Found 89 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231044
(CHEMBL252011 | N-(2-(4,7-dihydroxynaphthalen-1-yl)...)Show SMILES CC(CNC(=O)c1ccc(OC(F)(F)F)cc1)c1ccc(O)c2ccc(O)cc12 |w:1.0| Show InChI InChI=1S/C21H18F3NO4/c1-12(16-8-9-19(27)17-7-4-14(26)10-18(16)17)11-25-20(28)13-2-5-15(6-3-13)29-21(22,23)24/h2-10,12,26-27H,11H2,1H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231058
(CHEMBL438345 | N-((6-hydroxy-9-methyl-2,3,4,9-tetr...)Show SMILES Cn1c2CCCC(CNC(=O)c3ccc(OC(F)(F)F)cc3)c2c2cc(O)ccc12 |w:6.6| Show InChI InChI=1S/C22H21F3N2O3/c1-27-18-10-7-15(28)11-17(18)20-14(3-2-4-19(20)27)12-26-21(29)13-5-8-16(9-6-13)30-22(23,24)25/h5-11,14,28H,2-4,12H2,1H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50231044
(CHEMBL252011 | N-(2-(4,7-dihydroxynaphthalen-1-yl)...)Show SMILES CC(CNC(=O)c1ccc(OC(F)(F)F)cc1)c1ccc(O)c2ccc(O)cc12 |w:1.0| Show InChI InChI=1S/C21H18F3NO4/c1-12(16-8-9-19(27)17-7-4-14(26)10-18(16)17)11-25-20(28)13-2-5-15(6-3-13)29-21(22,23)24/h2-10,12,26-27H,11H2,1H3,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231043
(CHEMBL400086 | N-(4-tert-butylphenyl)-4-(1,1,2,2-t...)Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(OC(F)(F)C(F)F)cc2)cc1 Show InChI InChI=1S/C19H19F4NO2/c1-18(2,3)13-6-8-14(9-7-13)24-16(25)12-4-10-15(11-5-12)26-19(22,23)17(20)21/h4-11,17H,1-3H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231088
(CHEMBL253624 | N-(2-(4,7-dihydroxynaphthalen-1-yl)...)Show SMILES Oc1ccc2c(O)ccc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C20H16F3NO4/c21-20(22,23)28-15-5-1-13(2-6-15)19(27)24-10-9-12-3-8-18(26)16-7-4-14(25)11-17(12)16/h1-8,11,25-26H,9-10H2,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231110
(CHEMBL400779 | N-(1-(7-hydroxynaphthalen-1-yl)prop...)Show SMILES CC(Cc1cccc2ccc(O)cc12)NC(=O)c1ccc(OC(F)(F)F)cc1 |w:1.0| Show InChI InChI=1S/C21H18F3NO3/c1-13(11-16-4-2-3-14-5-8-17(26)12-19(14)16)25-20(27)15-6-9-18(10-7-15)28-21(22,23)24/h2-10,12-13,26H,11H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231051
(CHEMBL252226 | N-(4-tert-butylphenyl)-4-(trifluoro...)Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(OC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C18H18F3NO2/c1-17(2,3)13-6-8-14(9-7-13)22-16(23)12-4-10-15(11-5-12)24-18(19,20)21/h4-11H,1-3H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231076
(CHEMBL253623 | N-(2-(7-hydroxynaphthalen-1-yl)ethy...)Show SMILES Oc1ccc2cccc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C20H16F3NO3/c21-20(22,23)27-17-8-5-15(6-9-17)19(26)24-11-10-14-3-1-2-13-4-7-16(25)12-18(13)14/h1-9,12,25H,10-11H2,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231082
(CHEMBL252989 | N-((6-hydroxy-2,3,4,9-tetrahydro-1H...)Show SMILES Oc1ccc2[nH]c3CCCC(CNC(=O)c4ccc(OC(F)(F)F)cc4)c3c2c1 |w:10.10| Show InChI InChI=1S/C21H19F3N2O3/c22-21(23,24)29-15-7-4-12(5-8-15)20(28)25-11-13-2-1-3-18-19(13)16-10-14(27)6-9-17(16)26-18/h4-10,13,26-27H,1-3,11H2,(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231109
(CHEMBL254899 | N-(2,6-dichlorophenethyl)-4-(triflu...)Show InChI InChI=1S/C16H12Cl2F3NO2/c17-13-2-1-3-14(18)12(13)8-9-22-15(23)10-4-6-11(7-5-10)24-16(19,20)21/h1-7H,8-9H2,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 205 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231098
(CHEMBL253840 | N-(2,3-dihydro-1H-inden-5-yl)-4-(tr...)Show InChI InChI=1S/C17H14F3NO2/c18-17(19,20)23-15-8-5-12(6-9-15)16(22)21-14-7-4-11-2-1-3-13(11)10-14/h4-10H,1-3H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231068
(CHEMBL252782 | N-(4-tert-butylphenyl)-4-(trifluoro...)Show InChI InChI=1S/C18H18F3NO/c1-17(2,3)13-8-10-15(11-9-13)22-16(23)12-4-6-14(7-5-12)18(19,20)21/h4-11H,1-3H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231048
(4-(trifluoromethoxy)-N-(4-(trifluoromethyl)phenyl)...)Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C15H9F6NO2/c16-14(17,18)10-3-5-11(6-4-10)22-13(23)9-1-7-12(8-2-9)24-15(19,20)21/h1-8H,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231049
(CHEMBL400294 | N-(4-tert-butylphenyl)-4-(trifluoro...)Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(SC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C18H18F3NOS/c1-17(2,3)13-6-8-14(9-7-13)22-16(23)12-4-10-15(11-5-12)24-18(19,20)21/h4-11H,1-3H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 253 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50231043
(CHEMBL400086 | N-(4-tert-butylphenyl)-4-(1,1,2,2-t...)Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(OC(F)(F)C(F)F)cc2)cc1 Show InChI InChI=1S/C19H19F4NO2/c1-18(2,3)13-6-8-14(9-7-13)24-16(25)12-4-10-15(11-5-12)26-19(22,23)17(20)21/h4-11,17H,1-3H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231050
(CHEMBL252013 | N-(4-iodophenyl)-4-(trifluoromethox...)Show InChI InChI=1S/C14H9F3INO2/c15-14(16,17)21-12-7-1-9(2-8-12)13(20)19-11-5-3-10(18)4-6-11/h1-8H,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231097
(CHEMBL401308 | N-(4-iodophenyl)-4-(trifluoromethyl...)Show InChI InChI=1S/C14H9F3INO/c15-14(16,17)10-3-1-9(2-4-10)13(20)19-12-7-5-11(18)6-8-12/h1-8H,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231071
(CHEMBL400880 | biphenyl-4-carboxylic acid [2-(5-me...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(cc3)-c3ccccc3)c2c1 Show InChI InChI=1S/C24H22N2O2/c1-28-21-11-12-23-22(15-21)20(16-26-23)13-14-25-24(27)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h2-12,15-16,26H,13-14H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231064
(5-bromo-2-(4-(1,1,2,2-tetrafluoroethoxy)phenyl)-1H...)Show SMILES FC(F)C(F)(F)Oc1ccc(cc1)-c1nc2ccc(Br)cc2[nH]1 Show InChI InChI=1S/C15H9BrF4N2O/c16-9-3-6-11-12(7-9)22-13(21-11)8-1-4-10(5-2-8)23-15(19,20)14(17)18/h1-7,14H,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231053
(CHEMBL252583 | N-(2-(5-methoxy-1H-indol-3-yl)propy...)Show SMILES COc1ccc2[nH]cc(C(C)CNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 |w:9.9| Show InChI InChI=1S/C20H19F3N2O3/c1-12(17-11-24-18-8-7-15(27-2)9-16(17)18)10-25-19(26)13-3-5-14(6-4-13)28-20(21,22)23/h3-9,11-12,24H,10H2,1-2H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50231058
(CHEMBL438345 | N-((6-hydroxy-9-methyl-2,3,4,9-tetr...)Show SMILES Cn1c2CCCC(CNC(=O)c3ccc(OC(F)(F)F)cc3)c2c2cc(O)ccc12 |w:6.6| Show InChI InChI=1S/C22H21F3N2O3/c1-27-18-10-7-15(28)11-17(18)20-14(3-2-4-19(20)27)12-26-21(29)13-5-8-16(9-6-13)30-22(23,24)25/h5-11,14,28H,2-4,12H2,1H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231084
(5-tert-butyl-2-(4-(1,1,2,2-tetrafluoroethoxy)pheny...)Show SMILES CC(C)(C)c1ccc2nc([nH]c2c1)-c1ccc(OC(F)(F)C(F)F)cc1 Show InChI InChI=1S/C19H18F4N2O/c1-18(2,3)12-6-9-14-15(10-12)25-16(24-14)11-4-7-13(8-5-11)26-19(22,23)17(20)21/h4-10,17H,1-3H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 477 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231089
(CHEMBL398539 | N-((6-methoxy-9-methyl-2,3,4,9-tetr...)Show SMILES COc1ccc2n(C)c3CCCC(CNC(=O)c4ccc(OC(F)(F)F)cc4)c3c2c1 |w:12.12| Show InChI InChI=1S/C23H23F3N2O3/c1-28-19-11-10-17(30-2)12-18(19)21-15(4-3-5-20(21)28)13-27-22(29)14-6-8-16(9-7-14)31-23(24,25)26/h6-12,15H,3-5,13H2,1-2H3,(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231059
(CHEMBL252785 | N-(2-(5-hydroxy-1H-indol-3-yl)propy...)Show SMILES CC(CNC(=O)c1ccc(OC(F)(F)F)cc1)c1c[nH]c2ccc(O)cc12 |w:1.0| Show InChI InChI=1S/C19H17F3N2O3/c1-11(16-10-23-17-7-4-13(25)8-15(16)17)9-24-18(26)12-2-5-14(6-3-12)27-19(20,21)22/h2-8,10-11,23,25H,9H2,1H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231114
(CHEMBL254048 | N-(1-(6-hydroxyquinolin-4-yl)propan...)Show SMILES CC(Cc1ccnc2ccc(O)cc12)NC(=O)c1ccc(OC(F)(F)F)cc1 |w:1.0| Show InChI InChI=1S/C20H17F3N2O3/c1-12(10-14-8-9-24-18-7-4-15(26)11-17(14)18)25-19(27)13-2-5-16(6-3-13)28-20(21,22)23/h2-9,11-12,26H,10H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231108
(CHEMBL253014 | N-(2-chlorophenethyl)-4-(trifluorom...)Show InChI InChI=1S/C16H13ClF3NO2/c17-14-4-2-1-3-11(14)9-10-21-15(22)12-5-7-13(8-6-12)23-16(18,19)20/h1-8H,9-10H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 776 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231086
(CHEMBL251812 | N-(4-iodophenyl)-4-(2,2,2-trifluoro...)Show InChI InChI=1S/C15H9F3INO2/c16-15(17,18)13(21)9-1-3-10(4-2-9)14(22)20-12-7-5-11(19)6-8-12/h1-8H,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231057
(CHEMBL253843 | N-(2-(7-hydroxy-3,4-dihydroquinolin...)Show SMILES Oc1ccc2CCCN(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C19H19F3N2O3/c20-19(21,22)27-16-7-4-14(5-8-16)18(26)23-9-11-24-10-1-2-13-3-6-15(25)12-17(13)24/h3-8,12,25H,1-2,9-11H2,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231118
(4-cyclohexyl-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)b...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(cc3)C3CCCCC3)c2c1 Show InChI InChI=1S/C24H28N2O2/c1-28-21-11-12-23-22(15-21)20(16-26-23)13-14-25-24(27)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h7-12,15-17,26H,2-6,13-14H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231101
(CHEMBL253842 | N-(2-(6-hydroxyquinolin-4-yl)ethyl)...)Show SMILES Oc1ccc2nccc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C19H15F3N2O3/c20-19(21,22)27-15-4-1-13(2-5-15)18(26)24-10-8-12-7-9-23-17-6-3-14(25)11-16(12)17/h1-7,9,11,25H,8,10H2,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231123
(CHEMBL254673 | N-(2-(5-methoxy-1H-indol-3-yl)ethyl...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C19H17F3N2O3/c1-26-15-6-7-17-16(10-15)13(11-24-17)8-9-23-18(25)12-2-4-14(5-3-12)27-19(20,21)22/h2-7,10-11,24H,8-9H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231081
(CHEMBL399585 | N-(2-(7-hydroxy-1,2,3,4-tetrahydron...)Show SMILES Oc1ccc2CCCC(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 |w:8.8| Show InChI InChI=1S/C20H20F3NO3/c21-20(22,23)27-17-8-5-15(6-9-17)19(26)24-11-10-14-3-1-2-13-4-7-16(25)12-18(13)14/h4-9,12,14,25H,1-3,10-11H2,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231124
(CHEMBL400371 | N-(2-(7-methoxynaphthalen-1-yl)ethy...)Show SMILES COc1ccc2cccc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C21H18F3NO3/c1-27-18-10-5-14-3-2-4-15(19(14)13-18)11-12-25-20(26)16-6-8-17(9-7-16)28-21(22,23)24/h2-10,13H,11-12H2,1H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231042
(6,7-dichloro-5-(1-(pyridin-2-yl)propyl)quinoxaline...)Show SMILES CCC(c1ccccn1)c1c(Cl)c(Cl)cc2[nH]c(=O)c(=O)[nH]c12 |w:2.1| Show InChI InChI=1S/C16H13Cl2N3O2/c1-2-8(10-5-3-4-6-19-10)12-13(18)9(17)7-11-14(12)21-16(23)15(22)20-11/h3-8H,2H2,1H3,(H,20,22)(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231052
(2-(4-tert-butylphenyl)-5-(trifluoromethoxy)-1H-ben...)Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2ccc(OC(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C18H17F3N2O/c1-17(2,3)12-6-4-11(5-7-12)16-22-14-9-8-13(10-15(14)23-16)24-18(19,20)21/h4-10H,1-3H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231119
(CHEMBL254877 | N-(2-(5-methoxy-1H-indol-3-yl)ethyl...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(OC(F)(F)C(F)F)cc3)c2c1 Show InChI InChI=1S/C20H18F4N2O3/c1-28-15-6-7-17-16(10-15)13(11-26-17)8-9-25-18(27)12-2-4-14(5-3-12)29-20(23,24)19(21)22/h2-7,10-11,19,26H,8-9H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231074
(CHEMBL254878 | N-(2-(5-hydroxy-1H-indol-3-yl)ethyl...)Show SMILES Oc1ccc2[nH]cc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)26-14-4-1-11(2-5-14)17(25)22-8-7-12-10-23-16-6-3-13(24)9-15(12)16/h1-6,9-10,23-24H,7-8H2,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231104
(CHEMBL252987 | N-(2-(5-methoxy-1H-indol-3-yl)ethyl...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C24H22N2O3/c1-28-21-11-12-23-22(15-21)18(16-26-23)13-14-25-24(27)17-7-9-20(10-8-17)29-19-5-3-2-4-6-19/h2-12,15-16,26H,13-14H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231083
(CHEMBL254700 | N-(3-chlorophenethyl)-4-(trifluorom...)Show InChI InChI=1S/C16H13ClF3NO2/c17-13-3-1-2-11(10-13)8-9-21-15(22)12-4-6-14(7-5-12)23-16(18,19)20/h1-7,10H,8-9H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231106
(CHEMBL399709 | N-(2-(5-methoxy-1H-indol-3-yl)ethyl...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(cc3)C(F)(F)F)c2c1 Show InChI InChI=1S/C19H17F3N2O2/c1-26-15-6-7-17-16(10-15)13(11-24-17)8-9-23-18(25)12-2-4-14(5-3-12)19(20,21)22/h2-7,10-11,24H,8-9H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231085
(CHEMBL254905 | N-(2,4-dichlorophenethyl)-4-(triflu...)Show InChI InChI=1S/C16H12Cl2F3NO2/c17-12-4-1-10(14(18)9-12)7-8-22-15(23)11-2-5-13(6-3-11)24-16(19,20)21/h1-6,9H,7-8H2,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231100
(CHEMBL252990 | N-(2-(naphthalen-1-yl)ethyl)-4-(tri...)Show InChI InChI=1S/C20H16F3NO2/c21-20(22,23)26-17-10-8-16(9-11-17)19(25)24-13-12-15-6-3-5-14-4-1-2-7-18(14)15/h1-11H,12-13H2,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231072
(CHEMBL254697 | N-(2-(5-fluoro-1H-indol-3-yl)ethyl)...)Show SMILES Fc1ccc2[nH]cc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C18H14F4N2O2/c19-13-3-6-16-15(9-13)12(10-24-16)7-8-23-17(25)11-1-4-14(5-2-11)26-18(20,21)22/h1-6,9-10,24H,7-8H2,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231078
(CHEMBL253844 | N-(1-(7-methoxynaphthalen-1-yl)prop...)Show SMILES COc1ccc2cccc(CC(C)NC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 |w:11.11| Show InChI InChI=1S/C22H20F3NO3/c1-14(12-17-5-3-4-15-6-11-19(28-2)13-20(15)17)26-21(27)16-7-9-18(10-8-16)29-22(23,24)25/h3-11,13-14H,12H2,1-2H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231067
(CHEMBL252988 | N-(2-(5-hydroxy-2-methyl-1H-indol-3...)Show SMILES CC(CNC(=O)c1ccc(OC(F)(F)F)cc1)c1c(C)[nH]c2ccc(O)cc12 |w:1.0| Show InChI InChI=1S/C20H19F3N2O3/c1-11(18-12(2)25-17-8-5-14(26)9-16(17)18)10-24-19(27)13-3-6-15(7-4-13)28-20(21,22)23/h3-9,11,25-26H,10H2,1-2H3,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231107
(CHEMBL252178 | N-(2-(5-methoxy-1H-indol-3-yl)ethyl...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(OCC(F)(F)F)nc3)c2c1 Show InChI InChI=1S/C19H18F3N3O3/c1-27-14-3-4-16-15(8-14)12(9-24-16)6-7-23-18(26)13-2-5-17(25-10-13)28-11-19(20,21)22/h2-5,8-10,24H,6-7,11H2,1H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231070
(4-isobutyl-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)ben...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(CC(C)C)cc3)c2c1 Show InChI InChI=1S/C22H26N2O2/c1-15(2)12-16-4-6-17(7-5-16)22(25)23-11-10-18-14-24-21-9-8-19(26-3)13-20(18)21/h4-9,13-15,24H,10-12H2,1-3H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231063
(CHEMBL258008 | N-(2-fluorophenethyl)-4-(trifluorom...)Show InChI InChI=1S/C16H13F4NO2/c17-14-4-2-1-3-11(14)9-10-21-15(22)12-5-7-13(8-6-12)23-16(18,19)20/h1-8H,9-10H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231079
(CHEMBL400372 | N-(2-(6-methoxy-1H-indol-1-yl)ethyl...)Show SMILES COc1ccc2ccn(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C19H17F3N2O3/c1-26-16-7-2-13-8-10-24(17(13)12-16)11-9-23-18(25)14-3-5-15(6-4-14)27-19(20,21)22/h2-8,10,12H,9,11H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231113
(CHEMBL254906 | N-(3,4-dichlorophenethyl)-4-(triflu...)Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)NCCc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H12Cl2F3NO2/c17-13-6-1-10(9-14(13)18)7-8-22-15(23)11-2-4-12(5-3-11)24-16(19,20)21/h1-6,9H,7-8H2,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231087
(CHEMBL251781 | N-(2-(5-chloro-1H-indol-3-yl)ethyl)...)Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)NCCc1c[nH]c2ccc(Cl)cc12 Show InChI InChI=1S/C18H14ClF3N2O2/c19-13-3-6-16-15(9-13)12(10-24-16)7-8-23-17(25)11-1-4-14(5-2-11)26-18(20,21)22/h1-6,9-10,24H,7-8H2,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231066
(CHEMBL252177 | N-(2-(5-methoxy-1H-indol-3-yl)ethyl...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(nc3)-c3ccccc3)c2c1 Show InChI InChI=1S/C23H21N3O2/c1-28-19-8-10-22-20(13-19)17(14-26-22)11-12-24-23(27)18-7-9-21(25-15-18)16-5-3-2-4-6-16/h2-10,13-15,26H,11-12H2,1H3,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231061
(CHEMBL398275 | N-(2-(1H-indol-3-yl)ethyl)-4-(trifl...)Show InChI InChI=1S/C18H15F3N2O/c19-18(20,21)14-7-5-12(6-8-14)17(24)22-10-9-13-11-23-16-4-2-1-3-15(13)16/h1-8,11,23H,9-10H2,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231122
(CHEMBL253199 | N-(2-(3,4-dihydroquinolin-1(2H)-yl)...)Show InChI InChI=1S/C19H19F3N2O2/c20-19(21,22)26-16-9-7-15(8-10-16)18(25)23-11-13-24-12-3-5-14-4-1-2-6-17(14)24/h1-2,4,6-10H,3,5,11-13H2,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231105
(CHEMBL253622 | N-(2-(7-methoxy-1,2,3,4-tetrahydron...)Show SMILES COc1ccc2CCCC(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 |w:9.9| Show InChI InChI=1S/C21H22F3NO3/c1-27-18-10-5-14-3-2-4-15(19(14)13-18)11-12-25-20(26)16-6-8-17(9-7-16)28-21(22,23)24/h5-10,13,15H,2-4,11-12H2,1H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231112
(2-(4-tert-butylcyclohexyl)-5-(trifluoromethoxy)-1H...)Show SMILES CC(C)(C)C1CCC(CC1)c1nc2ccc(OC(F)(F)F)cc2[nH]1 |(4.16,-35.37,;2.62,-35.37,;2.62,-33.83,;2.62,-36.91,;1.08,-35.38,;.32,-36.71,;-1.22,-36.72,;-1.99,-35.39,;-1.24,-34.06,;.3,-34.04,;-3.53,-35.4,;-4.43,-36.65,;-5.9,-36.19,;-7.24,-36.97,;-8.58,-36.19,;-8.57,-34.65,;-9.91,-33.88,;-9.91,-32.34,;-9.92,-30.8,;-8.37,-32.34,;-11.45,-32.35,;-7.24,-33.88,;-5.91,-34.64,;-4.45,-34.16,)| Show InChI InChI=1S/C18H23F3N2O/c1-17(2,3)12-6-4-11(5-7-12)16-22-14-9-8-13(10-15(14)23-16)24-18(19,20)21/h8-12H,4-7H2,1-3H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231094
(CHEMBL252786 | N-(2-(5-methoxy-2-methyl-1H-indol-3...)Show SMILES COc1ccc2[nH]c(C)c(C(C)CNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 |w:10.10| Show InChI InChI=1S/C21H21F3N2O3/c1-12(19-13(2)26-18-9-8-16(28-3)10-17(18)19)11-25-20(27)14-4-6-15(7-5-14)29-21(22,23)24/h4-10,12,26H,11H2,1-3H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50231053
(CHEMBL252583 | N-(2-(5-methoxy-1H-indol-3-yl)propy...)Show SMILES COc1ccc2[nH]cc(C(C)CNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 |w:9.9| Show InChI InChI=1S/C20H19F3N2O3/c1-12(17-11-24-18-8-7-15(27-2)9-16(17)18)10-25-19(26)13-3-5-14(6-4-13)28-20(21,22)23/h3-9,11-12,24H,10H2,1-2H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231116
(CHEMBL253200 | N-(2-(1,2,3,4-tetrahydronaphthalen-...)Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)NCCC1CCCc2ccccc12 |w:16.16| Show InChI InChI=1S/C20H20F3NO2/c21-20(22,23)26-17-10-8-16(9-11-17)19(25)24-13-12-15-6-3-5-14-4-1-2-7-18(14)15/h1-2,4,7-11,15H,3,5-6,12-13H2,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231121
(5-(4-bromophenyl)-2-(4-(trifluoromethyl)phenyl)-1H...)Show SMILES FC(F)(F)c1ccc(cc1)-c1nc(c[nH]1)-c1ccc(Br)cc1 Show InChI InChI=1S/C16H10BrF3N2/c17-13-7-3-10(4-8-13)14-9-21-15(22-14)11-1-5-12(6-2-11)16(18,19)20/h1-9H,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231073
(CHEMBL398540 | N-(2-(isoquinolin-8-yl)ethyl)-4-(tr...)Show InChI InChI=1S/C19H15F3N2O2/c20-19(21,22)26-16-6-4-15(5-7-16)18(25)24-11-9-14-3-1-2-13-8-10-23-12-17(13)14/h1-8,10,12H,9,11H2,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231040
(CHEMBL253405 | N-(2-(1H-indol-1-yl)ethyl)-4-(trifl...)Show InChI InChI=1S/C18H15F3N2O2/c19-18(20,21)25-15-7-5-14(6-8-15)17(24)22-10-12-23-11-9-13-3-1-2-4-16(13)23/h1-9,11H,10,12H2,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231102
(CHEMBL254671 | N-(2-(1H-indol-3-yl)ethyl)-4-(trifl...)Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)NCCc1c[nH]c2ccccc12 Show InChI InChI=1S/C18H15F3N2O2/c19-18(20,21)25-14-7-5-12(6-8-14)17(24)22-10-9-13-11-23-16-4-2-1-3-15(13)16/h1-8,11,23H,9-10H2,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231090
(CHEMBL254047 | N-(1-(6-methoxyquinolin-4-yl)propan...)Show SMILES COc1ccc2nccc(CC(C)NC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 |w:11.11| Show InChI InChI=1S/C21H19F3N2O3/c1-13(11-15-9-10-25-19-8-7-17(28-2)12-18(15)19)26-20(27)14-3-5-16(6-4-14)29-21(22,23)24/h3-10,12-13H,11H2,1-2H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231046
(CHEMBL253841 | N-(3,5-di-tert-butylphenyl)-4-(trif...)Show SMILES CC(C)(C)c1cc(NC(=O)c2ccc(OC(F)(F)F)cc2)cc(c1)C(C)(C)C Show InChI InChI=1S/C22H26F3NO2/c1-20(2,3)15-11-16(21(4,5)6)13-17(12-15)26-19(27)14-7-9-18(10-8-14)28-22(23,24)25/h7-13H,1-6H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231055
(CHEMBL254252 | N-(4-tert-butylphenyl)-N-methyl-4-(...)Show SMILES CN(C(=O)c1ccc(OC(F)(F)F)cc1)c1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C19H20F3NO2/c1-18(2,3)14-7-9-15(10-8-14)23(4)17(24)13-5-11-16(12-6-13)25-19(20,21)22/h5-12H,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231115
(2-amino-2-(4-tert-butylphenyl)-1-(4-(trifluorometh...)Show SMILES CC(C)(C)c1ccc(cc1)C(N)C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C19H20F3NO2/c1-18(2,3)14-8-4-12(5-9-14)16(23)17(24)13-6-10-15(11-7-13)25-19(20,21)22/h4-11,16H,23H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231091
(2-(4-tert-butylphenyl)-1-(4-(trifluoromethyl)pheny...)Show InChI InChI=1S/C19H19F3O/c1-18(2,3)15-8-4-13(5-9-15)12-17(23)14-6-10-16(11-7-14)19(20,21)22/h4-11H,12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231093
(CHEMBL400676 | N-(4-tert-butylphenyl)-4-(2,2,2-tri...)Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(OCC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C19H20F3NO2/c1-18(2,3)14-6-8-15(9-7-14)23-17(24)13-4-10-16(11-5-13)25-12-19(20,21)22/h4-11H,12H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231077
(CHEMBL437395 | N-(2-(7-methoxy-3,4-dihydroquinolin...)Show SMILES COc1ccc2CCCN(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C20H21F3N2O3/c1-27-17-9-4-14-3-2-11-25(18(14)13-17)12-10-24-19(26)15-5-7-16(8-6-15)28-20(21,22)23/h4-9,13H,2-3,10-12H2,1H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231065
(CHEMBL254672 | N-(2-(1-methyl-1H-indol-3-yl)ethyl)...)Show InChI InChI=1S/C19H17F3N2O/c1-24-12-14(16-4-2-3-5-17(16)24)10-11-23-18(25)13-6-8-15(9-7-13)19(20,21)22/h2-9,12H,10-11H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231060
(CHEMBL253198 | N-(2-(quinolin-4-yl)ethyl)-4-(trifl...)Show InChI InChI=1S/C19H15F3N2O2/c20-19(21,22)26-15-7-5-14(6-8-15)18(25)24-12-10-13-9-11-23-17-4-2-1-3-16(13)17/h1-9,11H,10,12H2,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231041
(4-iodo-N-(4-(trifluoromethyl)phenyl)benzamide | CH...)Show InChI InChI=1S/C14H9F3INO/c15-14(16,17)10-3-7-12(8-4-10)19-13(20)9-1-5-11(18)6-2-9/h1-8H,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231054
(CHEMBL398909 | N-(2-(5-methoxy-1H-indol-3-yl)ethyl...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(nc3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H16F3N3O2/c1-26-13-3-4-15-14(8-13)11(9-23-15)6-7-22-17(25)12-2-5-16(24-10-12)18(19,20)21/h2-5,8-10,23H,6-7H2,1H3,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231103
(4-(2-(dimethylamino)ethoxy)-N-(2-(5-methoxy-1H-ind...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(OCCN(C)C)cc3)c2c1 Show InChI InChI=1S/C22H27N3O3/c1-25(2)12-13-28-18-6-4-16(5-7-18)22(26)23-11-10-17-15-24-21-9-8-19(27-3)14-20(17)21/h4-9,14-15,24H,10-13H2,1-3H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231117
(CHEMBL398908 | N-(2-(5-methoxy-1H-indol-3-yl)ethyl...)Show SMILES COc1ccc2[nH]cc(CCNC(=O)c3ccc(cc3)-c3ccncc3)c2c1 Show InChI InChI=1S/C23H21N3O2/c1-28-20-6-7-22-21(14-20)19(15-26-22)10-13-25-23(27)18-4-2-16(3-5-18)17-8-11-24-12-9-17/h2-9,11-12,14-15,26H,10,13H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231095
(CHEMBL252225 | N-(4-iodophenyl)-2-(trifluoromethyl...)Show InChI InChI=1S/C14H9F3INO/c15-14(16,17)12-4-2-1-3-11(12)13(20)19-10-7-5-9(18)6-8-10/h1-8H,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231056
(5-tert-butyl-2-(4-tert-butylphenyl)-1H-indole | CH...)Show SMILES CC(C)(C)c1ccc(cc1)-c1cc2cc(ccc2[nH]1)C(C)(C)C Show InChI InChI=1S/C22H27N/c1-21(2,3)17-9-7-15(8-10-17)20-14-16-13-18(22(4,5)6)11-12-19(16)23-20/h7-14,23H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231096
(CHEMBL251979 | N-(2-(5-tert-butyl-1H-indol-3-yl)et...)Show SMILES CC(C)(C)c1ccc2[nH]cc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C22H23F3N2O2/c1-21(2,3)16-6-9-19-18(12-16)15(13-27-19)10-11-26-20(28)14-4-7-17(8-5-14)29-22(23,24)25/h4-9,12-13,27H,10-11H2,1-3H3,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231045
(CHEMBL253407 | N-(2-(6-methoxyquinolin-4-yl)ethyl)...)Show SMILES COc1ccc2nccc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C20H17F3N2O3/c1-27-16-6-7-18-17(12-16)13(8-10-24-18)9-11-25-19(26)14-2-4-15(5-3-14)28-20(21,22)23/h2-8,10,12H,9,11H2,1H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231099
((Z)-3-(4-tert-butylphenyl)-2-(4-(trifluoromethyl)p...)Show SMILES CC(C)(C)c1ccc(\C=C(/C#N)c2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H18F3N/c1-19(2,3)17-8-4-14(5-9-17)12-16(13-24)15-6-10-18(11-7-15)20(21,22)23/h4-12H,1-3H3/b16-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231092
(CHEMBL254044 | N-(4-cyclohexylphenyl)-4-(trifluoro...)Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)Nc1ccc(cc1)C1CCCCC1 Show InChI InChI=1S/C20H20F3NO2/c21-20(22,23)26-18-12-8-16(9-13-18)19(25)24-17-10-6-15(7-11-17)14-4-2-1-3-5-14/h6-14H,1-5H2,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231120
(CHEMBL400930 | N-(4-iodophenyl)-4-(methylsulfonyl)...)Show InChI InChI=1S/C14H12INO3S/c1-20(18,19)13-8-2-10(3-9-13)14(17)16-12-6-4-11(15)5-7-12/h2-9H,1H3,(H,16,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231069
(CHEMBL253406 | N-(2-(4,7-dimethoxynaphthalen-1-yl)...)Show SMILES COc1ccc2c(OC)ccc(CCNC(=O)c3ccc(OC(F)(F)F)cc3)c2c1 Show InChI InChI=1S/C22H20F3NO4/c1-28-17-8-9-18-19(13-17)14(5-10-20(18)29-2)11-12-26-21(27)15-3-6-16(7-4-15)30-22(23,24)25/h3-10,13H,11-12H2,1-2H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231080
(4-acetyl-N-(4-iodophenyl)benzamide | CHEMBL252012)Show InChI InChI=1S/C15H12INO2/c1-10(18)11-2-4-12(5-3-11)15(19)17-14-8-6-13(16)7-9-14/h2-9H,1H3,(H,17,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231047
(2-(4-tert-butylphenyl)-5-(4-(trifluoromethyl)pheny...)Show SMILES CC(C)(C)c1ccc(cc1)-n1nnc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C18H17F3N4/c1-17(2,3)13-8-10-15(11-9-13)25-23-16(22-24-25)12-4-6-14(7-5-12)18(19,20)21/h4-11H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231111
(1-(4-iodophenyl)-3-(4-(trifluoromethyl)phenyl)urea...)Show InChI InChI=1S/C14H10F3IN2O/c15-14(16,17)9-1-5-11(6-2-9)19-13(21)20-12-7-3-10(18)4-8-12/h1-8H,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231062
(CHEMBL254045 | N-biphenyl-4-yl-4-trifluoromethoxy-...)Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14F3NO2/c21-20(22,23)26-18-12-8-16(9-13-18)19(25)24-17-10-6-15(7-11-17)14-4-2-1-3-5-14/h1-13H,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50231075
(CHEMBL252014 | N-(4-iodophenyl)-3-(trifluoromethyl...)Show InChI InChI=1S/C14H9F3INO/c15-14(16,17)10-3-1-2-9(8-10)13(20)19-12-6-4-11(18)5-7-12/h1-8H,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells |
Bioorg Med Chem Lett 18: 1072-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.007
BindingDB Entry DOI: 10.7270/Q2PZ58K9 |
More data for this
Ligand-Target Pair | |
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