BindingDB PrimarySearch

Found 6 hits Enz. Inhib. hit(s) with Target = 'Polyphenol oxidase (PPO)'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] (Agaricus bisporus (Mushroom))	BDBM173587 ((2E)-3-(3,5-dihydroxyphenyl)-1-(3-hydroxynaphthale...) Show SMILES Oc1cc(O)cc(\C=C\C(=O)c2cc3ccccc3cc2O)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.80E+3	n/a	1.04E+4	n/a	n/a	n/a	n/a	6.8	n/a
University of Technology Sydney					Assay Description The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...				Bioorg Chem 63: 116-22 (2015) Article DOI: 10.1016/j.bioorg.2015.10.003 BindingDB Entry DOI: 10.7270/Q2MS3RH3
University of Technology Sydney					More data for this Ligand-Target Pair
Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] (Agaricus bisporus (Mushroom))	BDBM173584 ((2E)-3-(2,4-dihydroxyphenyl)-1-(3-hydroxynaphthale...) Show SMILES Oc1ccc(\C=C\C(=O)c2cc3ccccc3cc2O)c(O)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	4.50E+3	n/a	1.44E+4	n/a	n/a	n/a	n/a	6.8	n/a
University of Technology Sydney					Assay Description The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...				Bioorg Chem 63: 116-22 (2015) Article DOI: 10.1016/j.bioorg.2015.10.003 BindingDB Entry DOI: 10.7270/Q2MS3RH3
University of Technology Sydney					More data for this Ligand-Target Pair
Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] (Agaricus bisporus (Mushroom))	BDBM173583 ((2E)-3-(2,5-dihydroxyphenyl)-1-(3-hydroxynaphthale...) Show SMILES Oc1ccc(O)c(\C=C\C(=O)c2cc3ccccc3cc2O)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.08E+4	n/a	2.04E+4	n/a	n/a	n/a	n/a	6.8	n/a
University of Technology Sydney					Assay Description The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...				Bioorg Chem 63: 116-22 (2015) Article DOI: 10.1016/j.bioorg.2015.10.003 BindingDB Entry DOI: 10.7270/Q2MS3RH3
University of Technology Sydney					More data for this Ligand-Target Pair
Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] (Agaricus bisporus (Mushroom))	BDBM173585 ((2E)-1-(3-hydroxynaphthalen-2-yl)-3-(2-hydroxy-4-n...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.12E+4	n/a	2.29E+4	n/a	n/a	n/a	n/a	6.8	n/a
University of Technology Sydney					Assay Description The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...				Bioorg Chem 63: 116-22 (2015) Article DOI: 10.1016/j.bioorg.2015.10.003 BindingDB Entry DOI: 10.7270/Q2MS3RH3
University of Technology Sydney					More data for this Ligand-Target Pair
Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] (Agaricus bisporus (Mushroom))	BDBM173586 ((2E)-1-(3-hydroxynaphthalen-2-yl)-3-(4-hydroxy-3-n...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.19E+4	n/a	2.56E+4	n/a	n/a	n/a	n/a	6.8	n/a
University of Technology Sydney					Assay Description The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...				Bioorg Chem 63: 116-22 (2015) Article DOI: 10.1016/j.bioorg.2015.10.003 BindingDB Entry DOI: 10.7270/Q2MS3RH3
University of Technology Sydney					More data for this Ligand-Target Pair
Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] (Agaricus bisporus (Mushroom))	BDBM50031467 (5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE \| 5-Hyd...) Show SMILES OCc1cc(=O)c(O)co1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.22E+4	n/a	2.75E+4	n/a	n/a	n/a	n/a	6.8	n/a
University of Technology Sydney					Assay Description The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...				Bioorg Chem 63: 116-22 (2015) Article DOI: 10.1016/j.bioorg.2015.10.003 BindingDB Entry DOI: 10.7270/Q2MS3RH3
University of Technology Sydney					More data for this Ligand-Target Pair