BindingDB logo
myBDB logout

Patent code US10562916

Compile Data Set for Download or QSAR

Found 209 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362593
PNG
(US10562916, Compound 153 | US9834564, Compound 153)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc2c3ncccc3ccn2n1
Show InChI InChI=1S/C20H15N5/c1-2-6-17-14(4-1)7-8-16(22-17)9-10-18-23-20-19-15(5-3-12-21-19)11-13-25(20)24-18/h1-8,11-13H,9-10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362612
PNG
(US10562916, Compound 172 | US9834564, Compound 172)
Show SMILES Cc1cnc(C)c(CCc2nc(cn2C)-c2ccccc2)n1
Show InChI InChI=1S/C18H20N4/c1-13-11-19-14(2)16(20-13)9-10-18-21-17(12-22(18)3)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50003991
PNG
(CHEMBL2180008 | US10562916, Compound 204 | US98345...)
Show SMILES Cn1c(CCc2ccc3ncccc3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C21H17N5/c1-26-19-10-9-16-15(4-2-12-22-16)21(19)25-20(26)11-7-14-6-8-17-18(24-14)5-3-13-23-17/h2-6,8-10,12-13H,7,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362649
PNG
(Compound 211 | US9834564, Compound 211)
Show SMILES Cn1c(CCc2cnc3ccccc3n2)nc2c3OCCOc3ccc12
Show InChI InChI=1S/C20H18N4O2/c1-24-16-7-8-17-20(26-11-10-25-17)19(16)23-18(24)9-6-13-12-21-14-4-2-3-5-15(14)22-13/h2-5,7-8,12H,6,9-11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362576
PNG
(US10562916, Compound 136 | US9834564, Compound 136)
Show SMILES Cc1ccc2nc(CCc3nc4c(C)ncc(C)n4n3)cnc2c1C
Show InChI InChI=1S/C19H20N6/c1-11-5-7-16-18(13(11)3)21-10-15(22-16)6-8-17-23-19-14(4)20-9-12(2)25(19)24-17/h5,7,9-10H,6,8H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362430
PNG
(US10562916, Compound 14 | US9834564, Compound 3)
Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)nc2ccccc12
Show InChI InChI=1S/C19H16N4O/c24-19-14-8-4-5-9-15(14)21-18(23-19)11-10-17-20-12-16(22-17)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,20,22)(H,21,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362432
PNG
(US10562916, Compound 5 | US9834564, Compound 5)
Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)nc2ccncc12
Show InChI InChI=1S/C18H15N5O/c24-18-13-10-19-9-8-14(13)21-17(23-18)7-6-16-20-11-15(22-16)12-4-2-1-3-5-12/h1-5,8-11H,6-7H2,(H,20,22)(H,21,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362446
PNG
(US10562916, Compound 13 | US9834564, Compound 13)
Show SMILES C(Cc1ncc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C19H16N4/c1-2-6-14(7-3-1)17-13-21-19(23-17)11-10-18-20-12-15-8-4-5-9-16(15)22-18/h1-9,12-13H,10-11H2,(H,21,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362485
PNG
(US10562916, Compound 45 | US9834564, Compound 45)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccco1
Show InChI InChI=1S/C18H16N4O/c1-22-12-16(17-7-4-10-23-17)21-18(22)9-8-13-11-19-14-5-2-3-6-15(14)20-13/h2-7,10-12H,8-9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362492
PNG
(US10562916, Compound 52 | US9834564, Compound 52)
Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccco2)nc2ccccc12
Show InChI InChI=1S/C17H14N4O2/c22-17-11-4-1-2-5-12(11)19-16(21-17)8-7-15-18-10-13(20-15)14-6-3-9-23-14/h1-6,9-10H,7-8H2,(H,18,20)(H,19,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362510
PNG
(US10562916, Compound 70 | US9834564, Compound 70)
Show SMILES Fc1cccc(c1)-c1c[nH]c(CCc2ccc3ccccc3n2)n1
Show InChI InChI=1S/C20H16FN3/c21-16-6-3-5-15(12-16)19-13-22-20(24-19)11-10-17-9-8-14-4-1-2-7-18(14)23-17/h1-9,12-13H,10-11H2,(H,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362527
PNG
(US10562916, Compound 87 | US9834564, Compound 87)
Show SMILES Cc1ccc(C)c2nc(CCc3nc4c(ccc5ncccc45)[nH]3)cnc12
Show InChI InChI=1S/C22H19N5/c1-13-5-6-14(2)21-20(13)24-12-15(25-21)7-10-19-26-18-9-8-17-16(22(18)27-19)4-3-11-23-17/h3-6,8-9,11-12H,7,10H2,1-2H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362543
PNG
(US10562916, Compound 103 | US9834564, Compound 103)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2c(ccc3ccccc23)[nH]1
Show InChI InChI=1S/C21H16N4/c1-2-6-16-14(5-1)9-11-19-21(16)25-20(24-19)12-10-15-13-22-17-7-3-4-8-18(17)23-15/h1-9,11,13H,10,12H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362556
PNG
(US10562916, Compound 116 | US9834564, Compound 116)
Show SMILES O=c1[nH]c(CCc2nc(cs2)-c2ccccc2)nc2ccccc12
Show InChI InChI=1S/C19H15N3OS/c23-19-14-8-4-5-9-15(14)20-17(22-19)10-11-18-21-16(12-24-18)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,20,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362560
PNG
(US10562916, Compound 120 | US9834564, Compound 120)
Show SMILES C(Oc1cnc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C18H14N4O/c1-2-6-13(7-3-1)16-10-20-17(21-16)12-23-18-11-19-14-8-4-5-9-15(14)22-18/h1-11H,12H2,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362567
PNG
(US10562916, Compound 127 | US9834564, Compound 127)
Show SMILES Cc1ncc(C)n2nc(CCc3nc4ccccc4cc3F)nc12
Show InChI InChI=1S/C18H16FN5/c1-11-10-20-12(2)18-22-17(23-24(11)18)8-7-16-14(19)9-13-5-3-4-6-15(13)21-16/h3-6,9-10H,7-8H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362637
PNG
(US10562916, Compound 199 | US9834564, Compound 199)
Show SMILES C(Cc1ccc2ncccc2n1)c1cn2ccc3ncccc3c2n1
Show InChI InChI=1S/C20H15N5/c1-3-16-17(21-10-1)9-12-25-13-15(24-20(16)25)6-5-14-7-8-18-19(23-14)4-2-11-22-18/h1-4,7-13H,5-6H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362639
PNG
(US10562916, Compound 201 | US9834564, Compound 201)
Show SMILES Cc1c(CCc2ccc3ncccc3n2)nc2c3cccnc3ccn12
Show InChI InChI=1S/C21H17N5/c1-14-17(8-6-15-7-9-19-20(24-15)5-3-12-23-19)25-21-16-4-2-11-22-18(16)10-13-26(14)21/h2-5,7,9-13H,6,8H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362648
PNG
(US10562916, Compound 210 | US9834564, Compound 210)
Show SMILES Cc1nc(CCc2nc3c(ccc4ncccc34)n2C)nc2CCCc12
Show InChI InChI=1S/C21H21N5/c1-13-14-5-3-7-17(14)24-19(23-13)10-11-20-25-21-15-6-4-12-22-16(15)8-9-18(21)26(20)2/h4,6,8-9,12H,3,5,7,10-11H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362584
PNG
(US10562916, Compound 144 | US9834564, Compound 144)
Show SMILES COc1nc2ccccc2nc1CCc1nc2c(ccc3ncccc23)n1C
Show InChI InChI=1S/C22H19N5O/c1-27-19-11-9-15-14(6-5-13-23-15)21(19)26-20(27)12-10-18-22(28-2)25-17-8-4-3-7-16(17)24-18/h3-9,11,13H,10,12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50004053
PNG
(CHEMBL2180006 | US10562916, Compound 1 | US9834564...)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C19H16N4/c1-2-6-14(7-3-1)18-13-21-19(23-18)11-10-15-12-20-16-8-4-5-9-17(16)22-15/h1-9,12-13H,10-11H2,(H,21,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents
PDB
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362458
PNG
(US10562916, Compound 18 | US9834564, Compound 18)
Show SMILES Cn1cc(nc1CCc1ncc2ccccc2n1)-c1ccccc1
Show InChI InChI=1S/C20H18N4/c1-24-14-18(15-7-3-2-4-8-15)23-20(24)12-11-19-21-13-16-9-5-6-10-17(16)22-19/h2-10,13-14H,11-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362488
PNG
(US10562916, Compound 48 | US9834564, Compound 48)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccccc1F
Show InChI InChI=1S/C20H17FN4/c1-25-13-19(15-6-2-3-7-16(15)21)24-20(25)11-10-14-12-22-17-8-4-5-9-18(17)23-14/h2-9,12-13H,10-11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362518
PNG
(US10562916, Compound 78 | US9834564, Compound 78)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc(c[nH]1)-c1cccnc1
Show InChI InChI=1S/C18H15N5/c1-2-6-16-15(5-1)20-11-14(22-16)7-8-18-21-12-17(23-18)13-4-3-9-19-10-13/h1-6,9-12H,7-8H2,(H,21,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362524
PNG
(US10562916, Compound 84 | US9834564, Compound 84)
Show SMILES Cn1c(CCc2cnc3ccccc3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C21H17N5/c1-26-19-10-9-16-15(5-4-12-22-16)21(19)25-20(26)11-8-14-13-23-17-6-2-3-7-18(17)24-14/h2-7,9-10,12-13H,8,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362530
PNG
(US10562916, Compound 90 | US9834564, Compound 90)
Show SMILES Cn1c(CCc2ccc3ccccc3n2)nc2c1ccc1ccccc21
Show InChI InChI=1S/C23H19N3/c1-26-21-14-11-16-6-2-4-8-19(16)23(21)25-22(26)15-13-18-12-10-17-7-3-5-9-20(17)24-18/h2-12,14H,13,15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362532
PNG
(US10562916, Compound 92 | US9834564, Compound 92)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C17H14N4/c1-2-6-14-13(5-1)18-11-12(19-14)9-10-17-20-15-7-3-4-8-16(15)21-17/h1-8,11H,9-10H2,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362542
PNG
(US10562916, Compound 102 | US9834564, Compound 102)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2c(ccc3ncccc23)[nH]1
Show InChI InChI=1S/C20H15N5/c1-2-6-17-16(5-1)22-12-13(23-17)7-10-19-24-18-9-8-15-14(20(18)25-19)4-3-11-21-15/h1-6,8-9,11-12H,7,10H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362566
PNG
(US10562916, Compound 126 | US9834564, Compound 126)
Show SMILES Cc1cnc(C)n2nc(CCc3ccc4ccccc4n3)nc12
Show InChI InChI=1S/C18H17N5/c1-12-11-19-13(2)23-18(12)21-17(22-23)10-9-15-8-7-14-5-3-4-6-16(14)20-15/h3-8,11H,9-10H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362573
PNG
(US10562916, Compound 133 | US9834564, Compound 133)
Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccc5cccnc5c4n3)nc12
Show InChI InChI=1S/C21H18N6/c1-13-12-23-14(2)21-25-18(26-27(13)21)10-9-17-8-7-16-6-5-15-4-3-11-22-19(15)20(16)24-17/h3-8,11-12H,9-10H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362577
PNG
(US10562916, Compound 137 | US9834564, Compound 137)
Show SMILES Cc1cnc(C)c2nc(CCc3ccc4ccc5CCCNc5c4n3)nn12
Show InChI InChI=1S/C21H22N6/c1-13-12-23-14(2)21-25-18(26-27(13)21)10-9-17-8-7-16-6-5-15-4-3-11-22-19(15)20(16)24-17/h5-8,12,22H,3-4,9-11H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362603
PNG
(US10562916, Compound 163 | US9834564, Compound 163)
Show SMILES Cn1c(CCc2ccc3cnccc3n2)nc2c1ccc1cccnc21
Show InChI InChI=1S/C21H17N5/c1-26-18-8-5-14-3-2-11-23-20(14)21(18)25-19(26)9-7-16-6-4-15-13-22-12-10-17(15)24-16/h2-6,8,10-13H,7,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362606
PNG
(US10562916, Compound 166 | US9834564, Compound 166)
Show SMILES Cc1cnc(C)c2ccc(CCc3nc4c(ccc5ncccc45)[nH]3)nc12
Show InChI InChI=1S/C22H19N5/c1-13-12-24-14(2)16-7-5-15(25-21(13)16)6-10-20-26-19-9-8-18-17(22(19)27-20)4-3-11-23-18/h3-5,7-9,11-12H,6,10H2,1-2H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362610
PNG
(US10562916, Compound 170 | US9834564, Compound 170)
Show SMILES Cc1cc2ncccc2c2nc(CCc3ccc4ccccc4n3)n(C)c12
Show InChI InChI=1S/C23H20N4/c1-15-14-20-18(7-5-13-24-20)22-23(15)27(2)21(26-22)12-11-17-10-9-16-6-3-4-8-19(16)25-17/h3-10,13-14H,11-12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362611
PNG
(US10562916, Compound 171 | US9834564, Compound 171)
Show SMILES Cn1c(CCc2ccc3ccc4cccnc4c3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C25H19N5/c1-30-21-12-11-20-19(5-3-14-26-20)25(21)29-22(30)13-10-18-9-8-17-7-6-16-4-2-15-27-23(16)24(17)28-18/h2-9,11-12,14-15H,10,13H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362618
PNG
(US10562916, Compound 180 | US9834564, Compound 180)
Show SMILES Cc1cnc2nc(CCc3nc4c5cccnc5ccn4n3)ccc2c1
Show InChI InChI=1S/C20H16N6/c1-13-11-14-4-5-15(23-19(14)22-12-13)6-7-18-24-20-16-3-2-9-21-17(16)8-10-26(20)25-18/h2-5,8-12H,6-7H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362628
PNG
(US10562916, Compound 190 | US9834564, Compound 190)
Show SMILES Cc1c(CCc2cnc3ccccc3n2)nc2c3cccnc3ccn12
Show InChI InChI=1S/C21H17N5/c1-14-17(9-8-15-13-23-19-6-2-3-7-20(19)24-15)25-21-16-5-4-11-22-18(16)10-12-26(14)21/h2-7,10-13H,8-9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362629
PNG
(US10562916, Compound 191 | US9834564, Compound 191)
Show SMILES Cn1c(CCc2cnc3cccc(Cl)c3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C21H16ClN5/c1-27-18-9-8-16-14(4-3-11-23-16)20(18)26-19(27)10-7-13-12-24-17-6-2-5-15(22)21(17)25-13/h2-6,8-9,11-12H,7,10H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362647
PNG
(US10562916, Compound 209 | US9834564, Compound 209)
Show SMILES Cc1nc(CCc2nc3c(ccc4ncccc34)n2C)nc2ccccc12
Show InChI InChI=1S/C22H19N5/c1-14-15-6-3-4-8-18(15)25-20(24-14)11-12-21-26-22-16-7-5-13-23-17(16)9-10-19(22)27(21)2/h3-10,13H,11-12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362526
PNG
(US10562916, Compound 86 | US9834564, Compound 86)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc2c(ccc3ncccc23)[nH]1
Show InChI InChI=1S/C21H16N4/c1-2-6-17-14(4-1)7-8-15(23-17)9-12-20-24-19-11-10-18-16(21(19)25-20)5-3-13-22-18/h1-8,10-11,13H,9,12H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362499
PNG
(US10562916, Compound 59 | US9834564, Compound 59)
Show SMILES Fc1ccccc1-c1c[nH]c(CCc2nc3ccccc3c(=O)[nH]2)n1
Show InChI InChI=1S/C19H15FN4O/c20-14-7-3-1-5-12(14)16-11-21-17(23-16)9-10-18-22-15-8-4-2-6-13(15)19(25)24-18/h1-8,11H,9-10H2,(H,21,23)(H,22,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362509
PNG
(US10562916, Compound 69 | US9834564, Compound 69)
Show SMILES Fc1ccccc1-c1c[nH]c(CCc2ccc3ccccc3n2)n1
Show InChI InChI=1S/C20H16FN3/c21-17-7-3-2-6-16(17)19-13-22-20(24-19)12-11-15-10-9-14-5-1-4-8-18(14)23-15/h1-10,13H,11-12H2,(H,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362516
PNG
(US10562916, Compound 76 | US9834564, Compound 76)
Show SMILES Fc1cccc(c1)-c1c[nH]c(CCc2cnc3ccccc3n2)n1
Show InChI InChI=1S/C19H15FN4/c20-14-5-3-4-13(10-14)18-12-22-19(24-18)9-8-15-11-21-16-6-1-2-7-17(16)23-15/h1-7,10-12H,8-9H2,(H,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362525
PNG
(US10562916, Compound 85 | US9834564, Compound 85)
Show SMILES Cn1c(CCc2ccc3ccccc3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C22H18N4/c1-26-20-12-11-19-17(6-4-14-23-19)22(20)25-21(26)13-10-16-9-8-15-5-2-3-7-18(15)24-16/h2-9,11-12,14H,10,13H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362528
PNG
(US10562916, Compound 88 | US9834564, Compound 88)
Show SMILES Cc1ccc(C)c2nc(CCc3nc4c(ccc5ncccc45)n3C)cnc12
Show InChI InChI=1S/C23H21N5/c1-14-6-7-15(2)22-21(14)25-13-16(26-22)8-11-20-27-23-17-5-4-12-24-18(17)9-10-19(23)28(20)3/h4-7,9-10,12-13H,8,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362564
PNG
(US10562916, Compound 124 | US9834564, Compound 124)
Show SMILES S(c1nc(c[nH]1)-c1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C17H12N4S/c1-2-6-12(7-3-1)15-10-19-17(21-15)22-16-11-18-13-8-4-5-9-14(13)20-16/h1-11H,(H,19,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362582
PNG
(US10562916, Compound 142 | US9834564, Compound 142)
Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccc5ncccc5c4n3)nc12
Show InChI InChI=1S/C21H18N6/c1-13-12-23-14(2)21-25-19(26-27(13)21)10-8-16-7-5-15-6-9-18-17(20(15)24-16)4-3-11-22-18/h3-7,9,11-12H,8,10H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362583
PNG
(US10562916, Compound 143 | US9834564, Compound 143)
Show SMILES Cn1c(CCc2cnc3c(ccc(c3n2)C(F)(F)F)C(F)(F)F)nc2c1ccc1ncccc21
Show InChI InChI=1S/C23H15F6N5/c1-34-17-8-7-16-13(3-2-10-30-16)19(17)33-18(34)9-4-12-11-31-20-14(22(24,25)26)5-6-15(21(20)32-12)23(27,28)29/h2-3,5-8,10-11H,4,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362589
PNG
(US10562916, Compound 149 | US9834564, Compound 149)
Show SMILES Cn1c(CCc2cnc3c(Cl)ccc(Cl)c3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C21H15Cl2N5/c1-28-17-8-7-16-13(3-2-10-24-16)19(17)27-18(28)9-4-12-11-25-20-14(22)5-6-15(23)21(20)26-12/h2-3,5-8,10-11H,4,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM362597
PNG
(US10562916, Compound 157 | US9834564, Compound 157)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2c3ncccc3ccn2n1
Show InChI InChI=1S/C19H14N6/c1-2-6-16-15(5-1)21-12-14(22-16)7-8-17-23-19-18-13(4-3-10-20-18)9-11-25(19)24-17/h1-6,9-12H,7-8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 209 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%