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PubMed code 16777413

Compile data set for download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189188
PNG
(3-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Show SMILES CCC(C)[C@H](NC(=O)CCN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C28H35Cl2F3N4O2/c1-3-18(2)27(35-25(38)10-11-34)22-16-20(28(31,32)33)6-8-24(22)36-12-14-37(15-13-36)26(39)9-5-19-4-7-21(29)17-23(19)30/h4,6-8,16-18,27H,3,5,9-15,34H2,1-2H3,(H,35,38)/t18?,27-/m0/s1
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 13n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189232
PNG
(2-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Show SMILES CCC(C)[C@H](NC(=O)CN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H33Cl2F3N4O2/c1-3-17(2)26(34-24(37)16-33)21-14-19(27(30,31)32)6-8-23(21)35-10-12-36(13-11-35)25(38)9-5-18-4-7-20(28)15-22(18)29/h4,6-8,14-15,17,26H,3,5,9-13,16,33H2,1-2H3,(H,34,37)/t17?,26-/m0/s1
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 18n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189210
PNG
((S)-2-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)prop...)
Show SMILES CC(C)C[C@H](NC(=O)CN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H33Cl2F3N4O2/c1-17(2)13-23(34-25(37)16-33)21-14-19(27(30,31)32)5-7-24(21)35-9-11-36(12-10-35)26(38)8-4-18-3-6-20(28)15-22(18)29/h3,5-7,14-15,17,23H,4,8-13,16,33H2,1-2H3,(H,34,37)/t23-/m0/s1
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 19n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189202
PNG
((S)-3-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)prop...)
Show SMILES CC(C)C[C@H](NC(=O)CCN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C28H35Cl2F3N4O2/c1-18(2)15-24(35-26(38)9-10-34)22-16-20(28(31,32)33)5-7-25(22)36-11-13-37(14-12-36)27(39)8-4-19-3-6-21(29)17-23(19)30/h3,5-7,16-18,24H,4,8-15,34H2,1-2H3,(H,35,38)/t24-/m0/s1
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 25n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189223
PNG
(1-(4-(2-((1S)-1-(3-aminopropylamino)-2-methylbutyl...)
Show SMILES CCC(C)[C@H](NCCCN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C28H37Cl2F3N4O/c1-3-19(2)27(35-12-4-11-34)23-17-21(28(31,32)33)7-9-25(23)36-13-15-37(16-14-36)26(38)10-6-20-5-8-22(29)18-24(20)30/h5,7-9,17-19,27,35H,3-4,6,10-16,34H2,1-2H3/t19?,27-/m0/s1
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 30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189200
PNG
(1-(4-(2-((1S)-1-(2-aminoethylamino)-2-methylbutyl)...)
Show SMILES CCC(C)[C@H](NCCN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H35Cl2F3N4O/c1-3-18(2)26(34-11-10-33)22-16-20(27(30,31)32)6-8-24(22)35-12-14-36(15-13-35)25(37)9-5-19-4-7-21(28)17-23(19)29/h4,6-8,16-18,26,34H,3,5,9-15,33H2,1-2H3/t18?,26-/m0/s1
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 56n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189192
PNG
(1-(4-(2-((1S)-1-amino-2-methylbutyl)-4-(trifluorom...)
Show SMILES CCC(C)[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(OC)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C26H33ClF3N3O2/c1-4-17(2)25(31)21-15-19(26(28,29)30)7-9-23(21)32-11-13-33(14-12-32)24(34)10-6-18-5-8-20(35-3)16-22(18)27/h5,7-9,15-17,25H,4,6,10-14,31H2,1-3H3/t17?,25-/m0/s1
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 57n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189217
PNG
(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-2-methyl-1-((...)
Show SMILES CCC(C)[C@H](NC[C@@H]1CCCN1)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C30H39Cl2F3N4O/c1-3-20(2)29(37-19-24-5-4-12-36-24)25-17-22(30(33,34)35)8-10-27(25)38-13-15-39(16-14-38)28(40)11-7-21-6-9-23(31)18-26(21)32/h6,8-10,17-18,20,24,29,36-37H,3-5,7,11-16,19H2,1-2H3/t20?,24-,29-/m0/s1
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 64n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189237
PNG
((1S)-[2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-pip...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C25H30Cl2F3N3O/c1-16(2)13-22(31)20-14-18(25(28,29)30)5-7-23(20)32-9-11-33(12-10-32)24(34)8-4-17-3-6-19(26)15-21(17)27/h3,5-7,14-16,22H,4,8-13,31H2,1-2H3/t22-/m0/s1
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 74n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189211
PNG
(1-(4-(2-((2S)-1-amino-2-methylbutyl)-4-(trifluorom...)
Show SMILES CC[C@H](C)C(N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O/c1-3-16(2)24(31)20-14-18(25(28,29)30)6-8-22(20)32-10-12-33(13-11-32)23(34)9-5-17-4-7-19(26)15-21(17)27/h4,6-8,14-16,24H,3,5,9-13,31H2,1-2H3/t16-,24?/m0/s1
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 75n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189231
PNG
(1-(4-(2-((1S)-1-amino-2-methylbutyl)-4-(trifluorom...)
Show SMILES CCC(C)[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C25H31ClF3N3O/c1-3-17(2)24(30)21-16-19(25(27,28)29)7-10-22(21)31-12-14-32(15-13-31)23(33)11-6-18-4-8-20(26)9-5-18/h4-5,7-10,16-17,24H,3,6,11-15,30H2,1-2H3/t17?,24-/m0/s1
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 86n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189234
PNG
(1-(4-(2-((1S)-1-((S)-2-aminopropylamino)-2-methylb...)
Show SMILES CCC(C)[C@H](NC[C@H](C)N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C28H37Cl2F3N4O/c1-4-18(2)27(35-17-19(3)34)23-15-21(28(31,32)33)7-9-25(23)36-11-13-37(14-12-36)26(38)10-6-20-5-8-22(29)16-24(20)30/h5,7-9,15-16,18-19,27,35H,4,6,10-14,17,34H2,1-3H3/t18?,19-,27-/m0/s1
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 89n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189208
PNG
(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-1-(ethylamino...)
Show SMILES CCN[C@@H](C(C)CC)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H34Cl2F3N3O/c1-4-18(3)26(33-5-2)22-16-20(27(30,31)32)8-10-24(22)34-12-14-35(15-13-34)25(36)11-7-19-6-9-21(28)17-23(19)29/h6,8-10,16-18,26,33H,4-5,7,11-15H2,1-3H3/t18?,26-/m0/s1
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 92n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189193
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-fluorophenyl...)
Show SMILES CC(C)C[C@H](N)c1cc(F)ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H30Cl2FN3O/c1-16(2)13-22(28)20-15-19(27)6-7-23(20)29-9-11-30(12-10-29)24(31)8-4-17-3-5-18(25)14-21(17)26/h3,5-7,14-16,22H,4,8-13,28H2,1-2H3/t22-/m0/s1
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 94n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189205
PNG
(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-2-methyl-1-((...)
Show SMILES CCC(C)[C@H](NC[C@H]1CCCN1)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C30H39Cl2F3N4O/c1-3-20(2)29(37-19-24-5-4-12-36-24)25-17-22(30(33,34)35)8-10-27(25)38-13-15-39(16-14-38)28(40)11-7-21-6-9-23(31)18-26(21)32/h6,8-10,17-18,20,24,29,36-37H,3-5,7,11-16,19H2,1-2H3/t20?,24-,29+/m1/s1
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 110n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189183
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-6-fluorophenyl...)
Show SMILES CC(C)C[C@H](N)c1cccc(F)c1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H30Cl2FN3O/c1-16(2)14-22(28)19-4-3-5-21(27)24(19)30-12-10-29(11-13-30)23(31)9-7-17-6-8-18(25)15-20(17)26/h3-6,8,15-16,22H,7,9-14,28H2,1-2H3/t22-/m0/s1
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 110n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189229
PNG
(1-(4-(2-(1-amino-2-methylpropyl)-4-(trifluoromethy...)
Show SMILES CC(C)C(N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O/c1-15(2)23(30)19-13-17(24(27,28)29)5-7-21(19)31-9-11-32(12-10-31)22(33)8-4-16-3-6-18(25)14-20(16)26/h3,5-7,13-15,23H,4,8-12,30H2,1-2H3
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 140n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189235
PNG
(1-(4-(2-(1-amino-2-methylbutyl)-4-(trifluoromethyl...)
Show SMILES CCC(C)C(N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O/c1-3-16(2)24(31)20-14-18(25(28,29)30)6-8-22(20)32-10-12-33(13-11-32)23(34)9-5-17-4-7-19(26)15-21(17)27/h4,6-8,14-16,24H,3,5,9-13,31H2,1-2H3
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 160n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189206
PNG
((S)-3-(2,4-dichlorophenyl)-1-(4-(2-(1-(ethylamino)...)
Show SMILES CCN[C@@H](CC(C)C)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H34Cl2F3N3O/c1-4-33-24(15-18(2)3)22-16-20(27(30,31)32)7-9-25(22)34-11-13-35(14-12-34)26(36)10-6-19-5-8-21(28)17-23(19)29/h5,7-9,16-18,24,33H,4,6,10-15H2,1-3H3/t24-/m0/s1
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 170n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50189188
PNG
(3-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Show SMILES CCC(C)[C@H](NC(=O)CCN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C28H35Cl2F3N4O2/c1-3-18(2)27(35-25(38)10-11-34)22-16-20(28(31,32)33)6-8-24(22)36-12-14-37(15-13-36)26(39)9-5-19-4-7-21(29)17-23(19)30/h4,6-8,16-18,27H,3,5,9-15,34H2,1-2H3,(H,35,38)/t18?,27-/m0/s1
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 170n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189236
PNG
(1-(4-(2-(1-aminopentyl)-4-(trifluoromethyl)phenyl)...)
Show SMILES CCCCC(N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O/c1-2-3-4-22(31)20-15-18(25(28,29)30)7-9-23(20)32-11-13-33(14-12-32)24(34)10-6-17-5-8-19(26)16-21(17)27/h5,7-9,15-16,22H,2-4,6,10-14,31H2,1H3
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 190n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189221
PNG
(3-amino-N-(2-(benzyloxy)-1-(2-(4-(3-(2,4-dichlorop...)
Show SMILES NCCC(=O)NC(COCc1ccccc1)c1cc(F)ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C31H35Cl2FN4O3/c32-24-8-6-23(27(33)18-24)7-11-31(40)38-16-14-37(15-17-38)29-10-9-25(34)19-26(29)28(36-30(39)12-13-35)21-41-20-22-4-2-1-3-5-22/h1-6,8-10,18-19,28H,7,11-17,20-21,35H2,(H,36,39)
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 210n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189222
PNG
(3-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)propanoy...)
Show SMILES CCOCC(NC(=O)CCN)c1cc(F)ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C26H33Cl2FN4O3/c1-2-36-17-23(31-25(34)9-10-30)21-16-20(29)6-7-24(21)32-11-13-33(14-12-32)26(35)8-4-18-3-5-19(27)15-22(18)28/h3,5-7,15-16,23H,2,4,8-14,17,30H2,1H3,(H,31,34)
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 300n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189219
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1ccc(CCC(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)cc1
Show InChI InChI=1S/C26H34F3N3O2/c1-18(2)16-23(30)22-17-20(26(27,28)29)7-10-24(22)31-12-14-32(15-13-31)25(33)11-6-19-4-8-21(34-3)9-5-19/h4-5,7-10,17-18,23H,6,11-16,30H2,1-3H3/t23-/m0/s1
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 350n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189194
PNG
(CHEMBL212303 | N-((1S)-1-(2-(4-(3-(2,4-dichlorophe...)
Show SMILES CCC(C)[C@H](NC(C)=O)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H32Cl2F3N3O2/c1-4-17(2)26(33-18(3)36)22-15-20(27(30,31)32)7-9-24(22)34-11-13-35(14-12-34)25(37)10-6-19-5-8-21(28)16-23(19)29/h5,7-9,15-17,26H,4,6,10-14H2,1-3H3,(H,33,36)/t17?,26-/m0/s1
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 360n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189218
PNG
(1-(4-(2-(1-(2-aminoethylamino)-2-(benzyloxy)ethyl)...)
Show SMILES NCCNC(COCc1ccccc1)c1cc(F)ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C30H35Cl2FN4O2/c31-24-8-6-23(27(32)18-24)7-11-30(38)37-16-14-36(15-17-37)29-10-9-25(33)19-26(29)28(35-13-12-34)21-39-20-22-4-2-1-3-5-22/h1-6,8-10,18-19,28,35H,7,11-17,20-21,34H2
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 400n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189214
PNG
(1-(4-(2-(1-aminoethyl)-4-(trifluoromethyl)phenyl)p...)
Show SMILES CC(N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C22H24Cl2F3N3O/c1-14(28)18-12-16(22(25,26)27)4-6-20(18)29-8-10-30(11-9-29)21(31)7-3-15-2-5-17(23)13-19(15)24/h2,4-6,12-14H,3,7-11,28H2,1H3
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 490n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50189210
PNG
((S)-2-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)prop...)
Show SMILES CC(C)C[C@H](NC(=O)CN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H33Cl2F3N4O2/c1-17(2)13-23(34-25(37)16-33)21-14-19(27(30,31)32)5-7-24(21)35-9-11-36(12-10-35)26(38)8-4-18-3-6-20(28)15-22(18)29/h3,5-7,14-15,17,23H,4,8-13,16,33H2,1-2H3,(H,34,37)/t23-/m0/s1
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 500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189191
PNG
((S)-3-(2,4-dichlorophenyl)-1-(4-(2-(1-(2-methoxyet...)
Show SMILES COCCN[C@@H](CC(C)C)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C28H36Cl2F3N3O2/c1-19(2)16-25(34-10-15-38-3)23-17-21(28(31,32)33)6-8-26(23)35-11-13-36(14-12-35)27(37)9-5-20-4-7-22(29)18-24(20)30/h4,6-8,17-19,25,34H,5,9-16H2,1-3H3/t25-/m0/s1
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 620n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189224
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1c[nH]c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C27H33F3N4O/c1-18(2)15-23(31)22-16-20(27(28,29)30)8-9-25(22)33-11-13-34(14-12-33)26(35)10-7-19-17-32-24-6-4-3-5-21(19)24/h3-6,8-9,16-18,23,32H,7,10-15,31H2,1-2H3/t23-/m0/s1
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 640n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189195
PNG
(1-(4-(2-(1-amino-2-ethoxyethyl)-4-fluorophenyl)pip...)
Show SMILES CCOCC(N)c1cc(F)ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H28Cl2FN3O2/c1-2-31-15-21(27)19-14-18(26)6-7-22(19)28-9-11-29(12-10-28)23(30)8-4-16-3-5-17(24)13-20(16)25/h3,5-7,13-14,21H,2,4,8-12,15,27H2,1H3
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 690n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189197
PNG
(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-2-methyl-1-((...)
Show SMILES CCC(C)[C@H](NCC1CCCO1)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C30H38Cl2F3N3O2/c1-3-20(2)29(36-19-24-5-4-16-40-24)25-17-22(30(33,34)35)8-10-27(25)37-12-14-38(15-13-37)28(39)11-7-21-6-9-23(31)18-26(21)32/h6,8-10,17-18,20,24,29,36H,3-5,7,11-16,19H2,1-2H3/t20?,24?,29-/m0/s1
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 780n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50189188
PNG
(3-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Show SMILES CCC(C)[C@H](NC(=O)CCN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C28H35Cl2F3N4O2/c1-3-18(2)27(35-25(38)10-11-34)22-16-20(28(31,32)33)6-8-24(22)36-12-14-37(15-13-36)26(39)9-5-19-4-7-21(29)17-23(19)30/h4,6-8,16-18,27H,3,5,9-15,34H2,1-2H3,(H,35,38)/t18?,27-/m0/s1
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 800n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189189
PNG
(1-(4-(2-(1-amino-2-(benzyloxy)ethyl)-4-fluoropheny...)
Show SMILES NC(COCc1ccccc1)c1cc(F)ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C28H30Cl2FN3O2/c29-22-8-6-21(25(30)16-22)7-11-28(35)34-14-12-33(13-15-34)27-10-9-23(31)17-24(27)26(32)19-36-18-20-4-2-1-3-5-20/h1-6,8-10,16-17,26H,7,11-15,18-19,32H2
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 1.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50189183
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-6-fluorophenyl...)
Show SMILES CC(C)C[C@H](N)c1cccc(F)c1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H30Cl2FN3O/c1-16(2)14-22(28)19-4-3-5-21(27)24(19)30-12-10-29(11-13-30)23(31)9-7-17-6-8-18(25)15-20(17)26/h3-6,8,15-16,22H,7,9-14,28H2,1-2H3/t22-/m0/s1
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 1.20E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50189210
PNG
((S)-2-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)prop...)
Show SMILES CC(C)C[C@H](NC(=O)CN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H33Cl2F3N4O2/c1-17(2)13-23(34-25(37)16-33)21-14-19(27(30,31)32)5-7-24(21)35-9-11-36(12-10-35)26(38)8-4-18-3-6-20(28)15-22(18)29/h3,5-7,14-15,17,23H,4,8-13,16,33H2,1-2H3,(H,34,37)/t23-/m0/s1
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 1.20E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189190
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1ccccc1CCC(=O)N1CCN(CC1)c1ccc(cc1[C@@H](N)CC(C)C)C(F)(F)F
Show InChI InChI=1S/C26H34F3N3O2/c1-18(2)16-22(30)21-17-20(26(27,28)29)9-10-23(21)31-12-14-32(15-13-31)25(33)11-8-19-6-4-5-7-24(19)34-3/h4-7,9-10,17-18,22H,8,11-16,30H2,1-3H3/t22-/m0/s1
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 1.40E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50189183
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-6-fluorophenyl...)
Show SMILES CC(C)C[C@H](N)c1cccc(F)c1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H30Cl2FN3O/c1-16(2)14-22(28)19-4-3-5-21(27)24(19)30-12-10-29(11-13-30)23(31)9-7-17-6-8-18(25)15-20(17)26/h3-6,8,15-16,22H,7,9-14,28H2,1-2H3/t22-/m0/s1
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 1.40E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189182
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc2OCOc2c1)C(F)(F)F
Show InChI InChI=1S/C26H32F3N3O3/c1-17(2)13-21(30)20-15-19(26(27,28)29)5-6-22(20)31-9-11-32(12-10-31)25(33)8-4-18-3-7-23-24(14-18)35-16-34-23/h3,5-7,14-15,17,21H,4,8-13,16,30H2,1-2H3/t21-/m0/s1
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 1.50E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189196
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1c(C)[nH]c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C28H35F3N4O/c1-18(2)16-24(32)23-17-20(28(29,30)31)8-10-26(23)34-12-14-35(15-13-34)27(36)11-9-21-19(3)33-25-7-5-4-6-22(21)25/h4-8,10,17-18,24,33H,9,11-16,32H2,1-3H3/t24-/m0/s1
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 1.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189213
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccccc1Cl)C(F)(F)F
Show InChI InChI=1S/C25H31ClF3N3O/c1-17(2)15-22(30)20-16-19(25(27,28)29)8-9-23(20)31-11-13-32(14-12-31)24(33)10-7-18-5-3-4-6-21(18)26/h3-6,8-9,16-17,22H,7,10-15,30H2,1-2H3/t22-/m0/s1
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 1.70E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189212
PNG
(CHEMBL212553 | N-((1S)-1-(2-(4-(3-(2,4-dichlorophe...)
Show SMILES CCC(C)[C@H](NS(C)(=O)=O)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C26H32Cl2F3N3O3S/c1-4-17(2)25(32-38(3,36)37)21-15-19(26(29,30)31)7-9-23(21)33-11-13-34(14-12-33)24(35)10-6-18-5-8-20(27)16-22(18)28/h5,7-9,15-17,25,32H,4,6,10-14H2,1-3H3/t17?,25-/m0/s1
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 1.80E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189209
PNG
((S)-3-(2,4-dichlorophenyl)-1-(4-(2-(3-methyl-1-(me...)
Show SMILES CN[C@@H](CC(C)C)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C26H32Cl2F3N3O/c1-17(2)14-23(32-3)21-15-19(26(29,30)31)6-8-24(21)33-10-12-34(13-11-33)25(35)9-5-18-4-7-20(27)16-22(18)28/h4,6-8,15-17,23,32H,5,9-14H2,1-3H3/t23-/m0/s1
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 1.90E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189215
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1cccc(C)c1)C(F)(F)F
Show InChI InChI=1S/C26H34F3N3O/c1-18(2)15-23(30)22-17-21(26(27,28)29)8-9-24(22)31-11-13-32(14-12-31)25(33)10-7-20-6-4-5-19(3)16-20/h4-6,8-9,16-18,23H,7,10-15,30H2,1-3H3/t23-/m0/s1
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 2.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189226
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1cccc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H31F6N3O/c1-17(2)14-22(33)21-16-20(26(30,31)32)7-8-23(21)34-10-12-35(13-11-34)24(36)9-6-18-4-3-5-19(15-18)25(27,28)29/h3-5,7-8,15-17,22H,6,9-14,33H2,1-2H3/t22-/m0/s1
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 2.20E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189198
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1csc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C27H32F3N3OS/c1-18(2)15-23(31)22-16-20(27(28,29)30)8-9-24(22)32-11-13-33(14-12-32)26(34)10-7-19-17-35-25-6-4-3-5-21(19)25/h3-6,8-9,16-18,23H,7,10-15,31H2,1-2H3/t23-/m0/s1
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 2.30E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189186
PNG
(CHEMBL213935 | methyl (1S)-1-(2-(4-(3-(2,4-dichlor...)
Show SMILES CCC(C)[C@H](NC(=O)OC)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H32Cl2F3N3O3/c1-4-17(2)25(33-26(37)38-3)21-15-19(27(30,31)32)7-9-23(21)34-11-13-35(14-12-34)24(36)10-6-18-5-8-20(28)16-22(18)29/h5,7-9,15-17,25H,4,6,10-14H2,1-3H3,(H,33,37)/t17?,25-/m0/s1
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 2.40E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189228
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1ccc(OC)c(CCC(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)c1
Show InChI InChI=1S/C27H36F3N3O3/c1-18(2)15-23(31)22-17-20(27(28,29)30)6-8-24(22)32-11-13-33(14-12-32)26(34)10-5-19-16-21(35-3)7-9-25(19)36-4/h6-9,16-18,23H,5,10-15,31H2,1-4H3/t23-/m0/s1
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 2.50E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189230
PNG
(1-(4-(2-((1S)-1-amino-2-methylbutyl)-4-(trifluorom...)
Show SMILES CCC(C)[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(OC)c(OC)c1Cl)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O3/c1-5-17(2)25(32)20-16-19(27(29,30)31)8-9-21(20)33-12-14-34(15-13-33)23(35)11-7-18-6-10-22(36-3)26(37-4)24(18)28/h6,8-10,16-17,25H,5,7,11-15,32H2,1-4H3/t17?,25-/m0/s1
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 2.50E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189187
PNG
(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-2-methyl-1-(p...)
Show SMILES CCC(C)[C@H](NCCc1ccccc1)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C33H38Cl2F3N3O/c1-3-23(2)32(39-16-15-24-7-5-4-6-8-24)28-21-26(33(36,37)38)11-13-30(28)40-17-19-41(20-18-40)31(42)14-10-25-9-12-27(34)22-29(25)35/h4-9,11-13,21-23,32,39H,3,10,14-20H2,1-2H3/t23?,32-/m0/s1
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 2.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189227
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1c(Cl)cccc1Cl)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O/c1-16(2)14-22(31)19-15-17(25(28,29)30)6-8-23(19)32-10-12-33(13-11-32)24(34)9-7-18-20(26)4-3-5-21(18)27/h3-6,8,15-16,22H,7,9-14,31H2,1-2H3/t22-/m0/s1
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 2.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189220
PNG
(3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-2-methyl-1-(2...)
Show SMILES CCC(C)CN[C@@H](C(C)CC)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C30H40Cl2F3N3O/c1-5-20(3)19-36-29(21(4)6-2)25-17-23(30(33,34)35)9-11-27(25)37-13-15-38(16-14-37)28(39)12-8-22-7-10-24(31)18-26(22)32/h7,9-11,17-18,20-21,29,36H,5-6,8,12-16,19H2,1-4H3/t20?,21?,29-/m0/s1
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 2.80E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189201
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccccc1F)C(F)(F)F
Show InChI InChI=1S/C25H31F4N3O/c1-17(2)15-22(30)20-16-19(25(27,28)29)8-9-23(20)31-11-13-32(14-12-31)24(33)10-7-18-5-3-4-6-21(18)26/h3-6,8-9,16-17,22H,7,10-15,30H2,1-2H3/t22-/m0/s1
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 2.80E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189207
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1cn(C)c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C28H35F3N4O/c1-19(2)16-24(32)23-17-21(28(29,30)31)9-10-26(23)34-12-14-35(15-13-34)27(36)11-8-20-18-33(3)25-7-5-4-6-22(20)25/h4-7,9-10,17-19,24H,8,11-16,32H2,1-3H3/t24-/m0/s1
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 3.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189238
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccccc1O)C(F)(F)F
Show InChI InChI=1S/C25H32F3N3O2/c1-17(2)15-21(29)20-16-19(25(26,27)28)8-9-22(20)30-11-13-31(14-12-30)24(33)10-7-18-5-3-4-6-23(18)32/h3-6,8-9,16-17,21,32H,7,10-15,29H2,1-2H3/t21-/m0/s1
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 3.30E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189199
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1cccc(CCC(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)c1
Show InChI InChI=1S/C26H34F3N3O2/c1-18(2)15-23(30)22-17-20(26(27,28)29)8-9-24(22)31-11-13-32(14-12-31)25(33)10-7-19-5-4-6-21(16-19)34-3/h4-6,8-9,16-18,23H,7,10-15,30H2,1-3H3/t23-/m0/s1
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 4.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189204
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1ccc(CCC(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)cc1OC
Show InChI InChI=1S/C27H36F3N3O3/c1-18(2)15-22(31)21-17-20(27(28,29)30)7-8-23(21)32-11-13-33(14-12-32)26(34)10-6-19-5-9-24(35-3)25(16-19)36-4/h5,7-9,16-18,22H,6,10-15,31H2,1-4H3/t22-/m0/s1
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 4.30E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189184
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1cccs1)C(F)(F)F
Show InChI InChI=1S/C23H30F3N3OS/c1-16(2)14-20(27)19-15-17(23(24,25)26)5-7-21(19)28-9-11-29(12-10-28)22(30)8-6-18-4-3-13-31-18/h3-5,7,13,15-16,20H,6,8-12,14,27H2,1-2H3/t20-/m0/s1
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 4.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189233
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(cc1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C26H34F3N3O3S/c1-18(2)16-23(30)22-17-20(26(27,28)29)7-10-24(22)31-12-14-32(15-13-31)25(33)11-6-19-4-8-21(9-5-19)36(3,34)35/h4-5,7-10,17-18,23H,6,11-16,30H2,1-3H3/t23-/m0/s1
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 4.90E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189216
PNG
(1-(4-(2-((1S)-1-(benzylamino)-2-methylbutyl)-4-(tr...)
Show SMILES CCC(C)[C@H](NCc1ccccc1)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C32H36Cl2F3N3O/c1-3-22(2)31(38-21-23-7-5-4-6-8-23)27-19-25(32(35,36)37)11-13-29(27)39-15-17-40(18-16-39)30(41)14-10-24-9-12-26(33)20-28(24)34/h4-9,11-13,19-20,22,31,38H,3,10,14-18,21H2,1-2H3/t22?,31-/m0/s1
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 5.90E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189225
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1cc(OC)c(OC)cc1CCC(=O)N1CCN(CC1)c1ccc(cc1[C@@H](N)CC(C)C)C(F)(F)F
Show InChI InChI=1S/C28H38F3N3O4/c1-18(2)14-22(32)21-16-20(28(29,30)31)7-8-23(21)33-10-12-34(13-11-33)27(35)9-6-19-15-25(37-4)26(38-5)17-24(19)36-3/h7-8,15-18,22H,6,9-14,32H2,1-5H3/t22-/m0/s1
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 6.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189185
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(O)cc1)C(F)(F)F
Show InChI InChI=1S/C25H32F3N3O2/c1-17(2)15-22(29)21-16-19(25(26,27)28)6-9-23(21)30-11-13-31(14-12-30)24(33)10-5-18-3-7-20(32)8-4-18/h3-4,6-9,16-17,22,32H,5,10-15,29H2,1-2H3/t22-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189203
PNG
(1-(4-(2-((1S)-1-(2-fluorobenzylamino)-2-methylbuty...)
Show SMILES CCC(C)[C@H](NCc1ccccc1F)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C32H35Cl2F4N3O/c1-3-21(2)31(39-20-23-6-4-5-7-28(23)35)26-18-24(32(36,37)38)10-12-29(26)40-14-16-41(17-15-40)30(42)13-9-22-8-11-25(33)19-27(22)34/h4-8,10-12,18-19,21,31,39H,3,9,13-17,20H2,1-2H3/t21?,31-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189188
PNG
(3-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Show SMILES CCC(C)[C@H](NC(=O)CCN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C28H35Cl2F3N4O2/c1-3-18(2)27(35-25(38)10-11-34)22-16-20(28(31,32)33)6-8-24(22)36-12-14-37(15-13-36)26(39)9-5-19-4-7-21(29)17-23(19)30/h4,6-8,16-18,27H,3,5,9-15,34H2,1-2H3,(H,35,38)/t18?,27-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Acitivity at MC4R assessed as inhibition of alphaMSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50189210
PNG
((S)-2-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)prop...)
Show SMILES CC(C)C[C@H](NC(=O)CN)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H33Cl2F3N4O2/c1-17(2)13-23(34-25(37)16-33)21-14-19(27(30,31)32)5-7-24(21)35-9-11-36(12-10-35)26(38)8-4-18-3-6-20(28)15-22(18)29/h3,5-7,14-15,17,23H,4,8-13,16,33H2,1-2H3,(H,34,37)/t23-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Acitivity at MC4R assessed as inhibition of alphaMSH-stimulated cAMP production

Bioorg Med Chem Lett 16: 4674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.088
BindingDB Entry DOI: 10.7270/Q2C53KFR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%