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Compile Data Set for Download or QSAR

Found 676 hits of ic50 data for polymerid = 50001875,50004671,9969   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024139
PNG
(1-Hydroxymethyl-5-phenethylamino-cyclohexane-1,2,3...)
Show SMILES OC[C@@]1(O)C[C@H](NCCc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H23NO5/c17-9-15(21)8-11(12(18)13(19)14(15)20)16-7-6-10-4-2-1-3-5-10/h1-5,11-14,16-21H,6-9H2/t11-,12?,13-,14-,15?/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024120
PNG
(1-Hydroxymethyl-5-[(thiophen-2-ylmethyl)-amino]-cy...)
Show SMILES OC[C@@]1(O)C[C@H](NCc2cccs2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C12H19NO5S/c14-6-12(18)4-8(9(15)10(16)11(12)17)13-5-7-2-1-3-19-7/h1-3,8-11,13-18H,4-6H2/t8-,9?,10-,11-,12?/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50156360
PNG
(2-Hydroxymethyl-6-nonyl-piperidine-3,4,5-triol | C...)
Show SMILES CCCCCCCCCC1NC(CO)C(O)C(O)C1O
Show InChI InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-11-13(18)15(20)14(19)12(10-17)16-11/h11-20H,2-10H2,1H3
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n/an/a 3.5n/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal isomaltase using disaccharide


Bioorg Med Chem Lett 14: 5991-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.086
BindingDB Entry DOI: 10.7270/Q27P904W
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50373983
PNG
(CHEMBL268675)
Show SMILES Nc1c(O)cc2oc(cc(=O)c2c1O)-c1ccccc1
Show InChI InChI=1S/C15H11NO4/c16-14-10(18)7-12-13(15(14)19)9(17)6-11(20-12)8-4-2-1-3-5-8/h1-7,18-19H,16H2
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n/an/a 4.40n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal maltase


Bioorg Med Chem Lett 18: 812-5 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.032
BindingDB Entry DOI: 10.7270/Q2MG7QC9
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50226273
PNG
(CHEMBL3349431)
Show SMILES OCN(CO)[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C9H19NO7/c11-2-9(17)1-5(10(3-12)4-13)6(14)7(15)8(9)16/h5-8,11-17H,1-4H2/t5-,6-,7+,8-,9-/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50373982
PNG
(CHEMBL402196)
Show SMILES CC(=O)c1ccc(O)c(N)c1O
Show InChI InChI=1S/C8H9NO3/c1-4(10)5-2-3-6(11)7(9)8(5)12/h2-3,11-12H,9H2,1H3
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n/an/a 5n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal maltase


Bioorg Med Chem Lett 18: 812-5 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.032
BindingDB Entry DOI: 10.7270/Q2MG7QC9
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024119
PNG
(5-(2-Hydroxy-cyclohexylamino)-1-hydroxymethyl-cycl...)
Show SMILES OC[C@@]1(O)C[C@H](N[C@@H]2CCCC[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C13H25NO6/c15-6-13(20)5-8(10(17)11(18)12(13)19)14-7-3-1-2-4-9(7)16/h7-12,14-20H,1-6H2/t7-,8-,9-,10?,11-,12-,13?/m0/s1
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n/an/a 5.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024137
PNG
(1-Hydroxymethyl-5-(2-hydroxy-2-phenyl-ethylamino)-...)
Show SMILES [H][C@](O)(CN[C@H]1C[C@](O)(CO)[C@H](O)[C@@H](O)[C@H]1O)c1ccccc1
Show InChI InChI=1S/C15H23NO6/c17-8-15(22)6-10(12(19)13(20)14(15)21)16-7-11(18)9-4-2-1-3-5-9/h1-5,10-14,16-22H,6-8H2/t10-,11-,12-,13-,14+,15-/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024136
PNG
(5-(3,5-Di-tert-butyl-4-hydroxy-benzylamino)-1-hydr...)
Show SMILES CC(C)(C)c1cc(CN[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)cc(c1O)C(C)(C)C |r|
Show InChI InChI=1S/C22H37NO6/c1-20(2,3)13-7-12(8-14(16(13)25)21(4,5)6)10-23-15-9-22(29,11-24)19(28)18(27)17(15)26/h7-8,15,17-19,23-29H,9-11H2,1-6H3/t15-,17?,18-,19-,22?/m0/s1
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n/an/a 6.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50405395
PNG
(CHEMBL2051761)
Show SMILES C[C@H]1C[C@H](N)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H28N2O7/c1-5-2-6(15)9(18)11(20)8(5)16-7-3-14(23,4-17)13(22)12(21)10(7)19/h5-13,16-23H,2-4,15H2,1H3/t5-,6-,7-,8+,9-,10-,11-,12+,13-,14-/m0/s1
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n/an/a 7.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50373981
PNG
(CHEMBL403239)
Show SMILES Nc1c(O)cccc1O
Show InChI InChI=1S/C6H7NO2/c7-6-4(8)2-1-3-5(6)9/h1-3,8-9H,7H2
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n/an/a 8.5n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal maltase


Bioorg Med Chem Lett 18: 812-5 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.032
BindingDB Entry DOI: 10.7270/Q2MG7QC9
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024114
PNG
(5-(Cyclohexylmethyl-amino)-1-hydroxymethyl-cyclohe...)
Show SMILES OC[C@@]1(O)C[C@H](NCC2CCCCC2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H27NO5/c16-8-14(20)6-10(11(17)12(18)13(14)19)15-7-9-4-2-1-3-5-9/h9-13,15-20H,1-8H2/t10-,11?,12-,13-,14?/m0/s1
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n/an/a 9.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50405397
PNG
(CHEMBL2051983)
Show SMILES CO[C@H]1O[C@H](C)[C@@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO9/c1-5-7(9(18)11(20)13(23-2)24-5)15-6-3-14(22,4-16)12(21)10(19)8(6)17/h5-13,15-22H,3-4H2,1-2H3/t5-,6+,7-,8+,9+,10-,11-,12+,13+,14+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024118
PNG
(5-(3,7-Dimethyl-octa-2,6-dienylamino)-1-hydroxymet...)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#7]-[#6@H]-1-[#6][C@]([#8])([#6]-[#8])[#6@@H](-[#8])-[#6@H](-[#8])-[#6@H]-1-[#8] |r|
Show InChI InChI=1S/C17H31NO5/c1-11(2)5-4-6-12(3)7-8-18-13-9-17(23,10-19)16(22)15(21)14(13)20/h5,7,13-16,18-23H,4,6,8-10H2,1-3H3/b12-7+/t13-,14?,15-,16-,17?/m0/s1
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n/an/a 11n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024124
PNG
(1-Hydroxymethyl-5-(2-hydroxy-1-phenyl-ethylamino)-...)
Show SMILES [H][C@@](CO)(N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O)c1ccccc1
Show InChI InChI=1S/C15H23NO6/c17-7-11(9-4-2-1-3-5-9)16-10-6-15(22,8-18)14(21)13(20)12(10)19/h1-5,10-14,16-22H,6-8H2/t10-,11-,12-,13+,14-,15-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024133
PNG
(1-Hydroxymethyl-5-(3-phenyl-allylamino)-cyclohexan...)
Show SMILES OC[C@@]1(O)C[C@H](NC\C=C\c2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C16H23NO5/c18-10-16(22)9-12(13(19)14(20)15(16)21)17-8-4-7-11-5-2-1-3-6-11/h1-7,12-15,17-22H,8-10H2/b7-4+/t12-,13?,14-,15-,16?/m0/s1
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n/an/a 14n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024128
PNG
(5-(4-Bromo-benzylamino)-1-hydroxymethyl-cyclohexan...)
Show SMILES OC[C@@]1(O)C[C@H](NCc2ccc(Br)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H20BrNO5/c15-9-3-1-8(2-4-9)6-16-10-5-14(21,7-17)13(20)12(19)11(10)18/h1-4,10-13,16-21H,5-7H2/t10-,11?,12-,13-,14?/m0/s1
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024126
PNG
(1-Hydroxymethyl-5-[(pyridin-3-ylmethyl)-amino]-cyc...)
Show SMILES OC[C@@]1(O)C[C@H](NCc2cccnc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C13H20N2O5/c16-7-13(20)4-9(10(17)11(18)12(13)19)15-6-8-2-1-3-14-5-8/h1-3,5,9-12,15-20H,4,6-7H2/t9-,10?,11-,12-,13?/m0/s1
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024117
PNG
(5-Cyclohexylamino-1-hydroxymethyl-cyclohexane-1,2,...)
Show SMILES OC[C@@]1(O)C[C@H](NC2CCCCC2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C13H25NO5/c15-7-13(19)6-9(10(16)11(17)12(13)18)14-8-4-2-1-3-5-8/h8-12,14-19H,1-7H2/t9-,10?,11-,12-,13?/m0/s1
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50048090
PNG
(CHEMBL3311519)
Show SMILES OC[C@@H]1N[C@@H](CCCCc2cc(F)cc(F)c2)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C15H21F2NO3/c16-10-5-9(6-11(17)7-10)3-1-2-4-12-14(20)15(21)13(8-19)18-12/h5-7,12-15,18-21H,1-4,8H2/t12-,13-,14-,15-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry


Bioorg Med Chem Lett 24: 3298-301 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins


Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal sucrase using sucrose as substrate


J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50333455
PNG
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry


Bioorg Med Chem Lett 24: 3298-301 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50405389
PNG
(CHEMBL2051982)
Show SMILES C[C@H]1C[C@@H](O)[C@H](O)[C@@H](O)[C@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO8/c1-5-2-7(17)10(19)11(20)8(5)15-6-3-14(23,4-16)13(22)12(21)9(6)18/h5-13,15-23H,2-4H2,1H3/t5-,6-,7+,8-,9-,10-,11-,12+,13-,14-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50405396
PNG
(CHEMBL2051762)
Show SMILES C[C@H]1C[C@H](O)[C@H](O)[C@@H](O)[C@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO8/c1-5-2-7(17)10(19)11(20)8(5)15-6-3-14(23,4-16)13(22)12(21)9(6)18/h5-13,15-23H,2-4H2,1H3/t5-,6-,7-,8-,9-,10-,11-,12+,13-,14-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM18353
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM18353
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50375510
PNG
(CHEMBL405957)
Show SMILES OC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of rat isomaltase


Bioorg Med Chem 16: 2734-40 (2008)


Article DOI: 10.1016/j.bmc.2008.01.032
BindingDB Entry DOI: 10.7270/Q2FB53T0
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50180584
PNG
(CHEMBL3814496)
Show SMILES [Cl-].OC[C@H](OCc1ccccc1[N+]([O-])=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C16H24NO8S.ClH/c18-5-14(25-7-10-3-1-2-4-11(10)17(23)24)12(20)8-26-9-13(21)16(22)15(26)6-19;/h1-4,12-16,18-22H,5-9H2;1H/q+1;/p-1/t12-,13-,14+,15-,16+,26?;/m1./s1
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n/an/a 42n/an/an/an/an/an/a



Kindai University

Curated by ChEMBL


Assay Description
Inhibition of rat small intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase method


Bioorg Med Chem 24: 3705-15 (2016)


Article DOI: 10.1016/j.bmc.2016.06.013
BindingDB Entry DOI: 10.7270/Q241700V
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50048086
PNG
(CHEMBL3311515)
Show SMILES Cc1ccc(CCCC[C@@H]2N[C@@H](CO)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C16H25NO3/c1-11-6-8-12(9-7-11)4-2-3-5-13-15(19)16(20)14(10-18)17-13/h6-9,13-20H,2-5,10H2,1H3/t13-,14-,15-,16-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry


Bioorg Med Chem Lett 24: 3298-301 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50024129
PNG
(5-Amino-1-hydroxymethyl-cyclohexane-1,2,3,4-tetrao...)
Show SMILES N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C7H15NO5/c8-3-1-7(13,2-9)6(12)5(11)4(3)10/h3-6,9-13H,1-2,8H2
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n/an/a 49n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50263044
PNG
(CHEMBL476960 | Voglibose)
Show SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal brush border membrane sucrase


Bioorg Med Chem 16: 7330-6 (2008)


Article DOI: 10.1016/j.bmc.2008.06.026
BindingDB Entry DOI: 10.7270/Q27D2W2B
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50375511
PNG
(CHEMBL406973)
Show SMILES OC[C@@H]1NC[C@H](O)[C@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of rat isomaltase


Bioorg Med Chem 16: 2734-40 (2008)


Article DOI: 10.1016/j.bmc.2008.01.032
BindingDB Entry DOI: 10.7270/Q2FB53T0
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Homo sapiens (Human))
BDBM50405393
PNG
(CHEMBL2051981)
Show SMILES CO[C@H]1O[C@H](CO)[C@@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO10/c1-24-13-11(21)9(19)7(6(3-16)25-13)15-5-2-14(23,4-17)12(22)10(20)8(5)18/h5-13,15-23H,2-4H2,1H3/t5-,6+,7+,8-,9-,10+,11+,12-,13-,14-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50180582
PNG
(CHEMBL3814988)
Show SMILES [Cl-].CC(C)CO[C@@H](CO)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C13H27O6S.ClH/c1-8(2)5-19-11(3-14)9(16)6-20-7-10(17)13(18)12(20)4-15;/h8-18H,3-7H2,1-2H3;1H/q+1;/p-1/t9-,10-,11+,12-,13+,20?;/m1./s1
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n/an/a 90n/an/an/an/an/an/a



Kindai University

Curated by ChEMBL


Assay Description
Inhibition of rat small intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase method


Bioorg Med Chem 24: 3705-15 (2016)


Article DOI: 10.1016/j.bmc.2016.06.013
BindingDB Entry DOI: 10.7270/Q241700V
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50156356
PNG
(2-Hydroxymethyl-6-octyl-piperidine-3,4,5-triol | C...)
Show SMILES CCCCCCCCC1NC(CO)C(O)C(O)C1O
Show InChI InChI=1S/C14H29NO4/c1-2-3-4-5-6-7-8-10-12(17)14(19)13(18)11(9-16)15-10/h10-19H,2-9H2,1H3
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n/an/a 90n/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal isomaltase using disaccharide


Bioorg Med Chem Lett 14: 5991-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.086
BindingDB Entry DOI: 10.7270/Q27P904W
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50180583
PNG
(CHEMBL3815109)
Show SMILES [Cl-].CC(C)(C)CO[C@@H](CO)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C14H29O6S.ClH/c1-14(2,3)8-20-11(4-15)9(17)6-21-7-10(18)13(19)12(21)5-16;/h9-13,15-19H,4-8H2,1-3H3;1H/q+1;/p-1/t9-,10-,11+,12-,13+,21?;/m1./s1
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n/an/a 90n/an/an/an/an/an/a



Kindai University

Curated by ChEMBL


Assay Description
Inhibition of rat small intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase method


Bioorg Med Chem 24: 3705-15 (2016)


Article DOI: 10.1016/j.bmc.2016.06.013
BindingDB Entry DOI: 10.7270/Q241700V
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50242818
PNG
(1-Oxo-1lambda-4-thia-cyclotridecan-3,4,5,6,8,10,11...)
Show SMILES OC1CC(O)C(O)C(O)CS(=O)CC(O)C(O)C(O)C(O)C1
Show InChI InChI=1S/C12H24O9S/c13-5-1-6(14)10(18)8(16)3-22(21)4-9(17)12(20)11(19)7(15)2-5/h5-20H,1-4H2
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n/an/a 99n/an/an/an/an/an/a



Fuji-Sangyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal isomaltase


J Nat Prod 71: 981-4 (2008)


Article DOI: 10.1021/np070604h
BindingDB Entry DOI: 10.7270/Q2XS5W9M
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50573735
PNG
(CHEMBL4860203)
Show SMILES Cl.CC[C@]1(CO)NC[C@H](O)[C@@H](O)[C@@H]1O |r|
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n/an/a 100n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat intestinal sucrase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113716
BindingDB Entry DOI: 10.7270/Q27W6H1P
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50375510
PNG
(CHEMBL405957)
Show SMILES OC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of rat sucrase


Bioorg Med Chem 16: 2734-40 (2008)


Article DOI: 10.1016/j.bmc.2008.01.032
BindingDB Entry DOI: 10.7270/Q2FB53T0
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50612995
PNG
(CHEMBL5276586)
Show SMILES Cl.[H][C@@]1(OC(OC[C@H]1O)c1ccccc1[N+]([O-])=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
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n/an/a 100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50242271
PNG
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)
Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal brush border membrane sucrase


Bioorg Med Chem 16: 7330-6 (2008)


Article DOI: 10.1016/j.bmc.2008.06.026
BindingDB Entry DOI: 10.7270/Q27D2W2B
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50333457
PNG
((2S,3S,4S,5S)-2-hexyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C11H23NO3/c1-2-3-4-5-6-8-10(14)11(15)9(7-13)12-8/h8-15H,2-7H2,1H3/t8-,9-,10-,11-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat small intestine sucrase after 30 mins


Bioorg Med Chem Lett 21: 738-41 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50333457
PNG
((2S,3S,4S,5S)-2-hexyl-5-(hydroxymethyl)pyrrolidine...)
Show SMILES CCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C11H23NO3/c1-2-3-4-5-6-8-10(14)11(15)9(7-13)12-8/h8-15H,2-7H2,1H3/t8-,9-,10-,11-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal sucrase using sucrose as substrate


J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50048088
PNG
(CHEMBL3311517)
Show SMILES OC[C@@H]1N[C@@H](CCCCc2ccc(O)cc2)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C15H23NO4/c17-9-13-15(20)14(19)12(16-13)4-2-1-3-10-5-7-11(18)8-6-10/h5-8,12-20H,1-4,9H2/t12-,13-,14-,15-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry


Bioorg Med Chem Lett 24: 3298-301 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50573741
PNG
(CHEMBL4873807)
Show SMILES Cl.CCCCCCCC[C@]1(CO)NC[C@H](O)[C@@H](O)[C@@H]1O |r|
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n/an/a 120n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat intestinal sucrase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113716
BindingDB Entry DOI: 10.7270/Q27W6H1P
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50180520
PNG
(CHEMBL3814838)
Show SMILES [Cl-].CCO[C@@H](CO)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C11H23O6S.ClH/c1-2-17-9(3-12)7(14)5-18-6-8(15)11(16)10(18)4-13;/h7-16H,2-6H2,1H3;1H/q+1;/p-1/t7-,8-,9+,10-,11+,18?;/m1./s1
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n/an/a 120n/an/an/an/an/an/a



Kindai University

Curated by ChEMBL


Assay Description
Inhibition of rat small intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase method


Bioorg Med Chem 24: 3705-15 (2016)


Article DOI: 10.1016/j.bmc.2016.06.013
BindingDB Entry DOI: 10.7270/Q241700V
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM18363
PNG
((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-octylpiperidi...)
Show SMILES CCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C14H29NO4/c1-2-3-4-5-6-7-8-10-12(17)14(19)13(18)11(9-16)15-10/h10-19H,2-9H2,1H3/t10-,11-,12+,13-,14-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal isomaltase using isomoltose as substrate


J Med Chem 55: 10347-62 (2012)


Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50342937
PNG
((1S,2R,3S,4S)-1-((2S,3S)-3-ethoxy-2,4-dihydroxybut...)
Show SMILES CCO[C@@H](CO)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C11H23O6S/c1-2-17-9(3-12)7(14)5-18-6-8(15)11(16)10(18)4-13/h7-16H,2-6H2,1H3/q+1/t7-,8-,9+,10-,11+,18-/m1/s1
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Kinki University

Curated by ChEMBL


Assay Description
Inhibition of rat small intestinal sucrase after 30 mins by glucose-oxidase method


Bioorg Med Chem Lett 21: 3159-62 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.109
BindingDB Entry DOI: 10.7270/Q2DF6RJC
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))
BDBM50048087
PNG
(CHEMBL3311516)
Show SMILES COc1ccc(CCCC[C@@H]2N[C@@H](CO)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C16H25NO4/c1-21-12-8-6-11(7-9-12)4-2-3-5-13-15(19)16(20)14(10-18)17-13/h6-9,13-20H,2-5,10H2,1H3/t13-,14-,15-,16-/m0/s1
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Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry


Bioorg Med Chem Lett 24: 3298-301 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS
More data for this
Ligand-Target Pair
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