Found 669 hits Enz. Inhib. hit(s) with Target = 'Glycine transporter 2' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50122872
(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)Show InChI InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23) | Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by PDSP Ki Database
| |
Eur J Pharmacol 423: 71-83 (2001)
Article DOI: 10.1016/s0014-2999(01)01087-1
BindingDB Entry DOI: 10.7270/Q23T9FSX |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50102692
(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C Show InChI InChI=1S/C24H32N2O4/c1-26(2)24(12-8-9-13-24)17-25-23(27)19-14-20(28-3)22(21(15-19)29-4)30-16-18-10-6-5-7-11-18/h5-7,10-11,14-15H,8-9,12-13,16-17H2,1-4H3,(H,25,27) | Reactome pathway
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| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023929
(CHEMBL3325502)Show SMILES CN(C)CCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C25H32F3N3O2/c1-30(2)14-3-15-31-16-12-22(13-17-31)29-24(32)20-6-4-19(5-7-20)18-33-23-10-8-21(9-11-23)25(26,27)28/h4-11,22H,3,12-18H2,1-2H3,(H,29,32) | Reactome pathway
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50102692
(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C Show InChI InChI=1S/C24H32N2O4/c1-26(2)24(12-8-9-13-24)17-25-23(27)19-14-20(28-3)22(21(15-19)29-4)30-16-18-10-6-5-7-11-18/h5-7,10-11,14-15H,8-9,12-13,16-17H2,1-4H3,(H,25,27) | Reactome pathway
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT-2 expressed in CHO cells assessed as reduction in [3H]-glycine uptake |
J Med Chem 61: 2652-2679 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00956
BindingDB Entry DOI: 10.7270/Q23B62RZ |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50102692
(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C Show InChI InChI=1S/C24H32N2O4/c1-26(2)24(12-8-9-13-24)17-25-23(27)19-14-20(28-3)22(21(15-19)29-4)30-16-18-10-6-5-7-11-18/h5-7,10-11,14-15H,8-9,12-13,16-17H2,1-4H3,(H,25,27) | Reactome pathway
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2 |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50102692
(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C Show InChI InChI=1S/C24H32N2O4/c1-26(2)24(12-8-9-13-24)17-25-23(27)19-14-20(28-3)22(21(15-19)29-4)30-16-18-10-6-5-7-11-18/h5-7,10-11,14-15H,8-9,12-13,16-17H2,1-4H3,(H,25,27) | Reactome pathway
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 stably expressed in CHO cells assessed as reduction in [3H]glycine uptake incubated for 10 mins by liquid scintillation cou... |
J Med Chem 63: 3834-3867 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01237
BindingDB Entry DOI: 10.7270/Q26113PD |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50102692
(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C Show InChI InChI=1S/C24H32N2O4/c1-26(2)24(12-8-9-13-24)17-25-23(27)19-14-20(28-3)22(21(15-19)29-4)30-16-18-10-6-5-7-11-18/h5-7,10-11,14-15H,8-9,12-13,16-17H2,1-4H3,(H,25,27) | Reactome pathway
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human Glycine Transporter type-2 |
J Med Chem 44: 2679-82 (2001)
BindingDB Entry DOI: 10.7270/Q2DN44BJ |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138590
(2-(7-Hydroxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl...)Show SMILES Oc1ccc2CCN(Cc3ccccc3C(=O)NCC\C=C\c3ccccc3)Cc2c1 Show InChI InChI=1S/C27H28N2O2/c30-25-14-13-22-15-17-29(20-24(22)18-25)19-23-11-4-5-12-26(23)27(31)28-16-7-6-10-21-8-2-1-3-9-21/h1-6,8-14,18,30H,7,15-17,19-20H2,(H,28,31)/b10-6+ | Reactome pathway
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537022
(CHEMBL4587165)Show SMILES Cl.CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H](CCCCN)C(O)=O |r| Show InChI InChI=1S/C24H46N2O3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-23(27)26-22(24(28)29)19-17-18-21-25;/h9-10,22H,2-8,11-21,25H2,1H3,(H,26,27)(H,28,29);1H/b10-9-;/t22-;/m0./s1 | Reactome pathway
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| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50256745
((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)Show SMILES N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1 | Reactome pathway
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| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas at El Paso
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 expressed in porcine aorta epithelial cells assessed as reduction in [3H]-Glycine uptake at pH 7.5 by scintillation spectro... |
ACS Med Chem Lett 10: 904-910 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00003
BindingDB Entry DOI: 10.7270/Q2DF6VR9 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537040
(CHEMBL4515597)Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H](CCSC)C(O)=O |r| Show InChI InChI=1S/C23H43NO3S/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22(25)24-21(23(26)27)19-20-28-2/h10-11,21H,3-9,12-20H2,1-2H3,(H,24,25)(H,26,27)/b11-10-/t21-/m0/s1 | Reactome pathway
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| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138578
(2-(7-Hydroxy-1-methyl-3,4-dihydro-1H-isoquinolin-2...)Show SMILES CC1N(Cc2ccccc2C(=O)NCC\C=C\c2ccccc2)CCc2ccc(O)cc12 Show InChI InChI=1S/C28H30N2O2/c1-21-27-19-25(31)15-14-23(27)16-18-30(21)20-24-12-5-6-13-26(24)28(32)29-17-8-7-11-22-9-3-2-4-10-22/h2-7,9-15,19,21,31H,8,16-18,20H2,1H3,(H,29,32)/b11-7+ | Reactome pathway
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50203568
((1-(4-(6-((5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl...)Show SMILES OCC1(CCCC1)N1CCN(CC1)C1CCc2ccc(OCc3noc(n3)-c3ccccc3F)cc12 |w:13.14| Show InChI InChI=1S/C28H33FN4O3/c29-24-6-2-1-5-22(24)27-30-26(31-36-27)18-35-21-9-7-20-8-10-25(23(20)17-21)32-13-15-33(16-14-32)28(19-34)11-3-4-12-28/h1-2,5-7,9,17,25,34H,3-4,8,10-16,18-19H2 | Reactome pathway
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| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 1675-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.109
BindingDB Entry DOI: 10.7270/Q25H7FXG |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537034
(CHEMBL4572247)Show SMILES Cl.CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H](CCCN)C(O)=O |r| Show InChI InChI=1S/C23H44N2O3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-22(26)25-21(23(27)28)18-17-20-24;/h9-10,21H,2-8,11-20,24H2,1H3,(H,25,26)(H,27,28);1H/b10-9-;/t21-;/m0./s1 | Reactome pathway
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| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138594
(2-(5-Hydroxy-1,3-dihydro-isoindol-2-ylmethyl)-N-(4...)Show SMILES Oc1ccc2CN(Cc3ccccc3C(=O)NCC\C=C\c3ccccc3)Cc2c1 Show InChI InChI=1S/C26H26N2O2/c29-24-14-13-21-17-28(19-23(21)16-24)18-22-11-4-5-12-25(22)26(30)27-15-7-6-10-20-8-2-1-3-9-20/h1-6,8-14,16,29H,7,15,17-19H2,(H,27,30)/b10-6+ | Reactome pathway
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| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138558
(2-[(6-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylam...)Show SMILES Oc1ccc2CC(CCc2c1)NCc1ccccc1C(=O)NCC\C=C\c1ccccc1 Show InChI InChI=1S/C28H30N2O2/c31-26-16-14-22-18-25(15-13-23(22)19-26)30-20-24-11-4-5-12-27(24)28(32)29-17-7-6-10-21-8-2-1-3-9-21/h1-6,8-12,14,16,19,25,30-31H,7,13,15,17-18,20H2,(H,29,32)/b10-6+ | Reactome pathway
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537044
(CHEMBL4562565)Show SMILES Cl.Cl.CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C24H46N4O3.2ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-22(29)28-21(23(30)31)18-17-20-27-24(25)26;;/h9-10,21H,2-8,11-20H2,1H3,(H,28,29)(H,30,31)(H4,25,26,27);2*1H/b10-9-;;/t21-;;/m0../s1 | Reactome pathway
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| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537033
(CHEMBL4535356)Show SMILES Cl.CCCCCCCC\C=C/CCCCCCCC(=O)N[C@H](CCCCN)C(O)=O |r| Show InChI InChI=1S/C24H46N2O3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-23(27)26-22(24(28)29)19-17-18-21-25;/h9-10,22H,2-8,11-21,25H2,1H3,(H,26,27)(H,28,29);1H/b10-9-;/t22-;/m1./s1 | Reactome pathway
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University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023797
(CHEMBL3325511)Show SMILES FC(F)(F)c1ccc(OCc2ccc(cc2)C(=O)NC2CCN(Cc3cccnc3)CC2)cc1 Show InChI InChI=1S/C26H26F3N3O2/c27-26(28,29)22-7-9-24(10-8-22)34-18-19-3-5-21(6-4-19)25(33)31-23-11-14-32(15-12-23)17-20-2-1-13-30-16-20/h1-10,13,16,23H,11-12,14-15,17-18H2,(H,31,33) | Reactome pathway
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| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537043
(CHEMBL4227139)Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r| Show InChI InChI=1S/C29H44N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-21-28(32)31-27(29(33)34)22-24-23-30-26-20-18-17-19-25(24)26/h9-10,17-20,23,27,30H,2-8,11-16,21-22H2,1H3,(H,31,32)(H,33,34)/b10-9-/t27-/m0/s1 | Reactome pathway
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| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138584
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-((E...)Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCC\C=C\c2ccccc2)cc1 Show InChI InChI=1S/C26H28N2O2/c29-24-15-13-22(14-16-24)17-19-27-20-23-11-4-5-12-25(23)26(30)28-18-7-6-10-21-8-2-1-3-9-21/h1-6,8-16,27,29H,7,17-20H2,(H,28,30)/b10-6+ | Reactome pathway
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| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138559
(2-(7-Hydroxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-y...)Show SMILES Oc1ccc2CCN(Cc3ccccc3C(=O)NCC\C=C\c3ccccc3)CCc2c1 Show InChI InChI=1S/C28H30N2O2/c31-26-14-13-23-15-18-30(19-16-24(23)20-26)21-25-11-4-5-12-27(25)28(32)29-17-7-6-10-22-8-2-1-3-9-22/h1-6,8-14,20,31H,7,15-19,21H2,(H,29,32)/b10-6+ | Reactome pathway
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| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023926
(CHEMBL3325505)Show SMILES FC(F)(F)c1ccc(OCc2ccc(cc2)C(=O)NC2CCN(Cc3ccccc3)CC2)cc1 Show InChI InChI=1S/C27H27F3N2O2/c28-27(29,30)23-10-12-25(13-11-23)34-19-21-6-8-22(9-7-21)26(33)31-24-14-16-32(17-15-24)18-20-4-2-1-3-5-20/h1-13,24H,14-19H2,(H,31,33) | Reactome pathway
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| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537049
(CHEMBL4527071)Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)N[C@H](CO)C(O)=O |r| Show InChI InChI=1S/C21H39NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(24)22-19(18-23)21(25)26/h9-10,19,23H,2-8,11-18H2,1H3,(H,22,24)(H,25,26)/b10-9-/t19-/m1/s1 | Reactome pathway
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| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023866
(CHEMBL3325509)Show SMILES OCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C22H25F3N2O3/c23-22(24,25)18-5-7-20(8-6-18)30-15-16-1-3-17(4-2-16)21(29)26-19-9-11-27(12-10-19)13-14-28/h1-8,19,28H,9-15H2,(H,26,29) | Reactome pathway
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| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138556
(2-(7-Hydroxy-3-methyl-3,4-dihydro-1H-isoquinolin-2...)Show SMILES CC1Cc2ccc(O)cc2CN1Cc1ccccc1C(=O)NCC\C=C\c1ccccc1 Show InChI InChI=1S/C28H30N2O2/c1-21-17-23-14-15-26(31)18-25(23)20-30(21)19-24-12-5-6-13-27(24)28(32)29-16-8-7-11-22-9-3-2-4-10-22/h2-7,9-15,18,21,31H,8,16-17,19-20H2,1H3,(H,29,32)/b11-7+ | Reactome pathway
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| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537023
(CHEMBL4542099)Show SMILES Cl.Cl.CCCCCCCC\C=C/CCCCCCCC(=O)N[C@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C24H46N4O3.2ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-22(29)28-21(23(30)31)18-17-20-27-24(25)26;;/h9-10,21H,2-8,11-20H2,1H3,(H,28,29)(H,30,31)(H4,25,26,27);2*1H/b10-9-;;/t21-;;/m1../s1 | Reactome pathway
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| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023928
(CHEMBL3325503)Show SMILES CN(C)CCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C24H30F3N3O2/c1-29(2)15-16-30-13-11-21(12-14-30)28-23(31)19-5-3-18(4-6-19)17-32-22-9-7-20(8-10-22)24(25,26)27/h3-10,21H,11-17H2,1-2H3,(H,28,31) | Reactome pathway
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| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50102687
(4-Butoxy-N-(1-dimethylamino-cyclopentylmethyl)-3,5...)Show InChI InChI=1S/C21H34N2O4/c1-6-7-12-27-19-17(25-4)13-16(14-18(19)26-5)20(24)22-15-21(23(2)3)10-8-9-11-21/h13-14H,6-12,15H2,1-5H3,(H,22,24) | Reactome pathway
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| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human Glycine Transporter type-2 |
J Med Chem 44: 2679-82 (2001)
BindingDB Entry DOI: 10.7270/Q2DN44BJ |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138565
(CHEMBL348200 | N-[4-(4-Chloro-phenyl)-butyl]-2-{[2...)Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCCCc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN2O2/c27-23-12-8-20(9-13-23)5-3-4-17-29-26(31)25-7-2-1-6-22(25)19-28-18-16-21-10-14-24(30)15-11-21/h1-2,6-15,28,30H,3-5,16-19H2,(H,29,31) | Reactome pathway
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| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023930
(CHEMBL3325501)Show SMILES CN1CCC(CC1)N1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C26H32F3N3O2/c1-31-14-12-23(13-15-31)32-16-10-22(11-17-32)30-25(33)20-4-2-19(3-5-20)18-34-24-8-6-21(7-9-24)26(27,28)29/h2-9,22-23H,10-18H2,1H3,(H,30,33) | Reactome pathway
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138555
(2-[(6-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylam...)Show SMILES Oc1ccc2CC(CCc2c1)NCc1ccccc1C(=O)NCCCCc1ccccc1 Show InChI InChI=1S/C28H32N2O2/c31-26-16-14-22-18-25(15-13-23(22)19-26)30-20-24-11-4-5-12-27(24)28(32)29-17-7-6-10-21-8-2-1-3-9-21/h1-5,8-9,11-12,14,16,19,25,30-31H,6-7,10,13,15,17-18,20H2,(H,29,32) | Reactome pathway
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| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50102688
(4-Benzyloxy-N-(1-dimethylamino-cyclohexylmethyl)-3...)Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCCC1)N(C)C Show InChI InChI=1S/C25H34N2O4/c1-27(2)25(13-9-6-10-14-25)18-26-24(28)20-15-21(29-3)23(22(16-20)30-4)31-17-19-11-7-5-8-12-19/h5,7-8,11-12,15-16H,6,9-10,13-14,17-18H2,1-4H3,(H,26,28) | Reactome pathway
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CHEMBL
PC cid
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| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human Glycine Transporter type-2 |
J Med Chem 44: 2679-82 (2001)
BindingDB Entry DOI: 10.7270/Q2DN44BJ |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138561
(2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-(4-...)Show SMILES Cc1ccc(CCCCNC(=O)c2ccccc2CNCCc2ccc(O)cc2)cc1 Show InChI InChI=1S/C27H32N2O2/c1-21-9-11-22(12-10-21)6-4-5-18-29-27(31)26-8-3-2-7-24(26)20-28-19-17-23-13-15-25(30)16-14-23/h2-3,7-16,28,30H,4-6,17-20H2,1H3,(H,29,31) | Reactome pathway
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| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138569
(2-(7-Hydroxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl...)Show SMILES Oc1ccc2CCN(Cc3ccccc3C(=O)NCCCCc3ccccc3)Cc2c1 Show InChI InChI=1S/C27H30N2O2/c30-25-14-13-22-15-17-29(20-24(22)18-25)19-23-11-4-5-12-26(23)27(31)28-16-7-6-10-21-8-2-1-3-9-21/h1-5,8-9,11-14,18,30H,6-7,10,15-17,19-20H2,(H,28,31) | Reactome pathway
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| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537054
(CHEMBL4549008)Show SMILES Cl.CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)OC |r| Show InChI InChI=1S/C25H48N2O3.ClH/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21-24(28)27-23(25(29)30-2)20-18-19-22-26;/h10-11,23H,3-9,12-22,26H2,1-2H3,(H,27,28);1H/b11-10-;/t23-;/m0./s1 | Reactome pathway
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| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023874
(CHEMBL3325508)Show SMILES FCCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C22H24F4N2O2/c23-11-14-28-12-9-19(10-13-28)27-21(29)17-3-1-16(2-4-17)15-30-20-7-5-18(6-8-20)22(24,25)26/h1-8,19H,9-15H2,(H,27,29) | Reactome pathway
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| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138572
(CHEMBL153410 | N-[4-(3-Chloro-phenyl)-butyl]-2-{[2...)Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCCCc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C26H29ClN2O2/c27-23-9-5-7-21(18-23)6-3-4-16-29-26(31)25-10-2-1-8-22(25)19-28-17-15-20-11-13-24(30)14-12-20/h1-2,5,7-14,18,28,30H,3-4,6,15-17,19H2,(H,29,31) | Reactome pathway
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| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50256745
((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)Show SMILES N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1 | Reactome pathway
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT-2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake preincubated for 30 mins followed by 3H]-glycine ad... |
J Med Chem 61: 2652-2679 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00956
BindingDB Entry DOI: 10.7270/Q23B62RZ |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50256745
((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)Show SMILES N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1 | Reactome pathway
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of full length human GlyT2 expressed in FreeStyle 293-F suspension cells incubated for 30 mins before [3H]glycine addition and measured af... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023924
(CHEMBL3325507)Show SMILES CN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C21H23F3N2O2/c1-26-12-10-18(11-13-26)25-20(27)16-4-2-15(3-5-16)14-28-19-8-6-17(7-9-19)21(22,23)24/h2-9,18H,10-14H2,1H3,(H,25,27) | Reactome pathway
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| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023924
(CHEMBL3325507)Show SMILES CN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C21H23F3N2O2/c1-26-12-10-18(11-13-26)25-20(27)16-4-2-15(3-5-16)14-28-19-8-6-17(7-9-19)21(22,23)24/h2-9,18H,10-14H2,1H3,(H,25,27) | Reactome pathway
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| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Reversible inhibition of recombinant human GlyT2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake after 2 hrs by top count assa... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023924
(CHEMBL3325507)Show SMILES CN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C21H23F3N2O2/c1-26-12-10-18(11-13-26)25-20(27)16-4-2-15(3-5-16)14-28-19-8-6-17(7-9-19)21(22,23)24/h2-9,18H,10-14H2,1H3,(H,25,27) | Reactome pathway
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| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT-2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake |
J Med Chem 61: 2652-2679 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00956
BindingDB Entry DOI: 10.7270/Q23B62RZ |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023925
(CHEMBL3325506)Show SMILES CCN1CCC(CC1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C22H25F3N2O2/c1-2-27-13-11-19(12-14-27)26-21(28)17-5-3-16(4-6-17)15-29-20-9-7-18(8-10-20)22(23,24)25/h3-10,19H,2,11-15H2,1H3,(H,26,28) | Reactome pathway
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| n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Rattus norvegicus) | BDBM50335008
(5-Biphenyl-4-yl-4-(2-fluorophenyl)-N-methyl-4H-1,2...)Show SMILES CNc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(17.26,-39.7,;16.11,-40.73,;14.65,-40.25,;14.17,-38.79,;12.63,-38.79,;12.16,-40.25,;10.83,-41.03,;10.84,-42.57,;9.51,-43.34,;8.17,-42.57,;8.16,-41.04,;9.49,-40.26,;6.85,-43.35,;5.51,-42.58,;4.18,-43.35,;4.18,-44.9,;5.51,-45.67,;6.85,-44.9,;13.4,-41.16,;13.4,-42.69,;12.06,-43.45,;12.06,-44.99,;13.39,-45.77,;14.73,-44.99,;14.73,-43.45,;16.06,-42.68,)| Show InChI InChI=1S/C21H17FN4/c1-23-21-25-24-20(26(21)19-10-6-5-9-18(19)22)17-13-11-16(12-14-17)15-7-3-2-4-8-15/h2-14H,1H3,(H,23,25) | KEGG
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells |
J Med Chem 54: 387-91 (2011)
Article DOI: 10.1021/jm101031u
BindingDB Entry DOI: 10.7270/Q2H9965H |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023993
(CHEMBL3325495)Show SMILES CN1CCC(CC1)N1CCC(C1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C25H30F3N3O2/c1-30-13-11-22(12-14-30)31-15-10-21(16-31)29-24(32)19-4-2-18(3-5-19)17-33-23-8-6-20(7-9-23)25(26,27)28/h2-9,21-22H,10-17H2,1H3,(H,29,32) | Reactome pathway
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| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50023932
(CHEMBL3325499)Show SMILES CN1CCC(CC1)N1CC[C@@H](C1)NC(=O)c1ccc(COc2ccc(cc2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C25H30F3N3O2/c1-30-13-11-22(12-14-30)31-15-10-21(16-31)29-24(32)19-4-2-18(3-5-19)17-33-23-8-6-20(7-9-23)25(26,27)28/h2-9,21-22H,10-17H2,1H3,(H,29,32)/t21-/m0/s1 | Reactome pathway
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| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs |
Bioorg Med Chem Lett 24: 4603-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.059
BindingDB Entry DOI: 10.7270/Q2K64KN1 |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138587
(CHEMBL348211 | N-[4-(3,4-Dichloro-phenyl)-butyl]-2...)Show SMILES Oc1ccc(CCNCc2ccccc2C(=O)NCCCCc2ccc(Cl)c(Cl)c2)cc1 Show InChI InChI=1S/C26H28Cl2N2O2/c27-24-13-10-20(17-25(24)28)5-3-4-15-30-26(32)23-7-2-1-6-21(23)18-29-16-14-19-8-11-22(31)12-9-19/h1-2,6-13,17,29,31H,3-5,14-16,18H2,(H,30,32) | Reactome pathway
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50537031
(CHEMBL4540633)Show SMILES Cl.CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O |r| Show InChI InChI=1S/C24H41N3O3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(28)27-22(24(29)30)18-21-19-25-20-26-21;/h9-10,19-20,22H,2-8,11-18H2,1H3,(H,25,26)(H,27,28)(H,29,30);1H/b10-9-;/t22-;/m0./s1 | Reactome pathway
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| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el... |
J Med Chem 62: 2466-2484 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01775
BindingDB Entry DOI: 10.7270/Q21R6V1K |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50138575
(2-[(2-Hydroxy-6,7,8,9-tetrahydro-5H-benzocyclohept...)Show SMILES Oc1ccc2CC(CCCc2c1)NCc1ccccc1C(=O)NCC\C=C\c1ccccc1 Show InChI InChI=1S/C29H32N2O2/c32-27-17-16-24-19-26(14-8-13-23(24)20-27)31-21-25-12-4-5-15-28(25)29(33)30-18-7-6-11-22-9-2-1-3-10-22/h1-6,9-12,15-17,20,26,31-32H,7-8,13-14,18-19,21H2,(H,30,33)/b11-6+ | Reactome pathway
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| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line |
Bioorg Med Chem Lett 14: 545-8 (2003)
BindingDB Entry DOI: 10.7270/Q2M9083Z |
More data for this
Ligand-Target Pair | |
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