(45)22-8-6-21(7-9-22)28-13-12-27(18-30(28)36(37,38)39)43-33(44)15-11-25-19-42-32-14-10-23(17-29(32)34(25)43)26-16-24-4-2-3-5-31(24)41-20-26/h2-20H,1H3,(H,40,45)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346965 (CHEMBL1795879) Show SMILES OC(=O)c1ccc(cc1)-c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C35H20F3N3O3/c36-35(37,38)29-17-26(11-12-27(29)20-5-7-21(8-6-20)34(43)44)41-32(42)14-10-24-18-40-31-13-9-22(16-28(31)33(24)41)25-15-23-3-1-2-4-30(23)39-19-25/h1-19H,(H,43,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341224 (5-(1-(4-fluoro-3-methylphenyl)-2-oxo-1,2-dihydrobe...) Show SMILES Fc1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1ccc(nc1)C#N Show InChI InChI=1S/C25H12F4N4O/c26-21-6-5-18(10-20(21)25(27,28)29)33-23(34)8-3-16-13-32-22-7-2-14(9-19(22)24(16)33)15-1-4-17(11-30)31-12-15/h1-10,12-13H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341223 (1-(4-fluoro-3-methylphenyl)-9-(6-methoxypyridin-3-...) Show SMILES COc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc(F)c(C)c4)c3c2c1 Show InChI InChI=1S/C25H18FN3O2/c1-15-11-19(6-7-21(15)26)29-24(30)10-5-18-14-27-22-8-3-16(12-20(22)25(18)29)17-4-9-23(31-2)28-13-17/h3-14H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346963 (CHEMBL1795877) Show SMILES FC(F)(F)c1cc(ccc1-c1ccc(COC2CCCCO2)cc1)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C40H30F3N3O3/c41-40(42,43)34-21-31(14-15-32(34)26-10-8-25(9-11-26)24-49-38-7-3-4-18-48-38)46-37(47)17-13-29-22-45-36-16-12-27(20-33(36)39(29)46)30-19-28-5-1-2-6-35(28)44-23-30/h1-2,5-6,8-17,19-23,38H,3-4,7,18,24H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346973 (CHEMBL1795887) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2[nH]ccc2c1 Show InChI InChI=1S/C39H34N6O2/c1-24-19-32(9-10-33(24)25-3-5-26(6-4-25)39(47)43-31-14-17-44(2)18-15-31)45-36(46)12-8-29-22-41-35-11-7-27(21-34(35)37(29)45)30-20-28-13-16-40-38(28)42-23-30/h3-13,16,19-23,31H,14-15,17-18H2,1-2H3,(H,40,42)(H,43,47)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341227 (1-(4-fluoro-2-(trifluoromethyl)phenyl)-9-(quinolin...) Show SMILES Fc1ccc(c(c1)C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 |(-4.38,-16.19,;-3.05,-16.97,;-3.06,-18.52,;-1.74,-19.3,;-.4,-18.55,;-.38,-17,;-1.7,-16.22,;.96,-16.25,;.98,-14.71,;2.5,-16.24,;2.05,-15.15,;.92,-19.33,;.9,-20.86,;2.22,-21.65,;3.56,-20.9,;3.59,-19.37,;2.26,-18.58,;2.28,-17.04,;2.21,-23.2,;.85,-23.95,;-.47,-23.16,;-1.82,-23.9,;-3.14,-23.1,;-3.1,-21.56,;-1.76,-20.82,;-.44,-21.61,;-4.42,-20.77,;-4.38,-19.22,;-5.7,-18.42,;-7.05,-19.17,;-8.36,-18.37,;-9.72,-19.12,;-9.74,-20.67,;-8.42,-21.46,;-7.08,-20.71,;-5.76,-21.51,)| Show InChI InChI=1S/C28H15F4N3O/c29-20-7-9-25(22(13-20)28(30,31)32)35-26(36)10-6-18-14-34-24-8-5-16(12-21(24)27(18)35)19-11-17-3-1-2-4-23(17)33-15-19/h1-15H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346967 (CHEMBL1795881) Show SMILES NC(=O)c1ccc(cc1)-c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C35H21F3N4O2/c36-35(37,38)29-17-26(11-12-27(29)20-5-7-21(8-6-20)34(39)44)42-32(43)14-10-24-18-41-31-13-9-22(16-28(31)33(24)42)25-15-23-3-1-2-4-30(23)40-19-25/h1-19H,(H2,39,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341226 (1-(4-fluoro-3-(trifluoromethyl)phenyl)-9-(1H-indaz...) Show SMILES Fc1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C26H14F4N4O/c27-21-5-4-18(11-20(21)26(28,29)30)34-24(35)8-3-16-12-31-23-7-2-15(10-19(23)25(16)34)14-1-6-22-17(9-14)13-32-33-22/h1-13H,(H,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341225 (1-(4-fluoro-3-(trifluoromethyl)phenyl)-9-(quinolin...) Show SMILES Fc1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C28H15F4N3O/c29-23-8-7-20(13-22(23)28(30,31)32)35-26(36)10-6-18-14-34-25-9-5-16(12-21(25)27(18)35)19-11-17-3-1-2-4-24(17)33-15-19/h1-15H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346964 (CHEMBL1795878) Show SMILES OCc1ccc(cc1)-c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C35H22F3N3O2/c36-35(37,38)30-17-27(11-12-28(30)22-7-5-21(20-42)6-8-22)41-33(43)14-10-25-18-40-32-13-9-23(16-29(32)34(25)41)26-15-24-3-1-2-4-31(24)39-19-26/h1-19,42H,20H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341228 (1-(4-fluoro-2-(trifluoromethyl)phenyl)-9-(1H-pyraz...) Show SMILES Fc1ccc(c(c1)C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cn[nH]c1 |(23.22,-16.91,;24.55,-17.69,;24.53,-19.24,;25.86,-20.02,;27.19,-19.26,;27.22,-17.72,;25.89,-16.93,;28.56,-16.97,;28.58,-15.43,;30.09,-16.96,;29.64,-15.86,;28.52,-20.05,;28.5,-21.58,;29.82,-22.37,;31.16,-21.62,;31.18,-20.09,;29.86,-19.3,;29.87,-17.76,;29.8,-23.92,;28.45,-24.67,;27.12,-23.88,;25.77,-24.62,;24.46,-23.82,;24.49,-22.28,;25.84,-21.54,;27.15,-22.33,;23.18,-21.48,;21.69,-21.89,;20.85,-20.6,;21.81,-19.41,;23.24,-19.95,)| Show InChI InChI=1S/C22H12F4N4O/c23-15-3-5-19(17(8-15)22(24,25)26)30-20(31)6-2-13-9-27-18-4-1-12(7-16(18)21(13)30)14-10-28-29-11-14/h1-11H,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341229 (1-(4-fluoro-3-(trifluoromethyl)phenyl)-9-(1-methyl...) Show SMILES Cn1cc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc(F)c(c4)C(F)(F)F)c3c2c1 Show InChI InChI=1S/C23H14F4N4O/c1-30-12-15(11-29-30)13-2-6-20-17(8-13)22-14(10-28-20)3-7-21(32)31(22)16-4-5-19(24)18(9-16)23(25,26)27/h2-12H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346975 (CHEMBL1795889) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1ccc(N)nc1 Show InChI InChI=1S/C37H34N6O2/c1-23-19-30(10-11-31(23)24-3-5-25(6-4-24)37(45)41-29-15-17-42(2)18-16-29)43-35(44)14-9-28-22-39-33-12-7-26(20-32(33)36(28)43)27-8-13-34(38)40-21-27/h3-14,19-22,29H,15-18H2,1-2H3,(H2,38,40)(H,41,45)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341230 (1-(4-fluoro-3-methylphenyl)-9-(1-methyl-1H-pyrazol...) Show SMILES Cc1cc(ccc1F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnn(C)c1 Show InChI InChI=1S/C23H17FN4O/c1-14-9-18(5-6-20(14)24)28-22(29)8-4-16-11-25-21-7-3-15(10-19(21)23(16)28)17-12-26-27(2)13-17/h3-13H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341231 (1-(3-chloro-4-fluorophenyl)-9-(1-methyl-1H-pyrazol...) Show SMILES Cn1cc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc(F)c(Cl)c4)c3c2c1 Show InChI InChI=1S/C22H14ClFN4O/c1-27-12-15(11-26-27)13-2-6-20-17(8-13)22-14(10-25-20)3-7-21(29)28(22)16-4-5-19(24)18(23)9-16/h2-12H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341232 (1-(3,4-difluorophenyl)-9-(1-methyl-1H-pyrazol-4-yl...) Show SMILES Cn1cc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc(F)c(F)c4)c3c2c1 Show InChI InChI=1S/C22H14F2N4O/c1-27-12-15(11-26-27)13-2-6-20-17(8-13)22-14(10-25-20)3-7-21(29)28(22)16-4-5-18(23)19(24)9-16/h2-12H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346971 (CHEMBL1795885) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cn[nH]c1 Show InChI InChI=1S/C35H32N6O2/c1-22-17-29(9-10-30(22)23-3-5-24(6-4-23)35(43)39-28-13-15-40(2)16-14-28)41-33(42)12-8-26-19-36-32-11-7-25(18-31(32)34(26)41)27-20-37-38-21-27/h3-12,17-21,28H,13-16H2,1-2H3,(H,37,38)(H,39,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346972 (CHEMBL1795886) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnn(C)c1 Show InChI InChI=1S/C36H34N6O2/c1-23-18-30(10-11-31(23)24-4-6-25(7-5-24)36(44)39-29-14-16-40(2)17-15-29)42-34(43)13-9-27-20-37-33-12-8-26(19-32(33)35(27)42)28-21-38-41(3)22-28/h4-13,18-22,29H,14-17H2,1-3H3,(H,39,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346966 (CHEMBL1795880) Show SMILES COC(=O)c1ccc(cc1)-c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1 Show InChI InChI=1S/C36H22F3N3O3/c1-45-35(44)22-8-6-21(7-9-22)28-13-12-27(18-30(28)36(37,38)39)42-33(43)15-11-25-19-41-32-14-10-23(17-29(32)34(25)42)26-16-24-4-2-3-5-31(24)40-20-26/h2-20H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50341233 (1-(4-fluoro-2-(trifluoromethyl)phenyl)-9-(1-methyl...) Show SMILES Cn1cc(cn1)-c1ccc2ncc3ccc(=O)n(-c4ccc(F)cc4C(F)(F)F)c3c2c1 |(7.5,-18.43,;7.9,-19.92,;9.34,-20.46,;9.27,-22,;7.78,-22.4,;6.94,-21.12,;10.59,-22.79,;10.55,-24.33,;11.87,-25.13,;13.22,-24.39,;14.54,-25.19,;15.9,-24.44,;15.92,-22.88,;17.26,-22.14,;17.28,-20.6,;15.95,-19.81,;15.97,-18.27,;14.62,-20.56,;13.29,-19.78,;11.95,-20.53,;10.63,-19.75,;10.64,-18.2,;9.32,-17.42,;11.99,-17.45,;13.31,-18.23,;14.66,-17.48,;14.68,-15.94,;16.19,-17.48,;15.74,-16.38,;14.6,-22.09,;13.25,-22.84,;11.93,-22.05,)| Show InChI InChI=1S/C23H14F4N4O/c1-30-12-15(11-29-30)13-2-5-19-17(8-13)22-14(10-28-19)3-7-21(32)31(22)20-6-4-16(24)9-18(20)23(25,26)27/h2-12H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblotting				J Med Chem 54: 1473-80 (2011) Article DOI: 10.1021/jm101520v BindingDB Entry DOI: 10.7270/Q2S46S8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM50346974 (CHEMBL1795888) Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C)-n1c2c(ccc1=O)cnc1ccccc21 Show InChI InChI=1S/C32H30N4O2/c1-21-19-26(36-30(37)14-11-24-20-33-29-6-4-3-5-28(29)31(24)36)12-13-27(21)22-7-9-23(10-8-22)32(38)34-25-15-17-35(2)18-16-25/h3-14,19-20,25H,15-18H2,1-2H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Dana Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of mTOR-dependent S6K phosphorylation at T389 residue in MEF cells				Bioorg Med Chem Lett 21: 4036-40 (2011) Article DOI: 10.1016/j.bmcl.2011.04.129 BindingDB Entry DOI: 10.7270/Q2Z60PD1
					More data for this Ligand-Target Pair