Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50244449 ((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [3H]PDBu from recombinant RasGRP1 C1 domain (unknown origin) after 10 mins by scintillation counting analysis in presence of phosphat... | Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50017890 (CHEMBL3289012) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [3H]PDBu from recombinant RasGRP1 C1 domain (unknown origin) after 10 mins by scintillation counting analysis in presence of phosphat... | Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50244449 ((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [20-3H]phorbol 12,13-dibutyrate from RasGRP1 (unknown origin) in the presence of porcine brain phosphatidylserine by scintillation co... | Bioorg Med Chem 25: 2971-2980 (2017) Article DOI: 10.1016/j.bmc.2017.03.022 BindingDB Entry DOI: 10.7270/Q28P62P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50017892 (CHEMBL3289014) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [3H]PDBu from recombinant RasGRP1 C1 domain (unknown origin) after 10 mins by scintillation counting analysis in presence of phosphat... | Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Rattus norvegicus) | BDBM50057514 ((10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Binding affinity against RAS guanyl releasing protein using [3H]- PDBu as the labeled ligand | J Med Chem 45: 853-60 (2002) BindingDB Entry DOI: 10.7270/Q20C4V25 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50017891 (CHEMBL3289013) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [3H]PDBu from recombinant RasGRP1 C1 domain (unknown origin) after 10 mins by scintillation counting analysis in presence of phosphat... | Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50017889 (CHEMBL3289011) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [3H]PDBu from recombinant RasGRP1 C1 domain (unknown origin) after 10 mins by scintillation counting analysis in presence of phosphat... | Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Rattus norvegicus) | BDBM50057511 ((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | 2.54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Binding affinity against RAS guanyl releasing protein using [3H]- PDBu as the labeled ligand | J Med Chem 45: 853-60 (2002) BindingDB Entry DOI: 10.7270/Q20C4V25 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Rattus norvegicus) | BDBM50057509 ((2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 6.15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Binding affinity against RAS guanyl releasing protein using [3H]- PDBu as the labeled ligand | J Med Chem 45: 853-60 (2002) BindingDB Entry DOI: 10.7270/Q20C4V25 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Rattus norvegicus) | BDBM50096601 ((2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-7...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 13.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Binding affinity against RAS guanyl releasing protein using [3H]- PDBu as the labeled ligand | J Med Chem 45: 853-60 (2002) BindingDB Entry DOI: 10.7270/Q20C4V25 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50241849 (CHEMBL4070999) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [20-3H]phorbol 12,13-dibutyrate from RasGRP1 (unknown origin) in the presence of porcine brain phosphatidylserine by scintillation co... | Bioorg Med Chem 25: 2971-2980 (2017) Article DOI: 10.1016/j.bmc.2017.03.022 BindingDB Entry DOI: 10.7270/Q28P62P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50241856 (CHEMBL4097154) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [20-3H]phorbol 12,13-dibutyrate from RasGRP1 (unknown origin) in the presence of porcine brain phosphatidylserine by scintillation co... | Bioorg Med Chem 25: 2971-2980 (2017) Article DOI: 10.1016/j.bmc.2017.03.022 BindingDB Entry DOI: 10.7270/Q28P62P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50241855 (CHEMBL4075373) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [20-3H]phorbol 12,13-dibutyrate from RasGRP1 (unknown origin) in the presence of porcine brain phosphatidylserine by scintillation co... | Bioorg Med Chem 25: 2971-2980 (2017) Article DOI: 10.1016/j.bmc.2017.03.022 BindingDB Entry DOI: 10.7270/Q28P62P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50241846 (CHEMBL4069954) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [20-3H]phorbol 12,13-dibutyrate from RasGRP1 (unknown origin) in the presence of porcine brain phosphatidylserine by scintillation co... | Bioorg Med Chem 25: 2971-2980 (2017) Article DOI: 10.1016/j.bmc.2017.03.022 BindingDB Entry DOI: 10.7270/Q28P62P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50241851 (CHEMBL4099579) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [20-3H]phorbol 12,13-dibutyrate from RasGRP1 (unknown origin) in the presence of porcine brain phosphatidylserine by scintillation co... | Bioorg Med Chem 25: 2971-2980 (2017) Article DOI: 10.1016/j.bmc.2017.03.022 BindingDB Entry DOI: 10.7270/Q28P62P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50241850 (CHEMBL4081576) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 133 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [20-3H]phorbol 12,13-dibutyrate from RasGRP1 (unknown origin) in the presence of porcine brain phosphatidylserine by scintillation co... | Bioorg Med Chem 25: 2971-2980 (2017) Article DOI: 10.1016/j.bmc.2017.03.022 BindingDB Entry DOI: 10.7270/Q28P62P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50241854 (CHEMBL4066764) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 666 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Industrial Technology Curated by ChEMBL | Assay Description Displacement of [20-3H]phorbol 12,13-dibutyrate from RasGRP1 (unknown origin) in the presence of porcine brain phosphatidylserine by scintillation co... | Bioorg Med Chem 25: 2971-2980 (2017) Article DOI: 10.1016/j.bmc.2017.03.022 BindingDB Entry DOI: 10.7270/Q28P62P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50280749 (CHEMBL4169454) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.73E+3 | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Activation of GFP-tagged RasGRP1 (unknown origin) expressed in human LNCAP cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot metho... | J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50280749 (CHEMBL4169454) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 860 | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Activation of GFP-tagged RasGRP1 (unknown origin) expressed in HEK293 cells after 30 mins by immunoblot method | J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50280749 (CHEMBL4169454) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.88E+3 | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Activation of GFP-tagged RasGRP1 (unknown origin) expressed in HEK293 cells assessed as ERK1/2 phosphorylation after 30 mins by immunoblot method | J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAS guanyl-releasing protein 1 (Homo sapiens (Human)) | BDBM50280749 (CHEMBL4169454) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 970 | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Activation of GFP-tagged RasGRP1 (unknown origin) expressed in human LNCAP cells after 30 mins by immunoblot method | J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D | |||||||||||
More data for this Ligand-Target Pair |