Found 63 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098037
(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1 |TLB:10:9:12:5.4.6,THB:8:9:4:7.12.6| Show InChI InChI=1S/C27H34N6O/c28-15-20-1-3-21(4-2-20)17-33-19-29-16-25(33)18-31-5-7-32(8-6-31)26(34)30-27-12-22-9-23(13-27)11-24(10-22)14-27/h1-4,16,19,22-24H,5-14,17-18H2,(H,30,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098005
(CHEMBL354677 | N-Isopropyl-2-(1-methyl-2-o-tolyl-1...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2C)n(C)c2ccccc12 |(15.98,-4.23,;14.93,-3.09,;15.42,-1.62,;13.44,-3.41,;12.41,-2.27,;10.9,-2.6,;9.87,-1.47,;8.38,-1.8,;7.91,-3.26,;8.96,-4.41,;10.46,-4.07,;12.97,-4.88,;11.47,-5.21,;14.02,-6.02,;13.55,-7.47,;14.47,-8.73,;16,-8.72,;16.75,-7.38,;18.29,-7.37,;19.08,-8.71,;18.32,-10.04,;16.78,-10.05,;16.01,-11.39,;13.56,-9.98,;14.05,-11.44,;12.09,-9.52,;10.75,-10.29,;9.42,-9.52,;9.42,-7.98,;10.75,-7.21,;12.09,-7.98,)| Show InChI InChI=1S/C27H29N3O/c1-19(2)30(18-21-13-15-28-16-14-21)26(31)17-24-23-11-7-8-12-25(23)29(4)27(24)22-10-6-5-9-20(22)3/h5-16,19H,17-18H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase 5 nM ATP |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098027
(CHEMBL169607 | N-Isopropyl-N-pyridin-4-ylmethyl-2-...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1C Show InChI InChI=1S/C26H27N3O/c1-18(2)29(17-20-12-14-27-15-13-20)25(30)16-23-22-10-6-7-11-24(22)28-26(23)21-9-5-4-8-19(21)3/h4-15,18,28H,16-17H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098039
(CHEMBL355028 | N-Isopropyl-2-(2-phenyl-1H-indol-3-...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C25H25N3O/c1-18(2)28(17-19-12-14-26-15-13-19)24(29)16-22-21-10-6-7-11-23(21)27-25(22)20-8-4-3-5-9-20/h3-15,18,27H,16-17H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase with 5 nM ATP |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098022
(CHEMBL353493 | N-Cyclobutyl-2-(2-phenyl-1H-indol-3...)Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N(Cc1cccnc1)C1CCC1 Show InChI InChI=1S/C26H25N3O/c30-25(29(21-11-6-12-21)18-19-8-7-15-27-17-19)16-23-22-13-4-5-14-24(22)28-26(23)20-9-2-1-3-10-20/h1-5,7-10,13-15,17,21,28H,6,11-12,16,18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098030
(CHEMBL169986 | N-Cyclopropyl-2-(2-phenyl-1H-indol-...)Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N(Cc1cccnc1)C1CC1 Show InChI InChI=1S/C25H23N3O/c29-24(28(20-12-13-20)17-18-7-6-14-26-16-18)15-22-21-10-4-5-11-23(21)27-25(22)19-8-2-1-3-9-19/h1-11,14,16,20,27H,12-13,15,17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098034
(2-[2-(2-Chloro-phenyl)-1H-indol-3-yl]-N-isopropyl-...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1Cl Show InChI InChI=1S/C25H24ClN3O/c1-17(2)29(16-18-11-13-27-14-12-18)24(30)15-21-19-7-4-6-10-23(19)28-25(21)20-8-3-5-9-22(20)26/h3-14,17,28H,15-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase with 5 nM ATP |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098035
(CHEMBL352665 | N-Isopropyl-2-(2-phenyl-1H-indol-3-...)Show SMILES CC(C)N(Cc1cccnc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C25H25N3O/c1-18(2)28(17-19-9-8-14-26-16-19)24(29)15-22-21-12-6-7-13-23(21)27-25(22)20-10-4-3-5-11-20/h3-14,16,18,27H,15,17H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase with 5 nM ATP |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50366777
(CHEMBL1788269)Show SMILES CC[C@H](C)N(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 |r| Show InChI InChI=1S/C26H27N3O/c1-3-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28-26(23)21-9-5-4-6-10-21/h4-16,19,28H,3,17-18H2,1-2H3/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098018
(CHEMBL355842 | N-Furan-3-ylmethyl-N-isopropyl-2-(2...)Show SMILES CC(C)N(Cc1ccoc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H24N2O2/c1-17(2)26(15-18-12-13-28-16-18)23(27)14-21-20-10-6-7-11-22(20)25-24(21)19-8-4-3-5-9-19/h3-13,16-17,25H,14-15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098006
(CHEMBL169069 | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(...)Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N(CCC#N)C1CC1 Show InChI InChI=1S/C22H21N3O/c23-13-6-14-25(17-11-12-17)21(26)15-19-18-9-4-5-10-20(18)24-22(19)16-7-2-1-3-8-16/h1-5,7-10,17,24H,6,11-12,14-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098025
(CHEMBL169326 | N-Cyclobutyl-2-(2-phenyl-1H-indol-3...)Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N(Cc1ccncc1)C1CCC1 Show InChI InChI=1S/C26H25N3O/c30-25(29(21-9-6-10-21)18-19-13-15-27-16-14-19)17-23-22-11-4-5-12-24(22)28-26(23)20-7-2-1-3-8-20/h1-5,7-8,11-16,21,28H,6,9-10,17-18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098016
(CHEMBL171214 | N-Cyclopropyl-2-(2-phenyl-1H-indol-...)Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N(Cc1ccncc1)C1CC1 Show InChI InChI=1S/C25H23N3O/c29-24(28(20-10-11-20)17-18-12-14-26-15-13-18)16-22-21-8-4-5-9-23(21)27-25(22)19-6-2-1-3-7-19/h1-9,12-15,20,27H,10-11,16-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 171 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098020
(2-[2-(3-Chloro-phenyl)-1H-indol-3-yl]-N-isopropyl-...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C25H24ClN3O/c1-17(2)29(16-18-10-12-27-13-11-18)24(30)15-22-21-8-3-4-9-23(21)28-25(22)19-6-5-7-20(26)14-19/h3-14,17,28H,15-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 172 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098023
(CHEMBL353398 | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(...)Show SMILES Cn1c(c(CC(=O)N(CCC#N)C2CC2)c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C23H23N3O/c1-25-21-11-6-5-10-19(21)20(23(25)17-8-3-2-4-9-17)16-22(27)26(15-7-14-24)18-12-13-18/h2-6,8-11,18H,7,12-13,15-16H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase with 5 nM ATP |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098010
(CHEMBL433529 | N-Isopropyl-2-(2-phenyl-1H-indol-3-...)Show SMILES CC(C)N(Cc1cncnc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H24N4O/c1-17(2)28(15-18-13-25-16-26-14-18)23(29)12-21-20-10-6-7-11-22(20)27-24(21)19-8-4-3-5-9-19/h3-11,13-14,16-17,27H,12,15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 232 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098009
(CHEMBL169997 | N-Furan-2-ylmethyl-N-isopropyl-2-(2...)Show SMILES CC(C)N(Cc1ccco1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H24N2O2/c1-17(2)26(16-19-11-8-14-28-19)23(27)15-21-20-12-6-7-13-22(20)25-24(21)18-9-4-3-5-10-18/h3-14,17,25H,15-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 241 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098019
(CHEMBL355654 | N-Isopropyl-N-(2-methyl-2H-pyrazol-...)Show SMILES CC(C)N(Cc1ccnn1C)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H26N4O/c1-17(2)28(16-19-13-14-25-27(19)3)23(29)15-21-20-11-7-8-12-22(20)26-24(21)18-9-5-4-6-10-18/h4-14,17,26H,15-16H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 245 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098014
(CHEMBL169374 | N-(Cyano-methyl-methyl)-2-(2-phenyl...)Show SMILES CC(C#N)N(Cc1cccnc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C25H22N4O/c1-18(15-26)29(17-19-8-7-13-27-16-19)24(30)14-22-21-11-5-6-12-23(21)28-25(22)20-9-3-2-4-10-20/h2-13,16,18,28H,14,17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098036
(CHEMBL353289 | N-Isopropyl-2-(2-phenyl-1H-indol-3-...)Show SMILES CC(C)N(Cc1cnccn1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H24N4O/c1-17(2)28(16-19-15-25-12-13-26-19)23(29)14-21-20-10-6-7-11-22(20)27-24(21)18-8-4-3-5-9-18/h3-13,15,17,27H,14,16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098037
(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1 |TLB:10:9:12:5.4.6,THB:8:9:4:7.12.6| Show InChI InChI=1S/C27H34N6O/c28-15-20-1-3-21(4-2-20)17-33-19-29-16-25(33)18-31-5-7-32(8-6-31)26(34)30-27-12-22-9-23(13-27)11-24(10-22)14-27/h1-4,16,19,22-24H,5-14,17-18H2,(H,30,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 517 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098011
(CHEMBL422557 | N-Isopropyl-N-(1-methyl-1H-pyrazol-...)Show SMILES CC(C)N(Cc1cnn(C)c1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H26N4O/c1-17(2)28(16-18-14-25-27(3)15-18)23(29)13-21-20-11-7-8-12-22(20)26-24(21)19-9-5-4-6-10-19/h4-12,14-15,17,26H,13,16H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 527 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098028
(CHEMBL366672 | N-Isopropyl-N-(1-methyl-1H-pyrazol-...)Show SMILES CC(C)N(Cc1ccn(C)n1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H26N4O/c1-17(2)28(16-19-13-14-27(3)26-19)23(29)15-21-20-11-7-8-12-22(20)25-24(21)18-9-5-4-6-10-18/h4-14,17,25H,15-16H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 568 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase with 5 nM ATP |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098040
(2-[1-(2-Bromo-benzyl)-1H-indol-3-yl]-N-isopropyl-N...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1cn(Cc2ccccc2Br)c2ccccc12 Show InChI InChI=1S/C26H26BrN3O/c1-19(2)30(16-20-11-13-28-14-12-20)26(31)15-22-18-29(25-10-6-4-8-23(22)25)17-21-7-3-5-9-24(21)27/h3-14,18-19H,15-17H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 572 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098015
(CHEMBL355773 | N-Isopropyl-2-(2-phenyl-1H-indol-3-...)Show SMILES CC(C)N(Cc1ccccn1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C25H25N3O/c1-18(2)28(17-20-12-8-9-15-26-20)24(29)16-22-21-13-6-7-14-23(21)27-25(22)19-10-4-3-5-11-19/h3-15,18,27H,16-17H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 684 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098045
(CHEMBL352766 | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(...)Show SMILES Cc1ccccc1-c1[nH]c2ccccc2c1CC(=O)N(CCC#N)C1CC1 Show InChI InChI=1S/C23H23N3O/c1-16-7-2-3-8-18(16)23-20(19-9-4-5-10-21(19)25-23)15-22(27)26(14-6-13-24)17-11-12-17/h2-5,7-10,17,25H,6,11-12,14-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 712 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098021
(CHEMBL169817 | N-Isopropyl-2-[2-(2-methoxy-phenyl)...)Show SMILES COc1ccccc1-c1[nH]c2ccccc2c1CC(=O)N(Cc1ccncc1)C(C)C Show InChI InChI=1S/C26H27N3O2/c1-18(2)29(17-19-12-14-27-15-13-19)25(30)16-22-20-8-4-6-10-23(20)28-26(22)21-9-5-7-11-24(21)31-3/h4-15,18,28H,16-17H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098044
(CHEMBL353724 | N-Isobutyl-2-(2-phenyl-1H-indol-3-y...)Show SMILES CC(C)CN(Cc1ccccn1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C26H27N3O/c1-19(2)17-29(18-21-12-8-9-15-27-21)25(30)16-23-22-13-6-7-14-24(22)28-26(23)20-10-4-3-5-11-20/h3-15,19,28H,16-18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098032
(2-[2-(2-Chloro-phenyl)-1H-indol-3-yl]-N-(2-cyano-e...)Show SMILES Clc1ccccc1-c1[nH]c2ccccc2c1CC(=O)N(CCC#N)C1CC1 Show InChI InChI=1S/C22H20ClN3O/c23-19-8-3-1-7-17(19)22-18(16-6-2-4-9-20(16)25-22)14-21(27)26(13-5-12-24)15-10-11-15/h1-4,6-9,15,25H,5,10-11,13-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098013
(2-[1-(4-Bromo-benzyl)-1H-indol-3-yl]-N-isopropyl-N...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1cn(Cc2ccc(Br)cc2)c2ccccc12 Show InChI InChI=1S/C26H26BrN3O/c1-19(2)30(17-21-11-13-28-14-12-21)26(31)15-22-18-29(25-6-4-3-5-24(22)25)16-20-7-9-23(27)10-8-20/h3-14,18-19H,15-17H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098004
(2-[1-(3-Bromo-benzyl)-1H-indol-3-yl]-N-isopropyl-N...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1cn(Cc2cccc(Br)c2)c2ccccc12 Show InChI InChI=1S/C26H26BrN3O/c1-19(2)30(17-20-10-12-28-13-11-20)26(31)15-22-18-29(25-9-4-3-8-24(22)25)16-21-6-5-7-23(27)14-21/h3-14,18-19H,15-17H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098042
(CHEMBL354580 | N-Isobutyl-2-(2-phenyl-1H-indol-3-y...)Show SMILES CC(C)CN(Cc1cccnc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C26H27N3O/c1-19(2)17-29(18-20-9-8-14-27-16-20)25(30)15-23-22-12-6-7-13-24(22)28-26(23)21-10-4-3-5-11-21/h3-14,16,19,28H,15,17-18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098029
(2-(2-Phenyl-1H-indol-3-yl)-N,N-bis-pyridin-3-ylmet...)Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N(Cc1cccnc1)Cc1cccnc1 Show InChI InChI=1S/C28H24N4O/c33-27(32(19-21-8-6-14-29-17-21)20-22-9-7-15-30-18-22)16-25-24-12-4-5-13-26(24)31-28(25)23-10-2-1-3-11-23/h1-15,17-18,31H,16,19-20H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098012
(2-(1-Ethyl-2-phenyl-1H-indol-3-yl)-N-isopropyl-N-p...)Show SMILES CCn1c(c(CC(=O)N(Cc2ccncc2)C(C)C)c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C27H29N3O/c1-4-29-25-13-9-8-12-23(25)24(27(29)22-10-6-5-7-11-22)18-26(31)30(20(2)3)19-21-14-16-28-17-15-21/h5-17,20H,4,18-19H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098008
(CHEMBL367709 | N-Isobutyl-2-(2-phenyl-1H-indol-3-y...)Show SMILES CC(C)CN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C26H27N3O/c1-19(2)17-29(18-20-12-14-27-15-13-20)25(30)16-23-22-10-6-7-11-24(22)28-26(23)21-8-4-3-5-9-21/h3-15,19,28H,16-18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FPP incorporation into biotinylated K-Ras-derived peptide by human farnesyl transferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098038
(CHEMBL170889 | N-Cyclopentyl-2-(2-phenyl-1H-indol-...)Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N(Cc1ccncc1)C1CCCC1 Show InChI InChI=1S/C27H27N3O/c31-26(30(22-10-4-5-11-22)19-20-14-16-28-17-15-20)18-24-23-12-6-7-13-25(23)29-27(24)21-8-2-1-3-9-21/h1-3,6-9,12-17,22,29H,4-5,10-11,18-19H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50366776
(CHEMBL1744068)Show SMILES CC[C@@H](C)N(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 |r| Show InChI InChI=1S/C26H27N3O/c1-3-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28-26(23)21-9-5-4-6-10-21/h4-16,19,28H,3,17-18H2,1-2H3/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098033
(CHEMBL353527 | N-(2-Cyano-ethyl)-N-cyclopropyl-2-[...)Show SMILES COc1ccccc1-c1[nH]c2ccccc2c1CC(=O)N(CCC#N)C1CC1 Show InChI InChI=1S/C23H23N3O2/c1-28-21-10-5-3-8-18(21)23-19(17-7-2-4-9-20(17)25-23)15-22(27)26(14-6-13-24)16-11-12-16/h2-5,7-10,16,25H,6,11-12,14-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098024
(2-(1-Benzyl-1H-indol-3-yl)-N-isopropyl-N-pyridin-4...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1cn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-20(2)29(18-22-12-14-27-15-13-22)26(30)16-23-19-28(17-21-8-4-3-5-9-21)25-11-7-6-10-24(23)25/h3-15,19-20H,16-18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098041
(CHEMBL435070 | N-Cyclopentyl-2-(2-phenyl-1H-indol-...)Show SMILES O=C(Cc1c([nH]c2ccccc12)-c1ccccc1)N(Cc1cccnc1)C1CCCC1 Show InChI InChI=1S/C27H27N3O/c31-26(30(22-12-4-5-13-22)19-20-9-8-16-28-18-20)17-24-23-14-6-7-15-25(23)29-27(24)21-10-2-1-3-11-21/h1-3,6-11,14-16,18,22,29H,4-5,12-13,17,19H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098026
(2-[2-(4-Bromo-phenyl)-1H-indol-3-yl]-N-isopropyl-N...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(Br)cc1 Show InChI InChI=1S/C25H24BrN3O/c1-17(2)29(16-18-11-13-27-14-12-18)24(30)15-22-21-5-3-4-6-23(21)28-25(22)19-7-9-20(26)10-8-19/h3-14,17,28H,15-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098003
(CHEMBL355301 | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-...)Show SMILES CCN(Cc1ccncc1)C(=O)Cc1c([nH]c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H23N3O/c1-2-27(17-18-12-14-25-15-13-18)23(28)16-21-20-10-6-7-11-22(20)26-24(21)19-8-4-3-5-9-19/h3-15,26H,2,16-17H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098043
(CHEMBL354877 | N-Isopropyl-2-(2-phenyl-1-propyl-1H...)Show SMILES CCCn1c(c(CC(=O)N(Cc2ccncc2)C(C)C)c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C28H31N3O/c1-4-18-30-26-13-9-8-12-24(26)25(28(30)23-10-6-5-7-11-23)19-27(32)31(21(2)3)20-22-14-16-29-17-15-22/h5-17,21H,4,18-20H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.99E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098031
(2-(1-Butyl-2-phenyl-1H-indol-3-yl)-N-isopropyl-N-p...)Show SMILES CCCCn1c(c(CC(=O)N(Cc2ccncc2)C(C)C)c2ccccc12)-c1ccccc1 Show InChI InChI=1S/C29H33N3O/c1-4-5-19-31-27-14-10-9-13-25(27)26(29(31)24-11-7-6-8-12-24)20-28(33)32(22(2)3)21-23-15-17-30-18-16-23/h6-18,22H,4-5,19-21H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098017
(2-(1H-Indol-3-yl)-N-isopropyl-N-pyridin-4-ylmethyl...)Show InChI InChI=1S/C19H21N3O/c1-14(2)22(13-15-7-9-20-10-8-15)19(23)11-16-12-21-18-6-4-3-5-17(16)18/h3-10,12,14,21H,11,13H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of K-Ras farnesylation in PSN-1 cells with 100 nM GGT1 |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of HDJ-2 farnesylation in PSN-1 cells at without GGT1 |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of HDJ-2 farnesylation in PSN-1 cells with 100 nM GGT1 |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of HDJ-2 farnesylation in PSN-1 cells |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098005
(CHEMBL354677 | N-Isopropyl-2-(1-methyl-2-o-tolyl-1...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2C)n(C)c2ccccc12 |(15.98,-4.23,;14.93,-3.09,;15.42,-1.62,;13.44,-3.41,;12.41,-2.27,;10.9,-2.6,;9.87,-1.47,;8.38,-1.8,;7.91,-3.26,;8.96,-4.41,;10.46,-4.07,;12.97,-4.88,;11.47,-5.21,;14.02,-6.02,;13.55,-7.47,;14.47,-8.73,;16,-8.72,;16.75,-7.38,;18.29,-7.37,;19.08,-8.71,;18.32,-10.04,;16.78,-10.05,;16.01,-11.39,;13.56,-9.98,;14.05,-11.44,;12.09,-9.52,;10.75,-10.29,;9.42,-9.52,;9.42,-7.98,;10.75,-7.21,;12.09,-7.98,)| Show InChI InChI=1S/C27H29N3O/c1-19(2)30(18-21-13-15-28-16-14-21)26(31)17-24-23-11-7-8-12-25(23)29(4)27(24)22-10-6-5-9-20(22)3/h5-16,19H,17-18H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of HDJ-2 farnesylation in PSN-1 cells |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of K-Ras farnesylation in PSN-1 cells without GGT1 |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
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