Found 44 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076142
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1 Show InChI InChI=1S/C23H31N3O3S/c1-15(2)11-21(23(28)29-3)26-22(27)19-10-9-18(25-13-17(24)14-30)12-20(19)16-7-5-4-6-8-16/h4-10,12,15,17,21,25,30H,11,13-14,24H2,1-3H3,(H,26,27)/t17-,21+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076142
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1 Show InChI InChI=1S/C23H31N3O3S/c1-15(2)11-21(23(28)29-3)26-22(27)19-10-9-18(25-13-17(24)14-30)12-20(19)16-7-5-4-6-8-16/h4-10,12,15,17,21,25,30H,11,13-14,24H2,1-3H3,(H,26,27)/t17-,21+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076127
((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(OCCn2ccnc2)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C24H27N3O4/c1-17(2)14-22(24(29)30)26-23(28)20-9-8-19(31-13-12-27-11-10-25-16-27)15-21(20)18-6-4-3-5-7-18/h3-11,15-17,22H,12-14H2,1-2H3,(H,26,28)(H,29,30)/t22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076135
((2S)-2-(4-((1H-imidazol-4-yl)methylamino)-2-(napht...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C27H28N4O3/c1-17(2)12-25(27(33)34)31-26(32)23-11-10-19(29-15-20-14-28-16-30-20)13-24(23)22-9-5-7-18-6-3-4-8-21(18)22/h3-11,13-14,16-17,25,29H,12,15H2,1-2H3,(H,28,30)(H,31,32)(H,33,34)/t25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076130
((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C28H30N4O3/c1-18(2)12-26(28(34)35)32-27(33)24-11-10-19(14-29-15-21-16-30-17-31-21)13-25(24)23-9-5-7-20-6-3-4-8-22(20)23/h3-11,13,16-18,26,29H,12,14-15H2,1-2H3,(H,30,31)(H,32,33)(H,34,35)/t26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076141
((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C26H31N3O3S/c1-16(2)12-24(26(31)32)29-25(30)22-11-10-19(28-14-18(27)15-33)13-23(22)21-9-5-7-17-6-3-4-8-20(17)21/h3-11,13,16,18,24,28,33H,12,14-15,27H2,1-2H3,(H,29,30)(H,31,32)/t18-,24+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076126
((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C23H26N4O3/c1-15(2)10-21(23(29)30)27-22(28)19-9-8-17(25-13-18-12-24-14-26-18)11-20(19)16-6-4-3-5-7-16/h3-9,11-12,14-15,21,25H,10,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076133
((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-3',5'-d...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cc(C)cc(C)c1)C(O)=O Show InChI InChI=1S/C25H30N4O3/c1-15(2)7-23(25(31)32)29-24(30)21-6-5-19(27-13-20-12-26-14-28-20)11-22(21)18-9-16(3)8-17(4)10-18/h5-6,8-12,14-15,23,27H,7,13H2,1-4H3,(H,26,28)(H,29,30)(H,31,32)/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076128
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C22H29N3O3S/c1-14(2)10-20(22(27)28)25-21(26)18-9-8-17(24-12-16(23)13-29)11-19(18)15-6-4-3-5-7-15/h3-9,11,14,16,20,24,29H,10,12-13,23H2,1-2H3,(H,25,26)(H,27,28)/t16-,20+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 183 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076141
((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C26H31N3O3S/c1-16(2)12-24(26(31)32)29-25(30)22-11-10-19(28-14-18(27)15-33)13-23(22)21-9-5-7-17-6-3-4-8-20(17)21/h3-11,13,16,18,24,28,33H,12,14-15,27H2,1-2H3,(H,29,30)(H,31,32)/t18-,24+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 203 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076131
((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ncc[nH]2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C27H28N4O3/c1-17(2)14-24(27(33)34)31-26(32)22-11-10-19(30-16-25-28-12-13-29-25)15-23(22)21-9-5-7-18-6-3-4-8-20(18)21/h3-13,15,17,24,30H,14,16H2,1-2H3,(H,28,29)(H,31,32)(H,33,34)/t24-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076128
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C22H29N3O3S/c1-14(2)10-20(22(27)28)25-21(26)18-9-8-17(24-12-16(23)13-29)11-19(18)15-6-4-3-5-7-15/h3-9,11,14,16,20,24,29H,10,12-13,23H2,1-2H3,(H,25,26)(H,27,28)/t16-,20+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076127
((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(OCCn2ccnc2)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C24H27N3O4/c1-17(2)14-22(24(29)30)26-23(28)20-9-8-19(31-13-12-27-11-10-25-16-27)15-21(20)18-6-4-3-5-7-18/h3-11,15-17,22H,12-14H2,1-2H3,(H,26,28)(H,29,30)/t22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 303 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076132
((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)Show SMILES CC(C)C[C@H](NC(=O)c1cc(NCc2ccncc2)ccc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H27N3O3/c1-17(2)14-23(25(30)31)28-24(29)22-15-20(27-16-18-10-12-26-13-11-18)8-9-21(22)19-6-4-3-5-7-19/h3-13,15,17,23,27H,14,16H2,1-2H3,(H,28,29)(H,30,31)/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076133
((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-3',5'-d...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cc(C)cc(C)c1)C(O)=O Show InChI InChI=1S/C25H30N4O3/c1-15(2)7-23(25(31)32)29-24(30)21-6-5-19(27-13-20-12-26-14-28-20)11-22(21)18-9-16(3)8-17(4)10-18/h5-6,8-12,14-15,23,27H,7,13H2,1-4H3,(H,26,28)(H,29,30)(H,31,32)/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076126
((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C23H26N4O3/c1-15(2)10-21(23(29)30)27-22(28)19-9-8-17(25-13-18-12-24-14-26-18)11-20(19)16-6-4-3-5-7-16/h3-9,11-12,14-15,21,25H,10,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076145
((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C29H29N3O3/c1-19(2)16-27(29(34)35)32-28(33)25-11-10-22(31-18-20-12-14-30-15-13-20)17-26(25)24-9-5-7-21-6-3-4-8-23(21)24/h3-15,17,19,27,31H,16,18H2,1-2H3,(H,32,33)(H,34,35)/t27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076136
((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-2-yl...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ccccn2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C29H29N3O3/c1-19(2)16-27(29(34)35)32-28(33)25-14-13-21(31-18-22-10-5-6-15-30-22)17-26(25)24-12-7-9-20-8-3-4-11-23(20)24/h3-15,17,19,27,31H,16,18H2,1-2H3,(H,32,33)(H,34,35)/t27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076135
((2S)-2-(4-((1H-imidazol-4-yl)methylamino)-2-(napht...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C27H28N4O3/c1-17(2)12-25(27(33)34)31-26(32)23-11-10-19(29-15-20-14-28-16-30-20)13-24(23)22-9-5-7-18-6-3-4-8-21(18)22/h3-11,13-14,16-17,25,29H,12,15H2,1-2H3,(H,28,30)(H,31,32)(H,33,34)/t25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50076137
((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)Show SMILES CC(C)C[C@H](NC(=O)c1c(NCc2cnc[nH]2)cccc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C23H26N4O3/c1-15(2)11-20(23(29)30)27-22(28)21-18(16-7-4-3-5-8-16)9-6-10-19(21)25-13-17-12-24-14-26-17/h3-10,12,14-15,20,25H,11,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076131
((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ncc[nH]2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C27H28N4O3/c1-17(2)14-24(27(33)34)31-26(32)22-11-10-19(30-16-25-28-12-13-29-25)15-23(22)21-9-5-7-18-6-3-4-8-20(18)21/h3-13,15,17,24,30H,14,16H2,1-2H3,(H,28,29)(H,31,32)(H,33,34)/t24-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076140
((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(OCCn2ccnc2)cc1-c1ccccc1 Show InChI InChI=1S/C25H29N3O4/c1-18(2)15-23(25(30)31-3)27-24(29)21-10-9-20(32-14-13-28-12-11-26-17-28)16-22(21)19-7-5-4-6-8-19/h4-12,16-18,23H,13-15H2,1-3H3,(H,27,29)/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076127
((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(OCCn2ccnc2)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C24H27N3O4/c1-17(2)14-22(24(29)30)26-23(28)20-9-8-19(31-13-12-27-11-10-25-16-27)15-21(20)18-6-4-3-5-7-18/h3-11,15-17,22H,12-14H2,1-2H3,(H,26,28)(H,29,30)/t22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076130
((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C28H30N4O3/c1-18(2)12-26(28(34)35)32-27(33)24-11-10-19(14-29-15-21-16-30-17-31-21)13-25(24)23-9-5-7-20-6-3-4-8-22(20)23/h3-11,13,16-18,26,29H,12,14-15H2,1-2H3,(H,30,31)(H,32,33)(H,34,35)/t26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076126
((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C23H26N4O3/c1-15(2)10-21(23(29)30)27-22(28)19-9-8-17(25-13-18-12-24-14-26-18)11-20(19)16-6-4-3-5-7-16/h3-9,11-12,14-15,21,25H,10,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076144
((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1cccc2ccccc12 Show InChI InChI=1S/C29H32N4O3/c1-19(2)13-27(29(35)36-3)33-28(34)25-12-11-20(15-30-16-22-17-31-18-32-22)14-26(25)24-10-6-8-21-7-4-5-9-23(21)24/h4-12,14,17-19,27,30H,13,15-16H2,1-3H3,(H,31,32)(H,33,34)/t27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076138
((2S)-methyl 2-(4-((R)-2-amino-3-mercaptopropylamin...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1cccc2ccccc12 Show InChI InChI=1S/C27H33N3O3S/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31)/t19-,25+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076145
((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C29H29N3O3/c1-19(2)16-27(29(34)35)32-28(33)25-11-10-22(31-18-20-12-14-30-15-13-20)17-26(25)24-9-5-7-21-6-3-4-8-23(21)24/h3-15,17,19,27,31H,16,18H2,1-2H3,(H,32,33)(H,34,35)/t27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076129
((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12 Show InChI InChI=1S/C30H31N3O3/c1-20(2)17-28(30(35)36-3)33-29(34)26-12-11-23(32-19-21-13-15-31-16-14-21)18-27(26)25-10-6-8-22-7-4-5-9-24(22)25/h4-16,18,20,28,32H,17,19H2,1-3H3,(H,33,34)/t28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076141
((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C26H31N3O3S/c1-16(2)12-24(26(31)32)29-25(30)22-11-10-19(28-14-18(27)15-33)13-23(22)21-9-5-7-17-6-3-4-8-20(17)21/h3-11,13,16,18,24,28,33H,12,14-15,27H2,1-2H3,(H,29,30)(H,31,32)/t18-,24+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076143
((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NCc2ncc[nH]2)cc1-c1cccc2ccccc12 Show InChI InChI=1S/C28H30N4O3/c1-18(2)15-25(28(34)35-3)32-27(33)23-12-11-20(31-17-26-29-13-14-30-26)16-24(23)22-10-6-8-19-7-4-5-9-21(19)22/h4-14,16,18,25,31H,15,17H2,1-3H3,(H,29,30)(H,32,33)/t25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076128
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C22H29N3O3S/c1-14(2)10-20(22(27)28)25-21(26)18-9-8-17(24-12-16(23)13-29)11-19(18)15-6-4-3-5-7-15/h3-9,11,14,16,20,24,29H,10,12-13,23H2,1-2H3,(H,25,26)(H,27,28)/t16-,20+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076139
((S)-2-{4-[(1H-Imidazol-4-ylmethyl)-amino]-2-naphth...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cccc2ccccc12 Show InChI InChI=1S/C28H30N4O3/c1-18(2)13-26(28(34)35-3)32-27(33)24-12-11-20(30-16-21-15-29-17-31-21)14-25(24)23-10-6-8-19-7-4-5-9-22(19)23/h4-12,14-15,17-18,26,30H,13,16H2,1-3H3,(H,29,31)(H,32,33)/t26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076135
((2S)-2-(4-((1H-imidazol-4-yl)methylamino)-2-(napht...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C27H28N4O3/c1-17(2)12-25(27(33)34)31-26(32)23-11-10-19(29-15-20-14-28-16-30-20)13-24(23)22-9-5-7-18-6-3-4-8-21(18)22/h3-11,13-14,16-17,25,29H,12,15H2,1-2H3,(H,28,30)(H,31,32)(H,33,34)/t25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076134
((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1 Show InChI InChI=1S/C24H28N4O3/c1-16(2)11-22(24(30)31-3)28-23(29)20-10-9-18(26-14-19-13-25-15-27-19)12-21(20)17-7-5-4-6-8-17/h4-10,12-13,15-16,22,26H,11,14H2,1-3H3,(H,25,27)(H,28,29)/t22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076131
((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ncc[nH]2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C27H28N4O3/c1-17(2)14-24(27(33)34)31-26(32)22-11-10-19(30-16-25-28-12-13-29-25)15-23(22)21-9-5-7-18-6-3-4-8-20(18)21/h3-13,15,17,24,30H,14,16H2,1-2H3,(H,28,29)(H,31,32)(H,33,34)/t24-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076137
((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)Show SMILES CC(C)C[C@H](NC(=O)c1c(NCc2cnc[nH]2)cccc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C23H26N4O3/c1-15(2)11-20(23(29)30)27-22(28)21-18(16-7-4-3-5-8-16)9-6-10-19(21)25-13-17-12-24-14-26-17/h3-10,12,14-15,20,25H,11,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076132
((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)Show SMILES CC(C)C[C@H](NC(=O)c1cc(NCc2ccncc2)ccc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H27N3O3/c1-17(2)14-23(25(30)31)28-24(29)22-15-20(27-16-18-10-12-26-13-11-18)8-9-21(22)19-6-4-3-5-7-19/h3-13,15,17,23,27H,14,16H2,1-2H3,(H,28,29)(H,30,31)/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076145
((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C29H29N3O3/c1-19(2)16-27(29(34)35)32-28(33)25-11-10-22(31-18-20-12-14-30-15-13-20)17-26(25)24-9-5-7-21-6-3-4-8-23(21)24/h3-15,17,19,27,31H,16,18H2,1-2H3,(H,32,33)(H,34,35)/t27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076137
((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)Show SMILES CC(C)C[C@H](NC(=O)c1c(NCc2cnc[nH]2)cccc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C23H26N4O3/c1-15(2)11-20(23(29)30)27-22(28)21-18(16-7-4-3-5-8-16)9-6-10-19(21)25-13-17-12-24-14-26-17/h3-10,12,14-15,20,25H,11,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076133
((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-3',5'-d...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cc(C)cc(C)c1)C(O)=O Show InChI InChI=1S/C25H30N4O3/c1-15(2)7-23(25(31)32)29-24(30)21-6-5-19(27-13-20-12-26-14-28-20)11-22(21)18-9-16(3)8-17(4)10-18/h5-6,8-12,14-15,23,27H,7,13H2,1-4H3,(H,26,28)(H,29,30)(H,31,32)/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50076136
((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-2-yl...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ccccn2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C29H29N3O3/c1-19(2)16-27(29(34)35)32-28(33)25-14-13-21(31-18-22-10-5-6-15-30-22)17-26(25)24-12-7-9-20-8-3-4-11-23(20)24/h3-15,17,19,27,31H,16,18H2,1-2H3,(H,32,33)(H,34,35)/t27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076130
((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)Show SMILES CC(C)C[C@H](NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C28H30N4O3/c1-18(2)12-26(28(34)35)32-27(33)24-11-10-19(14-29-15-21-16-30-17-31-21)13-25(24)23-9-5-7-20-6-3-4-8-22(20)23/h3-11,13,16-18,26,29H,12,14-15H2,1-2H3,(H,30,31)(H,32,33)(H,34,35)/t26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50076132
((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)Show SMILES CC(C)C[C@H](NC(=O)c1cc(NCc2ccncc2)ccc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H27N3O3/c1-17(2)14-23(25(30)31)28-24(29)22-15-20(27-16-18-10-12-26-13-11-18)8-9-21(22)19-6-4-3-5-7-19/h3-13,15,17,23,27H,14,16H2,1-2H3,(H,28,29)(H,30,31)/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing. |
J Med Chem 42: 1333-40 (1999)
Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7 |
More data for this
Ligand-Target Pair | |
Search and Browse
