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PubMed code 12798330

Compile data set for download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129426
PNG
(CHEMBL69451 | N-(4-(4-(2,3-dichlorophenyl)piperazi...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccn3)CC2)c1Cl
Show InChI InChI=1S/C26H28Cl2N4O/c27-22-6-5-8-24(25(22)28)32-18-16-31(17-19-32)15-4-3-14-30-26(33)21-11-9-20(10-12-21)23-7-1-2-13-29-23/h1-2,5-13H,3-4,14-19H2,(H,30,33)
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 0.600n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50071959
PNG
(9H-Fluorene-2-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C28H29Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-2,5-11,19H,3-4,12-18H2,(H,31,34)
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 1.10n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129433
PNG
(CHEMBL71327 | N-{(E)-4-[4-(2,3-Dichloro-phenyl)-pi...)
Show SMILES Clc1cccc(N2CCN(C\C=C\CNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H23Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-10H,11-16H2,(H,24,27)/b5-4+
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 1.30n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129428
PNG
(CHEMBL302374 | N-{4-[4-(2,3-Dichloro-phenyl)-piper...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3ccc(I)cc3)CC2)c1Cl
Show InChI InChI=1S/C21H24Cl2IN3O/c22-18-4-3-5-19(20(18)23)27-14-12-26(13-15-27)11-2-1-10-25-21(28)16-6-8-17(24)9-7-16/h3-9H,1-2,10-15H2,(H,25,28)
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 1.40n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50104122
PNG
(9-Oxo-9H-fluorene-4-carboxylic acid {4-[4-(2,3-dic...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cccc4C(=O)c5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O2/c29-23-11-6-12-24(26(23)30)33-17-15-32(16-18-33)14-4-3-13-31-28(35)22-10-5-9-21-25(22)19-7-1-2-8-20(19)27(21)34/h1-2,5-12H,3-4,13-18H2,(H,31,35)
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 1.60n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129432
PNG
(CHEMBL262724 | Quinoxaline-2-carboxylic acid {4-[4...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cnc4ccccc4n3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N5O/c24-17-6-5-9-21(22(17)25)30-14-12-29(13-15-30)11-4-3-10-26-23(31)20-16-27-18-7-1-2-8-19(18)28-20/h1-2,5-9,16H,3-4,10-15H2,(H,26,31)
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 1.90n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50104130
PNG
(9-Oxo-9H-fluorene-4-carboxylic acid {5-[4-(2,3-dic...)
Show SMILES Clc1cccc(N2CCN(CCCCCNC(=O)c3cccc4C(=O)c5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C29H29Cl2N3O2/c30-24-12-7-13-25(27(24)31)34-18-16-33(17-19-34)15-5-1-4-14-32-29(36)23-11-6-10-22-26(23)20-8-2-3-9-21(20)28(22)35/h2-3,6-13H,1,4-5,14-19H2,(H,32,36)
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 2n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129425
PNG
(5-Fluoro-1H-indole-2-carboxylic acid {4-[4-(2,3-di...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-4-3-5-21(22(18)25)30-12-10-29(11-13-30)9-2-1-8-27-23(31)20-15-16-14-17(26)6-7-19(16)28-20/h3-7,14-15,28H,1-2,8-13H2,(H,27,31)
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 2.60n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129438
PNG
(6-Amino-9H-fluorene-4-carboxylic acid {4-[4-(2,3-d...)
Show SMILES Nc1ccc2Cc3cccc(C(=O)NCCCCN4CCN(CC4)c4cccc(Cl)c4Cl)c3-c2c1
Show InChI InChI=1S/C28H30Cl2N4O/c29-24-7-4-8-25(27(24)30)34-15-13-33(14-16-34)12-2-1-11-32-28(35)22-6-3-5-20-17-19-9-10-21(31)18-23(19)26(20)22/h3-10,18H,1-2,11-17,31H2,(H,32,35)
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 3.5n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129434
PNG
(9H-Fluorene-4-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H29Cl2N3O/c29-24-11-6-12-25(27(24)30)33-17-15-32(16-18-33)14-4-3-13-31-28(34)23-10-5-8-21-19-20-7-1-2-9-22(20)26(21)23/h1-2,5-12H,3-4,13-19H2,(H,31,34)
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 4.5n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50104125
PNG
(2-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-buty...)
Show SMILES Clc1cccc(N2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c1Cl
Show InChI InChI=1S/C22H23Cl2N3O2/c23-18-8-5-9-19(20(18)24)26-14-12-25(13-15-26)10-3-4-11-27-21(28)16-6-1-2-7-17(16)22(27)29/h1-2,5-9H,3-4,10-15H2
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 4.80n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129430
PNG
(CHEMBL71865 | N-{(Z)-4-[4-(2,3-Dichloro-phenyl)-pi...)
Show SMILES Clc1cccc(N2CCN(C\C=C/CNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H23Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-10H,11-16H2,(H,24,27)/b5-4-
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 4.90n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50104133
PNG
(2-{5-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-pent...)
Show SMILES Clc1cccc(N2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N3O2/c24-19-9-6-10-20(21(19)25)27-15-13-26(14-16-27)11-4-1-5-12-28-22(29)17-7-2-3-8-18(17)23(28)30/h2-3,6-10H,1,4-5,11-16H2
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 5.60n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129429
PNG
(9H-Fluorene-2-carboxylic acid {(E)-4-[4-(2,3-dichl...)
Show SMILES Clc1cccc(N2CCN(C\C=C\CNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-11,19H,12-18H2,(H,31,34)/b4-3+
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 5.90n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129436
PNG
(9H-Fluorene-2-carboxylic acid {(Z)-4-[4-(2,3-dichl...)
Show SMILES Clc1cccc(N2CCN(C\C=C/CNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-11,19H,12-18H2,(H,31,34)/b4-3-
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 6n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129439
PNG
(9H-Fluorene-4-carboxylic acid {(Z)-4-[4-(2,3-dichl...)
Show SMILES Clc1cccc(N2CCN(C\C=C/CNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O/c29-24-11-6-12-25(27(24)30)33-17-15-32(16-18-33)14-4-3-13-31-28(34)23-10-5-8-21-19-20-7-1-2-9-22(20)26(21)23/h1-12H,13-19H2,(H,31,34)/b4-3-
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 6.5n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50104140
PNG
(9H-Fluorene-9-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)C3c4ccccc4-c4ccccc34)CC2)c1Cl
Show InChI InChI=1S/C28H29Cl2N3O/c29-24-12-7-13-25(27(24)30)33-18-16-32(17-19-33)15-6-5-14-31-28(34)26-22-10-3-1-8-20(22)21-9-2-4-11-23(21)26/h1-4,7-13,26H,5-6,14-19H2,(H,31,34)
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 11n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129439
PNG
(9H-Fluorene-4-carboxylic acid {(Z)-4-[4-(2,3-dichl...)
Show SMILES Clc1cccc(N2CCN(C\C=C/CNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O/c29-24-11-6-12-25(27(24)30)33-17-15-32(16-18-33)14-4-3-13-31-28(34)23-10-5-8-21-19-20-7-1-2-9-22(20)26(21)23/h1-12H,13-19H2,(H,31,34)/b4-3-
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 11n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129431
PNG
(9H-Fluorene-4-carboxylic acid {(E)-4-[4-(2,3-dichl...)
Show SMILES Clc1cccc(N2CCN(C\C=C\CNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O/c29-24-11-6-12-25(27(24)30)33-17-15-32(16-18-33)14-4-3-13-31-28(34)23-10-5-8-21-19-20-7-1-2-9-22(20)26(21)23/h1-12H,13-19H2,(H,31,34)/b4-3+
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 19n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129430
PNG
(CHEMBL71865 | N-{(Z)-4-[4-(2,3-Dichloro-phenyl)-pi...)
Show SMILES Clc1cccc(N2CCN(C\C=C/CNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H23Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-10H,11-16H2,(H,24,27)/b5-4-
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 20n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50104142
PNG
(9H-Fluorene-9-carboxylic acid {3-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCNC(=O)C3c4ccccc4-c4ccccc34)CC2)c1Cl
Show InChI InChI=1S/C27H27Cl2N3O/c28-23-11-5-12-24(26(23)29)32-17-15-31(16-18-32)14-6-13-30-27(33)25-21-9-3-1-7-19(21)20-8-2-4-10-22(20)25/h1-5,7-12,25H,6,13-18H2,(H,30,33)
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 34n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50104130
PNG
(9-Oxo-9H-fluorene-4-carboxylic acid {5-[4-(2,3-dic...)
Show SMILES Clc1cccc(N2CCN(CCCCCNC(=O)c3cccc4C(=O)c5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C29H29Cl2N3O2/c30-24-12-7-13-25(27(24)31)34-18-16-33(17-19-34)15-5-1-4-14-32-29(36)23-11-6-10-22-26(23)20-8-2-3-9-21(20)28(22)35/h2-3,6-13H,1,4-5,14-19H2,(H,32,36)
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 35n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50104129
PNG
(9-Oxo-9H-fluorene-4-carboxylic acid {3-[4-(2,3-dic...)
Show SMILES Clc1cccc(N2CCN(CCCNC(=O)c3cccc4C(=O)c5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C27H25Cl2N3O2/c28-22-10-4-11-23(25(22)29)32-16-14-31(15-17-32)13-5-12-30-27(34)21-9-3-8-20-24(21)18-6-1-2-7-19(18)26(20)33/h1-4,6-11H,5,12-17H2,(H,30,34)
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 43n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129433
PNG
(CHEMBL71327 | N-{(E)-4-[4-(2,3-Dichloro-phenyl)-pi...)
Show SMILES Clc1cccc(N2CCN(C\C=C\CNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H23Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-10H,11-16H2,(H,24,27)/b5-4+
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 50n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50104140
PNG
(9H-Fluorene-9-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)C3c4ccccc4-c4ccccc34)CC2)c1Cl
Show InChI InChI=1S/C28H29Cl2N3O/c29-24-12-7-13-25(27(24)30)33-18-16-32(17-19-33)15-6-5-14-31-28(34)26-22-10-3-1-8-20(22)21-9-2-4-11-23(21)26/h1-4,7-13,26H,5-6,14-19H2,(H,31,34)
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 55n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129426
PNG
(CHEMBL69451 | N-(4-(4-(2,3-dichlorophenyl)piperazi...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccn3)CC2)c1Cl
Show InChI InChI=1S/C26H28Cl2N4O/c27-22-6-5-8-24(25(22)28)32-18-16-31(17-19-32)15-4-3-14-30-26(33)21-11-9-20(10-12-21)23-7-1-2-13-29-23/h1-2,5-13H,3-4,14-19H2,(H,30,33)
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 58n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129438
PNG
(6-Amino-9H-fluorene-4-carboxylic acid {4-[4-(2,3-d...)
Show SMILES Nc1ccc2Cc3cccc(C(=O)NCCCCN4CCN(CC4)c4cccc(Cl)c4Cl)c3-c2c1
Show InChI InChI=1S/C28H30Cl2N4O/c29-24-7-4-8-25(27(24)30)34-15-13-33(14-16-34)12-2-1-11-32-28(35)22-6-3-5-20-17-19-9-10-21(31)18-23(19)26(20)22/h3-10,18H,1-2,11-17,31H2,(H,32,35)
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 79n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129425
PNG
(5-Fluoro-1H-indole-2-carboxylic acid {4-[4-(2,3-di...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-4-3-5-21(22(18)25)30-12-10-29(11-13-30)9-2-1-8-27-23(31)20-15-16-14-17(26)6-7-19(16)28-20/h3-7,14-15,28H,1-2,8-13H2,(H,27,31)
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 83n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50104121
PNG
(9H-Fluorene-9-carboxylic acid [3-(4-phenyl-piperaz...)
Show SMILES O=C(NCCCN1CCN(CC1)c1ccccc1)C1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C27H29N3O/c31-27(26-24-13-6-4-11-22(24)23-12-5-7-14-25(23)26)28-15-8-16-29-17-19-30(20-18-29)21-9-2-1-3-10-21/h1-7,9-14,26H,8,15-20H2,(H,28,31)
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 85n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50104133
PNG
(2-{5-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-pent...)
Show SMILES Clc1cccc(N2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N3O2/c24-19-9-6-10-20(21(19)25)27-15-13-26(14-16-27)11-4-1-5-12-28-22(29)17-7-2-3-8-18(17)23(28)30/h2-3,6-10H,1,4-5,11-16H2
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 86n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129436
PNG
(9H-Fluorene-2-carboxylic acid {(Z)-4-[4-(2,3-dichl...)
Show SMILES Clc1cccc(N2CCN(C\C=C/CNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-11,19H,12-18H2,(H,31,34)/b4-3-
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 87n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129428
PNG
(CHEMBL302374 | N-{4-[4-(2,3-Dichloro-phenyl)-piper...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3ccc(I)cc3)CC2)c1Cl
Show InChI InChI=1S/C21H24Cl2IN3O/c22-18-4-3-5-19(20(18)23)27-14-12-26(13-15-27)11-2-1-10-25-21(28)16-6-8-17(24)9-7-16/h3-9H,1-2,10-15H2,(H,25,28)
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 88n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50104125
PNG
(2-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-buty...)
Show SMILES Clc1cccc(N2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c1Cl
Show InChI InChI=1S/C22H23Cl2N3O2/c23-18-8-5-9-19(20(18)24)26-14-12-25(13-15-26)10-3-4-11-27-21(28)16-6-1-2-7-17(16)22(27)29/h1-2,5-9H,3-4,10-15H2
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 102n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129431
PNG
(9H-Fluorene-4-carboxylic acid {(E)-4-[4-(2,3-dichl...)
Show SMILES Clc1cccc(N2CCN(C\C=C\CNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O/c29-24-11-6-12-25(27(24)30)33-17-15-32(16-18-33)14-4-3-13-31-28(34)23-10-5-8-21-19-20-7-1-2-9-22(20)26(21)23/h1-12H,13-19H2,(H,31,34)/b4-3+
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 106n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129432
PNG
(CHEMBL262724 | Quinoxaline-2-carboxylic acid {4-[4...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cnc4ccccc4n3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N5O/c24-17-6-5-9-21(22(17)25)30-14-12-29(13-15-30)11-4-3-10-26-23(31)20-16-27-18-7-1-2-8-19(18)28-20/h1-2,5-9,16H,3-4,10-15H2,(H,26,31)
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 109n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129434
PNG
(9H-Fluorene-4-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H29Cl2N3O/c29-24-11-6-12-25(27(24)30)33-17-15-32(16-18-33)14-4-3-13-31-28(34)23-10-5-8-21-19-20-7-1-2-9-22(20)26(21)23/h1-2,5-12H,3-4,13-19H2,(H,31,34)
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 134n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129440
PNG
(9H-Fluorene-4-carboxylic acid {3-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C27H27Cl2N3O/c28-23-10-4-11-24(26(23)29)32-16-14-31(15-17-32)13-5-12-30-27(33)22-9-3-7-20-18-19-6-1-2-8-21(19)25(20)22/h1-4,6-11H,5,12-18H2,(H,30,33)
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 139n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50104122
PNG
(9-Oxo-9H-fluorene-4-carboxylic acid {4-[4-(2,3-dic...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cccc4C(=O)c5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O2/c29-23-11-6-12-24(26(23)30)33-17-15-32(16-18-33)14-4-3-13-31-28(35)22-10-5-9-21-25(22)19-7-1-2-8-20(19)27(21)34/h1-2,5-12H,3-4,13-18H2,(H,31,35)
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 150n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50104129
PNG
(9-Oxo-9H-fluorene-4-carboxylic acid {3-[4-(2,3-dic...)
Show SMILES Clc1cccc(N2CCN(CCCNC(=O)c3cccc4C(=O)c5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C27H25Cl2N3O2/c28-22-10-4-11-23(25(22)29)32-16-14-31(15-17-32)13-5-12-30-27(34)21-9-3-8-20-24(21)18-6-1-2-7-19(18)26(20)33/h1-4,6-11H,5,12-17H2,(H,30,34)
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 153n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129429
PNG
(9H-Fluorene-2-carboxylic acid {(E)-4-[4-(2,3-dichl...)
Show SMILES Clc1cccc(N2CCN(C\C=C\CNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-11,19H,12-18H2,(H,31,34)/b4-3+
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 198n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50104124
PNG
(9H-Fluorene-2-carboxylic acid {3-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C27H27Cl2N3O/c28-24-7-3-8-25(26(24)29)32-15-13-31(14-16-32)12-4-11-30-27(33)20-9-10-23-21(18-20)17-19-5-1-2-6-22(19)23/h1-3,5-10,18H,4,11-17H2,(H,30,33)
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 199n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129437
PNG
(9H-Fluorene-2-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CC#CCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C28H25Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-2,5-11,19H,12-18H2,(H,31,34)
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 214n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50104142
PNG
(9H-Fluorene-9-carboxylic acid {3-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCNC(=O)C3c4ccccc4-c4ccccc34)CC2)c1Cl
Show InChI InChI=1S/C27H27Cl2N3O/c28-23-11-5-12-24(26(23)29)32-17-15-31(16-18-32)14-6-13-30-27(33)25-21-9-3-1-7-19(21)20-8-2-4-10-22(20)25/h1-5,7-12,25H,6,13-18H2,(H,30,33)
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 250n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129440
PNG
(9H-Fluorene-4-carboxylic acid {3-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C27H27Cl2N3O/c28-23-10-4-11-24(26(23)29)32-16-14-31(15-17-32)13-5-12-30-27(33)22-9-3-7-20-18-19-6-1-2-8-21(19)25(20)22/h1-4,6-11H,5,12-18H2,(H,30,33)
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 376n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129435
PNG
(CHEMBL71783 | N-{4-[4-(2,3-Dichloro-phenyl)-pipera...)
Show SMILES Clc1cccc(N2CCN(CC#CCNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H21Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-3,6-10H,11-16H2,(H,24,27)
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 394n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50104124
PNG
(9H-Fluorene-2-carboxylic acid {3-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C27H27Cl2N3O/c28-24-7-3-8-25(26(24)29)32-15-13-31(14-16-32)12-4-11-30-27(33)20-9-10-23-21(18-20)17-19-5-1-2-6-22(19)23/h1-3,5-10,18H,4,11-17H2,(H,30,33)
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 396n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129427
PNG
(9H-Fluorene-4-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CC#CCNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H25Cl2N3O/c29-24-11-6-12-25(27(24)30)33-17-15-32(16-18-33)14-4-3-13-31-28(34)23-10-5-8-21-19-20-7-1-2-9-22(20)26(21)23/h1-2,5-12H,13-19H2,(H,31,34)
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 891n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071959
PNG
(9H-Fluorene-2-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C28H29Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-2,5-11,19H,3-4,12-18H2,(H,31,34)
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 911n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129437
PNG
(9H-Fluorene-2-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CC#CCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C28H25Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-2,5-11,19H,12-18H2,(H,31,34)
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 1.00E+3n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50104121
PNG
(9H-Fluorene-9-carboxylic acid [3-(4-phenyl-piperaz...)
Show SMILES O=C(NCCCN1CCN(CC1)c1ccccc1)C1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C27H29N3O/c31-27(26-24-13-6-4-11-22(24)23-12-5-7-14-25(23)26)28-15-8-16-29-17-19-30(20-18-29)21-9-2-1-3-10-21/h1-7,9-14,26H,8,15-20H2,(H,28,31)
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 1.02E+3n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50129427
PNG
(9H-Fluorene-4-carboxylic acid {4-[4-(2,3-dichloro-...)
Show SMILES Clc1cccc(N2CCN(CC#CCNC(=O)c3cccc4Cc5ccccc5-c34)CC2)c1Cl
Show InChI InChI=1S/C28H25Cl2N3O/c29-24-11-6-12-25(27(24)30)33-17-15-32(16-18-33)14-4-3-13-31-28(34)23-10-5-8-21-19-20-7-1-2-9-22(20)26(21)23/h1-2,5-12H,13-19H2,(H,31,34)
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 1.08E+3n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50129435
PNG
(CHEMBL71783 | N-{4-[4-(2,3-Dichloro-phenyl)-pipera...)
Show SMILES Clc1cccc(N2CCN(CC#CCNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H21Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-3,6-10H,11-16H2,(H,24,27)
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 1.70E+3n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]-IABN as radioligand

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129430
PNG
(CHEMBL71865 | N-{(Z)-4-[4-(2,3-Dichloro-phenyl)-pi...)
Show SMILES Clc1cccc(N2CCN(C\C=C/CNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H23Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-10H,11-16H2,(H,24,27)/b5-4-
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n/an/a 6n/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129433
PNG
(CHEMBL71327 | N-{(E)-4-[4-(2,3-Dichloro-phenyl)-pi...)
Show SMILES Clc1cccc(N2CCN(C\C=C\CNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H23Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-10H,11-16H2,(H,24,27)/b5-4+
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n/an/a 7.70n/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Stimulation of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129432
PNG
(CHEMBL262724 | Quinoxaline-2-carboxylic acid {4-[4...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cnc4ccccc4n3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N5O/c24-17-6-5-9-21(22(17)25)30-14-12-29(13-15-30)11-4-3-10-26-23(31)20-16-27-18-7-1-2-8-19(18)28-20/h1-2,5-9,16H,3-4,10-15H2,(H,26,31)
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n/an/a 27n/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Antagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129425
PNG
(5-Fluoro-1H-indole-2-carboxylic acid {4-[4-(2,3-di...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-4-3-5-21(22(18)25)30-12-10-29(11-13-30)9-2-1-8-27-23(31)20-15-16-14-17(26)6-7-19(16)28-20/h3-7,14-15,28H,1-2,8-13H2,(H,27,31)
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n/an/a 52n/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129428
PNG
(CHEMBL302374 | N-{4-[4-(2,3-Dichloro-phenyl)-piper...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3ccc(I)cc3)CC2)c1Cl
Show InChI InChI=1S/C21H24Cl2IN3O/c22-18-4-3-5-19(20(18)23)27-14-12-26(13-15-27)11-2-1-10-25-21(28)16-6-8-17(24)9-7-16/h3-9H,1-2,10-15H2,(H,25,28)
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n/an/an/an/a 32n/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129425
PNG
(5-Fluoro-1H-indole-2-carboxylic acid {4-[4-(2,3-di...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C23H25Cl2FN4O/c24-18-4-3-5-21(22(18)25)30-12-10-29(11-13-30)9-2-1-8-27-23(31)20-15-16-14-17(26)6-7-19(16)28-20/h3-7,14-15,28H,1-2,8-13H2,(H,27,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129433
PNG
(CHEMBL71327 | N-{(E)-4-[4-(2,3-Dichloro-phenyl)-pi...)
Show SMILES Clc1cccc(N2CCN(C\C=C\CNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H23Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-10H,11-16H2,(H,24,27)/b5-4+
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Agonistic activity of quinpirole stimulation of mitogenesis in human dopamine D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129432
PNG
(CHEMBL262724 | Quinoxaline-2-carboxylic acid {4-[4...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cnc4ccccc4n3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N5O/c24-17-6-5-9-21(22(17)25)30-14-12-29(13-15-30)11-4-3-10-26-23(31)20-16-27-18-7-1-2-8-19(18)28-20/h1-2,5-9,16H,3-4,10-15H2,(H,26,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129430
PNG
(CHEMBL71865 | N-{(Z)-4-[4-(2,3-Dichloro-phenyl)-pi...)
Show SMILES Clc1cccc(N2CCN(C\C=C/CNC(=O)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C21H23Cl2N3O/c22-18-9-6-10-19(20(18)23)26-15-13-25(14-16-26)12-5-4-11-24-21(27)17-7-2-1-3-8-17/h1-10H,11-16H2,(H,24,27)/b5-4-
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Antagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129429
PNG
(9H-Fluorene-2-carboxylic acid {(E)-4-[4-(2,3-dichl...)
Show SMILES Clc1cccc(N2CCN(C\C=C\CNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
Show InChI InChI=1S/C28H27Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-11,19H,12-18H2,(H,31,34)/b4-3+
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n/an/an/an/a 173n/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50129426
PNG
(CHEMBL69451 | N-(4-(4-(2,3-dichlorophenyl)piperazi...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccn3)CC2)c1Cl
Show InChI InChI=1S/C26H28Cl2N4O/c27-22-6-5-8-24(25(22)28)32-18-16-31(17-19-32)15-4-3-14-30-26(33)21-11-9-20(10-12-21)23-7-1-2-13-29-23/h1-2,5-13H,3-4,14-19H2,(H,30,33)
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n/an/an/an/a 6.30n/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells

Bioorg Med Chem Lett 13: 2179-83 (2003)


BindingDB Entry DOI: 10.7270/Q21Z43SN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%