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PubMed code 11055332

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092989
PNG
(1-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-4-cyclohexy...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H32N2O2S/c1-20(25-16-18-26(19-17-25)22-8-4-2-5-9-22)21-12-14-24(15-13-21)29(27,28)23-10-6-3-7-11-23/h3,6-7,10-15,20,22H,2,4-5,8-9,16-19H2,1H3
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 0.200n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092996
PNG
(1-Cyclohexyl-4-{1-[4-(4-methoxy-benzenesulfonyl)-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C(C)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H34N2O3S/c1-20(26-16-18-27(19-17-26)22-6-4-3-5-7-22)21-8-12-24(13-9-21)31(28,29)25-14-10-23(30-2)11-15-25/h8-15,20,22H,3-7,16-19H2,1-2H3
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 0.600n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092984
PNG
(1-{1-[4-(4-Chloro-benzenesulfonyl)-phenyl]-ethyl}-...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClN2O2S/c1-19(26-15-17-27(18-16-26)22-5-3-2-4-6-22)20-7-11-23(12-8-20)30(28,29)24-13-9-21(25)10-14-24/h7-14,19,22H,2-6,15-18H2,1H3
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 0.600n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092995
PNG
(1-Cyclohexyl-4-{1-[4-(toluene-4-sulfonyl)-phenyl]-...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C25H34N2O2S/c1-20-8-12-24(13-9-20)30(28,29)25-14-10-22(11-15-25)21(2)26-16-18-27(19-17-26)23-6-4-3-5-7-23/h8-15,21,23H,3-7,16-19H2,1-2H3
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 0.800n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092319
PNG
(1-Cyclohexyl-4-{1-[4-(4-methoxy-benzenesulfinyl)-p...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(C)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H34N2O2S/c1-20(26-16-18-27(19-17-26)22-6-4-3-5-7-22)21-8-12-24(13-9-21)30(28)25-14-10-23(29-2)11-15-25/h8-15,20,22H,3-7,16-19H2,1-2H3
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 1n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092989
PNG
(1-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-4-cyclohexy...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H32N2O2S/c1-20(25-16-18-26(19-17-25)22-8-4-2-5-9-22)21-12-14-24(15-13-21)29(27,28)23-10-6-3-7-11-23/h3,6-7,10-15,20,22H,2,4-5,8-9,16-19H2,1H3
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 1.30n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 2.70n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 3.80n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 3.80n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092993
PNG
(1-Cyclohexyl-4-{2,2,2-trifluoro-1-[4-(4-methoxy-be...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C25H31F3N2O2S/c1-32-21-9-13-23(14-10-21)33(31)22-11-7-19(8-12-22)24(25(26,27)28)30-17-15-29(16-18-30)20-5-3-2-4-6-20/h7-14,20,24H,2-6,15-18H2,1H3
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 5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092996
PNG
(1-Cyclohexyl-4-{1-[4-(4-methoxy-benzenesulfonyl)-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C(C)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H34N2O3S/c1-20(26-16-18-27(19-17-26)22-6-4-3-5-7-22)21-8-12-24(13-9-21)31(28,29)25-14-10-23(30-2)11-15-25/h8-15,20,22H,3-7,16-19H2,1-2H3
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 6n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092319
PNG
(1-Cyclohexyl-4-{1-[4-(4-methoxy-benzenesulfinyl)-p...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(C)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H34N2O2S/c1-20(26-16-18-27(19-17-26)22-6-4-3-5-7-22)21-8-12-24(13-9-21)30(28)25-14-10-23(29-2)11-15-25/h8-15,20,22H,3-7,16-19H2,1-2H3
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 6n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092984
PNG
(1-{1-[4-(4-Chloro-benzenesulfonyl)-phenyl]-ethyl}-...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClN2O2S/c1-19(26-15-17-27(18-16-26)22-5-3-2-4-6-22)20-7-11-23(12-8-20)30(28,29)24-13-9-21(25)10-14-24/h7-14,19,22H,2-6,15-18H2,1H3
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 8n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092317
PNG
((4-Cyclohexyl-piperazin-1-yl)-[4-(4-methoxy-benzen...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3
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 8n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 9n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092995
PNG
(1-Cyclohexyl-4-{1-[4-(toluene-4-sulfonyl)-phenyl]-...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C25H34N2O2S/c1-20-8-12-24(13-9-20)30(28,29)25-14-10-22(11-15-25)21(2)26-16-18-27(19-17-26)23-6-4-3-5-7-23/h8-15,21,23H,3-7,16-19H2,1-2H3
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 11n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092986
PNG
(1-Cyclohexyl-4-{cyclohexyl-[4-(4-methoxy-benzenesu...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(C1CCCCC1)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C30H42N2O2S/c1-34-27-14-18-29(19-15-27)35(33)28-16-12-25(13-17-28)30(24-8-4-2-5-9-24)32-22-20-31(21-23-32)26-10-6-3-7-11-26/h12-19,24,26,30H,2-11,20-23H2,1H3
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 17n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 20n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092993
PNG
(1-Cyclohexyl-4-{2,2,2-trifluoro-1-[4-(4-methoxy-be...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C25H31F3N2O2S/c1-32-21-9-13-23(14-10-21)33(31)22-11-7-19(8-12-22)24(25(26,27)28)30-17-15-29(16-18-30)20-5-3-2-4-6-20/h7-14,20,24H,2-6,15-18H2,1H3
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 23n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092992
PNG
(2-{4-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-piperazi...)
Show SMILES CC(N1CCN(CCO)CC1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H26N2O3S/c1-17(22-13-11-21(12-14-22)15-16-23)18-7-9-20(10-8-18)26(24,25)19-5-3-2-4-6-19/h2-10,17,23H,11-16H2,1H3
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 26n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092987
PNG
(1-{1-[4-(4-tert-Butyl-benzenesulfonyl)-phenyl]-eth...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C28H40N2O2S/c1-22(29-18-20-30(21-19-29)25-8-6-5-7-9-25)23-10-14-26(15-11-23)33(31,32)27-16-12-24(13-17-27)28(2,3)4/h10-17,22,25H,5-9,18-21H2,1-4H3
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 33n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092988
PNG
(1-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-4-methyl-pi...)
Show SMILES CC(N1CCN(C)CC1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H24N2O2S/c1-16(21-14-12-20(2)13-15-21)17-8-10-19(11-9-17)24(22,23)18-6-4-3-5-7-18/h3-11,16H,12-15H2,1-2H3
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 34n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092983
PNG
(1-Cyclohexyl-4-{1-[4-(4-methanesulfonyl-benzenesul...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H34N2O4S2/c1-20(26-16-18-27(19-17-26)22-6-4-3-5-7-22)21-8-10-24(11-9-21)33(30,31)25-14-12-23(13-15-25)32(2,28)29/h8-15,20,22H,3-7,16-19H2,1-2H3
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 36n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092990
PNG
(1-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-piperazine ...)
Show SMILES CC(N1CCNCC1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H22N2O2S/c1-15(20-13-11-19-12-14-20)16-7-9-18(10-8-16)23(21,22)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3
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 37n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092985
PNG
(2-(4-Cyclohexyl-piperazin-1-yl)-2-[4-(4-methoxy-be...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C25H33N3O3S/c1-31-21-9-13-23(14-10-21)32(30)22-11-7-19(8-12-22)24(25(26)29)28-17-15-27(16-18-28)20-5-3-2-4-6-20/h7-14,20,24H,2-6,15-18H2,1H3,(H2,26,29)
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 40n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092986
PNG
(1-Cyclohexyl-4-{cyclohexyl-[4-(4-methoxy-benzenesu...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(C1CCCCC1)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C30H42N2O2S/c1-34-27-14-18-29(19-15-27)35(33)28-16-12-25(13-17-28)30(24-8-4-2-5-9-24)32-22-20-31(21-23-32)26-10-6-3-7-11-26/h12-19,24,26,30H,2-11,20-23H2,1H3
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 52n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092990
PNG
(1-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-piperazine ...)
Show SMILES CC(N1CCNCC1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H22N2O2S/c1-15(20-13-11-19-12-14-20)16-7-9-18(10-8-16)23(21,22)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3
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 57n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092992
PNG
(2-{4-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-piperazi...)
Show SMILES CC(N1CCN(CCO)CC1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H26N2O3S/c1-17(22-13-11-21(12-14-22)15-16-23)18-7-9-20(10-8-18)26(24,25)19-5-3-2-4-6-19/h2-10,17,23H,11-16H2,1H3
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 77n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 83n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 83n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092987
PNG
(1-{1-[4-(4-tert-Butyl-benzenesulfonyl)-phenyl]-eth...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C28H40N2O2S/c1-22(29-18-20-30(21-19-29)25-8-6-5-7-9-25)23-10-14-26(15-11-23)33(31,32)27-16-12-24(13-17-27)28(2,3)4/h10-17,22,25H,5-9,18-21H2,1-4H3
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 85n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092988
PNG
(1-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-4-methyl-pi...)
Show SMILES CC(N1CCN(C)CC1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H24N2O2S/c1-16(21-14-12-20(2)13-15-21)17-8-10-19(11-9-17)24(22,23)18-6-4-3-5-7-18/h3-11,16H,12-15H2,1-2H3
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 96n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092983
PNG
(1-Cyclohexyl-4-{1-[4-(4-methanesulfonyl-benzenesul...)
Show SMILES CC(N1CCN(CC1)C1CCCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H34N2O4S2/c1-20(26-16-18-27(19-17-26)22-6-4-3-5-7-22)21-8-10-24(11-9-21)33(30,31)25-14-12-23(13-15-25)32(2,28)29/h8-15,20,22H,3-7,16-19H2,1-2H3
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 106n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 112n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092317
PNG
((4-Cyclohexyl-piperazin-1-yl)-[4-(4-methoxy-benzen...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3
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 117n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092991
PNG
(4-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-piperazine-...)
Show SMILES CCOC(=O)N1CCN(CC1)C(C)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H26N2O4S/c1-3-27-21(24)23-15-13-22(14-16-23)17(2)18-9-11-20(12-10-18)28(25,26)19-7-5-4-6-8-19/h4-12,17H,3,13-16H2,1-2H3
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 135n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 140n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50451110
PNG
(CHEMBL2111540)
Show SMILES COc1ccc(cc1)[S@@+]([O-])c1ccc(cc1)C(C#N)N1CCN(CC1)C1CCCCC1 |r|
Show InChI InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3/t25?,31-/m0/s1
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 180n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092991
PNG
(4-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-piperazine-...)
Show SMILES CCOC(=O)N1CCN(CC1)C(C)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H26N2O4S/c1-3-27-21(24)23-15-13-22(14-16-23)17(2)18-9-11-20(12-10-18)28(25,26)19-7-5-4-6-8-19/h4-12,17H,3,13-16H2,1-2H3
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 200n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092985
PNG
(2-(4-Cyclohexyl-piperazin-1-yl)-2-[4-(4-methoxy-be...)
Show SMILES COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C25H33N3O3S/c1-31-21-9-13-23(14-10-21)32(30)22-11-7-19(8-12-22)24(25(26)29)28-17-15-27(16-18-28)20-5-3-2-4-6-20/h7-14,20,24H,2-6,15-18H2,1H3,(H2,26,29)
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 242n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50092994
PNG
(1-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-4-phenyl-pi...)
Show SMILES CC(N1CCN(CC1)c1ccccc1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H26N2O2S/c1-20(25-16-18-26(19-17-25)22-8-4-2-5-9-22)21-12-14-24(15-13-21)29(27,28)23-10-6-3-7-11-23/h2-15,20H,16-19H2,1H3
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 4.60E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50092994
PNG
(1-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-4-phenyl-pi...)
Show SMILES CC(N1CCN(CC1)c1ccccc1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H26N2O2S/c1-20(25-16-18-26(19-17-25)22-8-4-2-5-9-22)21-12-14-24(15-13-21)29(27,28)23-10-6-3-7-11-23/h2-15,20H,16-19H2,1H3
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 4.77E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1

Bioorg Med Chem Lett 10: 2255-7 (2001)


BindingDB Entry DOI: 10.7270/Q2TD9WMF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%