Found 18 hits Enz. Inhib. hit(s) with Target = 'Cholinergic, Nicotinic Muscle' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50100712
(2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptan...)Show InChI InChI=1S/C11H13IN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by PDSP Ki Database
| |
Mol Pharmacol 57: 642-9 (2000)
Article DOI: 10.1124/mol.57.3.642 BindingDB Entry DOI: 10.7270/Q21C1VF8 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB
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| 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by PDSP Ki Database
| |
Mol Pharmacol 57: 642-9 (2000)
Article DOI: 10.1124/mol.57.3.642 BindingDB Entry DOI: 10.7270/Q21C1VF8 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50107863
((-)-cytisine | (1R,9R)-7,11-diazatricyclo[7.3.1.0~...)Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2 | PDB
Reactome pathway KEGG
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| Article PubMed
| 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by PDSP Ki Database
| |
Mol Pharmacol 57: 642-9 (2000)
Article DOI: 10.1124/mol.57.3.642 BindingDB Entry DOI: 10.7270/Q21C1VF8 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50049750
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1 | PDB
Reactome pathway KEGG
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| 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by PDSP Ki Database
| |
Mol Pharmacol 57: 642-9 (2000)
Article DOI: 10.1124/mol.57.3.642 BindingDB Entry DOI: 10.7270/Q21C1VF8 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50004108
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 | PDB
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
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| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by PDSP Ki Database
| |
Mol Pharmacol 57: 642-9 (2000)
Article DOI: 10.1124/mol.57.3.642 BindingDB Entry DOI: 10.7270/Q21C1VF8 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50066789
(3-((S)-1-Azetidin-2-ylmethoxy)-5-iodo-pyridine | A...)Show InChI InChI=1S/C9H11IN2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8/h3-5,8,12H,1-2,6H2/t8-/m0/s1 | PDB
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| 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by PDSP Ki Database
| |
Mol Pharmacol 57: 642-9 (2000)
Article DOI: 10.1124/mol.57.3.642 BindingDB Entry DOI: 10.7270/Q21C1VF8 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM86694
(N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyform...)Show InChI InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14) | PDB
Reactome pathway KEGG
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| PC cid PC sid UniChem
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 314: 77-85 (2005)
Article DOI: 10.1124/jpet.105.083964 BindingDB Entry DOI: 10.7270/Q2MW2FQQ |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
Reactome pathway KEGG
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KEGG PC cid PC sid PDB UniChem
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| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity towards Nicotinic acetylcholine receptor by the displacement of [3H]-nicotine from rat cortical membranes |
J Med Chem 42: 1684-6 (1999)
Article DOI: 10.1021/jm990035d BindingDB Entry DOI: 10.7270/Q2QC02PQ |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50077117
(4-[2-(1-Methyl-pyrrolidin-2-yl)-ethylsulfanyl]-phe...)Show InChI InChI=1S/C13H19NOS/c1-14-9-2-3-11(14)8-10-16-13-6-4-12(15)5-7-13/h4-7,11,15H,2-3,8-10H2,1H3 | PDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity towards Nicotinic acetylcholine receptor by the displacement of [3H]-nicotine from rat cortical membranes |
J Med Chem 42: 1684-6 (1999)
Article DOI: 10.1021/jm990035d BindingDB Entry DOI: 10.7270/Q2QC02PQ |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50079884
(2-(3-Pentyl-3H-diazirin-3-yl)-ethanol | CHEMBL1118...)Show InChI InChI=1S/C8H16N2O/c1-2-3-4-5-8(6-7-11)9-10-8/h11H,2-7H2,1H3 | PDB
Reactome pathway KEGG
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| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description The compound was tested for inhibitory potency against Nicotinic acetylcholine receptor in Rat muscle. |
J Med Chem 42: 3300-7 (1999)
Article DOI: 10.1021/jm9806300 BindingDB Entry DOI: 10.7270/Q28P5ZPF |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50408545
(CHEMBL135897)Show InChI InChI=1S/C12H14ClN/c13-9-3-1-8(2-4-9)11-7-10-5-6-12(11)14-10/h1-4,10-12,14H,5-7H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by ChEMBL
| Assay Description The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain. |
J Med Chem 41: 4199-206 (1998)
Article DOI: 10.1021/jm980233p BindingDB Entry DOI: 10.7270/Q2FT8N7Z |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50408546
(CHEMBL335204)Show SMILES CCN1C2CCC1C(C2)c1ccc(Cl)cc1 |TLB:9:7:2:5.4| Show InChI InChI=1S/C14H18ClN/c1-2-16-12-7-8-14(16)13(9-12)10-3-5-11(15)6-4-10/h3-6,12-14H,2,7-9H2,1H3 | PDB
Reactome pathway KEGG
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | n/a | 13.6 | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by ChEMBL
| Assay Description The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain. |
J Med Chem 41: 4199-206 (1998)
Article DOI: 10.1021/jm980233p BindingDB Entry DOI: 10.7270/Q2FT8N7Z |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50408547
(CHEMBL135684)Show InChI InChI=1S/C12H14BrN/c13-9-3-1-8(2-4-9)11-7-10-5-6-12(11)14-10/h1-4,10-12,14H,5-7H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.0450 | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by ChEMBL
| Assay Description The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain. |
J Med Chem 41: 4199-206 (1998)
Article DOI: 10.1021/jm980233p BindingDB Entry DOI: 10.7270/Q2FT8N7Z |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50408544
(CHEMBL134341)Show InChI InChI=1S/C13H16ClN/c1-15-11-6-7-13(15)12(8-11)9-2-4-10(14)5-3-9/h2-5,11-13H,6-8H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by ChEMBL
| Assay Description The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain. |
J Med Chem 41: 4199-206 (1998)
Article DOI: 10.1021/jm980233p BindingDB Entry DOI: 10.7270/Q2FT8N7Z |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50408543
(CHEMBL336118)Show InChI InChI=1S/C12H14FN/c13-9-3-1-8(2-4-9)11-7-10-5-6-12(11)14-10/h1-4,10-12,14H,5-7H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.0370 | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by ChEMBL
| Assay Description The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain. |
J Med Chem 41: 4199-206 (1998)
Article DOI: 10.1021/jm980233p BindingDB Entry DOI: 10.7270/Q2FT8N7Z |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50408542
(CHEMBL337276)Show InChI InChI=1S/C13H16BrN/c1-15-11-6-7-13(15)12(8-11)9-2-4-10(14)5-3-9/h2-5,11-13H,6-8H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.0360 | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by ChEMBL
| Assay Description The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain. |
J Med Chem 41: 4199-206 (1998)
Article DOI: 10.1021/jm980233p BindingDB Entry DOI: 10.7270/Q2FT8N7Z |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM50408541
(CHEMBL134418)Show InChI InChI=1S/C13H16FN/c1-15-11-6-7-13(15)12(8-11)9-2-4-10(14)5-3-9/h2-5,11-13H,6-8H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.0280 | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by ChEMBL
| Assay Description The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain. |
J Med Chem 41: 4199-206 (1998)
Article DOI: 10.1021/jm980233p BindingDB Entry DOI: 10.7270/Q2FT8N7Z |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-9
(RAT) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
Reactome pathway KEGG
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KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by ChEMBL
| Assay Description The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain. |
J Med Chem 41: 4199-206 (1998)
Article DOI: 10.1021/jm980233p BindingDB Entry DOI: 10.7270/Q2FT8N7Z |
More data for this Ligand-Target Pair | |