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PubMed code 15566292

Compile data set for download or QSAR
Found 153 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156616
PNG
((7RS,9aRS)-5-[7-(3-fluoro-phenoxymethyl)-octahydro...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3cccc(F)c3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H25FN8O2/c24-16-3-1-4-18(11-16)34-14-15-6-7-17-13-31(9-8-30(17)12-15)22-27-21(25)32-23(28-22)26-20(29-32)19-5-2-10-33-19/h1-5,10-11,15,17H,6-9,12-14H2,(H2,25,26,27,28,29)/t15-,17-/m0/s1
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 0.200n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156605
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-imidazol-1-ylmethyloc...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](Cn3ccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C20H24N10O/c21-18-24-19(25-20-23-17(26-30(18)20)16-2-1-9-31-16)29-8-7-28-11-14(3-4-15(28)12-29)10-27-6-5-22-13-27/h1-2,5-6,9,13-15H,3-4,7-8,10-12H2,(H2,21,23,24,25,26)/t14-,15+/m1/s1
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 0.300n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156606
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(pyridin-3-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3cccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)18-4-2-10-32-18)30-9-8-29-12-15(5-6-16(29)13-30)14-33-17-3-1-7-24-11-17/h1-4,7,10-11,15-16H,5-6,8-9,12-14H2,(H2,23,25,26,27,28)/t15-,16-/m0/s1
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 0.300n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156595
PNG
((7RS,9aRS)-2-furan-2-yl-N5-(2-pyrimidin-2-yloctahy...)
Show SMILES Nc1nc(NC[C@@H]2CC[C@@H]3CN(CCN3C2)c2ncccn2)nc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C21H25N11O/c22-18-27-19(28-21-26-17(29-32(18)21)16-3-1-10-33-16)25-11-14-4-5-15-13-31(9-8-30(15)12-14)20-23-6-2-7-24-20/h1-3,6-7,10,14-15H,4-5,8-9,11-13H2,(H3,22,25,26,27,28,29)/t14-,15+/m0/s1
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 0.300n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156646
PNG
(2-(furan-2-yl)-5-((7S,9aS)-7-((quinolin-6-yloxy)me...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccc4ncccc4c3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)22-4-2-12-36-22)34-11-10-33-14-17(5-6-19(33)15-34)16-37-20-7-8-21-18(13-20)3-1-9-28-21/h1-4,7-9,12-13,17,19H,5-6,10-11,14-16H2,(H2,27,29,30,31,32)/t17-,19-/m0/s1
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 0.600n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156638
PNG
((7RS,9aRS)-5-[7-(2-fluoro-phenoxymethyl)-octahydro...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccccc3F)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H25FN8O2/c24-17-4-1-2-5-18(17)34-14-15-7-8-16-13-31(10-9-30(16)12-15)22-27-21(25)32-23(28-22)26-20(29-32)19-6-3-11-33-19/h1-6,11,15-16H,7-10,12-14H2,(H2,25,26,27,28,29)/t15-,16-/m0/s1
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 0.900n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156650
PNG
(5-((7R,9aS)-7-((bis(pyridin-3-ylmethyl)amino)methy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3cccnc3)Cc3cccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C29H33N11O/c30-27-34-28(35-29-33-26(36-40(27)29)25-6-3-13-41-25)39-12-11-38-19-23(7-8-24(38)20-39)18-37(16-21-4-1-9-31-14-21)17-22-5-2-10-32-15-22/h1-6,9-10,13-15,23-24H,7-8,11-12,16-20H2,(H2,30,33,34,35,36)/t23-,24+/m1/s1
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 2n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156660
PNG
(5-((7R,9aS)-7-((2,4-difluorobenzylamino)methyl)-he...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNCc3ccc(F)cc3F)CC[C@H]2C1 |r|
Show InChI InChI=1S/C24H27F2N9O/c25-17-5-4-16(19(26)10-17)12-28-11-15-3-6-18-14-34(8-7-33(18)13-15)23-30-22(27)35-24(31-23)29-21(32-35)20-2-1-9-36-20/h1-2,4-5,9-10,15,18,28H,3,6-8,11-14H2,(H2,27,29,30,31,32)/t15-,18+/m1/s1
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 2n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156635
PNG
(5-((7S,9aS)-7-(aminomethyl)-hexahydro-1H-pyrido[1,...)
Show SMILES NC[C@@H]1CC[C@H]2CN(CCN2C1)c1nc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C17H23N9O/c18-8-11-3-4-12-10-25(6-5-24(12)9-11)16-21-15(19)26-17(22-16)20-14(23-26)13-2-1-7-27-13/h1-2,7,11-12H,3-6,8-10,18H2,(H2,19,20,21,22,23)/t11-,12-/m0/s1
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 2n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156662
PNG
((6RS,9aRS)-[2-(7-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](CO)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C17H22N8O2/c18-15-20-16(21-17-19-14(22-25(15)17)13-5-2-8-27-13)23-6-7-24-11(9-23)3-1-4-12(24)10-26/h2,5,8,11-12,26H,1,3-4,6-7,9-10H2,(H2,18,19,20,21,22)/t11-,12+/m0/s1
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 3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156644
PNG
((7RS,9aRS)-5-{7-[(bispyridin-4-ylmethylamino)-meth...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3ccncc3)Cc3ccncc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C29H33N11O/c30-27-34-28(35-29-33-26(36-40(27)29)25-2-1-15-41-25)39-14-13-38-19-23(3-4-24(38)20-39)18-37(16-21-5-9-31-10-6-21)17-22-7-11-32-12-8-22/h1-2,5-12,15,23-24H,3-4,13-14,16-20H2,(H2,30,33,34,35,36)/t23-,24+/m1/s1
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 3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156604
PNG
(CHEMBL173672 | N*5*-[(R)-1-(2,6-Difluoro-benzyl)-p...)
Show SMILES Nc1nc(NC[C@H]2CCCN2Cc2c(F)cccc2F)nc2nc(nn12)-c1ccco1
Show InChI InChI=1S/C20H20F2N8O/c21-14-5-1-6-15(22)13(14)11-29-8-2-4-12(29)10-24-19-26-18(23)30-20(27-19)25-17(28-30)16-7-3-9-31-16/h1,3,5-7,9,12H,2,4,8,10-11H2,(H3,23,24,25,26,27,28)/t12-/m1/s1
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 3.60n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156640
PNG
((7RS,9aRS)-5-[7-(3-fluoro-phenoxymethyl)-octahydro...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccc(F)cc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H25FN8O2/c24-16-4-7-18(8-5-16)34-14-15-3-6-17-13-31(10-9-30(17)12-15)22-27-21(25)32-23(28-22)26-20(29-32)19-2-1-11-33-19/h1-2,4-5,7-8,11,15,17H,3,6,9-10,12-14H2,(H2,25,26,27,28,29)/t15-,17-/m0/s1
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 4n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156652
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-[1,2,4]triazol-1-ylme...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](Cn3cncn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C19H23N11O/c20-17-24-18(25-19-23-16(26-30(17)19)15-2-1-7-31-15)28-6-5-27-8-13(3-4-14(27)10-28)9-29-12-21-11-22-29/h1-2,7,11-14H,3-6,8-10H2,(H2,20,23,24,25,26)/t13-,14-/m0/s1
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 4n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156624
PNG
(5-((7S,9aS)-7-((bis(pyridin-3-ylmethyl)amino)methy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CN(Cc3cccnc3)Cc3cccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C29H33N11O/c30-27-34-28(35-29-33-26(36-40(27)29)25-6-3-13-41-25)39-12-11-38-19-23(7-8-24(38)20-39)18-37(16-21-4-1-9-31-14-21)17-22-5-2-10-32-15-22/h1-6,9-10,13-15,23-24H,7-8,11-12,16-20H2,(H2,30,33,34,35,36)/t23-,24-/m0/s1
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 4n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50370922
PNG
(CHEMBL1237041)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ncnc4n[nH]cc34)CC[C@@H]2C1 |r|
Show InChI InChI=1S/C22H24N12O2/c23-20-28-21(29-22-27-18(31-34(20)22)16-2-1-7-35-16)33-6-5-32-9-13(3-4-14(32)10-33)11-36-19-15-8-26-30-17(15)24-12-25-19/h1-2,7-8,12-14H,3-6,9-11H2,(H,24,25,26,30)(H2,23,27,28,29,31)/t13-,14+/m0/s1
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 5n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156633
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(isoquinolin-5-yloxym...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3cccc4cnccc34)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)22-5-2-12-36-22)34-11-10-33-14-17(6-7-19(33)15-34)16-37-21-4-1-3-18-13-28-9-8-20(18)21/h1-5,8-9,12-13,17,19H,6-7,10-11,14-16H2,(H2,27,29,30,31,32)/t17-,19-/m0/s1
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 6n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156643
PNG
(2-(furan-2-yl)-5-((7R,9aS)-7-((quinolin-2-yloxy)me...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ccc4ccccc4n3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)21-6-3-13-36-21)34-12-11-33-14-17(7-9-19(33)15-34)16-37-22-10-8-18-4-1-2-5-20(18)28-22/h1-6,8,10,13,17,19H,7,9,11-12,14-16H2,(H2,27,29,30,31,32)/t17-,19+/m1/s1
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 7n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156667
PNG
(5-((7R,9aS)-7-((bis(pyridin-2-ylmethyl)amino)methy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3ccccn3)Cc3ccccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C29H33N11O/c30-27-34-28(35-29-33-26(36-40(27)29)25-8-5-15-41-25)39-14-13-38-17-21(9-10-24(38)20-39)16-37(18-22-6-1-3-11-31-22)19-23-7-2-4-12-32-23/h1-8,11-12,15,21,24H,9-10,13-14,16-20H2,(H2,30,33,34,35,36)/t21-,24+/m1/s1
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 9n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156618
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(pyrimidin-2-ylaminom...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNc3ncccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C21H25N11O/c22-18-27-20(28-21-26-17(29-32(18)21)16-3-1-10-33-16)31-9-8-30-12-14(4-5-15(30)13-31)11-25-19-23-6-2-7-24-19/h1-3,6-7,10,14-15H,4-5,8-9,11-13H2,(H,23,24,25)(H2,22,26,27,28,29)/t14-,15+/m1/s1
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 9n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156621
PNG
((+/-)-2-furan-2-yl-5-(octahydropyrido[1,2-a]pyrazi...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2CCCCC2C1
Show InChI InChI=1S/C16H20N8O/c17-14-19-15(23-8-7-22-6-2-1-4-11(22)10-23)20-16-18-13(21-24(14)16)12-5-3-9-25-12/h3,5,9,11H,1-2,4,6-8,10H2,(H2,17,18,19,20,21)
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 12n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156599
PNG
((6RS,9aRS)-2-furan-2-yl-5-(6-phenoxymethyl-octahyd...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](COc3ccccc3)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C23H26N8O2/c24-21-26-22(27-23-25-20(28-31(21)23)19-10-5-13-32-19)29-11-12-30-16(14-29)6-4-7-17(30)15-33-18-8-2-1-3-9-18/h1-3,5,8-10,13,16-17H,4,6-7,11-12,14-15H2,(H2,24,25,26,27,28)/t16-,17+/m0/s1
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 13n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50151188
PNG
(5-(4-((5-chloro-1-methyl-3-(trifluoromethyl)-1H-py...)
Show SMILES Cn1nc(c(CN2CCN(CC2)c2nc(N)n3nc(nc3n2)-c2ccco2)c1Cl)C(F)(F)F
Show InChI InChI=1S/C18H18ClF3N10O/c1-29-13(19)10(12(27-29)18(20,21)22)9-30-4-6-31(7-5-30)16-25-15(23)32-17(26-16)24-14(28-32)11-3-2-8-33-11/h2-3,8H,4-7,9H2,1H3,(H2,23,24,25,26,28)
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 14n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156659
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-tetrazol-1-ylmethyl-o...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](Cn3cnnn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H22N12O/c19-16-22-17(23-18-21-15(24-30(16)18)14-2-1-7-31-14)28-6-5-27-8-12(3-4-13(27)10-28)9-29-11-20-25-26-29/h1-2,7,11-13H,3-6,8-10H2,(H2,19,21,22,23,24)/t12-,13-/m0/s1
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 14n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156612
PNG
((7RS,9aRS)-5-(7-aminomethyloctahydropyrido[1,2-a]-...)
Show SMILES NC[C@H]1CC[C@H]2CN(CCN2C1)c1nc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C17H23N9O/c18-8-11-3-4-12-10-25(6-5-24(12)9-11)16-21-15(19)26-17(22-16)20-14(23-26)13-2-1-7-27-13/h1-2,7,11-12H,3-6,8-10,18H2,(H2,19,20,21,22,23)/t11-,12+/m1/s1
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 16n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156610
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(quinazolin-2-yloxyme...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ncnc4ccccc34)CC[C@H]2C1 |r|
Show InChI InChI=1S/C25H26N10O2/c26-23-30-24(31-25-29-21(32-35(23)25)20-6-3-11-36-20)34-10-9-33-12-16(7-8-17(33)13-34)14-37-22-18-4-1-2-5-19(18)27-15-28-22/h1-6,11,15-17H,7-10,12-14H2,(H2,26,29,30,31,32)/t16-,17-/m0/s1
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 19n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156627
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(pyridin-2-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)17-4-3-11-32-17)30-10-9-29-12-15(6-7-16(29)13-30)14-33-18-5-1-2-8-24-18/h1-5,8,11,15-16H,6-7,9-10,12-14H2,(H2,23,25,26,27,28)/t15-,16-/m0/s1
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 20n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156666
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(quinolin-6-yloxymeth...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccccc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H26N8O2/c24-21-26-22(27-23-25-20(28-31(21)23)19-7-4-12-32-19)30-11-10-29-13-16(8-9-17(29)14-30)15-33-18-5-2-1-3-6-18/h1-7,12,16-17H,8-11,13-15H2,(H2,24,25,26,27,28)/t16-,17-/m0/s1
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 21n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156609
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(pyridin-4-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccncc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)18-2-1-11-32-18)30-10-9-29-12-15(3-4-16(29)13-30)14-33-17-5-7-24-8-6-17/h1-2,5-8,11,15-16H,3-4,9-10,12-14H2,(H2,23,25,26,27,28)/t15-,16-/m0/s1
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 25n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156647
PNG
(5-((7R,9aS)-7-(((5-chloro-1,3-dimethyl-1H-pyrazol-...)
Show SMILES Cc1nn(C)c(Cl)c1CNC[C@H]1CC[C@H]2CN(CCN2C1)c1nc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C23H30ClN11O/c1-14-17(19(24)32(2)30-14)11-26-10-15-5-6-16-13-34(8-7-33(16)12-15)22-28-21(25)35-23(29-22)27-20(31-35)18-4-3-9-36-18/h3-4,9,15-16,26H,5-8,10-13H2,1-2H3,(H2,25,27,28,29,31)/t15-,16+/m1/s1
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 30n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156625
PNG
((7RS,9aRS)-3-amino-5-{7-[(7-amino-2-furan-2-yl[1,2...)
Show SMILES COC(=O)c1nc(Cl)c(nc1N)N1CCN2C[C@H](CNc3nc(N)n4nc(nc4n3)-c3ccco3)CC[C@@H]2C1 |r|
Show InChI InChI=1S/C23H27ClN12O3/c1-38-20(37)15-17(25)29-19(16(24)28-15)35-7-6-34-10-12(4-5-13(34)11-35)9-27-22-31-21(26)36-23(32-22)30-18(33-36)14-3-2-8-39-14/h2-3,8,12-13H,4-7,9-11H2,1H3,(H2,25,29)(H3,26,27,30,31,32,33)/t12-,13+/m0/s1
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 34n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156608
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(4-methoxy-phenoxymet...)
Show SMILES COc1ccc(OC[C@H]2CC[C@H]3CN(CCN3C2)c2nc(N)n3nc(nc3n2)-c2ccco2)cc1 |r|
Show InChI InChI=1S/C24H28N8O3/c1-33-18-6-8-19(9-7-18)35-15-16-4-5-17-14-31(11-10-30(17)13-16)23-27-22(25)32-24(28-23)26-21(29-32)20-3-2-12-34-20/h2-3,6-9,12,16-17H,4-5,10-11,13-15H2,1H3,(H2,25,26,27,28,29)/t16-,17-/m0/s1
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 35n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156668
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(isoquinolin-3-yloxym...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3cc4ccccc4cn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)21-6-3-11-36-21)34-10-9-33-14-17(7-8-20(33)15-34)16-37-22-12-18-4-1-2-5-19(18)13-28-22/h1-6,11-13,17,20H,7-10,14-16H2,(H2,27,29,30,31,32)/t17-,20-/m0/s1
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 36n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156658
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-{[(pyridin-4-ylmethyl...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNCc3ccncc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H28N10O/c24-21-28-22(29-23-27-20(30-33(21)23)19-2-1-11-34-19)32-10-9-31-14-17(3-4-18(31)15-32)13-26-12-16-5-7-25-8-6-16/h1-2,5-8,11,17-18,26H,3-4,9-10,12-15H2,(H2,24,27,28,29,30)/t17-,18+/m1/s1
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 36n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50048466
PNG
(2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,...)
Show SMILES Nc1nc2n(CCc3ccccc3)ncc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
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 37n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156629
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(quinazolin-2-yloxyme...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ncnc4ccccc34)CC[C@H]2C1 |r|
Show InChI InChI=1S/C25H26N10O2/c26-23-30-24(31-25-29-21(32-35(23)25)20-6-3-11-36-20)34-10-9-33-12-16(7-8-17(33)13-34)14-37-22-18-4-1-2-5-19(18)27-15-28-22/h1-6,11,15-17H,7-10,12-14H2,(H2,26,29,30,31,32)/t16-,17+/m1/s1
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 37n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156620
PNG
((+/-)-2-furan-2-yl-5-(octahydro-pyrido[1,2-a]pyraz...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2CCCCC2C1
Show InChI InChI=1S/C17H21N7O/c18-14-10-15(23-8-7-22-6-2-1-4-12(22)11-23)19-17-20-16(21-24(14)17)13-5-3-9-25-13/h3,5,9-10,12H,1-2,4,6-8,11,18H2
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 38n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156661
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(pyridin-2-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ccccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)17-4-3-11-32-17)30-10-9-29-12-15(6-7-16(29)13-30)14-33-18-5-1-2-8-24-18/h1-5,8,11,15-16H,6-7,9-10,12-14H2,(H2,23,25,26,27,28)/t15-,16+/m1/s1
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 41n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156649
PNG
(2-(furan-2-yl)-5-((7S,9aS)-7-((pyrimidin-2-ylamino...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CNc3ncccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C21H25N11O/c22-18-27-20(28-21-26-17(29-32(18)21)16-3-1-10-33-16)31-9-8-30-12-14(4-5-15(30)13-31)11-25-19-23-6-2-7-24-19/h1-3,6-7,10,14-15H,4-5,8-9,11-13H2,(H,23,24,25)(H2,22,26,27,28,29)/t14-,15-/m0/s1
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 45n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156611
PNG
((7RS,9aRS)-[2-(7-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C17H22N8O2/c18-15-20-16(21-17-19-14(22-25(15)17)13-2-1-7-27-13)24-6-5-23-8-11(10-26)3-4-12(23)9-24/h1-2,7,11-12,26H,3-6,8-10H2,(H2,18,19,20,21,22)/t11-,12-/m0/s1
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 45n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156663
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-phenoxymethyl-octahyd...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccccc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C24H27N7O2/c25-21-13-22(26-24-27-23(28-31(21)24)20-7-4-12-32-20)30-11-10-29-14-17(8-9-18(29)15-30)16-33-19-5-2-1-3-6-19/h1-7,12-13,17-18H,8-11,14-16,25H2/t17-,18-/m0/s1
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 45n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156626
PNG
((R)-2-furan-2-yl-5-(hexahydro-pyrrolo[1,2-a]pyrazi...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2CCC[C@H]2C1 |r|
Show InChI InChI=1S/C15H18N8O/c16-13-18-14(22-7-6-21-5-1-3-10(21)9-22)19-15-17-12(20-23(13)15)11-4-2-8-24-11/h2,4,8,10H,1,3,5-7,9H2,(H2,16,17,18,19,20)/t10-/m0/s1
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 46n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156622
PNG
(2-(furan-2-yl)-7-((7R,9aS)-7-((pyrimidin-2-ylamino...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNc3ncccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H26N10O/c23-21-28-18(11-19-27-20(29-32(19)21)17-3-1-10-33-17)31-9-8-30-13-15(4-5-16(30)14-31)12-26-22-24-6-2-7-25-22/h1-3,6-7,10-11,15-16H,4-5,8-9,12-14H2,(H2,23,28)(H,24,25,26)/t15-,16+/m1/s1
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 47n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156623
PNG
(5-((7R,9aS)-7-((bis(furan-2-ylmethyl)amino)methyl)...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3ccco3)Cc3ccco3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C27H31N9O3/c28-25-30-26(31-27-29-24(32-36(25)27)23-6-3-13-39-23)35-10-9-34-15-19(7-8-20(34)16-35)14-33(17-21-4-1-11-37-21)18-22-5-2-12-38-22/h1-6,11-13,19-20H,7-10,14-18H2,(H2,28,29,30,31,32)/t19-,20+/m1/s1
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 47n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156617
PNG
((7RS,9aRS)-N5-[2-(3,5-difluorophenyl)octahydropyri...)
Show SMILES Nc1nc(NC[C@@H]2CC[C@@H]3CN(CCN3C2)c2cc(F)cc(F)c2)nc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C23H25F2N9O/c24-15-8-16(25)10-18(9-15)33-6-5-32-12-14(3-4-17(32)13-33)11-27-22-29-21(26)34-23(30-22)28-20(31-34)19-2-1-7-35-19/h1-2,7-10,14,17H,3-6,11-13H2,(H3,26,27,28,29,30,31)/t14-,17+/m0/s1
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 49n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156657
PNG
(2-(furan-2-yl)-5-((7R,9aS)-7-((pyridin-3-ylmethyla...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNCc3cccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H28N10O/c24-21-28-22(29-23-27-20(30-33(21)23)19-4-2-10-34-19)32-9-8-31-14-17(5-6-18(31)15-32)13-26-12-16-3-1-7-25-11-16/h1-4,7,10-11,17-18,26H,5-6,8-9,12-15H2,(H2,24,27,28,29,30)/t17-,18+/m1/s1
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 51n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156602
PNG
((7RS,9aSR)-2-furan-2-yl-5-(7-phenoxymethyl-octahyd...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ccccc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H26N8O2/c24-21-26-22(27-23-25-20(28-31(21)23)19-7-4-12-32-19)30-11-10-29-13-16(8-9-17(29)14-30)15-33-18-5-2-1-3-6-18/h1-7,12,16-17H,8-11,13-15H2,(H2,24,25,26,27,28)/t16-,17+/m1/s1
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 53n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156655
PNG
((7RS,9aSR)-5-[7-(3-fluoro-phenoxymethyl)-octahydro...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3cccc(F)c3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H25FN8O2/c24-16-3-1-4-18(11-16)34-14-15-6-7-17-13-31(9-8-30(17)12-15)22-27-21(25)32-23(28-22)26-20(29-32)19-5-2-10-33-19/h1-5,10-11,15,17H,6-9,12-14H2,(H2,25,26,27,28,29)/t15-,17+/m1/s1
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 53n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156597
PNG
(7-((7R,9aS)-7-(aminomethyl)-hexahydro-1H-pyrido[1,...)
Show SMILES NC[C@H]1CC[C@H]2CN(CCN2C1)c1cc2nc(nn2c(N)n1)-c1ccco1 |r|
Show InChI InChI=1S/C18H24N8O/c19-9-12-3-4-13-11-25(6-5-24(13)10-12)15-8-16-21-17(14-2-1-7-27-14)23-26(16)18(20)22-15/h1-2,7-8,12-13H,3-6,9-11,19H2,(H2,20,22)/t12-,13+/m1/s1
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 56n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156628
PNG
((R)-2-furan-2-yl-7-(hexahydropyrrolo[1,2-a]pyrazin...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2CCC[C@@H]2C1 |r|
Show InChI InChI=1S/C16H19N7O/c17-16-19-13(22-7-6-21-5-1-3-11(21)10-22)9-14-18-15(20-23(14)16)12-4-2-8-24-12/h2,4,8-9,11H,1,3,5-7,10H2,(H2,17,19)/t11-/m1/s1
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 63n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156607
PNG
((7RS,9aSR)-5-[7-(2, 4-difluoro-phenoxymethyl)-octa...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccc(F)cc3F)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H24F2N8O2/c24-15-4-6-18(17(25)10-15)35-13-14-3-5-16-12-32(8-7-31(16)11-14)22-28-21(26)33-23(29-22)27-20(30-33)19-2-1-9-34-19/h1-2,4,6,9-10,14,16H,3,5,7-8,11-13H2,(H2,26,27,28,29,30)/t14-,16-/m0/s1
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 70n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156641
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(4-methoxy-phenoxymet...)
Show SMILES COc1ccc(OC[C@@H]2CC[C@H]3CN(CCN3C2)c2nc(N)n3nc(nc3n2)-c2ccco2)cc1 |r|
Show InChI InChI=1S/C24H28N8O3/c1-33-18-6-8-19(9-7-18)35-15-16-4-5-17-14-31(11-10-30(17)13-16)23-27-22(25)32-24(28-23)26-21(29-32)20-3-2-12-34-20/h2-3,6-9,12,16-17H,4-5,10-11,13-15H2,1H3,(H2,25,26,27,28,29)/t16-,17+/m1/s1
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 70n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156656
PNG
((7RS,9aSR)-[2-(7-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C17H22N8O2/c18-15-20-16(21-17-19-14(22-25(15)17)13-2-1-7-27-13)24-6-5-23-8-11(10-26)3-4-12(23)9-24/h1-2,7,11-12,26H,3-6,8-10H2,(H2,18,19,20,21,22)/t11-,12+/m1/s1
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 71n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156615
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(isoquinolin-5-yloxym...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3cccc4cnccc34)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)22-5-2-12-36-22)34-11-10-33-14-17(6-7-19(33)15-34)16-37-21-4-1-3-18-13-28-9-8-20(18)21/h1-5,8-9,12-13,17,19H,6-7,10-11,14-16H2,(H2,27,29,30,31,32)/t17-,19+/m1/s1
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 73n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156630
PNG
((6RS,9aSR)-2-furan-2-yl-5-[6-(1H-indol-5-yloxymeth...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](COc3ccc4[nH]ccc4c3)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C26H28N8O2/c27-23-14-24(29-26-30-25(31-34(23)26)22-5-2-12-35-22)32-10-11-33-18(15-32)3-1-4-19(33)16-36-20-6-7-21-17(13-20)8-9-28-21/h2,5-9,12-14,18-19,28H,1,3-4,10-11,15-16,27H2/t18-,19+/m0/s1
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 76n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156654
PNG
((6RS,9aRS)-2-furan-2-yl-5-[6-(pyridin-3-yloxymethy...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](COc3cccnc3)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C23H26N8O2/c24-20-12-21(26-23-27-22(28-31(20)23)19-7-3-11-32-19)29-9-10-30-16(14-29)4-1-5-17(30)15-33-18-6-2-8-25-13-18/h2-3,6-8,11-13,16-17H,1,4-5,9-10,14-15,24H2/t16-,17+/m0/s1
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 80n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156600
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(pyridin-4-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ccncc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)18-2-1-11-32-18)30-10-9-29-12-15(3-4-16(29)13-30)14-33-17-5-7-24-8-6-17/h1-2,5-8,11,15-16H,3-4,9-10,12-14H2,(H2,23,25,26,27,28)/t15-,16+/m1/s1
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 81n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156619
PNG
((7RS,9aRS)-[2-(5-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-18-21-15(8-16-20-17(22-25(16)18)14-2-1-7-27-14)24-6-5-23-9-12(11-26)3-4-13(23)10-24/h1-2,7-8,12-13,26H,3-6,9-11H2,(H2,19,21)/t12-,13-/m0/s1
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 96n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156645
PNG
(5-((7R,9aS)-7-(aminomethyl)-hexahydro-1H-pyrido[1,...)
Show SMILES NC[C@H]1CC[C@H]2CN(CCN2C1)c1cc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C18H24N8O/c19-9-12-3-4-13-11-25(6-5-24(13)10-12)16-8-15(20)26-18(21-16)22-17(23-26)14-2-1-7-27-14/h1-2,7-8,12-13H,3-6,9-11,19-20H2/t12-,13+/m1/s1
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 110n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156596
PNG
((6RS,9aRS)-[2-(5-amino-2-furan-2-yl-[1,2,4]triazol...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2[C@@H](CO)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-18-21-15(9-16-20-17(22-25(16)18)14-5-2-8-27-14)23-6-7-24-12(10-23)3-1-4-13(24)11-26/h2,5,8-9,12-13,26H,1,3-4,6-7,10-11H2,(H2,19,21)/t12-,13+/m0/s1
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 110n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156603
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(isoquinolin-3-yloxym...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3cc4ccccc4cn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)21-6-3-11-36-21)34-10-9-33-14-17(7-8-20(33)15-34)16-37-22-12-18-4-1-2-5-19(18)13-28-22/h1-6,11-13,17,20H,7-10,14-16H2,(H2,27,29,30,31,32)/t17-,20+/m1/s1
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 130n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156651
PNG
((7RS,9aRS)-N5-[2-(2,4-difluorobenzyl)octahydropyri...)
Show SMILES Nc1nc(NC[C@@H]2CC[C@@H]3CN(Cc4ccc(F)cc4F)CCN3C2)nc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C24H27F2N9O/c25-17-5-4-16(19(26)10-17)13-33-7-8-34-12-15(3-6-18(34)14-33)11-28-23-30-22(27)35-24(31-23)29-21(32-35)20-2-1-9-36-20/h1-2,4-5,9-10,15,18H,3,6-8,11-14H2,(H3,27,28,29,30,31,32)/t15-,18+/m0/s1
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 130n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156598
PNG
((+/-)-2-furan-2-yl-7-(octahydro-pyrido[1,2-a]pyraz...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2CCCCC2C1
Show InChI InChI=1S/C17H21N7O/c18-17-20-14(23-8-7-22-6-2-1-4-12(22)11-23)10-15-19-16(21-24(15)17)13-5-3-9-25-13/h3,5,9-10,12H,1-2,4,6-8,11H2,(H2,18,20)
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 140n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156665
PNG
((S)-2-furan-2-yl-7-(hexahydro-pyrrolo[1,2-a]pyrazi...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2CCC[C@H]2C1 |r|
Show InChI InChI=1S/C16H19N7O/c17-13-9-14(22-7-6-21-5-1-3-11(21)10-22)18-16-19-15(20-23(13)16)12-4-2-8-24-12/h2,4,8-9,11H,1,3,5-7,10,17H2/t11-/m0/s1
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 170n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156613
PNG
(5-((7R,9aS)-7-((bis((5-chloro-1,3-dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)c(Cl)c1CN(C[C@H]1CC[C@H]2CN(CCN2C1)c1nc(N)n2nc(nc2n1)-c1ccco1)Cc1c(C)nn(C)c1Cl |r|
Show InChI InChI=1S/C29H37Cl2N13O/c1-17-21(24(30)39(3)36-17)15-41(16-22-18(2)37-40(4)25(22)31)12-19-7-8-20-14-43(10-9-42(20)13-19)28-34-27(32)44-29(35-28)33-26(38-44)23-6-5-11-45-23/h5-6,11,19-20H,7-10,12-16H2,1-4H3,(H2,32,33,34,35,38)/t19-,20+/m1/s1
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 180n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156615
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(isoquinolin-5-yloxym...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3cccc4cnccc34)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)22-5-2-12-36-22)34-11-10-33-14-17(6-7-19(33)15-34)16-37-21-4-1-3-18-13-28-9-8-20(18)21/h1-5,8-9,12-13,17,19H,6-7,10-11,14-16H2,(H2,27,29,30,31,32)/t17-,19+/m1/s1
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 210n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156637
PNG
((7RS,9aSR)-N5-[2-(5-chloro-1-methyl-3-trifluoromet...)
Show SMILES Nc1nc(NC[C@H]2CC[C@@H]3CN(CCN3C2)c2ncccn2)nc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C21H25N11O/c22-18-27-19(28-21-26-17(29-32(18)21)16-3-1-10-33-16)25-11-14-4-5-15-13-31(9-8-30(15)12-14)20-23-6-2-7-24-20/h1-3,6-7,10,14-15H,4-5,8-9,11-13H2,(H3,22,25,26,27,28,29)/t14-,15-/m1/s1
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 230n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156631
PNG
(CHEMBL221947 | N7-(((7S,9aR)-2-(2,4-difluorobenzyl...)
Show SMILES Nc1nc(NC[C@@H]2CC[C@@H]3CN(Cc4ccc(F)cc4F)CCN3C2)cc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C25H28F2N8O/c26-18-5-4-17(20(27)10-18)14-33-7-8-34-13-16(3-6-19(34)15-33)12-29-22-11-23-31-24(21-2-1-9-36-21)32-35(23)25(28)30-22/h1-2,4-5,9-11,16,19,29H,3,6-8,12-15H2,(H2,28,30)/t16-,19+/m0/s1
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 230n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156632
PNG
((7RS,9aRS)-[2-(7-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-15-8-16(20-18-21-17(22-25(15)18)14-2-1-7-27-14)24-6-5-23-9-12(11-26)3-4-13(23)10-24/h1-2,7-8,12-13,26H,3-6,9-11,19H2/t12-,13-/m0/s1
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 230n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156648
PNG
((7RS,9aRS)-[2-(5-amino-2-furan-2-yl-[1,2,4]triazol...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-18-21-15(8-16-20-17(22-25(16)18)14-2-1-7-27-14)24-6-5-23-9-12(11-26)3-4-13(23)10-24/h1-2,7-8,12-13,26H,3-6,9-11H2,(H2,19,21)/t12-,13+/m1/s1
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 240n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156653
PNG
(5-((7S,9aS)-7-(aminomethyl)-hexahydro-1H-pyrido[1,...)
Show SMILES NC[C@@H]1CC[C@H]2CN(CCN2C1)c1cc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C18H24N8O/c19-9-12-3-4-13-11-25(6-5-24(13)10-12)16-8-15(20)26-18(21-16)22-17(23-26)14-2-1-7-27-14/h1-2,7-8,12-13H,3-6,9-11,19-20H2/t12-,13-/m0/s1
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 370n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50048466
PNG
(2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,...)
Show SMILES Nc1nc2n(CCc3ccccc3)ncc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
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 390n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156604
PNG
(CHEMBL173672 | N*5*-[(R)-1-(2,6-Difluoro-benzyl)-p...)
Show SMILES Nc1nc(NC[C@H]2CCCN2Cc2c(F)cccc2F)nc2nc(nn12)-c1ccco1
Show InChI InChI=1S/C20H20F2N8O/c21-14-5-1-6-15(22)13(14)11-29-8-2-4-12(29)10-24-19-26-18(23)30-20(27-19)25-17(28-30)16-7-3-9-31-16/h1,3,5-7,9,12H,2,4,8,10-11H2,(H3,23,24,25,26,27,28)/t12-/m1/s1
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 427n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156664
PNG
((S,S)-5-(3-benzyl-hexahydro-pyrrolo[1,2-a]pyrazin-...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 |r|
Show InChI InChI=1S/C22H24N8O/c23-20-25-21(26-22-24-19(27-30(20)22)18-9-5-11-31-18)29-14-16-8-4-10-28(16)13-17(29)12-15-6-2-1-3-7-15/h1-3,5-7,9,11,16-17H,4,8,10,12-14H2,(H2,23,24,25,26,27)/t16-,17-/m0/s1
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 490n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156598
PNG
((+/-)-2-furan-2-yl-7-(octahydro-pyrido[1,2-a]pyraz...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2CCCCC2C1
Show InChI InChI=1S/C17H21N7O/c18-17-20-14(23-8-7-22-6-2-1-4-12(22)11-23)10-15-19-16(21-24(15)17)13-5-3-9-25-13/h3,5,9-10,12H,1-2,4,6-8,11H2,(H2,18,20)
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156666
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(quinolin-6-yloxymeth...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccccc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H26N8O2/c24-21-26-22(27-23-25-20(28-31(21)23)19-7-4-12-32-19)30-11-10-29-13-16(8-9-17(29)14-30)15-33-18-5-2-1-3-6-18/h1-7,12,16-17H,8-11,13-15H2,(H2,24,25,26,27,28)/t16-,17-/m0/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156601
PNG
((6RS,9aRS)-[2-(5-amino-2-furan-2-yl-[1,2,4]triazol...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](CO)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-15-9-16(20-18-21-17(22-25(15)18)14-5-2-8-27-14)23-6-7-24-12(10-23)3-1-4-13(24)11-26/h2,5,8-9,12-13,26H,1,3-4,6-7,10-11,19H2/t12-,13+/m0/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156652
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-[1,2,4]triazol-1-ylme...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](Cn3cncn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C19H23N11O/c20-17-24-18(25-19-23-16(26-30(17)19)15-2-1-7-31-15)28-6-5-27-8-13(3-4-14(27)10-28)9-29-12-21-11-22-29/h1-2,7,11-14H,3-6,8-10H2,(H2,20,23,24,25,26)/t13-,14-/m0/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156653
PNG
(5-((7S,9aS)-7-(aminomethyl)-hexahydro-1H-pyrido[1,...)
Show SMILES NC[C@@H]1CC[C@H]2CN(CCN2C1)c1cc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C18H24N8O/c19-9-12-3-4-13-11-25(6-5-24(13)10-12)16-8-15(20)26-18(21-16)22-17(23-26)14-2-1-7-27-14/h1-2,7-8,12-13H,3-6,9-11,19-20H2/t12-,13-/m0/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156638
PNG
((7RS,9aRS)-5-[7-(2-fluoro-phenoxymethyl)-octahydro...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccccc3F)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H25FN8O2/c24-17-4-1-2-5-18(17)34-14-15-7-8-16-13-31(10-9-30(16)12-15)22-27-21(25)32-23(28-22)26-20(29-32)19-6-3-11-33-19/h1-6,11,15-16H,7-10,12-14H2,(H2,25,26,27,28,29)/t15-,16-/m0/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156661
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(pyridin-2-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ccccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)17-4-3-11-32-17)30-10-9-29-12-15(6-7-16(29)13-30)14-33-18-5-1-2-8-24-18/h1-5,8,11,15-16H,6-7,9-10,12-14H2,(H2,23,25,26,27,28)/t15-,16+/m1/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156597
PNG
(7-((7R,9aS)-7-(aminomethyl)-hexahydro-1H-pyrido[1,...)
Show SMILES NC[C@H]1CC[C@H]2CN(CCN2C1)c1cc2nc(nn2c(N)n1)-c1ccco1 |r|
Show InChI InChI=1S/C18H24N8O/c19-9-12-3-4-13-11-25(6-5-24(13)10-12)15-8-16-21-17(14-2-1-7-27-14)23-26(16)18(20)22-15/h1-2,7-8,12-13H,3-6,9-11,19H2,(H2,20,22)/t12-,13+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156610
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(quinazolin-2-yloxyme...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ncnc4ccccc34)CC[C@H]2C1 |r|
Show InChI InChI=1S/C25H26N10O2/c26-23-30-24(31-25-29-21(32-35(23)25)20-6-3-11-36-20)34-10-9-33-12-16(7-8-17(33)13-34)14-37-22-18-4-1-2-5-19(18)27-15-28-22/h1-6,11,15-17H,7-10,12-14H2,(H2,26,29,30,31,32)/t16-,17-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156641
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(4-methoxy-phenoxymet...)
Show SMILES COc1ccc(OC[C@@H]2CC[C@H]3CN(CCN3C2)c2nc(N)n3nc(nc3n2)-c2ccco2)cc1 |r|
Show InChI InChI=1S/C24H28N8O3/c1-33-18-6-8-19(9-7-18)35-15-16-4-5-17-14-31(11-10-30(17)13-16)23-27-22(25)32-24(28-23)26-21(29-32)20-3-2-12-34-20/h2-3,6-9,12,16-17H,4-5,10-11,13-15H2,1H3,(H2,25,26,27,28,29)/t16-,17+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156596
PNG
((6RS,9aRS)-[2-(5-amino-2-furan-2-yl-[1,2,4]triazol...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2[C@@H](CO)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-18-21-15(9-16-20-17(22-25(16)18)14-5-2-8-27-14)23-6-7-24-12(10-23)3-1-4-13(24)11-26/h2,5,8-9,12-13,26H,1,3-4,6-7,10-11H2,(H2,19,21)/t12-,13+/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156602
PNG
((7RS,9aSR)-2-furan-2-yl-5-(7-phenoxymethyl-octahyd...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ccccc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H26N8O2/c24-21-26-22(27-23-25-20(28-31(21)23)19-7-4-12-32-19)30-11-10-29-13-16(8-9-17(29)14-30)15-33-18-5-2-1-3-6-18/h1-7,12,16-17H,8-11,13-15H2,(H2,24,25,26,27,28)/t16-,17+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156667
PNG
(5-((7R,9aS)-7-((bis(pyridin-2-ylmethyl)amino)methy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3ccccn3)Cc3ccccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C29H33N11O/c30-27-34-28(35-29-33-26(36-40(27)29)25-8-5-15-41-25)39-14-13-38-17-21(9-10-24(38)20-39)16-37(18-22-6-1-3-11-31-22)19-23-7-2-4-12-32-23/h1-8,11-12,15,21,24H,9-10,13-14,16-20H2,(H2,30,33,34,35,36)/t21-,24+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50370922
PNG
(CHEMBL1237041)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ncnc4n[nH]cc34)CC[C@@H]2C1 |r|
Show InChI InChI=1S/C22H24N12O2/c23-20-28-21(29-22-27-18(31-34(20)22)16-2-1-7-35-16)33-6-5-32-9-13(3-4-14(32)10-33)11-36-19-15-8-26-30-17(15)24-12-25-19/h1-2,7-8,12-14H,3-6,9-11H2,(H,24,25,26,30)(H2,23,27,28,29,31)/t13-,14+/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156607
PNG
((7RS,9aSR)-5-[7-(2, 4-difluoro-phenoxymethyl)-octa...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccc(F)cc3F)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H24F2N8O2/c24-15-4-6-18(17(25)10-15)35-13-14-3-5-16-12-32(8-7-31(16)11-14)22-28-21(26)33-23(29-22)27-20(30-33)19-2-1-9-34-19/h1-2,4,6,9-10,14,16H,3,5,7-8,11-13H2,(H2,26,27,28,29,30)/t14-,16-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156658
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-{[(pyridin-4-ylmethyl...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNCc3ccncc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H28N10O/c24-21-28-22(29-23-27-20(30-33(21)23)19-2-1-11-34-19)32-10-9-31-14-17(3-4-18(31)15-32)13-26-12-16-5-7-25-8-6-16/h1-2,5-8,11,17-18,26H,3-4,9-10,12-15H2,(H2,24,27,28,29,30)/t17-,18+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156634
PNG
(5-((7R,9aS)-7-((bis(2,4-difluorobenzyl)amino)methy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3ccc(F)cc3F)Cc3ccc(F)cc3F)CC[C@H]2C1 |r|
Show InChI InChI=1S/C31H31F4N9O/c32-22-6-4-20(25(34)12-22)16-41(17-21-5-7-23(33)13-26(21)35)14-19-3-8-24-18-43(10-9-42(24)15-19)30-38-29(36)44-31(39-30)37-28(40-44)27-2-1-11-45-27/h1-2,4-7,11-13,19,24H,3,8-10,14-18H2,(H2,36,37,38,39,40)/t19-,24+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156599
PNG
((6RS,9aRS)-2-furan-2-yl-5-(6-phenoxymethyl-octahyd...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](COc3ccccc3)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C23H26N8O2/c24-21-26-22(27-23-25-20(28-31(21)23)19-10-5-13-32-19)29-11-12-30-16(14-29)6-4-7-17(30)15-33-18-8-2-1-3-9-18/h1-3,5,8-10,13,16-17H,4,6-7,11-12,14-15H2,(H2,24,25,26,27,28)/t16-,17+/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156657
PNG
(2-(furan-2-yl)-5-((7R,9aS)-7-((pyridin-3-ylmethyla...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNCc3cccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H28N10O/c24-21-28-22(29-23-27-20(30-33(21)23)19-4-2-10-34-19)32-9-8-31-14-17(5-6-18(31)15-32)13-26-12-16-3-1-7-25-11-16/h1-4,7,10-11,17-18,26H,5-6,8-9,12-15H2,(H2,24,27,28,29,30)/t17-,18+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156608
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(4-methoxy-phenoxymet...)
Show SMILES COc1ccc(OC[C@H]2CC[C@H]3CN(CCN3C2)c2nc(N)n3nc(nc3n2)-c2ccco2)cc1 |r|
Show InChI InChI=1S/C24H28N8O3/c1-33-18-6-8-19(9-7-18)35-15-16-4-5-17-14-31(11-10-30(17)13-16)23-27-22(25)32-24(28-23)26-21(29-32)20-3-2-12-34-20/h2-3,6-9,12,16-17H,4-5,10-11,13-15H2,1H3,(H2,25,26,27,28,29)/t16-,17-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156639
PNG
((7RS,9aSR)-2-furan-2-yl-N5-(2-pyrimidin-2-yloctahy...)
Show SMILES Cn1nc(c(CN2CCN3C[C@@H](CNc4nc(N)n5nc(nc5n4)-c4ccco4)CC[C@@H]3C2)c1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C23H27ClF3N11O/c1-35-18(24)15(17(33-35)23(25,26)27)12-36-6-7-37-10-13(4-5-14(37)11-36)9-29-21-31-20(28)38-22(32-21)30-19(34-38)16-3-2-8-39-16/h2-3,8,13-14H,4-7,9-12H2,1H3,(H3,28,29,30,31,32,34)/t13-,14-/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156659
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-tetrazol-1-ylmethyl-o...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](Cn3cnnn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H22N12O/c19-16-22-17(23-18-21-15(24-30(16)18)14-2-1-7-31-14)28-6-5-27-8-12(3-4-13(27)10-28)9-29-11-20-25-26-29/h1-2,7,11-13H,3-6,8-10H2,(H2,19,21,22,23,24)/t12-,13-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156665
PNG
((S)-2-furan-2-yl-7-(hexahydro-pyrrolo[1,2-a]pyrazi...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2CCC[C@H]2C1 |r|
Show InChI InChI=1S/C16H19N7O/c17-13-9-14(22-7-6-21-5-1-3-11(21)10-22)18-16-19-15(20-23(13)16)12-4-2-8-24-12/h2,4,8-9,11H,1,3,5-7,10,17H2/t11-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156617
PNG
((7RS,9aRS)-N5-[2-(3,5-difluorophenyl)octahydropyri...)
Show SMILES Nc1nc(NC[C@@H]2CC[C@@H]3CN(CCN3C2)c2cc(F)cc(F)c2)nc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C23H25F2N9O/c24-15-8-16(25)10-18(9-15)33-6-5-32-12-14(3-4-17(32)13-33)11-27-22-29-21(26)34-23(30-22)28-20(31-34)19-2-1-7-35-19/h1-2,7-10,14,17H,3-6,11-13H2,(H3,26,27,28,29,30,31)/t14-,17+/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156620
PNG
((+/-)-2-furan-2-yl-5-(octahydro-pyrido[1,2-a]pyraz...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2CCCCC2C1
Show InChI InChI=1S/C17H21N7O/c18-14-10-15(23-8-7-22-6-2-1-4-12(22)11-23)19-17-20-16(21-24(14)17)13-5-3-9-25-13/h3,5,9-10,12H,1-2,4,6-8,11,18H2
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156654
PNG
((6RS,9aRS)-2-furan-2-yl-5-[6-(pyridin-3-yloxymethy...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](COc3cccnc3)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C23H26N8O2/c24-20-12-21(26-23-27-22(28-31(20)23)19-7-3-11-32-19)29-9-10-30-16(14-29)4-1-5-17(30)15-33-18-6-2-8-25-13-18/h2-3,6-8,11-13,16-17H,1,4-5,9-10,14-15,24H2/t16-,17+/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156645
PNG
(5-((7R,9aS)-7-(aminomethyl)-hexahydro-1H-pyrido[1,...)
Show SMILES NC[C@H]1CC[C@H]2CN(CCN2C1)c1cc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C18H24N8O/c19-9-12-3-4-13-11-25(6-5-24(13)10-12)16-8-15(20)26-18(21-16)22-17(23-26)14-2-1-7-27-14/h1-2,7-8,12-13H,3-6,9-11,19-20H2/t12-,13+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156632
PNG
((7RS,9aRS)-[2-(7-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-15-8-16(20-18-21-17(22-25(15)18)14-2-1-7-27-14)24-6-5-23-9-12(11-26)3-4-13(23)10-24/h1-2,7-8,12-13,26H,3-6,9-11,19H2/t12-,13-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156626
PNG
((R)-2-furan-2-yl-5-(hexahydro-pyrrolo[1,2-a]pyrazi...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2CCC[C@H]2C1 |r|
Show InChI InChI=1S/C15H18N8O/c16-13-18-14(22-7-6-21-5-1-3-10(21)9-22)19-15-17-12(20-23(13)15)11-4-2-8-24-11/h2,4,8,10H,1,3,5-7,9H2,(H2,16,17,18,19,20)/t10-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156614
PNG
((6RS,9aRS)-2-furan-2-yl-5-[6-(quinolin-6-yloxymeth...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](COc3ccc4cccnc4c3)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C27H28N8O2/c28-24-15-25(30-27-31-26(32-35(24)27)23-7-3-13-36-23)33-11-12-34-19(16-33)5-1-6-20(34)17-37-21-9-8-18-4-2-10-29-22(18)14-21/h2-4,7-10,13-15,19-20H,1,5-6,11-12,16-17,28H2/t19-,20+/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156612
PNG
((7RS,9aRS)-5-(7-aminomethyloctahydropyrido[1,2-a]-...)
Show SMILES NC[C@H]1CC[C@H]2CN(CCN2C1)c1nc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C17H23N9O/c18-8-11-3-4-12-10-25(6-5-24(12)9-11)16-21-15(19)26-17(22-16)20-14(23-26)13-2-1-7-27-13/h1-2,7,11-12H,3-6,8-10,18H2,(H2,19,20,21,22,23)/t11-,12+/m1/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156619
PNG
((7RS,9aRS)-[2-(5-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-18-21-15(8-16-20-17(22-25(16)18)14-2-1-7-27-14)24-6-5-23-9-12(11-26)3-4-13(23)10-24/h1-2,7-8,12-13,26H,3-6,9-11H2,(H2,19,21)/t12-,13-/m0/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156647
PNG
(5-((7R,9aS)-7-(((5-chloro-1,3-dimethyl-1H-pyrazol-...)
Show SMILES Cc1nn(C)c(Cl)c1CNC[C@H]1CC[C@H]2CN(CCN2C1)c1nc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C23H30ClN11O/c1-14-17(19(24)32(2)30-14)11-26-10-15-5-6-16-13-34(8-7-33(16)12-15)22-28-21(25)35-23(29-22)27-20(31-35)18-4-3-9-36-18/h3-4,9,15-16,26H,5-8,10-13H2,1-2H3,(H2,25,27,28,29,31)/t15-,16+/m1/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156651
PNG
((7RS,9aRS)-N5-[2-(2,4-difluorobenzyl)octahydropyri...)
Show SMILES Nc1nc(NC[C@@H]2CC[C@@H]3CN(Cc4ccc(F)cc4F)CCN3C2)nc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C24H27F2N9O/c25-17-5-4-16(19(26)10-17)13-33-7-8-34-12-15(3-6-18(34)14-33)11-28-23-30-22(27)35-24(31-23)29-21(32-35)20-2-1-9-36-20/h1-2,4-5,9-10,15,18H,3,6-8,11-14H2,(H3,27,28,29,30,31,32)/t15-,18+/m0/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156640
PNG
((7RS,9aRS)-5-[7-(3-fluoro-phenoxymethyl)-octahydro...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccc(F)cc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H25FN8O2/c24-16-4-7-18(8-5-16)34-14-15-3-6-17-13-31(10-9-30(17)12-15)22-27-21(25)32-23(28-22)26-20(29-32)19-2-1-11-33-19/h1-2,4-5,7-8,11,15,17H,3,6,9-10,12-14H2,(H2,25,26,27,28,29)/t15-,17-/m0/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156663
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-phenoxymethyl-octahyd...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccccc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C24H27N7O2/c25-21-13-22(26-24-27-23(28-31(21)24)20-7-4-12-32-20)30-11-10-29-14-17(8-9-18(29)15-30)16-33-19-5-2-1-3-6-19/h1-7,12-13,17-18H,8-11,14-16,25H2/t17-,18-/m0/s1
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>500n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156601
PNG
((6RS,9aRS)-[2-(5-amino-2-furan-2-yl-[1,2,4]triazol...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](CO)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-15-9-16(20-18-21-17(22-25(15)18)14-5-2-8-27-14)23-6-7-24-12(10-23)3-1-4-13(24)11-26/h2,5,8-9,12-13,26H,1,3-4,6-7,10-11,19H2/t12-,13+/m0/s1
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 610n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156611
PNG
((7RS,9aRS)-[2-(7-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C17H22N8O2/c18-15-20-16(21-17-19-14(22-25(15)17)13-2-1-7-27-13)24-6-5-23-8-11(10-26)3-4-12(23)9-24/h1-2,7,11-12,26H,3-6,8-10H2,(H2,18,19,20,21,22)/t11-,12-/m0/s1
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 660n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156603
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(isoquinolin-3-yloxym...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3cc4ccccc4cn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)21-6-3-11-36-21)34-10-9-33-14-17(7-8-20(33)15-34)16-37-22-12-18-4-1-2-5-19(18)13-28-22/h1-6,11-13,17,20H,7-10,14-16H2,(H2,27,29,30,31,32)/t17-,20+/m1/s1
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 710n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156614
PNG
((6RS,9aRS)-2-furan-2-yl-5-[6-(quinolin-6-yloxymeth...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](COc3ccc4cccnc4c3)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C27H28N8O2/c28-24-15-25(30-27-31-26(32-35(24)27)23-7-3-13-36-23)33-11-12-34-19(16-33)5-1-6-20(34)17-37-21-9-8-18-4-2-10-29-22(18)14-21/h2-4,7-10,13-15,19-20H,1,5-6,11-12,16-17,28H2/t19-,20+/m0/s1
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 830n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156621
PNG
((+/-)-2-furan-2-yl-5-(octahydropyrido[1,2-a]pyrazi...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2CCCCC2C1
Show InChI InChI=1S/C16H20N8O/c17-14-19-15(23-8-7-22-6-2-1-4-11(22)10-23)20-16-18-13(21-24(14)16)12-5-3-9-25-12/h3,5,9,11H,1-2,4,6-8,10H2,(H2,17,18,19,20,21)
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 860n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50156636
PNG
((7RS,9aRS)-[2-(5-amino-2-furan-2-yl-[1,2,4]triazol...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-15-8-16(20-18-21-17(22-25(15)18)14-2-1-7-27-14)24-6-5-23-9-12(11-26)3-4-13(23)10-24/h1-2,7-8,12-13,26H,3-6,9-11,19H2/t12-,13+/m1/s1
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 860n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156655
PNG
((7RS,9aSR)-5-[7-(3-fluoro-phenoxymethyl)-octahydro...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3cccc(F)c3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H25FN8O2/c24-16-3-1-4-18(11-16)34-14-15-6-7-17-13-31(9-8-30(17)12-15)22-27-21(25)32-23(28-22)26-20(29-32)19-5-2-10-33-19/h1-5,10-11,15,17H,6-9,12-14H2,(H2,25,26,27,28,29)/t15-,17+/m1/s1
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 960n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156668
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(isoquinolin-3-yloxym...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3cc4ccccc4cn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)21-6-3-11-36-21)34-10-9-33-14-17(7-8-20(33)15-34)16-37-22-12-18-4-1-2-5-19(18)13-28-22/h1-6,11-13,17,20H,7-10,14-16H2,(H2,27,29,30,31,32)/t17-,20-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156630
PNG
((6RS,9aSR)-2-furan-2-yl-5-[6-(1H-indol-5-yloxymeth...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](COc3ccc4[nH]ccc4c3)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C26H28N8O2/c27-23-14-24(29-26-30-25(31-34(23)26)22-5-2-12-35-22)32-10-11-33-18(15-32)3-1-4-19(33)16-36-20-6-7-21-17(13-20)8-9-28-21/h2,5-9,12-14,18-19,28H,1,3-4,10-11,15-16,27H2/t18-,19+/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156664
PNG
((S,S)-5-(3-benzyl-hexahydro-pyrrolo[1,2-a]pyrazin-...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 |r|
Show InChI InChI=1S/C22H24N8O/c23-20-25-21(26-22-24-19(27-30(20)22)18-9-5-11-31-18)29-14-16-8-4-10-28(16)13-17(29)12-15-6-2-1-3-7-15/h1-3,5-7,9,11,16-17H,4,8,10,12-14H2,(H2,23,24,25,26,27)/t16-,17-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156622
PNG
(2-(furan-2-yl)-7-((7R,9aS)-7-((pyrimidin-2-ylamino...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNc3ncccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H26N10O/c23-21-28-18(11-19-27-20(29-32(19)21)17-3-1-10-33-17)31-9-8-30-13-15(4-5-16(30)14-31)12-26-22-24-6-2-7-25-22/h1-3,6-7,10-11,15-16H,4-5,8-9,12-14H2,(H2,23,28)(H,24,25,26)/t15-,16+/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156634
PNG
(5-((7R,9aS)-7-((bis(2,4-difluorobenzyl)amino)methy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3ccc(F)cc3F)Cc3ccc(F)cc3F)CC[C@H]2C1 |r|
Show InChI InChI=1S/C31H31F4N9O/c32-22-6-4-20(25(34)12-22)16-41(17-21-5-7-23(33)13-26(21)35)14-19-3-8-24-18-43(10-9-42(24)15-19)30-38-29(36)44-31(39-30)37-28(40-44)27-2-1-11-45-27/h1-2,4-7,11-13,19,24H,3,8-10,14-18H2,(H2,36,37,38,39,40)/t19-,24+/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156600
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(pyridin-4-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ccncc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)18-2-1-11-32-18)30-10-9-29-12-15(3-4-16(29)13-30)14-33-17-5-7-24-8-6-17/h1-2,5-8,11,15-16H,3-4,9-10,12-14H2,(H2,23,25,26,27,28)/t15-,16+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156637
PNG
((7RS,9aSR)-N5-[2-(5-chloro-1-methyl-3-trifluoromet...)
Show SMILES Nc1nc(NC[C@H]2CC[C@@H]3CN(CCN3C2)c2ncccn2)nc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C21H25N11O/c22-18-27-19(28-21-26-17(29-32(18)21)16-3-1-10-33-16)25-11-14-4-5-15-13-31(9-8-30(15)12-14)20-23-6-2-7-24-20/h1-3,6-7,10,14-15H,4-5,8-9,11-13H2,(H3,22,25,26,27,28,29)/t14-,15-/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156639
PNG
((7RS,9aSR)-2-furan-2-yl-N5-(2-pyrimidin-2-yloctahy...)
Show SMILES Cn1nc(c(CN2CCN3C[C@@H](CNc4nc(N)n5nc(nc5n4)-c4ccco4)CC[C@@H]3C2)c1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C23H27ClF3N11O/c1-35-18(24)15(17(33-35)23(25,26)27)12-36-6-7-37-10-13(4-5-14(37)11-36)9-29-21-31-20(28)38-22(32-21)30-19(34-38)16-3-2-8-39-16/h2-3,8,13-14H,4-7,9-12H2,1H3,(H3,28,29,30,31,32,34)/t13-,14-/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156629
PNG
((7RS,9aSR)-2-furan-2-yl-5-[7-(quinazolin-2-yloxyme...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ncnc4ccccc34)CC[C@H]2C1 |r|
Show InChI InChI=1S/C25H26N10O2/c26-23-30-24(31-25-29-21(32-35(23)25)20-6-3-11-36-20)34-10-9-33-12-16(7-8-17(33)13-34)14-37-22-18-4-1-2-5-19(18)27-15-28-22/h1-6,11,15-17H,7-10,12-14H2,(H2,26,29,30,31,32)/t16-,17+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156623
PNG
(5-((7R,9aS)-7-((bis(furan-2-ylmethyl)amino)methyl)...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3ccco3)Cc3ccco3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C27H31N9O3/c28-25-30-26(31-27-29-24(32-36(25)27)23-6-3-13-39-23)35-10-9-34-15-19(7-8-20(34)16-35)14-33(17-21-4-1-11-37-21)18-22-5-2-12-38-22/h1-6,11-13,19-20H,7-10,14-18H2,(H2,28,29,30,31,32)/t19-,20+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156650
PNG
(5-((7R,9aS)-7-((bis(pyridin-3-ylmethyl)amino)methy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3cccnc3)Cc3cccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C29H33N11O/c30-27-34-28(35-29-33-26(36-40(27)29)25-6-3-13-41-25)39-12-11-38-19-23(7-8-24(38)20-39)18-37(16-21-4-1-9-31-14-21)17-22-5-2-10-32-15-22/h1-6,9-10,13-15,23-24H,7-8,11-12,16-20H2,(H2,30,33,34,35,36)/t23-,24+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156636
PNG
((7RS,9aRS)-[2-(5-amino-2-furan-2-yl-[1,2,4]triazol...)
Show SMILES Nc1cc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-15-8-16(20-18-21-17(22-25(15)18)14-2-1-7-27-14)24-6-5-23-9-12(11-26)3-4-13(23)10-24/h1-2,7-8,12-13,26H,3-6,9-11,19H2/t12-,13+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156625
PNG
((7RS,9aRS)-3-amino-5-{7-[(7-amino-2-furan-2-yl[1,2...)
Show SMILES COC(=O)c1nc(Cl)c(nc1N)N1CCN2C[C@H](CNc3nc(N)n4nc(nc4n3)-c3ccco3)CC[C@@H]2C1 |r|
Show InChI InChI=1S/C23H27ClN12O3/c1-38-20(37)15-17(25)29-19(16(24)28-15)35-7-6-34-10-12(4-5-13(34)11-35)9-27-22-31-21(26)36-23(32-22)30-18(33-36)14-3-2-8-39-14/h2-3,8,12-13H,4-7,9-11H2,1H3,(H2,25,29)(H3,26,27,30,31,32,33)/t12-,13+/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156609
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(pyridin-4-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccncc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)18-2-1-11-32-18)30-10-9-29-12-15(3-4-16(29)13-30)14-33-17-5-7-24-8-6-17/h1-2,5-8,11,15-16H,3-4,9-10,12-14H2,(H2,23,25,26,27,28)/t15-,16-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156649
PNG
(2-(furan-2-yl)-5-((7S,9aS)-7-((pyrimidin-2-ylamino...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CNc3ncccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C21H25N11O/c22-18-27-20(28-21-26-17(29-32(18)21)16-3-1-10-33-16)31-9-8-30-12-14(4-5-15(30)13-31)11-25-19-23-6-2-7-24-19/h1-3,6-7,10,14-15H,4-5,8-9,11-13H2,(H,23,24,25)(H2,22,26,27,28,29)/t14-,15-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156643
PNG
(2-(furan-2-yl)-5-((7R,9aS)-7-((quinolin-2-yloxy)me...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](COc3ccc4ccccc4n3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)21-6-3-13-36-21)34-12-11-33-14-17(7-9-19(33)15-34)16-37-22-10-8-18-4-1-2-5-20(18)28-22/h1-6,8,10,13,17,19H,7,9,11-12,14-16H2,(H2,27,29,30,31,32)/t17-,19+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156613
PNG
(5-((7R,9aS)-7-((bis((5-chloro-1,3-dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)c(Cl)c1CN(C[C@H]1CC[C@H]2CN(CCN2C1)c1nc(N)n2nc(nc2n1)-c1ccco1)Cc1c(C)nn(C)c1Cl |r|
Show InChI InChI=1S/C29H37Cl2N13O/c1-17-21(24(30)39(3)36-17)15-41(16-22-18(2)37-40(4)25(22)31)12-19-7-8-20-14-43(10-9-42(20)13-19)28-34-27(32)44-29(35-28)33-26(38-44)23-6-5-11-45-23/h5-6,11,19-20H,7-10,12-16H2,1-4H3,(H2,32,33,34,35,38)/t19-,20+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156631
PNG
(CHEMBL221947 | N7-(((7S,9aR)-2-(2,4-difluorobenzyl...)
Show SMILES Nc1nc(NC[C@@H]2CC[C@@H]3CN(Cc4ccc(F)cc4F)CCN3C2)cc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C25H28F2N8O/c26-18-5-4-17(20(27)10-18)14-33-7-8-34-13-16(3-6-19(34)15-33)12-29-22-11-23-31-24(21-2-1-9-36-21)32-35(23)25(28)30-22/h1-2,4-5,9-11,16,19,29H,3,6-8,12-15H2,(H2,28,30)/t16-,19+/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156627
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(pyridin-2-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)17-4-3-11-32-17)30-10-9-29-12-15(6-7-16(29)13-30)14-33-18-5-1-2-8-24-18/h1-5,8,11,15-16H,6-7,9-10,12-14H2,(H2,23,25,26,27,28)/t15-,16-/m0/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156648
PNG
((7RS,9aRS)-[2-(5-amino-2-furan-2-yl-[1,2,4]triazol...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C18H23N7O2/c19-18-21-15(8-16-20-17(22-25(16)18)14-2-1-7-27-14)24-6-5-23-9-12(11-26)3-4-13(23)10-24/h1-2,7-8,12-13,26H,3-6,9-11H2,(H2,19,21)/t12-,13+/m1/s1
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Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156660
PNG
(5-((7R,9aS)-7-((2,4-difluorobenzylamino)methyl)-he...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNCc3ccc(F)cc3F)CC[C@H]2C1 |r|
Show InChI InChI=1S/C24H27F2N9O/c25-17-5-4-16(19(26)10-17)12-28-11-15-3-6-18-14-34(8-7-33(18)13-15)23-30-22(27)35-24(31-23)29-21(32-35)20-2-1-9-36-20/h1-2,4-5,9-10,15,18,28H,3,6-8,11-14H2,(H2,27,29,30,31,32)/t15-,18+/m1/s1
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 1.10E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50151188
PNG
(5-(4-((5-chloro-1-methyl-3-(trifluoromethyl)-1H-py...)
Show SMILES Cn1nc(c(CN2CCN(CC2)c2nc(N)n3nc(nc3n2)-c2ccco2)c1Cl)C(F)(F)F
Show InChI InChI=1S/C18H18ClF3N10O/c1-29-13(19)10(12(27-29)18(20,21)22)9-30-4-6-31(7-5-30)16-25-15(23)32-17(26-16)24-14(28-32)11-3-2-8-33-11/h2-3,8H,4-7,9H2,1H3,(H2,23,24,25,26,28)
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 1.10E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156628
PNG
((R)-2-furan-2-yl-7-(hexahydropyrrolo[1,2-a]pyrazin...)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)N1CCN2CCC[C@@H]2C1 |r|
Show InChI InChI=1S/C16H19N7O/c17-16-19-13(22-7-6-21-5-1-3-11(21)10-22)9-14-18-15(20-23(14)16)12-4-2-8-24-12/h2,4,8-9,11H,1,3,5-7,10H2,(H2,17,19)/t11-/m1/s1
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 1.10E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156605
PNG
((7RS,9aRS)-2-furan-2-yl-5-(7-imidazol-1-ylmethyloc...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](Cn3ccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C20H24N10O/c21-18-24-19(25-20-23-17(26-30(18)20)16-2-1-9-31-16)29-8-7-28-11-14(3-4-15(28)12-29)10-27-6-5-22-13-27/h1-2,5-6,9,13-15H,3-4,7-8,10-12H2,(H2,21,23,24,25,26)/t14-,15+/m1/s1
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 1.20E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156662
PNG
((6RS,9aRS)-[2-(7-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2[C@@H](CO)CCC[C@H]2C1 |r|
Show InChI InChI=1S/C17H22N8O2/c18-15-20-16(21-17-19-14(22-25(15)17)13-5-2-8-27-13)23-6-7-24-11(9-23)3-1-4-12(24)10-26/h2,5,8,11-12,26H,1,3-4,6-7,9-10H2,(H2,18,19,20,21,22)/t11-,12+/m0/s1
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 1.30E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156606
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(pyridin-3-yloxymethy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3cccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C22H25N9O2/c23-20-26-21(27-22-25-19(28-31(20)22)18-4-2-10-32-18)30-9-8-29-12-15(5-6-16(29)13-30)14-33-17-3-1-7-24-11-17/h1-4,7,10-11,15-16H,5-6,8-9,12-14H2,(H2,23,25,26,27,28)/t15-,16-/m0/s1
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 1.40E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156618
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(pyrimidin-2-ylaminom...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CNc3ncccn3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C21H25N11O/c22-18-27-20(28-21-26-17(29-32(18)21)16-3-1-10-33-16)31-9-8-30-12-14(4-5-15(30)13-31)11-25-19-23-6-2-7-24-19/h1-3,6-7,10,14-15H,4-5,8-9,11-13H2,(H,23,24,25)(H2,22,26,27,28,29)/t14-,15+/m1/s1
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 1.50E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156595
PNG
((7RS,9aRS)-2-furan-2-yl-N5-(2-pyrimidin-2-yloctahy...)
Show SMILES Nc1nc(NC[C@@H]2CC[C@@H]3CN(CCN3C2)c2ncccn2)nc2nc(nn12)-c1ccco1 |r|
Show InChI InChI=1S/C21H25N11O/c22-18-27-19(28-21-26-17(29-32(18)21)16-3-1-10-33-16)25-11-14-4-5-15-13-31(9-8-30(15)12-14)20-23-6-2-7-24-20/h1-3,6-7,10,14-15H,4-5,8-9,11-13H2,(H3,22,25,26,27,28,29)/t14-,15+/m0/s1
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 1.60E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156616
PNG
((7RS,9aRS)-5-[7-(3-fluoro-phenoxymethyl)-octahydro...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3cccc(F)c3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C23H25FN8O2/c24-16-3-1-4-18(11-16)34-14-15-6-7-17-13-31(9-8-30(17)12-15)22-27-21(25)32-23(28-22)26-20(29-32)19-5-2-10-33-19/h1-5,10-11,15,17H,6-9,12-14H2,(H2,25,26,27,28,29)/t15-,17-/m0/s1
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 3.30E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156646
PNG
(2-(furan-2-yl)-5-((7S,9aS)-7-((quinolin-6-yloxy)me...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3ccc4ncccc4c3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)22-4-2-12-36-22)34-11-10-33-14-17(5-6-19(33)15-34)16-37-20-7-8-21-18(13-20)3-1-9-28-21/h1-4,7-9,12-13,17,19H,5-6,10-11,14-16H2,(H2,27,29,30,31,32)/t17-,19-/m0/s1
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 3.50E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156635
PNG
(5-((7S,9aS)-7-(aminomethyl)-hexahydro-1H-pyrido[1,...)
Show SMILES NC[C@@H]1CC[C@H]2CN(CCN2C1)c1nc(N)n2nc(nc2n1)-c1ccco1 |r|
Show InChI InChI=1S/C17H23N9O/c18-8-11-3-4-12-10-25(6-5-24(12)9-11)16-21-15(19)26-17(22-16)20-14(23-26)13-2-1-7-27-13/h1-2,7,11-12H,3-6,8-10,18H2,(H2,19,20,21,22,23)/t11-,12-/m0/s1
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 3.50E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156633
PNG
((7RS,9aRS)-2-furan-2-yl-5-[7-(isoquinolin-5-yloxym...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](COc3cccc4cnccc34)CC[C@H]2C1 |r|
Show InChI InChI=1S/C26H27N9O2/c27-24-30-25(31-26-29-23(32-35(24)26)22-5-2-12-36-22)34-11-10-33-14-17(6-7-19(33)15-34)16-37-21-4-1-3-18-13-28-9-8-20(18)21/h1-5,8-9,12-13,17,19H,6-7,10-11,14-16H2,(H2,27,29,30,31,32)/t17-,19-/m0/s1
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 3.50E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Rattus norvegicus (rat))		BDBM50151206
PNG
(2-(furan-2-yl)-5-(piperazin-1-yl)-[1,2,4]triazolo[...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCNCC1
Show InChI InChI=1S/C12H14N8O/c13-10-16-11(19-5-3-14-4-6-19)17-12-15-9(18-20(10)12)8-2-1-7-21-8/h1-2,7,14H,3-6H2,(H2,13,15,16,17,18)
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>5.00E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156644
PNG
((7RS,9aRS)-5-{7-[(bispyridin-4-ylmethylamino)-meth...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@@H](CN(Cc3ccncc3)Cc3ccncc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C29H33N11O/c30-27-34-28(35-29-33-26(36-40(27)29)25-2-1-15-41-25)39-14-13-38-19-23(3-4-24(38)20-39)18-37(16-21-5-9-31-10-6-21)17-22-7-11-32-12-8-22/h1-2,5-12,15,23-24H,3-4,13-14,16-20H2,(H2,30,33,34,35,36)/t23-,24+/m1/s1
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 6.00E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156656
PNG
((7RS,9aSR)-[2-(7-amino-2-furan-2-yl[1,2,4]triazolo...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CO)CC[C@H]2C1 |r|
Show InChI InChI=1S/C17H22N8O2/c18-15-20-16(21-17-19-14(22-25(15)17)13-2-1-7-27-13)24-6-5-23-8-11(10-26)3-4-12(23)9-24/h1-2,7,11-12,26H,3-6,8-10H2,(H2,18,19,20,21,22)/t11-,12+/m1/s1
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 6.10E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50156624
PNG
(5-((7S,9aS)-7-((bis(pyridin-3-ylmethyl)amino)methy...)
Show SMILES Nc1nc(nc2nc(nn12)-c1ccco1)N1CCN2C[C@H](CN(Cc3cccnc3)Cc3cccnc3)CC[C@H]2C1 |r|
Show InChI InChI=1S/C29H33N11O/c30-27-34-28(35-29-33-26(36-40(27)29)25-6-3-13-41-25)39-12-11-38-19-23(7-8-24(38)20-39)18-37(16-21-4-1-9-31-14-21)17-22-5-2-10-32-15-22/h1-6,9-10,13-15,23-24H,7-8,11-12,16-20H2,(H2,30,33,34,35,36)/t23-,24-/m0/s1
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 7.80E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane

J Med Chem 47: 6218-29 (2004)


Article DOI: 10.1021/jm0494321
BindingDB Entry DOI: 10.7270/Q20V8DM9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%