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Patent code US10793574

Compile Data Set for Download or QSAR

Found 218 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399563
PNG
(US10323036, Compound I-6 | US10793574, Compound I-...)
Show SMILES COc1c(Nc2cc(Nc3cc(CO)ccn3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C22H22N10O3/c1-31-22(34)18-15(10-17(26-21(18)28-31)25-16-9-12(11-33)7-8-23-16)24-14-6-4-5-13(19(14)35-3)20-27-30-32(2)29-20/h4-10,33H,11H2,1-3H3,(H3,23,24,25,26,28)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399564
PNG
(US10323036, Compound I-7 | US10793574, Compound I-...)
Show SMILES COc1c(Nc2cc(Nc3ccc(cn3)N3CCOCC3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C25H27N11O3/c1-34-25(37)21-18(27-17-6-4-5-16(22(17)38-3)23-30-33-35(2)32-23)13-20(29-24(21)31-34)28-19-8-7-15(14-26-19)36-9-11-39-12-10-36/h4-8,13-14H,9-12H2,1-3H3,(H3,26,27,28,29,31)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399573
PNG
(US10323036, Compound I-16 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(Nc3ccc(C)cn3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1
Show InChI InChI=1S/C23H23N9O2/c1-13-8-9-17(24-11-13)27-18-10-16(19-22(28-18)30-32(3)23(19)33)26-15-7-5-6-14(20(15)34-4)21-25-12-31(2)29-21/h5-12H,1-4H3,(H3,24,26,27,28,30)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399578
PNG
(US10323036, Compound I-21 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(Nc3cc(C)c(F)cn3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1
Show InChI InChI=1S/C23H22FN9O2/c1-12-8-17(25-10-14(12)24)28-18-9-16(19-22(29-18)31-33(3)23(19)34)27-15-7-5-6-13(20(15)35-4)21-26-11-32(2)30-21/h5-11H,1-4H3,(H3,25,27,28,29,31)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399590
PNG
(US10323036, Compound I-34 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(Nc3ccc(C)cn3)nc3[nH]n(C)c(=O)c23)cccc1C#N
Show InChI InChI=1S/C21H19N7O2/c1-12-7-8-16(23-11-12)25-17-9-15(18-20(26-17)27-28(2)21(18)29)24-14-6-4-5-13(10-22)19(14)30-3/h4-9,11H,1-3H3,(H3,23,24,25,26,27)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399591
PNG
(US10323036, Compound I-35 | US10793574, Compound I...)
Show SMILES COCc1ccnc(Nc2cc(Nc3cccc(C#N)c3OC)c3c(n2)[nH]n(C)c3=O)c1
Show InChI InChI=1S/C22H21N7O3/c1-29-22(30)19-16(25-15-6-4-5-14(11-23)20(15)32-3)10-18(27-21(19)28-29)26-17-9-13(12-31-2)7-8-24-17/h4-10H,12H2,1-3H3,(H3,24,25,26,27,28)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399605
PNG
(US10323036, Compound I-49 | US10793574, Compound I...)
Show SMILES COc1c(Cl)cccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C18H18ClN5O3/c1-24-18(26)14-12(20-11-5-3-4-10(19)15(11)27-2)8-13(21-16(14)23-24)22-17(25)9-6-7-9/h3-5,8-9H,6-7H2,1-2H3,(H3,20,21,22,23,25)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399611
PNG
(US10323036, Compound I-55 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1cnn(C)c1
Show InChI InChI=1S/C22H23N7O3/c1-28-11-13(10-23-28)14-5-4-6-15(19(14)32-3)24-16-9-17(26-21(30)12-7-8-12)25-20-18(16)22(31)29(2)27-20/h4-6,9-12H,7-8H2,1-3H3,(H3,24,25,26,27,30)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399616
PNG
(US10323036, Compound I-60 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(Nc3cccc(n3)C(F)(F)F)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C22H19F3N10O2/c1-34-21(36)17-13(26-12-7-4-6-11(18(12)37-3)19-30-33-35(2)32-19)10-16(29-20(17)31-34)28-15-9-5-8-14(27-15)22(23,24)25/h4-10H,1-3H3,(H3,26,27,28,29,31)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399618
PNG
(US10323036, Compound I-62 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1n[nH]c(C)n1
Show InChI InChI=1S/C21H22N8O3/c1-10-22-18(27-26-10)12-5-4-6-13(17(12)32-3)23-14-9-15(25-20(30)11-7-8-11)24-19-16(14)21(31)29(2)28-19/h4-6,9,11H,7-8H2,1-3H3,(H,22,26,27)(H3,23,24,25,28,30)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399629
PNG
(US10323036, Compound I-73 | US10793574, Compound I...)
Show SMILES COc1c(F)cccc1Nc1cc(Nc2cc(C)c(F)cn2)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C20H18F2N6O2/c1-10-7-15(23-9-12(10)22)25-16-8-14(17-19(26-16)27-28(2)20(17)29)24-13-6-4-5-11(21)18(13)30-3/h4-9H,1-3H3,(H3,23,24,25,26,27)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399638
PNG
(US10323036, Compound I-82 | US10793574, Compound I...)
Show SMILES COc1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)C(=O)N1CCC1
Show InChI InChI=1S/C22H24N6O4/c1-27-22(31)18-15(11-17(24-19(18)26-27)25-20(29)12-4-5-12)23-14-7-6-13(10-16(14)32-2)21(30)28-8-3-9-28/h6-7,10-12H,3-5,8-9H2,1-2H3,(H3,23,24,25,26,29)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399643
PNG
(US10323036, Compound I-87 | US10793574, Compound I...)
Show SMILES COc1c(F)cccc1Nc1cc(Nc2cccc(n2)C2CC2)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C22H21FN6O2/c1-29-22(30)19-16(24-15-7-3-5-13(23)20(15)31-2)11-18(27-21(19)28-29)26-17-8-4-6-14(25-17)12-9-10-12/h3-8,11-12H,9-10H2,1-2H3,(H3,24,25,26,27,28)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399649
PNG
(US10323036, Compound I-93 | US10793574, Compound I...)
Show SMILES COCc1ccc(Nc2cc(Nc3ccc(C)c(n3)C(F)(F)F)nc3[nH]n(C)c(=O)c23)c(OC)c1
Show InChI InChI=1S/C23H23F3N6O3/c1-12-5-8-17(29-20(12)23(24,25)26)28-18-10-15(19-21(30-18)31-32(2)22(19)33)27-14-7-6-13(11-34-3)9-16(14)35-4/h5-10H,11H2,1-4H3,(H3,27,28,29,30,31)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399658
PNG
(US10323036, Compound I-102 | US10793574, Compound ...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1C(N)=O
Show InChI InChI=1S/C19H20N6O4/c1-25-19(28)14-12(21-11-5-3-4-10(16(20)26)15(11)29-2)8-13(22-17(14)24-25)23-18(27)9-6-7-9/h3-5,8-9H,6-7H2,1-2H3,(H2,20,26)(H3,21,22,23,24,27)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399662
PNG
(US10323036, Compound I-106 | US10793574, Compound ...)
Show SMILES COc1c(Nc2cc(Nc3cc(C)c(F)cn3)nc3[nH]n(C)c(=O)c23)cccc1C(N)=O
Show InChI InChI=1S/C21H20FN7O3/c1-10-7-15(24-9-12(10)22)26-16-8-14(17-20(27-16)28-29(2)21(17)31)25-13-6-4-5-11(19(23)30)18(13)32-3/h4-9H,1-3H3,(H2,23,30)(H3,24,25,26,27,28)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399668
PNG
(US10323036, Compound I-112 | US10793574, Compound ...)
Show SMILES Cn1[nH]c2nc(Nc3cccc(n3)C#N)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O
Show InChI InChI=1S/C20H17N7O3S/c1-27-20(28)18-14(23-13-7-3-4-8-15(13)31(2,29)30)10-17(25-19(18)26-27)24-16-9-5-6-12(11-21)22-16/h3-10H,1-2H3,(H3,22,23,24,25,26)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399669
PNG
(US10323036, Compound I-113 | US10793574, Compound ...)
Show SMILES Cn1[nH]c2nc(Nc3cccc(n3)C(F)(F)F)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O
Show InChI InChI=1S/C20H17F3N6O3S/c1-29-19(30)17-12(24-11-6-3-4-7-13(11)33(2,31)32)10-16(27-18(17)28-29)26-15-9-5-8-14(25-15)20(21,22)23/h3-10H,1-2H3,(H3,24,25,26,27,28)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399680
PNG
(US10323036, Compound I-124 | US10793574, Compound ...)
Show SMILES COc1c(Nc2cc(Nc3ccc(cn3)N3CCCCC3)nc3[nH]n(C)c(=O)c23)cccc1-c1ccn(C)n1
Show InChI InChI=1S/C28H31N9O2/c1-35-15-12-20(33-35)19-8-7-9-21(26(19)39-3)30-22-16-24(32-27-25(22)28(38)36(2)34-27)31-23-11-10-18(17-29-23)37-13-5-4-6-14-37/h7-12,15-17H,4-6,13-14H2,1-3H3,(H3,29,30,31,32,34)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399687
PNG
(US10323036, Compound I-131 | US10793574, Compound ...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1noc(C)n1
Show InChI InChI=1S/C21H21N7O4/c1-10-22-18(27-32-10)12-5-4-6-13(17(12)31-3)23-14-9-15(25-20(29)11-7-8-11)24-19-16(14)21(30)28(2)26-19/h4-6,9,11H,7-8H2,1-3H3,(H3,23,24,25,26,29)
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n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399696
PNG
(US10323036, Compound I-140 | US10793574, Compound ...)
Show SMILES COC1CN(C1)c1cccc(Nc2cc(Nc3ccccc3S(C)(=O)=O)c3c(n2)[nH]n(C)c3=O)n1
Show InChI InChI=1S/C23H25N7O4S/c1-29-23(31)21-16(24-15-7-4-5-8-17(15)35(3,32)33)11-19(27-22(21)28-29)25-18-9-6-10-20(26-18)30-12-14(13-30)34-2/h4-11,14H,12-13H2,1-3H3,(H3,24,25,26,27,28)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399698
PNG
(US10323036, Compound I-142 | US10793574, Compound ...)
Show SMILES Cn1[nH]c2nc(Nc3ccccn3)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O
Show InChI InChI=1S/C19H18N6O3S/c1-25-19(26)17-13(21-12-7-3-4-8-14(12)29(2,27)28)11-16(23-18(17)24-25)22-15-9-5-6-10-20-15/h3-11H,1-2H3,(H3,20,21,22,23,24)
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n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399712
PNG
(US10323036, Compound I-182 | US10793574, Compound ...)
Show SMILES Cn1[nH]c2nc(NC(=O)C3CC3)cc(Nc3ccc(cc3S(C)(=O)=O)C3CCC3)c2c1=O
Show InChI InChI=1S/C22H25N5O4S/c1-27-22(29)19-16(11-18(24-20(19)26-27)25-21(28)13-6-7-13)23-15-9-8-14(12-4-3-5-12)10-17(15)32(2,30)31/h8-13H,3-7H2,1-2H3,(H3,23,24,25,26,28)
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n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399720
PNG
(US10323036, Compound I-207 | US10793574, Compound ...)
Show SMILES Cc1ncc(Nc2cc(Nc3ccc(Cl)cc3S(C)(=O)=O)c3c(n2)[nH]n(C)c3=O)nc1C
Show InChI InChI=1S/C20H20ClN7O3S/c1-10-11(2)23-17(9-22-10)25-16-8-14(18-19(26-16)27-28(3)20(18)29)24-13-6-5-12(21)7-15(13)32(4,30)31/h5-9H,1-4H3,(H3,23,24,25,26,27)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399722
PNG
(US10323036, Compound I-209 | US10793574, Compound ...)
Show SMILES Cn1[nH]c2nc(Nc3cccc(n3)C(F)(F)F)cc(Nc3ccc(Cl)cc3S(C)(=O)=O)c2c1=O
Show InChI InChI=1S/C20H16ClF3N6O3S/c1-30-19(31)17-12(25-11-7-6-10(21)8-13(11)34(2,32)33)9-16(28-18(17)29-30)27-15-5-3-4-14(26-15)20(22,23)24/h3-9H,1-2H3,(H3,25,26,27,28,29)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399732
PNG
(US10323036, Compound I-219 | US10793574, Compound ...)
Show SMILES CN(c1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)N1CCC1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N7O4S/c1-27-22(31)19-16(12-18(24-20(19)26-27)25-21(30)13-5-6-13)23-15-8-7-14(29-9-4-10-29)11-17(15)28(2)34(3,32)33/h7-8,11-13H,4-6,9-10H2,1-3H3,(H3,23,24,25,26,30)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399744
PNG
(US10323036, Compound I-232 | US10793574, Compound ...)
Show SMILES CN(c1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)C1CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H26N6O4S/c1-27-22(30)19-16(11-18(24-20(19)26-27)25-21(29)13-6-7-13)23-15-9-8-14(12-4-5-12)10-17(15)28(2)33(3,31)32/h8-13H,4-7H2,1-3H3,(H3,23,24,25,26,29)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399747
PNG
(US10323036, Compound I-236 | US10793574, Compound ...)
Show SMILES CN(c1cc(ccc1Nc1cc(NC(=O)[C@@H]2C[C@@H]2F)nc2[nH]n(C)c(=O)c12)C1CCC1)S(C)(=O)=O |r|
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399753
PNG
(US10323036, Compound VIII-1 | US10793574, Compound...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)ncc2-c2ncc(Cl)s2)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C21H19ClN8O2S/c1-30-28-19(27-29-30)12-4-3-5-14(18(12)32-2)25-15-8-17(26-20(31)11-6-7-11)23-9-13(15)21-24-10-16(22)33-21/h3-5,8-11H,6-7H2,1-2H3,(H2,23,25,26,31)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399756
PNG
(US10323036, Compound VIII-4 | US10793574, Compound...)
Show SMILES COC(=O)c1nnc(o1)-c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Show InChI InChI=1S/C23H22N8O5/c1-31-11-25-19(30-31)13-5-4-6-15(18(13)34-2)26-16-9-17(27-20(32)12-7-8-12)24-10-14(16)21-28-29-22(36-21)23(33)35-3/h4-6,9-12H,7-8H2,1-3H3,(H2,24,26,27,32)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399757
PNG
(US10323036, Compound VIII-5 | US10793574, Compound...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)ncc2-c2nnc(CO)o2)cccc1-c1ncn(C)n1
Show InChI InChI=1S/C22H22N8O4/c1-30-11-24-20(29-30)13-4-3-5-15(19(13)33-2)25-16-8-17(26-21(32)12-6-7-12)23-9-14(16)22-28-27-18(10-31)34-22/h3-5,8-9,11-12,31H,6-7,10H2,1-2H3,(H2,23,25,26,32)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399760
PNG
(US10323036, Compound VIII-8 | US10793574, Compound...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)ncc2-c2ccon2)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C21H20N8O3/c1-29-26-20(25-28-29)13-4-3-5-16(19(13)31-2)23-17-10-18(24-21(30)12-6-7-12)22-11-14(17)15-8-9-32-27-15/h3-5,8-12H,6-7H2,1-2H3,(H2,22,23,24,30)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399763
PNG
(US10323036, Compound VIII-11 | US10793574, Compoun...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)ncc2-c2cccnn2)cccc1-c1ncn(C)n1
Show InChI InChI=1S/C23H22N8O2/c1-31-13-25-22(30-31)15-5-3-6-18(21(15)33-2)27-19-11-20(28-23(32)14-8-9-14)24-12-16(19)17-7-4-10-26-29-17/h3-7,10-14H,8-9H2,1-2H3,(H2,24,27,28,32)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399768
PNG
(US10323036, Compound VIII-16 | US10793574, Compoun...)
Show SMILES COc1c(Nc2cc(Nc3ccc(C)nn3)ncc2-c2ncc(Cl)s2)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C22H19ClN10OS/c1-12-7-8-18(29-28-12)27-19-9-16(14(10-24-19)22-25-11-17(23)35-22)26-15-6-4-5-13(20(15)34-3)21-30-32-33(2)31-21/h4-11H,1-3H3,(H2,24,26,27,29)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399565
PNG
(US10323036, Compound I-8 | US10793574, Compound I-...)
Show SMILES COc1c(Nc2cc(Nc3cc(C)c(F)cn3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C22H21FN10O2/c1-11-8-16(24-10-13(11)23)26-17-9-15(18-21(27-17)29-32(2)22(18)34)25-14-7-5-6-12(19(14)35-4)20-28-31-33(3)30-20/h5-10H,1-4H3,(H3,24,25,26,27,29)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399570
PNG
(US10323036, Compound I-13 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(Nc3ccn(C)n3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C20H21N11O2/c1-29-9-8-14(25-29)22-15-10-13(16-19(23-15)26-30(2)20(16)32)21-12-7-5-6-11(17(12)33-4)18-24-28-31(3)27-18/h5-10H,1-4H3,(H3,21,22,23,25,26)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399580
PNG
(US10323036, Compound I-23 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(Nc3ccc(C)nn3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1
Show InChI InChI=1S/C22H22N10O2/c1-12-8-9-16(28-27-12)25-17-10-15(18-21(26-17)30-32(3)22(18)33)24-14-7-5-6-13(19(14)34-4)20-23-11-31(2)29-20/h5-11H,1-4H3,(H3,24,25,26,28,30)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399588
PNG
(US10323036, Compound I-32 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(Nc3cc(ccn3)C#N)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C22H19N11O2/c1-32-22(34)18-15(10-17(27-21(18)29-32)26-16-9-12(11-23)7-8-24-16)25-14-6-4-5-13(19(14)35-3)20-28-31-33(2)30-20/h4-10H,1-3H3,(H3,24,25,26,27,29)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399610
PNG
(US10323036, Compound I-54 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncnn1C
Show InChI InChI=1S/C21H22N8O3/c1-28-19(22-10-23-28)12-5-4-6-13(17(12)32-3)24-14-9-15(26-20(30)11-7-8-11)25-18-16(14)21(31)29(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H3,24,25,26,27,30)
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n/an/an/a 0.75n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399612
PNG
(US10323036, Compound I-56 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-n1cccn1
Show InChI InChI=1S/C21H21N7O3/c1-27-21(30)17-14(11-16(24-19(17)26-27)25-20(29)12-7-8-12)23-13-5-3-6-15(18(13)31-2)28-10-4-9-22-28/h3-6,9-12H,7-8H2,1-2H3,(H3,23,24,25,26,29)
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n/an/an/a 0.75n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399613
PNG
(US10323036, Compound I-57 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1ccn(C)n1
Show InChI InChI=1S/C22H23N7O3/c1-28-10-9-14(26-28)13-5-4-6-15(19(13)32-3)23-16-11-17(25-21(30)12-7-8-12)24-20-18(16)22(31)29(2)27-20/h4-6,9-12H,7-8H2,1-3H3,(H3,23,24,25,27,30)
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n/an/an/a<0.100n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399617
PNG
(US10323036, Compound I-61 | US10793574, Compound I...)
Show SMILES COc1ccccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C18H19N5O3/c1-23-18(25)15-12(19-11-5-3-4-6-13(11)26-2)9-14(20-16(15)22-23)21-17(24)10-7-8-10/h3-6,9-10H,7-8H2,1-2H3,(H3,19,20,21,22,24)
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n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399639
PNG
(US10323036, Compound I-83 | US10793574, Compound I...)
Show SMILES COc1c(F)cccc1Nc1cc(Nc2cc(C)ccn2)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C20H19FN6O2/c1-11-7-8-22-15(9-11)24-16-10-14(17-19(25-16)26-27(2)20(17)28)23-13-6-4-5-12(21)18(13)29-3/h4-10H,1-3H3,(H3,22,23,24,25,26)
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n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399640
PNG
(US10323036, Compound I-84 | US10793574, Compound I...)
Show SMILES COc1c(F)cccc1Nc1cc(Nc2ccc(C)cn2)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C20H19FN6O2/c1-11-7-8-15(22-10-11)24-16-9-14(17-19(25-16)26-27(2)20(17)28)23-13-6-4-5-12(21)18(13)29-3/h4-10H,1-3H3,(H3,22,23,24,25,26)
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n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399645
PNG
(US10323036, Compound I-89 | US10793574, Compound I...)
Show SMILES COc1c(F)cccc1Nc1cc(Nc2ccc(cn2)N2CCOCC2)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C23H24FN7O3/c1-30-23(32)20-17(26-16-5-3-4-15(24)21(16)33-2)12-19(28-22(20)29-30)27-18-7-6-14(13-25-18)31-8-10-34-11-9-31/h3-7,12-13H,8-11H2,1-2H3,(H3,25,26,27,28,29)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399652
PNG
(US10323036, Compound I-96 | US10793574, Compound I...)
Show SMILES COc1c(Cl)cccc1Nc1cc(Nc2cc(C)nc(C)n2)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C20H20ClN7O2/c1-10-8-15(23-11(2)22-10)25-16-9-14(17-19(26-16)27-28(3)20(17)29)24-13-7-5-6-12(21)18(13)30-4/h5-9H,1-4H3,(H3,22,23,24,25,26,27)
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n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399655
PNG
(US10323036, Compound I-99 | US10793574, Compound I...)
Show SMILES COc1c(Cl)cccc1Nc1cc(Nc2cccc(n2)C#N)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C20H16ClN7O2/c1-28-20(29)17-14(24-13-7-4-6-12(21)18(13)30-2)9-16(26-19(17)27-28)25-15-8-3-5-11(10-22)23-15/h3-9H,1-2H3,(H3,23,24,25,26,27)
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n/an/an/a 0.75n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399657
PNG
(US10323036, Compound I-101 | US10793574, Compound ...)
Show SMILES COc1c(Cl)cccc1Nc1cc(Nc2cc(CO)ccn2)nc2[nH]n(C)c(=O)c12
Show InChI InChI=1S/C20H19ClN6O3/c1-27-20(29)17-14(23-13-5-3-4-12(21)18(13)30-2)9-16(25-19(17)26-27)24-15-8-11(10-28)6-7-22-15/h3-9,28H,10H2,1-2H3,(H3,22,23,24,25,26)
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n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399663
PNG
(US10323036, Compound I-107 | US10793574, Compound ...)
Show SMILES Cc1cc(Nc2cc(Nc3ccccc3S(C)(=O)=O)c3c(n2)[nH]n(C)c3=O)ncc1F
Show InChI InChI=1S/C20H19FN6O3S/c1-11-8-16(22-10-12(11)21)24-17-9-14(18-19(25-17)26-27(2)20(18)28)23-13-6-4-5-7-15(13)31(3,29)30/h4-10H,1-3H3,(H3,22,23,24,25,26)
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n/an/an/a 0.300n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888]


(Homo sapiens (Human))		BDBM399666
PNG
(US10323036, Compound I-110 | US10793574, Compound ...)
Show SMILES COCc1ccnc(Nc2cc(Nc3ccccc3S(C)(=O)=O)c3c(n2)[nH]n(C)c3=O)c1
Show InChI InChI=1S/C21H22N6O4S/c1-27-21(28)19-15(23-14-6-4-5-7-16(14)32(3,29)30)11-18(25-20(19)26-27)24-17-10-13(12-31-2)8-9-22-17/h4-11H,12H2,1-3H3,(H3,22,23,24,25,26)
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Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

US Patent US10793574 (2020)


BindingDB Entry DOI: 10.7270/Q2WM1HH6
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%