Found 53 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50067584
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1 | PDB
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| n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108065
(4'-(2-Amino-3-mercapto-propylamino)-[1,1';2',1'']t...)Show SMILES N[C@@H](CS)CNc1ccc(-c2cccc(c2)C(O)=O)c(c1)-c1ccccc1 Show InChI InChI=1S/C22H22N2O2S/c23-18(14-27)13-24-19-9-10-20(16-7-4-8-17(11-16)22(25)26)21(12-19)15-5-2-1-3-6-15/h1-12,18,24,27H,13-14,23H2,(H,25,26)/t18-/m1/s1 | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108067
(2-Amino-3-[3'-(5H-tetrazol-5-yl)-biphenyl-4-ylamin...)Show SMILES N[C@@H](CS)CNc1ccc(cc1)-c1cccc(c1)-c1nnn[nH]1 Show InChI InChI=1S/C16H18N6S/c17-14(10-23)9-18-15-6-4-11(5-7-15)12-2-1-3-13(8-12)16-19-21-22-20-16/h1-8,14,18,23H,9-10,17H2,(H,19,20,21,22)/t14-/m1/s1 | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048961
(4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...)Show InChI InChI=1S/C17H20N2O3S/c1-22-16-8-14(19-9-13(18)10-23)5-6-15(16)11-3-2-4-12(7-11)17(20)21/h2-8,13,19,23H,9-10,18H2,1H3,(H,20,21)/t13-/m1/s1 | PDB
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108058
(4'-(2-Amino-3-mercapto-propylamino)-2'-propoxy-bip...)Show SMILES CCCOc1cc(NC[C@@H](N)CS)ccc1-c1cccc(c1)C(O)=O Show InChI InChI=1S/C19H24N2O3S/c1-2-8-24-18-10-16(21-11-15(20)12-25)6-7-17(18)13-4-3-5-14(9-13)19(22)23/h3-7,9-10,15,21,25H,2,8,11-12,20H2,1H3,(H,22,23)/t15-/m1/s1 | PDB
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108070
(2-[4-(2-Amino-3-mercapto-propylamino)-benzoylamino...)Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1)C(O)=O Show InChI InChI=1S/C15H23N3O3S2/c1-23-7-6-13(15(20)21)18-14(19)10-2-4-12(5-3-10)17-8-11(16)9-22/h2-5,11,13,17,22H,6-9,16H2,1H3,(H,18,19)(H,20,21)/t11-,13+/m1/s1 | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048953
(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)Show InChI InChI=1S/C16H18N2O2S/c17-14(10-21)9-18-15-6-4-11(5-7-15)12-2-1-3-13(8-12)16(19)20/h1-8,14,18,21H,9-10,17H2,(H,19,20)/t14-/m1/s1 | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108075
(4'-{[3-(4-Nitro-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(cc2)[N+]([O-])=O)cc1-c1ccccc1 Show InChI InChI=1S/C31H26N4O4/c1-39-31(36)25-9-5-8-24(16-25)29-15-12-26(17-30(29)23-6-3-2-4-7-23)33-19-28-18-32-21-34(28)20-22-10-13-27(14-11-22)35(37)38/h2-18,21,33H,19-20H2,1H3 | PDB
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| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108076
((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](CCSC)C(O)=O Show InChI InChI=1S/C19H36N4O5S2/c1-6-11(4)15(18(26)21-13(19(27)28)7-8-30-5)23-17(25)14(10(2)3)22-16(24)12(20)9-29/h10-15,29H,6-9,20H2,1-5H3,(H,21,26)(H,22,24)(H,23,25)(H,27,28)/t11-,12-,13-,14-,15-/m0/s1 | PDB
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| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108055
(4'-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(cc2)C#N)cc1-c1ccccc1 Show InChI InChI=1S/C32H26N4O2/c1-38-32(37)27-9-5-8-26(16-27)30-15-14-28(17-31(30)25-6-3-2-4-7-25)35-20-29-19-34-22-36(29)21-24-12-10-23(18-33)11-13-24/h2-17,19,22,35H,20-21H2,1H3 | PDB
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| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108073
(4'-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(cc2)C#N)cc1-c1ccccc1 Show InChI InChI=1S/C31H24N4O2/c32-17-22-9-11-23(12-10-22)20-35-21-33-18-28(35)19-34-27-13-14-29(25-7-4-8-26(15-25)31(36)37)30(16-27)24-5-2-1-3-6-24/h1-16,18,21,34H,19-20H2,(H,36,37) | PDB
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| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108062
(4'-{[3-(4-Nitro-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(cc2)[N+]([O-])=O)cc1-c1ccccc1 Show InChI InChI=1S/C30H24N4O4/c35-30(36)24-8-4-7-23(15-24)28-14-11-25(16-29(28)22-5-2-1-3-6-22)32-18-27-17-31-20-33(27)19-21-9-12-26(13-10-21)34(37)38/h1-17,20,32H,18-19H2,(H,35,36) | PDB
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| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108065
(4'-(2-Amino-3-mercapto-propylamino)-[1,1';2',1'']t...)Show SMILES N[C@@H](CS)CNc1ccc(-c2cccc(c2)C(O)=O)c(c1)-c1ccccc1 Show InChI InChI=1S/C22H22N2O2S/c23-18(14-27)13-24-19-9-10-20(16-7-4-8-17(11-16)22(25)26)21(12-19)15-5-2-1-3-6-15/h1-12,18,24,27H,13-14,23H2,(H,25,26)/t18-/m1/s1 | PDB
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| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048956
((R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propa...)Show InChI InChI=1S/C16H20N2S/c1-12-3-2-4-14(9-12)13-5-7-16(8-6-13)18-10-15(17)11-19/h2-9,15,18-19H,10-11,17H2,1H3/t15-/m1/s1 | PDB
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| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048960
(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)Show InChI InChI=1S/C17H20N2O2S/c1-21-17(20)14-4-2-3-13(9-14)12-5-7-16(8-6-12)19-10-15(18)11-22/h2-9,15,19,22H,10-11,18H2,1H3/t15-/m1/s1 | PDB
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| n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048954
((R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol...)Show InChI InChI=1S/C15H18N2S/c16-14(11-18)10-17-15-8-6-13(7-9-15)12-4-2-1-3-5-12/h1-9,14,17-18H,10-11,16H2/t14-/m1/s1 | PDB
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| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108057
(4'-[(3H-Imidazol-4-ylmethyl)-amino]-[1,1';2',1'']t...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1 Show InChI InChI=1S/C23H19N3O2/c27-23(28)18-8-4-7-17(11-18)21-10-9-19(25-14-20-13-24-15-26-20)12-22(21)16-5-2-1-3-6-16/h1-13,15,25H,14H2,(H,24,26)(H,27,28) | PDB
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| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108058
(4'-(2-Amino-3-mercapto-propylamino)-2'-propoxy-bip...)Show SMILES CCCOc1cc(NC[C@@H](N)CS)ccc1-c1cccc(c1)C(O)=O Show InChI InChI=1S/C19H24N2O3S/c1-2-8-24-18-10-16(21-11-15(20)12-25)6-7-17(18)13-4-3-5-14(9-13)19(22)23/h3-7,9-10,15,21,25H,2,8,11-12,20H2,1H3,(H,22,23)/t15-/m1/s1 | PDB
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| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108066
(4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES Nc1ccc(Cn2cncc2CNc2ccc(-c3cccc(c3)C(O)=O)c(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C30H26N4O2/c31-25-11-9-21(10-12-25)19-34-20-32-17-27(34)18-33-26-13-14-28(23-7-4-8-24(15-23)30(35)36)29(16-26)22-5-2-1-3-6-22/h1-17,20,33H,18-19,31H2,(H,35,36) | PDB
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| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108061
(4'-(3-Mercapto-propionylamino)-[1,1';2',1'']terphe...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NC(=O)CCS)cc1-c1ccccc1 Show InChI InChI=1S/C22H19NO3S/c24-21(11-12-27)23-18-9-10-19(16-7-4-8-17(13-16)22(25)26)20(14-18)15-5-2-1-3-6-15/h1-10,13-14,27H,11-12H2,(H,23,24)(H,25,26) | PDB
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| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108062
(4'-{[3-(4-Nitro-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(cc2)[N+]([O-])=O)cc1-c1ccccc1 Show InChI InChI=1S/C30H24N4O4/c35-30(36)24-8-4-7-23(15-24)28-14-11-25(16-29(28)22-5-2-1-3-6-22)32-18-27-17-31-20-33(27)19-21-9-12-26(13-10-21)34(37)38/h1-17,20,32H,18-19H2,(H,35,36) | PDB
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| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108067
(2-Amino-3-[3'-(5H-tetrazol-5-yl)-biphenyl-4-ylamin...)Show SMILES N[C@@H](CS)CNc1ccc(cc1)-c1cccc(c1)-c1nnn[nH]1 Show InChI InChI=1S/C16H18N6S/c17-14(10-23)9-18-15-6-4-11(5-7-15)12-2-1-3-13(8-12)16-19-21-22-20-16/h1-8,14,18,23H,9-10,17H2,(H,19,20,21,22)/t14-/m1/s1 | PDB
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| PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108073
(4'-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(cc2)C#N)cc1-c1ccccc1 Show InChI InChI=1S/C31H24N4O2/c32-17-22-9-11-23(12-10-22)20-35-21-33-18-28(35)19-34-27-13-14-29(25-7-4-8-26(15-25)31(36)37)30(16-27)24-5-2-1-3-6-24/h1-16,18,21,34H,19-20H2,(H,36,37) | PDB
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| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108057
(4'-[(3H-Imidazol-4-ylmethyl)-amino]-[1,1';2',1'']t...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1 Show InChI InChI=1S/C23H19N3O2/c27-23(28)18-8-4-7-17(11-18)21-10-9-19(25-14-20-13-24-15-26-20)12-22(21)16-5-2-1-3-6-16/h1-13,15,25H,14H2,(H,24,26)(H,27,28) | PDB
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| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108056
(4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(N)cc2)cc1-c1ccccc1 Show InChI InChI=1S/C31H28N4O2/c1-37-31(36)25-9-5-8-24(16-25)29-15-14-27(17-30(29)23-6-3-2-4-7-23)34-19-28-18-33-21-35(28)20-22-10-12-26(32)13-11-22/h2-18,21,34H,19-20,32H2,1H3 | PDB
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| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108075
(4'-{[3-(4-Nitro-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(cc2)[N+]([O-])=O)cc1-c1ccccc1 Show InChI InChI=1S/C31H26N4O4/c1-39-31(36)25-9-5-8-24(16-25)29-15-12-26(17-30(29)23-6-3-2-4-7-23)33-19-28-18-32-21-34(28)20-22-10-13-27(14-11-22)35(37)38/h2-18,21,33H,19-20H2,1H3 | PDB
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| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108055
(4'-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(cc2)C#N)cc1-c1ccccc1 Show InChI InChI=1S/C32H26N4O2/c1-38-32(37)27-9-5-8-26(16-27)30-15-14-28(17-31(30)25-6-3-2-4-7-25)35-20-29-19-34-22-36(29)21-24-12-10-23(18-33)11-13-24/h2-17,19,22,35H,20-21H2,1H3 | PDB
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| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108066
(4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES Nc1ccc(Cn2cncc2CNc2ccc(-c3cccc(c3)C(O)=O)c(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C30H26N4O2/c31-25-11-9-21(10-12-25)19-34-20-32-17-27(34)18-33-26-13-14-28(23-7-4-8-24(15-23)30(35)36)29(16-26)22-5-2-1-3-6-22/h1-17,20,33H,18-19,31H2,(H,35,36) | PDB
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| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108060
(4'-(3-Mercapto-benzoylamino)-[1,1';2',1'']terpheny...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C27H21NO3S/c1-31-27(30)21-11-5-9-19(15-21)24-14-13-22(17-25(24)18-7-3-2-4-8-18)28-26(29)20-10-6-12-23(32)16-20/h2-17,32H,1H3,(H,28,29) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108056
(4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-am...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cncn2Cc2ccc(N)cc2)cc1-c1ccccc1 Show InChI InChI=1S/C31H28N4O2/c1-37-31(36)25-9-5-8-24(16-25)29-15-14-27(17-30(29)23-6-3-2-4-7-23)34-19-28-18-33-21-35(28)20-22-10-12-26(32)13-11-22/h2-18,21,34H,19-20,32H2,1H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108071
(4'-(3-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C27H23NO2S/c1-30-27(29)22-11-6-10-21(16-22)25-14-13-23(17-26(25)20-8-3-2-4-9-20)28-18-19-7-5-12-24(31)15-19/h2-17,28,31H,18H2,1H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108068
(4'-(3-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C26H21NO2S/c28-26(29)21-10-5-9-20(15-21)24-13-12-22(16-25(24)19-7-2-1-3-8-19)27-17-18-6-4-11-23(30)14-18/h1-16,27,30H,17H2,(H,28,29) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108071
(4'-(3-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C27H23NO2S/c1-30-27(29)22-11-6-10-21(16-22)25-14-13-23(17-26(25)20-8-3-2-4-9-20)28-18-19-7-5-12-24(31)15-19/h2-17,28,31H,18H2,1H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108069
(4'-[(3H-Imidazol-4-ylmethyl)-amino]-[1,1';2',1'']t...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1 Show InChI InChI=1S/C24H21N3O2/c1-29-24(28)19-9-5-8-18(12-19)22-11-10-20(26-15-21-14-25-16-27-21)13-23(22)17-6-3-2-4-7-17/h2-14,16,26H,15H2,1H3,(H,25,27) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108061
(4'-(3-Mercapto-propionylamino)-[1,1';2',1'']terphe...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NC(=O)CCS)cc1-c1ccccc1 Show InChI InChI=1S/C22H19NO3S/c24-21(11-12-27)23-18-9-10-19(16-7-4-8-17(13-16)22(25)26)20(14-18)15-5-2-1-3-6-15/h1-10,13-14,27H,11-12H2,(H,23,24)(H,25,26) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108059
(4'-(4-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2ccc(S)cc2)cc1-c1ccccc1 Show InChI InChI=1S/C26H21NO2S/c28-26(29)21-8-4-7-20(15-21)24-14-11-22(16-25(24)19-5-2-1-3-6-19)27-17-18-9-12-23(30)13-10-18/h1-16,27,30H,17H2,(H,28,29) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108072
(4'-(2-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2ccccc2S)cc1-c1ccccc1 Show InChI InChI=1S/C27H23NO2S/c1-30-27(29)21-12-7-11-20(16-21)24-15-14-23(17-25(24)19-8-3-2-4-9-19)28-18-22-10-5-6-13-26(22)31/h2-17,28,31H,18H2,1H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108060
(4'-(3-Mercapto-benzoylamino)-[1,1';2',1'']terpheny...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C27H21NO3S/c1-31-27(30)21-11-5-9-19(15-21)24-14-13-22(17-25(24)18-7-3-2-4-8-18)28-26(29)20-10-6-12-23(32)16-20/h2-17,32H,1H3,(H,28,29) | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108068
(4'-(3-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C26H21NO2S/c28-26(29)21-10-5-9-20(15-21)24-13-12-22(16-25(24)19-7-2-1-3-8-19)27-17-18-6-4-11-23(30)14-18/h1-16,27,30H,17H2,(H,28,29) | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108063
(4'-(4-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2ccc(S)cc2)cc1-c1ccccc1 Show InChI InChI=1S/C27H23NO2S/c1-30-27(29)22-9-5-8-21(16-22)25-15-12-23(17-26(25)20-6-3-2-4-7-20)28-18-19-10-13-24(31)14-11-19/h2-17,28,31H,18H2,1H3 | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108063
(4'-(4-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2ccc(S)cc2)cc1-c1ccccc1 Show InChI InChI=1S/C27H23NO2S/c1-30-27(29)22-9-5-8-21(16-22)25-15-12-23(17-26(25)20-6-3-2-4-7-20)28-18-19-10-13-24(31)14-11-19/h2-17,28,31H,18H2,1H3 | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108059
(4'-(4-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NCc2ccc(S)cc2)cc1-c1ccccc1 Show InChI InChI=1S/C26H21NO2S/c28-26(29)21-8-4-7-20(15-21)24-14-11-22(16-25(24)19-5-2-1-3-6-19)27-17-18-9-12-23(30)13-10-18/h1-16,27,30H,17H2,(H,28,29) | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108074
(4'-(3-Mercapto-propionylamino)-[1,1';2',1'']terphe...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)CCS)cc1-c1ccccc1 Show InChI InChI=1S/C23H21NO3S/c1-27-23(26)18-9-5-8-17(14-18)20-11-10-19(24-22(25)12-13-28)15-21(20)16-6-3-2-4-7-16/h2-11,14-15,28H,12-13H2,1H3,(H,24,25) | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108072
(4'-(2-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2ccccc2S)cc1-c1ccccc1 Show InChI InChI=1S/C27H23NO2S/c1-30-27(29)21-12-7-11-20(16-21)24-15-14-23(17-25(24)19-8-3-2-4-9-19)28-18-22-10-5-6-13-26(22)31/h2-17,28,31H,18H2,1H3 | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108074
(4'-(3-Mercapto-propionylamino)-[1,1';2',1'']terphe...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)CCS)cc1-c1ccccc1 Show InChI InChI=1S/C23H21NO3S/c1-27-23(26)18-9-5-8-17(14-18)20-11-10-19(24-22(25)12-13-28)15-21(20)16-6-3-2-4-7-16/h2-11,14-15,28H,12-13H2,1H3,(H,24,25) | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108069
(4'-[(3H-Imidazol-4-ylmethyl)-amino]-[1,1';2',1'']t...)Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cnc[nH]2)cc1-c1ccccc1 Show InChI InChI=1S/C24H21N3O2/c1-29-24(28)19-9-5-8-18(12-19)22-11-10-20(26-15-21-14-25-16-27-21)13-23(22)17-6-3-2-4-7-17/h2-14,16,26H,15H2,1H3,(H,25,27) | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50108064
(4'-(3-Mercapto-benzoylamino)-[1,1';2',1'']terpheny...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NC(=O)c2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C26H19NO3S/c28-25(19-9-5-11-22(31)15-19)27-21-12-13-23(18-8-4-10-20(14-18)26(29)30)24(16-21)17-6-2-1-3-7-17/h1-16,31H,(H,27,28)(H,29,30) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50108064
(4'-(3-Mercapto-benzoylamino)-[1,1';2',1'']terpheny...)Show SMILES OC(=O)c1cccc(c1)-c1ccc(NC(=O)c2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C26H19NO3S/c28-25(19-9-5-11-22(31)15-19)27-21-12-13-23(18-8-4-10-20(14-18)26(29)30)24(16-21)17-6-2-1-3-7-17/h1-16,31H,(H,27,28)(H,29,30) | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048961
(4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...)Show InChI InChI=1S/C17H20N2O3S/c1-22-16-8-14(19-9-13(18)10-23)5-6-15(16)11-3-2-4-12(7-11)17(20)21/h2-8,13,19,23H,9-10,18H2,1H3,(H,20,21)/t13-/m1/s1 | PDB
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| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048953
(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)Show InChI InChI=1S/C16H18N2O2S/c17-14(10-21)9-18-15-6-4-11(5-7-15)12-2-1-3-13(8-12)16(19)20/h1-8,14,18,21H,9-10,17H2,(H,19,20)/t14-/m1/s1 | PDB
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| n/a | n/a | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048954
((R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol...)Show InChI InChI=1S/C15H18N2S/c16-14(11-18)10-17-15-8-6-13(7-9-15)12-4-2-1-3-5-12/h1-9,14,17-18H,10-11,16H2/t14-/m1/s1 | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048960
(4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...)Show InChI InChI=1S/C17H20N2O2S/c1-21-17(20)14-4-2-3-13(9-14)12-5-7-16(8-6-12)19-10-15(18)11-22/h2-9,15,19,22H,10-11,18H2,1H3/t15-/m1/s1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048956
((R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propa...)Show InChI InChI=1S/C16H20N2S/c1-12-3-2-4-14(9-12)13-5-7-16(8-6-13)18-10-15(17)11-19/h2-9,15,18-19H,10-11,17H2,1H3/t15-/m1/s1 | PDB
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Yale University
Curated by ChEMBL
| Assay Description
Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells |
J Med Chem 45: 177-88 (2001)
BindingDB Entry DOI: 10.7270/Q22F7MQ7 |
More data for this
Ligand-Target Pair | |
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