BindingDB logo
myBDB logout

PubMed code 12419390

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))		BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C |r,c:14,20|
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
DrugBank
PDB
PubMed
n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))		BDBM50121165
PNG
(3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-5...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C17H13FN2O/c1-17(2)14-8-11(3-4-15(14)20-16(17)21)12-5-10(9-19)6-13(18)7-12/h3-8H,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 13n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121167
PNG
(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)C3(CCCC3)c2c1)C#N
Show InChI InChI=1S/C19H15FN2O/c20-15-8-12(11-21)7-14(9-15)13-3-4-17-16(10-13)19(18(23)22-17)5-1-2-6-19/h3-4,7-10H,1-2,5-6H2,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 14n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121163
PNG
(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Show SMILES O=C1Nc2ccc(cc2C11CCCCC1)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H18N2O/c21-13-14-5-4-6-15(11-14)16-7-8-18-17(12-16)20(19(23)22-18)9-2-1-3-10-20/h4-8,11-12H,1-3,9-10H2,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 15n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121172
PNG
(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1)C#N
Show InChI InChI=1S/C20H17FN2O/c21-16-9-13(12-22)8-15(10-16)14-4-5-18-17(11-14)20(19(24)23-18)6-2-1-3-7-20/h4-5,8-11H,1-3,6-7H2,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121176
PNG
(3-(2'-oxo-1',2'-dihydrospiro[cyclopentane-1,3'-ind...)
Show SMILES O=C1Nc2ccc(cc2C11CCCC1)-c1cccc(c1)C#N
Show InChI InChI=1S/C19H16N2O/c20-12-13-4-3-5-14(10-13)15-6-7-17-16(11-15)19(18(22)21-17)8-1-2-9-19/h3-7,10-11H,1-2,8-9H2,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 21n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121164
PNG
(3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-b...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H14N2O/c1-17(2)14-9-13(6-7-15(14)19-16(17)20)12-5-3-4-11(8-12)10-18/h3-9H,1-2H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 27n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121157
PNG
(5-(3-Fluoro-5-nitro-phenyl)-3,3-dimethyl-1,3-dihyd...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H13FN2O3/c1-16(2)13-7-9(3-4-14(13)18-15(16)20)10-5-11(17)8-12(6-10)19(21)22/h3-8H,1-2H3,(H,18,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 27n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121178
PNG
(5-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-t...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1ccc(s1)C#N
Show InChI InChI=1S/C15H12N2OS/c1-15(2)11-7-9(3-5-12(11)17-14(15)18)13-6-4-10(8-16)19-13/h3-7H,1-2H3,(H,17,18)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 28n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121184
PNG
(3,3-Dimethyl-5-(5-nitro-thiophen-2-yl)-1,3-dihydro...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1ccc(s1)[N+]([O-])=O
Show InChI InChI=1S/C14H12N2O3S/c1-14(2)9-7-8(3-4-10(9)15-13(14)17)11-5-6-12(20-11)16(18)19/h3-7H,1-2H3,(H,15,17)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
PubMed
n/an/a 29n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121161
PNG
(5-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-4...)
Show SMILES Cc1cc(sc1-c1ccc2NC(=O)C(C)(C)c2c1)C#N
Show InChI InChI=1S/C16H14N2OS/c1-9-6-11(8-17)20-14(9)10-4-5-13-12(7-10)16(2,3)15(19)18-13/h4-7H,1-3H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 29n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121183
PNG
(5-(3-Chloro-5-fluoro-phenyl)-3,3-dimethyl-1,3-dihy...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C16H13ClFNO/c1-16(2)13-7-9(3-4-14(13)19-15(16)20)10-5-11(17)8-12(18)6-10/h3-8H,1-2H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 29n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121168
PNG
(3,3-Dimethyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H14N2O3/c1-16(2)13-9-11(6-7-14(13)17-15(16)19)10-4-3-5-12(8-10)18(20)21/h3-9H,1-2H3,(H,17,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 31n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121158
PNG
(5'-(3-chlorophenyl)spiro[cyclopentane-1,3'-indol]-...)
Show SMILES Clc1cccc(c1)-c1ccc2NC(=O)C3(CCCC3)c2c1
Show InChI InChI=1S/C18H16ClNO/c19-14-5-3-4-12(10-14)13-6-7-16-15(11-13)18(17(21)20-16)8-1-2-9-18/h3-7,10-11H,1-2,8-9H2,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 32n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121166
PNG
(5'-(3-nitrophenyl)spiro[cyclopentane-1,3'-indol]-2...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccc2NC(=O)C3(CCCC3)c2c1
Show InChI InChI=1S/C18H16N2O3/c21-17-18(8-1-2-9-18)15-11-13(6-7-16(15)19-17)12-4-3-5-14(10-12)20(22)23/h3-7,10-11H,1-2,8-9H2,(H,19,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 38n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50066523
PNG
(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cccc(c1)[N+]([O-])=O |t:1|
Show InChI InChI=1S/C18H18N2O2/c1-12-11-18(2,3)19-17-8-7-14(10-16(12)17)13-5-4-6-15(9-13)20(21)22/h4-11,19H,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 41n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121172
PNG
(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1)C#N
Show InChI InChI=1S/C20H17FN2O/c21-16-9-13(12-22)8-15(10-16)14-4-5-18-17(11-14)20(19(24)23-18)6-2-1-3-7-20/h4-5,8-11H,1-3,6-7H2,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 51n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosol

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121180
PNG
(5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...)
Show SMILES Clc1cccc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1
Show InChI InChI=1S/C19H18ClNO/c20-15-6-4-5-13(11-15)14-7-8-17-16(12-14)19(18(22)21-17)9-2-1-3-10-19/h4-8,11-12H,1-3,9-10H2,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 56n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121156
PNG
(5-(3-Chloro-phenyl)-3,3-dimethyl-1,3-dihydro-indol...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C16H14ClNO/c1-16(2)13-9-11(6-7-14(13)18-15(16)19)10-4-3-5-12(17)8-10/h3-9H,1-2H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 66n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121173
PNG
(5'-(3-chlorophenyl)spiro[cyclobutane-1,3'-indol]-2...)
Show SMILES Clc1cccc(c1)-c1ccc2NC(=O)C3(CCC3)c2c1
Show InChI InChI=1S/C17H14ClNO/c18-13-4-1-3-11(9-13)12-5-6-15-14(10-12)17(7-2-8-17)16(20)19-15/h1,3-6,9-10H,2,7-8H2,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 71n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121162
PNG
(5'-(3-chlorophenyl)spiro[cyclopropane-1,3'-indol]-...)
Show SMILES Clc1cccc(c1)-c1ccc2NC(=O)C3(CC3)c2c1
Show InChI InChI=1S/C16H12ClNO/c17-12-3-1-2-10(8-12)11-4-5-14-13(9-11)16(6-7-16)15(19)18-14/h1-5,8-9H,6-7H2,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 85n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121170
PNG
(5'-(3-nitrophenyl)spiro[cyclohexane-1,3'-indol]-2'...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1
Show InChI InChI=1S/C19H18N2O3/c22-18-19(9-2-1-3-10-19)16-12-14(7-8-17(16)20-18)13-5-4-6-15(11-13)21(23)24/h4-8,11-12H,1-3,9-10H2,(H,20,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 96n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosol

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121170
PNG
(5'-(3-nitrophenyl)spiro[cyclohexane-1,3'-indol]-2'...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1
Show InChI InChI=1S/C19H18N2O3/c22-18-19(9-2-1-3-10-19)16-12-14(7-8-17(16)20-18)13-5-4-6-15(11-13)21(23)24/h4-8,11-12H,1-3,9-10H2,(H,20,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 96n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121160
PNG
(5-(3,5-Dichloro-phenyl)-3,3-dimethyl-1,3-dihydro-i...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C16H13Cl2NO/c1-16(2)13-7-9(3-4-14(13)19-15(16)20)10-5-11(17)8-12(18)6-10/h3-8H,1-2H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121177
PNG
(3-Methyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-2-on...)
Show SMILES CC1C(=O)Nc2ccc(cc12)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C15H12N2O3/c1-9-13-8-11(5-6-14(13)16-15(9)18)10-3-2-4-12(7-10)17(19)20/h2-9H,1H3,(H,16,18)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 102n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121181
PNG
(5-(3-Chloro-phenyl)-3-ethyl-1,3-dihydro-indol-2-on...)
Show SMILES CCC1C(=O)Nc2ccc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C16H14ClNO/c1-2-13-14-9-11(6-7-15(14)18-16(13)19)10-4-3-5-12(17)8-10/h3-9,13H,2H2,1H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 130n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121159
PNG
(5-(3-Chloro-phenyl)-3-methyl-1,3-dihydro-indol-2-o...)
Show SMILES CC1C(=O)Nc2ccc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H12ClNO/c1-9-13-8-11(5-6-14(13)17-15(9)18)10-3-2-4-12(16)7-10/h2-9H,1H3,(H,17,18)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 185n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121166
PNG
(5'-(3-nitrophenyl)spiro[cyclopentane-1,3'-indol]-2...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccc2NC(=O)C3(CCCC3)c2c1
Show InChI InChI=1S/C18H16N2O3/c21-17-18(8-1-2-9-18)15-11-13(6-7-16(15)19-17)12-4-3-5-14(10-12)20(22)23/h3-7,10-11H,1-2,8-9H2,(H,19,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 193n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosol

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121182
PNG
(5-(3-Acetyl-phenyl)-3,3-dimethyl-1,3-dihydro-indol...)
Show SMILES CC(=O)c1cccc(c1)-c1ccc2NC(=O)C(C)(C)c2c1
Show InChI InChI=1S/C18H17NO2/c1-11(20)12-5-4-6-13(9-12)14-7-8-16-15(10-14)18(2,3)17(21)19-16/h4-10H,1-3H3,(H,19,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 206n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121171
PNG
(5-(3-Chloro-phenyl)-3,3-diethyl-1,3-dihydro-indol-...)
Show SMILES CCC1(CC)C(=O)Nc2ccc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H18ClNO/c1-3-18(4-2)15-11-13(8-9-16(15)20-17(18)21)12-6-5-7-14(19)10-12/h5-11H,3-4H2,1-2H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 229n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121167
PNG
(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)
Show SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)C3(CCCC3)c2c1)C#N
Show InChI InChI=1S/C19H15FN2O/c20-15-8-12(11-21)7-14(9-15)13-3-4-17-16(10-13)19(18(23)22-17)5-1-2-6-19/h3-4,7-10H,1-2,5-6H2,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 230n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosol

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121175
PNG
(3-Benzyl-5-(3-chloro-phenyl)-3-methyl-1,3-dihydro-...)
Show SMILES CC1(Cc2ccccc2)C(=O)Nc2ccc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C22H18ClNO/c1-22(14-15-6-3-2-4-7-15)19-13-17(10-11-20(19)24-21(22)25)16-8-5-9-18(23)12-16/h2-13H,14H2,1H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 267n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121179
PNG
(5-(3-Chloro-phenyl)-1,3-dihydro-indol-2-one | CHEM...)
Show SMILES Clc1cccc(c1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C14H10ClNO/c15-12-3-1-2-9(7-12)10-4-5-13-11(6-10)8-14(17)16-13/h1-7H,8H2,(H,16,17)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 296n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121169
PNG
(5-(3-Nitro-phenyl)-1,3-dihydro-indol-2-one | CHEMB...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C14H10N2O3/c17-14-8-11-6-10(4-5-13(11)15-14)9-2-1-3-12(7-9)16(18)19/h1-7H,8H2,(H,15,17)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 299n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121155
PNG
(5-(3-Methoxy-phenyl)-3,3-dimethyl-1,3-dihydro-indo...)
Show SMILES COc1cccc(c1)-c1ccc2NC(=O)C(C)(C)c2c1
Show InChI InChI=1S/C17H17NO2/c1-17(2)14-10-12(7-8-15(14)18-16(17)19)11-5-4-6-13(9-11)20-3/h4-10H,1-3H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
PubMed
n/an/a 300n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121180
PNG
(5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...)
Show SMILES Clc1cccc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1
Show InChI InChI=1S/C19H18ClNO/c20-15-6-4-5-13(11-15)14-7-8-17-16(12-14)19(18(22)21-17)9-2-1-3-10-19/h4-8,11-12H,1-3,9-10H2,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 477n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosol

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50121168
PNG
(3,3-Dimethyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-...)
Show SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H14N2O3/c1-16(2)13-9-11(6-7-14(13)17-15(16)19)10-4-3-5-12(8-10)18(20)21/h3-9H,1-2H3,(H,17,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 509n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosol

Bioorg Med Chem Lett 12: 3487-90 (2002)


BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%