BindingDB logo
myBDB logout

PubMed code 15863313

Compile data set for download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166520
PNG
(1-Cyclopentyl-3-[(R)-1-(2,4-dichloro-benzyl)-2-oxo...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)NC2CCCC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C32H39Cl2N5O2S/c33-25-12-11-23(28(34)21-25)20-29(37-32(41)36-26-7-2-3-8-26)31(40)39-17-15-38(16-18-39)30-10-4-1-6-24(30)22-35-14-13-27-9-5-19-42-27/h1,4-6,9-12,19,21,26,29,35H,2-3,7-8,13-18,20,22H2,(H2,36,37,41)/t29-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166533
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES CC(C)NC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C30H37Cl2N5O2S/c1-21(2)34-30(39)35-27(18-22-9-10-24(31)19-26(22)32)29(38)37-15-13-36(14-16-37)28-8-4-3-6-23(28)20-33-12-11-25-7-5-17-40-25/h3-10,17,19,21,27,33H,11-16,18,20H2,1-2H3,(H2,34,35,39)/t27-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.40n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166523
PNG
(CHEMBL195110 | Pyrrolidine-1-carboxylic acid [(R)-...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)N2CCCC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C31H37Cl2N5O2S/c32-25-10-9-23(27(33)21-25)20-28(35-31(40)38-13-3-4-14-38)30(39)37-17-15-36(16-18-37)29-8-2-1-6-24(29)22-34-12-11-26-7-5-19-41-26/h1-2,5-10,19,21,28,34H,3-4,11-18,20,22H2,(H,35,40)/t28-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166544
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES CCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O2S/c1-2-33-29(38)34-26(18-21-9-10-23(30)19-25(21)31)28(37)36-15-13-35(14-16-36)27-8-4-3-6-22(27)20-32-12-11-24-7-5-17-39-24/h3-10,17,19,26,32H,2,11-16,18,20H2,1H3,(H2,33,34,38)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.70n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50158484
PNG
((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Show SMILES NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1 |r|
Show InChI InChI=1S/C29H35Cl2N5O2S/c30-23-8-7-21(25(31)19-23)18-26(34-28(37)9-11-32)29(38)36-15-13-35(14-16-36)27-6-2-1-4-22(27)20-33-12-10-24-5-3-17-39-24/h1-8,17,19,26,33H,9-16,18,20,32H2,(H,34,37)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 1.80n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166525
PNG
(3-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES CN(C)C(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O2S/c1-34(2)29(38)33-26(18-21-9-10-23(30)19-25(21)31)28(37)36-15-13-35(14-16-36)27-8-4-3-6-22(27)20-32-12-11-24-7-5-17-39-24/h3-10,17,19,26,32H,11-16,18,20H2,1-2H3,(H,33,38)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166534
PNG
(4-Amino-N-[(R)-1-(2,4-dichloro-benzyl)-2-oxo-2-(4-...)
Show SMILES NCCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C30H37Cl2N5O2S/c31-24-10-9-22(26(32)20-24)19-27(35-29(38)8-3-12-33)30(39)37-16-14-36(15-17-37)28-7-2-1-5-23(28)21-34-13-11-25-6-4-18-40-25/h1-2,4-7,9-10,18,20,27,34H,3,8,11-17,19,21,33H2,(H,35,38)/t27-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166540
PNG
(1-Cyclopropyl-3-[(R)-1-(2,4-dichloro-benzyl)-2-oxo...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)NC2CC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C30H35Cl2N5O2S/c31-23-8-7-21(26(32)19-23)18-27(35-30(39)34-24-9-10-24)29(38)37-15-13-36(14-16-37)28-6-2-1-4-22(28)20-33-12-11-25-5-3-17-40-25/h1-8,17,19,24,27,33H,9-16,18,20H2,(H2,34,35,39)/t27-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166539
PNG
(1-tert-Butyl-3-[(R)-1-(2,4-dichloro-benzyl)-2-oxo-...)
Show SMILES CC(C)(C)NC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C31H39Cl2N5O2S/c1-31(2,3)36-30(40)35-27(19-22-10-11-24(32)20-26(22)33)29(39)38-16-14-37(15-17-38)28-9-5-4-7-23(28)21-34-13-12-25-8-6-18-41-25/h4-11,18,20,27,34H,12-17,19,21H2,1-3H3,(H2,35,36,40)/t27-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.40n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166519
PNG
((R)-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(2-((2-(t...)
Show SMILES CC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C28H32Cl2N4O2S/c1-20(35)32-26(17-21-8-9-23(29)18-25(21)30)28(36)34-14-12-33(13-15-34)27-7-3-2-5-22(27)19-31-11-10-24-6-4-16-37-24/h2-9,16,18,26,31H,10-15,17,19H2,1H3,(H,32,35)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.40n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166535
PNG
(CHEMBL192090 | N-[(R)-1-(2,4-Dichloro-benzyl)-2-ox...)
Show SMILES COC(=O)CCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C31H36Cl2N4O4S/c1-41-30(39)11-10-29(38)35-27(19-22-8-9-24(32)20-26(22)33)31(40)37-16-14-36(15-17-37)28-7-3-2-5-23(28)21-34-13-12-25-6-4-18-42-25/h2-9,18,20,27,34H,10-17,19,21H2,1H3,(H,35,38)/t27-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.80n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166532
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES OCCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O3S/c30-23-8-7-21(25(31)19-23)18-26(34-29(39)33-11-16-37)28(38)36-14-12-35(13-15-36)27-6-2-1-4-22(27)20-32-10-9-24-5-3-17-40-24/h1-8,17,19,26,32,37H,9-16,18,20H2,(H2,33,34,39)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.90n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166537
PNG
(CHEMBL363641 | N-[(R)-1-(2,4-Dichloro-benzyl)-2-ox...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)c2ccccc2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C33H34Cl2N4O2S/c34-27-13-12-25(29(35)22-27)21-30(37-32(40)24-7-2-1-3-8-24)33(41)39-18-16-38(17-19-39)31-11-5-4-9-26(31)23-36-15-14-28-10-6-20-42-28/h1-13,20,22,30,36H,14-19,21,23H2,(H,37,40)/t30-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 3.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166521
PNG
(CHEMBL436122 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES FCCOC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H33Cl2FN4O3S/c30-23-8-7-21(25(31)19-23)18-26(34-29(38)39-16-10-32)28(37)36-14-12-35(13-15-36)27-6-2-1-4-22(27)20-33-11-9-24-5-3-17-40-24/h1-8,17,19,26,33H,9-16,18,20H2,(H,34,38)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 3.20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166524
PNG
(CHEMBL192464 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES CC(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C30H36Cl2N4O3S/c1-21(2)39-30(38)34-27(18-22-9-10-24(31)19-26(22)32)29(37)36-15-13-35(14-16-36)28-8-4-3-6-23(28)20-33-12-11-25-7-5-17-40-25/h3-10,17,19,21,27,33H,11-16,18,20H2,1-2H3,(H,34,38)/t27-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166538
PNG
(CHEMBL194393 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES CCOC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H34Cl2N4O3S/c1-2-38-29(37)33-26(18-21-9-10-23(30)19-25(21)31)28(36)35-15-13-34(14-16-35)27-8-4-3-6-22(27)20-32-12-11-24-7-5-17-39-24/h3-10,17,19,26,32H,2,11-16,18,20H2,1H3,(H,33,37)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.60n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166543
PNG
(CHEMBL373099 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES COC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C28H32Cl2N4O3S/c1-37-28(36)32-25(17-20-8-9-22(29)18-24(20)30)27(35)34-14-12-33(13-15-34)26-7-3-2-5-21(26)19-31-11-10-23-6-4-16-38-23/h2-9,16,18,25,31H,10-15,17,19H2,1H3,(H,32,36)/t25-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166530
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES Fc1ccccc1CNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C34H36Cl2FN5O2S/c35-27-12-11-24(29(36)21-27)20-31(40-34(44)39-23-25-6-1-3-9-30(25)37)33(43)42-17-15-41(16-18-42)32-10-4-2-7-26(32)22-38-14-13-28-8-5-19-45-28/h1-12,19,21,31,38H,13-18,20,22-23H2,(H2,39,40,44)/t31-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166529
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES COc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(CC2)C(C)C)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C34H47FN4O/c1-27(2)38-22-24-39(25-23-38)33(29-11-14-30(35)15-12-29)26-37-20-18-36(19-21-37)17-7-6-10-32-31-9-5-4-8-28(31)13-16-34(32)40-3/h4-5,8-9,11-16,27,33H,6-7,10,17-26H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 7.90n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166545
PNG
(CHEMBL195414 | N-[(R)-1-(2,4-Dichloro-benzyl)-2-ox...)
Show SMILES CS(=O)(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C27H32Cl2N4O3S2/c1-38(35,36)31-25(17-20-8-9-22(28)18-24(20)29)27(34)33-14-12-32(13-15-33)26-7-3-2-5-21(26)19-30-11-10-23-6-4-16-37-23/h2-9,16,18,25,30-31H,10-15,17,19H2,1H3/t25-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 14n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50155370
PNG
(CHEMBL186074 | Piperidine-3-carboxylic acid [(R)-1...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)C2CCCNC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)cc1
Show InChI InChI=1S/C32H40ClN5O2S/c33-27-11-9-24(10-12-27)21-29(36-31(39)26-6-3-14-34-23-26)32(40)38-18-16-37(17-19-38)30-8-2-1-5-25(30)22-35-15-13-28-7-4-20-41-28/h1-2,4-5,7-12,20,26,29,34-35H,3,6,13-19,21-23H2,(H,36,39)/t26?,29-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 15n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166542
PNG
((R)-3-(2,4-Dichloro-phenyl)-2-[(thiazol-2-ylmethyl...)
Show SMILES Clc1ccc(C[C@@H](NCc2nccs2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C30H33Cl2N5OS2/c31-24-8-7-22(26(32)19-24)18-27(35-21-29-34-11-17-40-29)30(38)37-14-12-36(13-15-37)28-6-2-1-4-23(28)20-33-10-9-25-5-3-16-39-25/h1-8,11,16-17,19,27,33,35H,9-10,12-15,18,20-21H2/t27-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
 16n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166528
PNG
((R)-2-(Cyclopropylmethyl-amino)-3-(2,4-dichloro-ph...)
Show SMILES Clc1ccc(C[C@@H](NCC2CC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C30H36Cl2N4OS/c31-25-10-9-23(27(32)19-25)18-28(34-20-22-7-8-22)30(37)36-15-13-35(14-16-36)29-6-2-1-4-24(29)21-33-12-11-26-5-3-17-38-26/h1-6,9-10,17,19,22,28,33-34H,7-8,11-16,18,20-21H2/t28-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 18n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166518
PNG
((R)-2-(2-Amino-ethylamino)-3-(2,4-dichloro-phenyl)...)
Show SMILES NCCN[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C28H35Cl2N5OS/c29-23-8-7-21(25(30)19-23)18-26(33-12-10-31)28(36)35-15-13-34(14-16-35)27-6-2-1-4-22(27)20-32-11-9-24-5-3-17-37-24/h1-8,17,19,26,32-33H,9-16,18,20,31H2/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 18n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50155390
PNG
(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)
Show SMILES NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H36ClN5O2S/c30-24-9-7-22(8-10-24)20-26(33-28(36)11-13-31)29(37)35-17-15-34(16-18-35)27-6-2-1-4-23(27)21-32-14-12-25-5-3-19-38-25/h1-10,19,26,32H,11-18,20-21,31H2,(H,33,36)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 21n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166541
PNG
(CHEMBL364913 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)OCc2ccccc2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C34H36Cl2N4O3S/c35-28-13-12-26(30(36)22-28)21-31(38-34(42)43-24-25-7-2-1-3-8-25)33(41)40-18-16-39(17-19-40)32-11-5-4-9-27(32)23-37-15-14-29-10-6-20-44-29/h1-13,20,22,31,37H,14-19,21,23-24H2,(H,38,42)/t31-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 23n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166548
PNG
((R)-3-(2,4-Dichloro-phenyl)-2-isobutylamino-1-(4-{...)
Show SMILES CC(C)CN[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C30H38Cl2N4OS/c1-22(2)20-34-28(18-23-9-10-25(31)19-27(23)32)30(37)36-15-13-35(14-16-36)29-8-4-3-6-24(29)21-33-12-11-26-7-5-17-38-26/h3-10,17,19,22,28,33-34H,11-16,18,20-21H2,1-2H3/t28-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 23n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166546
PNG
((R)-2-Benzylamino-3-(2,4-dichloro-phenyl)-1-(4-{2-...)
Show SMILES Clc1ccc(C[C@@H](NCc2ccccc2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C33H36Cl2N4OS/c34-28-13-12-26(30(35)22-28)21-31(37-23-25-7-2-1-3-8-25)33(40)39-18-16-38(17-19-39)32-11-5-4-9-27(32)24-36-15-14-29-10-6-20-41-29/h1-13,20,22,31,36-37H,14-19,21,23-24H2/t31-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 31n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166536
PNG
((R)-2-Amino-3-(2,4-dichloro-phenyl)-1-(4-{2-[(2-th...)
Show SMILES N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C26H30Cl2N4OS/c27-21-8-7-19(23(28)17-21)16-24(29)26(33)32-13-11-31(12-14-32)25-6-2-1-4-20(25)18-30-10-9-22-5-3-15-34-22/h1-8,15,17,24,30H,9-14,16,18,29H2/t24-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 94n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50142895
PNG
(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20|
Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 160n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50166523
PNG
(CHEMBL195110 | Pyrrolidine-1-carboxylic acid [(R)-...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)N2CCCC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C31H37Cl2N5O2S/c32-25-10-9-23(27(33)21-25)20-28(35-31(40)38-13-3-4-14-38)30(39)37-17-15-36(16-18-37)29-8-2-1-6-24(29)22-34-12-11-26-7-5-19-41-26/h1-2,5-10,19,21,28,34H,3-4,11-18,20,22H2,(H,35,40)/t28-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 160n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50166544
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES CCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O2S/c1-2-33-29(38)34-26(18-21-9-10-23(30)19-25(21)31)28(37)36-15-13-35(14-16-36)27-8-4-3-6-22(27)20-32-12-11-24-7-5-17-39-24/h3-10,17,19,26,32H,2,11-16,18,20H2,1H3,(H2,33,34,38)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 300n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50166525
PNG
(3-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES CN(C)C(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O2S/c1-34(2)29(38)33-26(18-21-9-10-23(30)19-25(21)31)28(37)36-15-13-35(14-16-36)27-8-4-3-6-22(27)20-32-12-11-24-7-5-17-39-24/h3-10,17,19,26,32H,11-16,18,20H2,1-2H3,(H,33,38)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 350n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50166532
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES OCCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O3S/c30-23-8-7-21(25(31)19-23)18-26(34-29(39)33-11-16-37)28(38)36-14-12-35(13-15-36)27-6-2-1-4-22(27)20-32-10-9-24-5-3-17-40-24/h1-8,17,19,26,32,37H,9-16,18,20H2,(H2,33,34,39)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
 350n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166532
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES OCCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O3S/c30-23-8-7-21(25(31)19-23)18-26(34-29(39)33-11-16-37)28(38)36-14-12-35(13-15-36)27-6-2-1-4-22(27)20-32-10-9-24-5-3-17-40-24/h1-8,17,19,26,32,37H,9-16,18,20H2,(H2,33,34,39)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
 390n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166547
PNG
(CHEMBL366171 | [(R)-1-Naphthalen-1-ylmethyl-2-oxo-...)
Show SMILES O=C(N[C@H](Cc1cccc2ccccc12)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1)OCc1ccccc1
Show InChI InChI=1S/C38H40N4O3S/c43-37(42-23-21-41(22-24-42)36-18-7-5-13-32(36)27-39-20-19-33-16-9-25-46-33)35(40-38(44)45-28-29-10-2-1-3-11-29)26-31-15-8-14-30-12-4-6-17-34(30)31/h1-18,25,35,39H,19-24,26-28H2,(H,40,44)/t35-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 420n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166533
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES CC(C)NC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C30H37Cl2N5O2S/c1-21(2)34-30(39)35-27(18-22-9-10-24(31)19-26(22)32)29(38)37-15-13-36(14-16-37)28-8-4-3-6-23(28)20-33-12-11-25-7-5-17-40-25/h3-10,17,19,21,27,33H,11-16,18,20H2,1-2H3,(H2,34,35,39)/t27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 450n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50166521
PNG
(CHEMBL436122 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES FCCOC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H33Cl2FN4O3S/c30-23-8-7-21(25(31)19-23)18-26(34-29(38)39-16-10-32)28(37)36-14-12-35(13-15-36)27-6-2-1-4-22(27)20-33-11-9-24-5-3-17-40-24/h1-8,17,19,26,33H,9-16,18,20H2,(H,34,38)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 560n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166525
PNG
(3-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES CN(C)C(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O2S/c1-34(2)29(38)33-26(18-21-9-10-23(30)19-25(21)31)28(37)36-15-13-35(14-16-36)27-8-4-3-6-22(27)20-32-12-11-24-7-5-17-39-24/h3-10,17,19,26,32H,11-16,18,20H2,1-2H3,(H,33,38)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 560n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166519
PNG
((R)-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(2-((2-(t...)
Show SMILES CC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C28H32Cl2N4O2S/c1-20(35)32-26(17-21-8-9-23(29)18-25(21)30)28(36)34-14-12-33(13-15-34)27-7-3-2-5-22(27)19-31-11-10-24-6-4-16-37-24/h2-9,16,18,26,31H,10-15,17,19H2,1H3,(H,32,35)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 570n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166520
PNG
(1-Cyclopentyl-3-[(R)-1-(2,4-dichloro-benzyl)-2-oxo...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)NC2CCCC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C32H39Cl2N5O2S/c33-25-12-11-23(28(34)21-25)20-29(37-32(41)36-26-7-2-3-8-26)31(40)39-17-15-38(16-18-39)30-10-4-1-6-24(30)22-35-14-13-27-9-5-19-42-27/h1,4-6,9-12,19,21,26,29,35H,2-3,7-8,13-18,20,22H2,(H2,36,37,41)/t29-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 580n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50158484
PNG
((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Show SMILES NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1 |r|
Show InChI InChI=1S/C29H35Cl2N5O2S/c30-23-8-7-21(25(31)19-23)18-26(34-28(37)9-11-32)29(38)36-15-13-35(14-16-36)27-6-2-1-4-22(27)20-33-12-10-24-5-3-17-39-24/h1-8,17,19,26,33H,9-16,18,20,32H2,(H,34,37)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 640n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166523
PNG
(CHEMBL195110 | Pyrrolidine-1-carboxylic acid [(R)-...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)N2CCCC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C31H37Cl2N5O2S/c32-25-10-9-23(27(33)21-25)20-28(35-31(40)38-13-3-4-14-38)30(39)37-17-15-36(16-18-37)29-8-2-1-6-24(29)22-34-12-11-26-7-5-19-41-26/h1-2,5-10,19,21,28,34H,3-4,11-18,20,22H2,(H,35,40)/t28-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 670n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50166524
PNG
(CHEMBL192464 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES CC(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C30H36Cl2N4O3S/c1-21(2)39-30(38)34-27(18-22-9-10-24(31)19-26(22)32)29(37)36-15-13-35(14-16-36)28-8-4-3-6-23(28)20-33-12-11-25-7-5-17-40-25/h3-10,17,19,21,27,33H,11-16,18,20H2,1-2H3,(H,34,38)/t27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 680n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50166519
PNG
((R)-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(2-((2-(t...)
Show SMILES CC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C28H32Cl2N4O2S/c1-20(35)32-26(17-21-8-9-23(29)18-25(21)30)28(36)34-14-12-33(13-15-34)27-7-3-2-5-22(27)19-31-11-10-24-6-4-16-37-24/h2-9,16,18,26,31H,10-15,17,19H2,1H3,(H,32,35)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 730n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166521
PNG
(CHEMBL436122 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES FCCOC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H33Cl2FN4O3S/c30-23-8-7-21(25(31)19-23)18-26(34-29(38)39-16-10-32)28(37)36-14-12-35(13-15-36)27-6-2-1-4-22(27)20-33-11-9-24-5-3-17-40-24/h1-8,17,19,26,33H,9-16,18,20H2,(H,34,38)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 790n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166544
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES CCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O2S/c1-2-33-29(38)34-26(18-21-9-10-23(30)19-25(21)31)28(37)36-15-13-35(14-16-36)27-8-4-3-6-22(27)20-32-12-11-24-7-5-17-39-24/h3-10,17,19,26,32H,2,11-16,18,20H2,1H3,(H2,33,34,38)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 790n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166538
PNG
(CHEMBL194393 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES CCOC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H34Cl2N4O3S/c1-2-38-29(37)33-26(18-21-9-10-23(30)19-25(21)31)28(36)35-15-13-34(14-16-35)27-8-4-3-6-22(27)20-32-12-11-24-7-5-17-39-24/h3-10,17,19,26,32H,2,11-16,18,20H2,1H3,(H,33,37)/t26-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 800n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166543
PNG
(CHEMBL373099 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES COC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C28H32Cl2N4O3S/c1-37-28(36)32-25(17-20-8-9-22(29)18-24(20)30)27(35)34-14-12-33(13-15-34)26-7-3-2-5-21(26)19-31-11-10-23-6-4-16-38-23/h2-9,16,18,25,31H,10-15,17,19H2,1H3,(H,32,36)/t25-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 810n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166535
PNG
(CHEMBL192090 | N-[(R)-1-(2,4-Dichloro-benzyl)-2-ox...)
Show SMILES COC(=O)CCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C31H36Cl2N4O4S/c1-41-30(39)11-10-29(38)35-27(19-22-8-9-24(32)20-26(22)33)31(40)37-16-14-36(15-17-37)28-7-3-2-5-23(28)21-34-13-12-25-6-4-18-42-25/h2-9,18,20,27,34H,10-17,19,21H2,1H3,(H,35,38)/t27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 830n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166540
PNG
(1-Cyclopropyl-3-[(R)-1-(2,4-dichloro-benzyl)-2-oxo...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)NC2CC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C30H35Cl2N5O2S/c31-23-8-7-21(26(32)19-23)18-27(35-30(39)34-24-9-10-24)29(38)37-15-13-36(14-16-37)28-6-2-1-4-22(28)20-33-12-11-25-5-3-17-40-25/h1-8,17,19,24,27,33H,9-16,18,20H2,(H2,34,35,39)/t27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 860n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166534
PNG
(4-Amino-N-[(R)-1-(2,4-dichloro-benzyl)-2-oxo-2-(4-...)
Show SMILES NCCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C30H37Cl2N5O2S/c31-24-10-9-22(26(32)20-24)19-27(35-29(38)8-3-12-33)30(39)37-16-14-36(15-17-37)28-7-2-1-5-23(28)21-34-13-11-25-6-4-18-40-25/h1-2,4-7,9-10,18,20,27,34H,3,8,11-17,19,21,33H2,(H,35,38)/t27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 950n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166539
PNG
(1-tert-Butyl-3-[(R)-1-(2,4-dichloro-benzyl)-2-oxo-...)
Show SMILES CC(C)(C)NC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C31H39Cl2N5O2S/c1-31(2,3)36-30(40)35-27(19-22-10-11-24(32)20-26(22)33)29(39)38-16-14-37(15-17-38)28-9-5-4-7-23(28)21-34-13-12-25-8-6-18-41-25/h4-11,18,20,27,34H,12-17,19,21H2,1-3H3,(H2,35,36,40)/t27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50166521
PNG
(CHEMBL436122 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES FCCOC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H33Cl2FN4O3S/c30-23-8-7-21(25(31)19-23)18-26(34-29(38)39-16-10-32)28(37)36-14-12-35(13-15-36)27-6-2-1-4-22(27)20-33-11-9-24-5-3-17-40-24/h1-8,17,19,26,33H,9-16,18,20H2,(H,34,38)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-1 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166522
PNG
(CHEMBL363561 | [(R)-1-Benzo[b]thiophen-3-ylmethyl-...)
Show SMILES O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1)OCc1ccccc1
Show InChI InChI=1S/C36H38N4O3S2/c41-35(40-20-18-39(19-21-40)33-14-6-4-11-28(33)24-37-17-16-30-12-8-22-44-30)32(23-29-26-45-34-15-7-5-13-31(29)34)38-36(42)43-25-27-9-2-1-3-10-27/h1-15,22,26,32,37H,16-21,23-25H2,(H,38,42)/t32-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166524
PNG
(CHEMBL192464 | [(R)-1-(2,4-Dichloro-benzyl)-2-oxo-...)
Show SMILES CC(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C30H36Cl2N4O3S/c1-21(2)39-30(38)34-27(18-22-9-10-24(31)19-26(22)32)29(37)36-15-13-35(14-16-36)28-8-4-3-6-23(28)20-33-12-11-25-7-5-17-40-25/h3-10,17,19,21,27,33H,11-16,18,20H2,1-2H3,(H,34,38)/t27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.30E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50166537
PNG
(CHEMBL363641 | N-[(R)-1-(2,4-Dichloro-benzyl)-2-ox...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)c2ccccc2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C33H34Cl2N4O2S/c34-27-13-12-25(29(35)22-27)21-30(37-32(40)24-7-2-1-3-8-24)33(41)39-18-16-38(17-19-39)31-11-5-4-9-26(31)23-36-15-14-28-10-6-20-42-28/h1-13,20,22,30,36H,14-19,21,23H2,(H,37,40)/t30-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166549
PNG
(CHEMBL193786 | [(R)-1-(1H-Indol-3-ylmethyl)-2-oxo-...)
Show SMILES O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1)OCc1ccccc1
Show InChI InChI=1S/C36H39N5O3S/c42-35(41-20-18-40(19-21-41)34-15-7-4-11-28(34)24-37-17-16-30-12-8-22-45-30)33(23-29-25-38-32-14-6-5-13-31(29)32)39-36(43)44-26-27-9-2-1-3-10-27/h1-15,22,25,33,37-38H,16-21,23-24,26H2,(H,39,43)/t33-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.30E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50166530
PNG
(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES Fc1ccccc1CNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C34H36Cl2FN5O2S/c35-27-12-11-24(29(36)21-27)20-31(40-34(44)39-23-25-6-1-3-9-30(25)37)33(43)42-17-15-41(16-18-42)32-10-4-2-7-26(32)22-38-14-13-28-8-5-19-45-28/h1-12,19,21,31,38H,13-18,20,22-23H2,(H2,39,40,44)/t31-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.30E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166527
PNG
(CHEMBL195172 | [(R)-1-(1H-Imidazol-4-ylmethyl)-2-o...)
Show SMILES O=C(N[C@H](Cc1cnc[nH]1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1)OCc1ccccc1
Show InChI InChI=1S/C31H36N6O3S/c38-30(28(19-26-21-33-23-34-26)35-31(39)40-22-24-7-2-1-3-8-24)37-16-14-36(15-17-37)29-11-5-4-9-25(29)20-32-13-12-27-10-6-18-41-27/h1-11,18,21,23,28,32H,12-17,19-20,22H2,(H,33,34)(H,35,39)/t28-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 3.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166526
PNG
(CHEMBL370926 | [(R)-1-(4-Hydroxy-benzyl)-2-oxo-2-(...)
Show SMILES Oc1ccc(C[C@@H](NC(=O)OCc2ccccc2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)cc1
Show InChI InChI=1S/C34H38N4O4S/c39-29-14-12-26(13-15-29)23-31(36-34(41)42-25-27-7-2-1-3-8-27)33(40)38-20-18-37(19-21-38)32-11-5-4-9-28(32)24-35-17-16-30-10-6-22-43-30/h1-15,22,31,35,39H,16-21,23-25H2,(H,36,41)/t31-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 5.70E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50166525
PNG
(3-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Show SMILES CN(C)C(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Show InChI InChI=1S/C29H35Cl2N5O2S/c1-34(2)29(38)33-26(18-21-9-10-23(30)19-25(21)31)28(37)36-15-13-35(14-16-36)27-8-4-3-6-22(27)20-32-12-11-24-7-5-17-39-24/h3-10,17,19,26,32H,11-16,18,20H2,1-2H3,(H,33,38)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 6.80E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-1 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50166523
PNG
(CHEMBL195110 | Pyrrolidine-1-carboxylic acid [(R)-...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)N2CCCC2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)c(Cl)c1
Show InChI InChI=1S/C31H37Cl2N5O2S/c32-25-10-9-23(27(33)21-25)20-28(35-31(40)38-13-3-4-14-38)30(39)37-17-15-36(16-18-37)29-8-2-1-6-24(29)22-34-12-11-26-7-5-19-41-26/h1-2,5-10,19,21,28,34H,3-4,11-18,20,22H2,(H,35,40)/t28-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 6.90E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at melanocortin-1 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166531
PNG
(CHEMBL194819 | [(R)-2-Oxo-1-thiazol-4-ylmethyl-2-(...)
Show SMILES O=C(N[C@H](Cc1cscn1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1)OCc1ccccc1
Show InChI InChI=1S/C31H35N5O3S2/c37-30(28(19-26-22-40-23-33-26)34-31(38)39-21-24-7-2-1-3-8-24)36-16-14-35(15-17-36)29-11-5-4-9-25(29)20-32-13-12-27-10-6-18-41-27/h1-11,18,22-23,28,32H,12-17,19-21H2,(H,34,38)/t28-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50152799
PNG
((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Show SMILES CC(NC1CCCNC1)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1
Show InChI InChI=1S/C36H45ClN6O2/c1-25(40-30-9-6-16-38-24-30)31-10-4-5-11-34(31)42-17-19-43(20-18-42)36(45)33(21-26-12-14-29(37)15-13-26)41-35(44)32-22-27-7-2-3-8-28(27)23-39-32/h2-5,7-8,10-15,25,30,32-33,38-40H,6,9,16-24H2,1H3,(H,41,44)/t25?,30?,32-,33-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.70n/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Agonistic effective concentration to stimulate cAMP in CHO cells stably expressing the human melanocortin-4 receptor

Bioorg Med Chem Lett 15: 2541-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.053
BindingDB Entry DOI: 10.7270/Q22Z1527
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%