Found 24 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097316
(CHEMBL351995 | Phosphoric acid 12-(2-{1-[2-(5-chlo...)Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)Cc1cn(CCn2ccc3cc(Cl)ccc23)c2ccccc12)Oc1cccc(Cl)c1 Show InChI InChI=1S/C38H46Cl2N3O5P/c39-32-14-13-15-34(28-32)48-49(45,46)47-25-12-8-6-4-2-1-3-5-7-11-21-41-38(44)27-31-29-43(37-17-10-9-16-35(31)37)24-23-42-22-20-30-26-33(40)18-19-36(30)42/h9-10,13-20,22,26,28-29H,1-8,11-12,21,23-25,27H2,(H,41,44)(H,45,46) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097324
(CHEMBL413033 | Phosphoric acid 3-chloro-phenyl est...)Show SMILES Cc1cn(CCCn2cc(CC(=O)NCCCCCCCCCCCCOP(O)(=O)Oc3cccc(Cl)c3)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C40H51ClN3O5P/c1-32-30-43(38-22-12-10-20-36(32)38)25-17-26-44-31-33(37-21-11-13-23-39(37)44)28-40(45)42-24-14-8-6-4-2-3-5-7-9-15-27-48-50(46,47)49-35-19-16-18-34(41)29-35/h10-13,16,18-23,29-31H,2-9,14-15,17,24-28H2,1H3,(H,42,45)(H,46,47) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of human geranylgeranyltransferase-I |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097326
((2-Chloro-phenyl)-phosphonic acid mono-(11-{2-[1-(...)Show SMILES OP(=O)(OCCCCCCCCCCCNC(=O)Cc1cn(CCCn2cccc2)c2ccccc12)c1ccccc1Cl Show InChI InChI=1S/C34H45ClN3O4P/c35-31-18-9-11-20-33(31)43(40,41)42-26-15-7-5-3-1-2-4-6-12-21-36-34(39)27-29-28-38(32-19-10-8-17-30(29)32)25-16-24-37-22-13-14-23-37/h8-11,13-14,17-20,22-23,28H,1-7,12,15-16,21,24-27H2,(H,36,39)(H,40,41) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097318
(CHEMBL155030 | Phosphoric acid 12-(2-{1-[2-(5-chlo...)Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)Cc1cn(CCn2ccc3cc(Cl)ccc23)c2ccccc12)Oc1ccccc1 Show InChI InChI=1S/C38H47ClN3O5P/c39-33-20-21-36-31(28-33)22-24-41(36)25-26-42-30-32(35-18-12-13-19-37(35)42)29-38(43)40-23-14-7-5-3-1-2-4-6-8-15-27-46-48(44,45)47-34-16-10-9-11-17-34/h9-13,16-22,24,28,30H,1-8,14-15,23,25-27,29H2,(H,40,43)(H,44,45) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Competitive inhibition against Candida albicans prolyl-tRNA synthetase (Ca. ProRS) with respect to ATP |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097327
(CHEMBL345715 | Phosphoric acid 12-(2-{1-[2-(5-chlo...)Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)Cc1cn(CCn2ccc3cc(Cl)ccc23)c2ccccc12)OC1CCCCC1 Show InChI InChI=1S/C38H53ClN3O5P/c39-33-20-21-36-31(28-33)22-24-41(36)25-26-42-30-32(35-18-12-13-19-37(35)42)29-38(43)40-23-14-7-5-3-1-2-4-6-8-15-27-46-48(44,45)47-34-16-10-9-11-17-34/h12-13,18-22,24,28,30,34H,1-11,14-17,23,25-27,29H2,(H,40,43)(H,44,45) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097332
(12-(2-{1-[3-(3-Methyl-indol-1-yl)-propyl]-1H-indol...)Show SMILES Cc1cn(CCCn2cc(CC(=O)NCCCCCCCCCCCC(O)=O)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C34H45N3O3/c1-27-25-36(31-18-12-10-16-29(27)31)22-15-23-37-26-28(30-17-11-13-19-32(30)37)24-33(38)35-21-14-8-6-4-2-3-5-7-9-20-34(39)40/h10-13,16-19,25-26H,2-9,14-15,20-24H2,1H3,(H,35,38)(H,39,40) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097320
(12-{2-[1-(3-Phenoxy-propyl)-1H-indol-3-yl]-acetyla...)Show SMILES OC(=O)CCCCCCCCCCCNC(=O)Cc1cn(CCCOc2ccccc2)c2ccccc12 Show InChI InChI=1S/C31H42N2O4/c34-30(32-21-14-7-5-3-1-2-4-6-11-20-31(35)36)24-26-25-33(29-19-13-12-18-28(26)29)22-15-23-37-27-16-9-8-10-17-27/h8-10,12-13,16-19,25H,1-7,11,14-15,20-24H2,(H,32,34)(H,35,36) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097328
(12-(2-{1-[2-(Naphthalen-1-yloxy)-ethyl]-1H-indol-3...)Show SMILES OC(=O)CCCCCCCCCCCNC(=O)Cc1cn(CCOc2cccc3ccccc23)c2ccccc12 Show InChI InChI=1S/C34H42N2O4/c37-33(35-22-13-7-5-3-1-2-4-6-8-21-34(38)39)25-28-26-36(31-19-12-11-17-29(28)31)23-24-40-32-20-14-16-27-15-9-10-18-30(27)32/h9-12,14-20,26H,1-8,13,21-25H2,(H,35,37)(H,38,39) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097323
(12-{2-[1-(2-Indol-1-yl-ethyl)-1H-indol-3-yl]-acety...)Show SMILES OC(=O)CCCCCCCCCCCNC(=O)Cc1cn(CCn2ccc3ccccc23)c2ccccc12 Show InChI InChI=1S/C32H41N3O3/c36-31(33-20-13-7-5-3-1-2-4-6-8-18-32(37)38)24-27-25-35(30-17-12-10-15-28(27)30)23-22-34-21-19-26-14-9-11-16-29(26)34/h9-12,14-17,19,21,25H,1-8,13,18,20,22-24H2,(H,33,36)(H,37,38) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097321
(12-[2-(15-Methyl-7,8-dihydro-6H-[1,4]diazepino[1,2...)Show SMILES Cc1c2-c3c(CC(=O)NCCCCCCCCCCCC(O)=O)c4ccccc4n3CCCn2c2ccccc12 Show InChI InChI=1S/C34H43N3O3/c1-25-26-16-10-12-18-29(26)36-22-15-23-37-30-19-13-11-17-27(30)28(34(37)33(25)36)24-31(38)35-21-14-8-6-4-2-3-5-7-9-20-32(39)40/h10-13,16-19H,2-9,14-15,20-24H2,1H3,(H,35,38)(H,39,40) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097318
(CHEMBL155030 | Phosphoric acid 12-(2-{1-[2-(5-chlo...)Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)Cc1cn(CCn2ccc3cc(Cl)ccc23)c2ccccc12)Oc1ccccc1 Show InChI InChI=1S/C38H47ClN3O5P/c39-33-20-21-36-31(28-33)22-24-41(36)25-26-42-30-32(35-18-12-13-19-37(35)42)29-38(43)40-23-14-7-5-3-1-2-4-6-8-15-27-46-48(44,45)47-34-16-10-9-11-17-34/h9-13,16-22,24,28,30H,1-8,14-15,23,25-27,29H2,(H,40,43)(H,44,45) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Compound was evaluated for its inhibitory activity against Klenow enzyme |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097325
(12-(2-6,7-Dihydro-pyrazino[1,2-a;4,3-a']diindol-13...)Show SMILES OC(=O)CCCCCCCCCCCNC(=O)Cc1c2-c3cc4ccccc4n3CCn2c2ccccc12 Show InChI InChI=1S/C32H39N3O3/c36-30(33-19-13-7-5-3-1-2-4-6-8-18-31(37)38)23-26-25-15-10-12-17-28(25)35-21-20-34-27-16-11-9-14-24(27)22-29(34)32(26)35/h9-12,14-17,22H,1-8,13,18-21,23H2,(H,33,36)(H,37,38) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097317
(12-{2-[1-(3-Cyclohexyloxy-propyl)-1H-indol-3-yl]-a...)Show SMILES OC(=O)CCCCCCCCCCCNC(=O)Cc1cn(CCCOC2CCCCC2)c2ccccc12 Show InChI InChI=1S/C31H48N2O4/c34-30(32-21-14-7-5-3-1-2-4-6-11-20-31(35)36)24-26-25-33(29-19-13-12-18-28(26)29)22-15-23-37-27-16-9-8-10-17-27/h12-13,18-19,25,27H,1-11,14-17,20-24H2,(H,32,34)(H,35,36) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097316
(CHEMBL351995 | Phosphoric acid 12-(2-{1-[2-(5-chlo...)Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)Cc1cn(CCn2ccc3cc(Cl)ccc23)c2ccccc12)Oc1cccc(Cl)c1 Show InChI InChI=1S/C38H46Cl2N3O5P/c39-32-14-13-15-34(28-32)48-49(45,46)47-25-12-8-6-4-2-1-3-5-7-11-21-41-38(44)27-31-29-43(37-17-10-9-16-35(31)37)24-23-42-22-20-30-26-33(40)18-19-36(30)42/h9-10,13-20,22,26,28-29H,1-8,11-12,21,23-25,27H2,(H,41,44)(H,45,46) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Binding affinity towards human Beta-1 adrenergic receptor |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097324
(CHEMBL413033 | Phosphoric acid 3-chloro-phenyl est...)Show SMILES Cc1cn(CCCn2cc(CC(=O)NCCCCCCCCCCCCOP(O)(=O)Oc3cccc(Cl)c3)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C40H51ClN3O5P/c1-32-30-43(38-22-12-10-20-36(32)38)25-17-26-44-31-33(37-21-11-13-23-39(37)44)28-40(45)42-24-14-8-6-4-2-3-5-7-9-15-27-48-50(46,47)49-35-19-16-18-34(41)29-35/h10-13,16,18-23,29-31H,2-9,14-15,17,24-28H2,1H3,(H,42,45)(H,46,47) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Compound was evaluated for its inhibitory activity against Klenow enzyme , and IC50 value was reported |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097329
(12-{2-[1-(3-Indol-1-yl-propyl)-1H-indol-3-yl]-acet...)Show SMILES OC(=O)CCCCCCCCCCCNC(=O)Cc1cn(CCCn2ccc3ccccc23)c2ccccc12 Show InChI InChI=1S/C33H43N3O3/c37-32(34-21-13-7-5-3-1-2-4-6-8-19-33(38)39)25-28-26-36(31-18-12-10-16-29(28)31)23-14-22-35-24-20-27-15-9-11-17-30(27)35/h9-12,15-18,20,24,26H,1-8,13-14,19,21-23,25H2,(H,34,37)(H,38,39) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 9.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097331
(12-{2-[1-(3-Pyrrolidin-1-yl-propyl)-1H-indol-3-yl]...)Show SMILES OC(=O)CCCCCCCCCCCNC(=O)Cc1cn(CCCN2CCCC2)c2ccccc12 Show InChI InChI=1S/C29H45N3O3/c33-28(30-18-11-7-5-3-1-2-4-6-8-17-29(34)35)23-25-24-32(27-16-10-9-15-26(25)27)22-14-21-31-19-12-13-20-31/h9-10,15-16,24H,1-8,11-14,17-23H2,(H,30,33)(H,34,35) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097314
(12-(2-{1-[2-(3-Methyl-indol-1-yl)-ethyl]-1H-indol-...)Show SMILES Cc1cn(CCn2cc(CC(=O)NCCCCCCCCCCCC(O)=O)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C33H43N3O3/c1-26-24-35(30-17-12-10-15-28(26)30)21-22-36-25-27(29-16-11-13-18-31(29)36)23-32(37)34-20-14-8-6-4-2-3-5-7-9-19-33(38)39/h10-13,15-18,24-25H,2-9,14,19-23H2,1H3,(H,34,37)(H,38,39) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097333
(CHEMBL154719 | Phosphoric acid 12-(2-{1-[2-(5-chlo...)Show SMILES Clc1cccc(OP(=O)(OCCCCCCCCCCCCNC(=O)Cc2cn(CCn3ccc4cc(Cl)ccc34)c3ccccc23)OCCC#N)c1 Show InChI InChI=1S/C41H49Cl2N4O5P/c42-35-15-13-16-37(31-35)52-53(49,51-28-14-22-44)50-27-12-8-6-4-2-1-3-5-7-11-23-45-41(48)30-34-32-47(40-18-10-9-17-38(34)40)26-25-46-24-21-33-29-36(43)19-20-39(33)46/h9-10,13,15-21,24,29,31-32H,1-8,11-12,14,23,25-28,30H2,(H,45,48) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097319
(12-[2-(1H,1'H-[2,2']Biindolyl-3-yloxy)-acetylamino...)Show SMILES OC(=O)CCCCCCCCCCCNC(=O)COc1c([nH]c2ccccc12)-c1cc2ccccc2[nH]1 Show InChI InChI=1S/C30H37N3O4/c34-27(31-19-13-7-5-3-1-2-4-6-8-18-28(35)36)21-37-30-23-15-10-12-17-25(23)33-29(30)26-20-22-14-9-11-16-24(22)32-26/h9-12,14-17,20,32-33H,1-8,13,18-19,21H2,(H,31,34)(H,35,36) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097315
(12-{2-[1-(3-Pyrrol-1-yl-propyl)-1H-indol-3-yl]-ace...)Show SMILES OC(=O)CCCCCCCCCCCNC(=O)Cc1cn(CCCn2cccc2)c2ccccc12 Show InChI InChI=1S/C29H41N3O3/c33-28(30-18-11-7-5-3-1-2-4-6-8-17-29(34)35)23-25-24-32(27-16-10-9-15-26(25)27)22-14-21-31-19-12-13-20-31/h9-10,12-13,15-16,19-20,24H,1-8,11,14,17-18,21-23H2,(H,30,33)(H,34,35) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097322
(CHEMBL153853 | Phosphoric acid 12-(2-{1-[2-(5-chlo...)Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)Cc1cn(CCn2ccc3cc(Cl)ccc23)c2ccccc12)OCCC#N Show InChI InChI=1S/C35H46ClN4O5P/c36-31-16-17-33-29(26-31)18-21-39(33)22-23-40-28-30(32-14-9-10-15-34(32)40)27-35(41)38-20-11-7-5-3-1-2-4-6-8-12-24-44-46(42,43)45-25-13-19-37/h9-10,14-18,21,26,28H,1-8,11-13,20,22-25,27H2,(H,38,41)(H,42,43) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097330
(CHEMBL346776 | Phosphoric acid 3-chloro-phenyl est...)Show SMILES Cc1cn(CCCn2cc(CC(=O)NCCCCCCCCCCCCOP(=O)(OCCC#N)Oc3cccc(Cl)c3)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C43H54ClN4O5P/c1-35-33-47(41-23-12-10-21-39(35)41)27-18-28-48-34-36(40-22-11-13-24-42(40)48)31-43(49)46-26-14-8-6-4-2-3-5-7-9-15-29-51-54(50,52-30-17-25-45)53-38-20-16-19-37(44)32-38/h10-13,16,19-24,32-34H,2-9,14-15,17-18,26-31H2,1H3,(H,46,49) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human telomerase |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50097327
(CHEMBL345715 | Phosphoric acid 12-(2-{1-[2-(5-chlo...)Show SMILES OP(=O)(OCCCCCCCCCCCCNC(=O)Cc1cn(CCn2ccc3cc(Cl)ccc23)c2ccccc12)OC1CCCCC1 Show InChI InChI=1S/C38H53ClN3O5P/c39-33-20-21-36-31(28-33)22-24-41(36)25-26-42-30-32(35-18-12-13-19-37(35)42)29-38(43)40-23-14-7-5-3-1-2-4-6-8-15-27-46-48(44,45)47-34-16-10-9-11-17-34/h12-13,18-22,24,28,30,34H,1-11,14-17,23,25-27,29H2,(H,40,43)(H,44,45) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.01E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyushu University
Curated by ChEMBL
| Assay Description
Inhibition of human geranylgeranyltransferase-I |
Bioorg Med Chem Lett 11: 583-5 (2001)
BindingDB Entry DOI: 10.7270/Q2XK8DV2 |
More data for this
Ligand-Target Pair | |
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