Found 8420 hits Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50408387
(CHEMBL5268482)Show SMILES CC(O)C(NC(C)=O)C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C2CCCCC2CC1C(=O)N(C)Cc1ccccc1 Show InChI InChI=1S/C36H45N5O6/c1-22(42)33(37-23(2)43)34(45)38-29(20-28-18-26-14-8-10-16-30(26)40(28)24(3)44)35(46)41-31-17-11-9-15-27(31)19-32(41)36(47)39(4)21-25-12-6-5-7-13-25/h5-8,10,12-14,16,18,22,27,29,31-33,42H,9,11,15,17,19-21H2,1-4H3,(H,37,43)(H,38,45)/t22?,27?,29-,31?,32?,33?/m1/s1 | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo... |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50191945
(CHEMBL3904768)Show SMILES Cn1nccc1-c1ccn2c(cnc2c1)C(=O)Nc1cc(ccc1F)C(=O)NCc1ccc(F)c(F)c1 Show InChI InChI=1S/C26H19F3N6O2/c1-34-22(6-8-32-34)16-7-9-35-23(14-30-24(35)12-16)26(37)33-21-11-17(3-5-19(21)28)25(36)31-13-15-2-4-18(27)20(29)10-15/h2-12,14H,13H2,1H3,(H,31,36)(H,33,37) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research (NIBR)
Curated by ChEMBL
| Assay Description Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresis |
J Med Chem 59: 7901-14 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00703 BindingDB Entry DOI: 10.7270/Q25X2BW1 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50477652
(CHEMBL250790)Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncc(s1)C(=O)NO Show InChI InChI=1S/C15H18N4O4S2/c1-11-2-4-12(5-3-11)25(22,23)19-8-6-18(7-9-19)15-16-10-13(24-15)14(20)17-21/h2-5,10,21H,6-9H2,1H3,(H,17,20) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM25117
(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 Show InChI InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 (unknown origin) |
Eur J Med Chem 142: 383-392 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.007 BindingDB Entry DOI: 10.7270/Q2WS8WZZ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM25117
(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 Show InChI InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Fuzhou University
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 (unknown origin) |
Eur J Med Chem 179: 916-935 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.070 BindingDB Entry DOI: 10.7270/Q2KD224D |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Inhibition of PDGFRalpha |
J Med Chem 52: 3191-204 (2009)
Article DOI: 10.1021/jm800861c BindingDB Entry DOI: 10.7270/Q23J3DWT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50206389
(CHEMBL3939307)Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1 Show InChI InChI=1S/C22H20N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-8,10-11,13-14H,9,12H2,1H3,(H,23,27)(H,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiwan National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 (unknown origin) |
Eur J Med Chem 124: 186-199 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.026 BindingDB Entry DOI: 10.7270/Q2668G5M |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265774
(4-Amino-3-benzimidazol-2-yl-5-(1-methyl(3-piperidy...)Show SMILES CN1CCCC(C1)Oc1cccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N)c12 Show InChI InChI=1S/C22H23N5O2/c1-27-11-5-6-13(12-27)29-17-10-4-9-16-18(17)20(23)19(22(28)26-16)21-24-14-7-2-3-8-15(14)25-21/h2-4,7-10,13H,5-6,11-12H2,1H3,(H,24,25)(H3,23,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50191977
(CHEMBL3983564)Show SMILES CN1CCN(CC1)c1ccccc1CNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(ccn23)-c2cc[nH]n2)c1 Show InChI InChI=1S/C30H29FN8O2/c1-37-12-14-38(15-13-37)26-5-3-2-4-22(26)18-33-29(40)21-6-7-23(31)25(16-21)35-30(41)27-19-32-28-17-20(9-11-39(27)28)24-8-10-34-36-24/h2-11,16-17,19H,12-15,18H2,1H3,(H,33,40)(H,34,36)(H,35,41) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research (NIBR)
Curated by ChEMBL
| Assay Description Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresis |
J Med Chem 59: 7901-14 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00703 BindingDB Entry DOI: 10.7270/Q25X2BW1 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265746
(CHEMBL526507 | {4-Amino-3-[6-(4-methylpiperazinyl)...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2cc(ccc2[nH]c1=O)C(=O)NCc1ccccc1 Show InChI InChI=1S/C29H29N7O2/c1-35-11-13-36(14-12-35)20-8-10-23-24(16-20)33-27(32-23)25-26(30)21-15-19(7-9-22(21)34-29(25)38)28(37)31-17-18-5-3-2-4-6-18/h2-10,15-16H,11-14,17H2,1H3,(H,31,37)(H,32,33)(H3,30,34,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50608338
(CHEMBL5268427) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM581371
(US11505527, Compound 4j)Show SMILES Cc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C1C(C(=O)c2ccccc2)=C(N)NC2=C1C(=O)CC(C)(C)C2 |c:32,t:28| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25B06BK |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50191981
(CHEMBL3979322)Show SMILES CN1CCN(CC1)c1ccccc1CNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(ccn23)-c2ccnn2C)c1 Show InChI InChI=1S/C31H31FN8O2/c1-37-13-15-39(16-14-37)27-6-4-3-5-23(27)19-34-30(41)22-7-8-24(32)25(17-22)36-31(42)28-20-33-29-18-21(10-12-40(28)29)26-9-11-35-38(26)2/h3-12,17-18,20H,13-16,19H2,1-2H3,(H,34,41)(H,36,42) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research (NIBR)
Curated by ChEMBL
| Assay Description Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresis |
J Med Chem 59: 7901-14 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00703 BindingDB Entry DOI: 10.7270/Q25X2BW1 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50191973
(CHEMBL3940697)Show SMILES Cn1cc(cn1)-c1ccn2c(cnc2c1)C(=O)Nc1cc(ccc1F)C(=O)NCCN1CCCC1(C)C Show InChI InChI=1S/C27H30FN7O2/c1-27(2)8-4-10-34(27)12-9-29-25(36)19-5-6-21(28)22(13-19)32-26(37)23-16-30-24-14-18(7-11-35(23)24)20-15-31-33(3)17-20/h5-7,11,13-17H,4,8-10,12H2,1-3H3,(H,29,36)(H,32,37) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research (NIBR)
Curated by ChEMBL
| Assay Description Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresis |
J Med Chem 59: 7901-14 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00703 BindingDB Entry DOI: 10.7270/Q25X2BW1 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265574
(3-(1H-benzo[d]imidazol-2-yl)-4-(4-ethyl-1-methylpi...)Show SMILES CCC1CCN(C)C(C1)Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C24H27N5O/c1-3-15-12-13-29(2)20(14-15)28-22-16-8-4-5-9-17(16)27-24(30)21(22)23-25-18-10-6-7-11-19(18)26-23/h4-11,15,20H,3,12-14H2,1-2H3,(H,25,26)(H2,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50191978
(CHEMBL3915941)Show SMILES Cc1ncc(cc1NC(=O)c1cnn2cc(ccc12)-c1cnn(C)c1)C(=O)NCCN1CCCC1(C)C Show InChI InChI=1S/C27H32N8O2/c1-18-23(12-20(13-29-18)25(36)28-9-11-34-10-5-8-27(34,2)3)32-26(37)22-15-31-35-17-19(6-7-24(22)35)21-14-30-33(4)16-21/h6-7,12-17H,5,8-11H2,1-4H3,(H,28,36)(H,32,37) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research (NIBR)
Curated by ChEMBL
| Assay Description Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresis |
J Med Chem 59: 7901-14 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00703 BindingDB Entry DOI: 10.7270/Q25X2BW1 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50381946
(CHEMBL2023485)Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)[nH]n1 Show InChI InChI=1S/C25H26N4O5/c1-5-16-11-24(29-28-16)27-25(30)10-15-6-7-17(12-21(15)31-2)34-20-8-9-26-19-14-23(33-4)22(32-3)13-18(19)20/h6-9,11-14H,5,10H2,1-4H3,(H2,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 22: 3050-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.074 BindingDB Entry DOI: 10.7270/Q298881Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50381945
(CHEMBL2023477)Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1noc(C)c1C Show InChI InChI=1S/C25H25N3O6/c1-14-15(2)34-28-25(14)27-24(29)10-16-6-7-17(11-21(16)30-3)33-20-8-9-26-19-13-23(32-5)22(31-4)12-18(19)20/h6-9,11-13H,10H2,1-5H3,(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 22: 3050-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.074 BindingDB Entry DOI: 10.7270/Q298881Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50608646
(CHEMBL5288936) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50608647
(CHEMBL5267724) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50518950
(CHEMBL4468881)Show SMILES COc1ccc2c3conc3c(=O)n(CCN3CCC(CC3)NCc3ccc4OCC(=O)Nc4n3)c2c1 Show InChI InChI=1S/C26H28N6O5/c1-35-18-3-4-19-20-14-37-30-24(20)26(34)32(21(19)12-18)11-10-31-8-6-16(7-9-31)27-13-17-2-5-22-25(28-17)29-23(33)15-36-22/h2-5,12,14,16,27H,6-11,13,15H2,1H3,(H,28,29,33) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50608648
(CHEMBL5286715) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50331095
(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 |
J Med Chem 55: 10797-822 (2012)
Article DOI: 10.1021/jm301085w BindingDB Entry DOI: 10.7270/Q2BP03XZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50608650
(CHEMBL5271348) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50608649
(CHEMBL5290499) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50450068
(CHEMBL5275288)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1ccccc1O)C(C)C)C(=O)N[C@@H](CO)C(O)=O Show InChI InChI=1S/C21H31N3O7/c1-11(2)9-14(19(28)23-15(10-25)21(30)31)22-20(29)17(12(3)4)24-18(27)13-7-5-6-8-16(13)26/h5-8,11-12,14-15,17,25-26H,9-10H2,1-4H3,(H,22,29)(H,23,28)(H,24,27)(H,30,31)/t14-,15-,17-/m0/s1 | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 0.216 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50450067
(CHEMBL5279750)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1ccccc1OCc1ccccc1)C(C)C)C(=O)N[C@@H](CO)C(O)=O Show InChI InChI=1S/C28H37N3O7/c1-17(2)14-21(26(34)30-22(15-32)28(36)37)29-27(35)24(18(3)4)31-25(33)20-12-8-9-13-23(20)38-16-19-10-6-5-7-11-19/h5-13,17-18,21-22,24,32H,14-16H2,1-4H3,(H,29,35)(H,30,34)(H,31,33)(H,36,37)/t21-,22-,24-/m0/s1 | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 0.216 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50336457
((3S,5Z,8S,9R,11E)-8,9,16-trihydroxy-14-methoxy-3-m...)Show SMILES COc1cc(O)c2c(CCCC(=O)C(=O)C(=O)CCC[C@H](C)OC2=O)c1 |r| Show InChI InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h9-11,22H,3-8H2,1-2H3/t11-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Ireland
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRalpha in cell free system after 60 mins |
Bioorg Med Chem Lett 21: 1167-70 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.100 BindingDB Entry DOI: 10.7270/Q23T9HH5 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50408386
(CHEMBL5287343)Show SMILES CC(O)C(NC(C)=O)C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1 Show InChI InChI=1S/C37H43N5O6/c1-23(28-16-10-7-11-17-28)41(5)37(48)32(20-27-14-8-6-9-15-27)40-35(46)31(39-36(47)34(24(2)43)38-25(3)44)22-30-21-29-18-12-13-19-33(29)42(30)26(4)45/h6-19,21,23-24,31-32,34,43H,20,22H2,1-5H3,(H,38,44)(H,39,47)(H,40,46)/t23?,24?,31-,32?,34?/m1/s1 | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo... |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank US Patent
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25B06BK |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472775
(US10829493, Example 1)Show InChI InChI=1S/C13H16N6O/c1-13(2,20)7-18-5-10(4-16-18)9-3-11-12(14)15-8-17-19(11)6-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50381931
(CHEMBL2023476)Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4ncc(C)s4)c(OC)c3)ccnc2c1 Show InChI InChI=1S/C23H21N3O4S/c1-14-13-25-23(31-14)26-22(27)10-15-4-5-17(12-21(15)29-3)30-20-8-9-24-19-11-16(28-2)6-7-18(19)20/h4-9,11-13H,10H2,1-3H3,(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 22: 3050-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.074 BindingDB Entry DOI: 10.7270/Q298881Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472777
(US10829493, Example 3)Show InChI InChI=1S/C12H14N6O/c1-8(19)4-17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)6-9/h2-3,5-8,19H,4H2,1H3,(H2,13,14,16)/t8-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472778
(US10829493, Example 4)Show InChI InChI=1S/C11H12N6O/c12-11-10-3-8(6-17(10)15-7-13-11)9-4-14-16(5-9)1-2-18/h3-7,18H,1-2H2,(H2,12,13,15) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472779
(US10829493, Example 5)Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472780
(US10829493, Example 6)Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472781
(US10829493, Example 7)Show InChI InChI=1S/C12H12N6O/c13-12-11-1-8(3-18(11)16-7-14-12)9-2-15-17(4-9)10-5-19-6-10/h1-4,7,10H,5-6H2,(H2,13,14,16) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472782
(US10829493, Example 8)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2COC2)c1 |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,23-2-4-25(30)5-3-23)24-12-32-28(33-13-24)38-8-6-37(7-9-38)27-26-10-21(16-40(26)36-19-34-27)22-11-35-39(15-22)14-20-17-41-18-20/h2-5,10-13,15-16,19-20H,6-9,14,17-18,31H2,1H3/t29-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472783
(US10829493, Example 9)Show SMILES C[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H31FN10O/c1-19(40)15-38-16-21(12-34-38)20-11-25-26(33-18-35-39(25)17-20)36-7-9-37(10-8-36)27-31-13-23(14-32-27)28(2,30)22-3-5-24(29)6-4-22/h3-6,11-14,16-19,40H,7-10,15,30H2,1-2H3/t19-,28-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472784
(US10829493, Example 10)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1 |r,wU:1.0,38.44,wD:1.1,(2.18,-6.48,;3.27,-5.39,;1.78,-4.99,;4.6,-6.16,;4.6,-7.7,;5.93,-8.47,;7.27,-7.7,;8.6,-8.47,;7.27,-6.16,;5.93,-5.39,;3.27,-3.85,;1.93,-3.08,;1.93,-1.54,;3.27,-.77,;4.6,-1.54,;4.6,-3.08,;3.27,.77,;1.93,1.54,;1.93,3.08,;3.27,3.85,;4.6,3.08,;4.6,1.54,;3.27,5.39,;4.6,6.16,;4.6,7.7,;3.27,8.47,;1.93,7.7,;.47,8.18,;-.44,6.93,;.47,5.68,;1.93,6.16,;-1.98,6.93,;-2.88,8.18,;-4.35,7.7,;-4.35,6.16,;-2.88,5.68,;-5.59,5.25,;-7.11,5.5,;-7.36,3.97,;-8.6,3.07,;-5.83,3.73,)| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472785
(US10829493, Example 11)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1 |r,wU:1.0,wD:1.1,38.44,(2.18,-6.48,;3.27,-5.39,;1.78,-4.99,;4.6,-6.16,;4.6,-7.7,;5.93,-8.47,;7.27,-7.7,;8.6,-8.47,;7.27,-6.16,;5.93,-5.39,;3.27,-3.85,;1.93,-3.08,;1.93,-1.54,;3.27,-.77,;4.6,-1.54,;4.6,-3.08,;3.27,.77,;1.93,1.54,;1.93,3.08,;3.27,3.85,;4.6,3.08,;4.6,1.54,;3.27,5.39,;4.6,6.16,;4.6,7.7,;3.27,8.47,;1.93,7.7,;.47,8.18,;-.44,6.93,;.47,5.68,;1.93,6.16,;-1.98,6.93,;-2.88,8.18,;-4.35,7.7,;-4.35,6.16,;-2.88,5.68,;-5.59,5.25,;-5.83,3.73,;-7.36,3.97,;-8.6,3.07,;-7.11,5.5,)| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472786
(US10829493, Example 12)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2(O)CC2)c1 |r| Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(17-40(25)36-19-34-26)21-13-35-39(16-21)18-29(41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472787
(US10829493, Example 13)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1(CO)CC1 |r| Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(16-39(25)36-19-34-26)21-13-35-40(17-21)29(18-41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472788
(US10829493, Example 14)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CCOC1 |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472789
(US10829493, Example 15)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CCOC1 |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472790
(US10829493, Example 16)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1CCOCC1 |r| Show InChI InChI=1S/C30H33FN10O/c1-30(32,23-2-4-25(31)5-3-23)24-16-33-29(34-17-24)39-10-8-38(9-11-39)28-27-14-21(18-41(27)37-20-35-28)22-15-36-40(19-22)26-6-12-42-13-7-26/h2-5,14-20,26H,6-13,32H2,1H3/t30-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472791
(US10829493, Example 17)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472792
(US10829493, Example 18)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472793
(US10829493, Example 19)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha [D842V]
(Homo sapiens (Human)) | BDBM472794
(US10829493, Example 20)Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Blueprint Medicines Corporation
US Patent
| Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu... |
US Patent US10829493 (2020)
BindingDB Entry DOI: 10.7270/Q2MP56BZ |
More data for this Ligand-Target Pair | |